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1
المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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2
المؤلفون: David A. Quincy, Nicholas R. Natale, Victoria Hulubei, John I. McKenna, Tina Houle, Scott A. Steiger, Mark E. Rogers, Scott B. Meikrantz
المصدر: Bioorganic & Medicinal Chemistry. 20:6613-6620
مصطلحات موضوعية: Dihydropyridines, Magnetic Resonance Spectroscopy, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Biochemistry, Article, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, Isoxazole, Molecular Biology, P-glycoprotein, biology, Voltage-dependent calcium channel, Organic Chemistry, Dihydropyridine, Transporter, Isoxazoles, Dicarbethoxydihydrocollidine, Multiple drug resistance, Models, Chemical, chemistry, biology.protein, Thermodynamics, Molecular Medicine, Calcium Channels, Caco-2 Cells, Protein Binding, medicine.drug
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3
المؤلفون: Roy K. Hom, Hing L. Sham, Kyle Powell, Gary Probst, Irene Griswold-Prenner, Simeon Bowers, Brian T. Peterson, Heather Zhang, Gergely Tóth, Frederique Bard, Jennifer Sealy, Karina Wong, Wayman Chan, May Lin, R. Jeffrey Neitz, Lany Ruslim, Bhushan Samant, David A. Quincy, Anh P. Truong, Robert A. Galemmo, Colin Lorentzen, Zhao Ren, Andrei W. Konradi, Mark Dryer, Wes Zmolek, Ted Yednock, Nanhua Yao, Erich Goldbach, Sarah J Wright, Hu Pan, Kevin P. Quinn, John-Michael Sauer, Dean R. Artis, George Tonn, Linda Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5521-5527
مصطلحات موضوعية: Models, Molecular, Drug, Metabolite, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Thiophenes, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Neurodegeneration, JNK Mitogen-Activated Protein Kinases, Brain, Stereoisomerism, medicine.disease, chemistry, Drug Design, Nerve Degeneration, Molecular Medicine, Penetrant (biochemical), Half-Life
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4
المؤلفون: Hing L. Sham, Gergley Tóth, Karina Wong, Ann Qin, Kyle Powell, David A. Quincy, Andrei W. Konradi, Nanhua Yao, Jennifer Sealy, David Chereau, Lany Ruslim, Gary Probst, Sarah J Wright, May Lin, Ted Yednock, Irene Griswold-Prenner, Wes Zmolek, Kevin P. Quinn, Hu Pan, Roy K. Hom, Simeon Bowers, Colin Lorentzen, Frederique Bard, John P. Anderson, Anh P. Truong, Zhao Ren, Robert A. Galemmo, John-Michael Sauer, Dean R. Artis, David F. Nakamura
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:315-319
مصطلحات موضوعية: Central Nervous System, Stereochemistry, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, Mitogen-Activated Protein Kinase 10, Drug Discovery, medicine, Animals, Humans, Mitogen-Activated Protein Kinase 9, Structure–activity relationship, Computer Simulation, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Triazines, Kinase, Chemistry, Organic Chemistry, Neurodegeneration, c-jun, Neurotoxicity, Neurodegenerative Diseases, medicine.disease, In vitro, Neuroprotective Agents, Mitogen-activated protein kinase, Microsomes, Liver, biology.protein, Molecular Medicine, Selectivity
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5
المؤلفون: David A. Quincy, William Shay, Charles R. Ross, James M. Takacs, Brian E. Jones
المصدر: Tetrahedron: Asymmetry. 8:3079-3087
مصطلحات موضوعية: Bicyclic molecule, Ligand, Organic Chemistry, Enantioselective synthesis, Oxazoline, Medicinal chemistry, Catalysis, Inorganic Chemistry, Metal, chemistry.chemical_compound, chemistry, visual_art, visual_art.visual_art_medium, Organic chemistry, Physical and Theoretical Chemistry, Enantiomeric excess, Trifluoromethanesulfonate
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6
المصدر: Tetrahedron: Asymmetry. 8:3073-3078
مصطلحات موضوعية: Cyclopentadiene, Ligand, Organic Chemistry, Enantioselective synthesis, Substituent, chemistry.chemical_element, Oxazoline, Zinc, Medicinal chemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Organic chemistry, Physical and Theoretical Chemistry, Trifluoromethanesulfonate
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7
المؤلفون: Angie Wadsworth, Wenxian Mao, Stellanie Simmonds, Eric Peterson, Christopher Vandevert, F. Bong San Pablo, Ted Yednock, Ying-Zi Xu, David A. Quincy, Carlos Lorenzana, Andrei W. Konradi, Kassandra Inez Rossiter, Michael S. Dappen, Michael A. Pleiss, Frederique Bard, Elizabeth Messersmith, Brian Wipke, Caroline Garrido, Jenifer L. Smith, Christopher M. Semko, Jacek Jagodzinski, Lilibeth Dofiles
المصدر: Bioorganicmedicinal chemistry letters. 23(14)
مصطلحات موضوعية: Injections, Subcutaneous, Integrin alpha4, Clinical Biochemistry, Pharmaceutical Science, Cleavage (embryo), Biochemistry, α4β7 integrin, Polyethylene Glycols, Jurkat Cells, In vivo, Drug Discovery, PEG ratio, Animals, Humans, α4 integrin, α4β1 integrin, Molecular Biology, Chemistry, Organic Chemistry, Antibodies, Monoclonal, Esters, Rats, Molecular Medicine, Conjugate, Half-Life
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8
المؤلفون: Bhushan Samant, Mark Shoemaker, Michael Krimm, Elizabeth Messersmith, Brent Welch, John-Michael Sauer, Linda Chen, Michael S. Dappen, Wenxian Mao, Zhenmei Liao, Ted Yednock, Jenifer L. Smith, Carrol Henschel, Nancy G. Wehner, Lilibeth Dofiles, Ian Gallager, Linda Mutter, Michael A. Pleiss, Mark Dreyer, David A. Quincy, Andrei W. Konradi, Hongbin Zhang, Christopher M. Semko, Kassandra Inez Rossiter, Eric Petersen, George Shopp, Juri Y Fukuda, Brian Wipke, Christopher Vandevert, Frederique Bard, Judevin Lugar, Ying-Zi Xu
المصدر: Bioorganicmedicinal chemistry letters. 23(15)
مصطلحات موضوعية: Integrins, Clinical Biochemistry, Rat model, Pharmaceutical Science, Arthritis, Administration, Oral, Pharmacology, Integrin alpha4beta1, Biochemistry, Jurkat cells, α4β7 integrin, Arthritis, Rheumatoid, Jurkat Cells, Crohn Disease, Drug Discovery, Area under curve, medicine, Animals, Humans, Molecular Biology, Chemistry, Organic Chemistry, medicine.disease, Rats, Disease Models, Animal, Liver metabolism, Rheumatoid arthritis, Area Under Curve, Microsomes, Liver, Molecular Medicine, Half-Life
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9
المؤلفون: Brian E. Jones, David A. Quincy, James M. Takacs, Charles R. Ross, William Shay
المصدر: ChemInform. 29
مصطلحات موضوعية: Bicyclic molecule, Ligand, Enantioselective synthesis, General Medicine, Oxazoline, Medicinal chemistry, Catalysis, Metal, chemistry.chemical_compound, chemistry, visual_art, visual_art.visual_art_medium, Enantiomeric excess, Trifluoromethanesulfonate
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10Structure-function studies in a series of carboxyl-terminal octapeptide analogs of anaphylatoxin C5a
المؤلفون: Karl W. Mollison, Jay R. Luly, Megumi Kawai, David A. Quincy, Benjamin C. Lane, Yat Sun Or, George W. Carter
المصدر: Journal of Medicinal Chemistry. 35:220-223
مصطلحات موضوعية: Agonist, Neutrophils, Stereochemistry, medicine.drug_class, Molecular Sequence Data, Complement C5a, In Vitro Techniques, Binding, Competitive, Structure-Activity Relationship, Cell surface receptor, Sequence Homology, Nucleic Acid, Drug Discovery, medicine, Animals, Humans, Anaphylatoxin, Amino Acid Sequence, Receptor, Anaphylatoxin C5a, Anaphylatoxin C5a, chemistry.chemical_classification, Oligopeptide, Structure function, Ligand (biochemistry), Receptors, Complement, Amino acid, Chemotaxis, Leukocyte, Biochemistry, chemistry, Molecular Medicine, Oligopeptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be466253f6814a7799325de62d1168d
https://doi.org/10.1021/jm00080a004
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