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1
المؤلفون: Niall M. B. Martin, Bastiaan Evers, Charlotte Knights, Janneke E. Jaspers, Jos Jonkers, Attilla Ting, Henry Brown, Keith W. Caldecott, Sven Rottenberg, Rajesh Odedra, Lenka Oplustil O'Connor, Robert Hugh Bradbury, Aaron Cranston, David Alan Rudge, Mark J. O'Connor, Marina Pajic, Louise J. Jones, Alan Lau, Stuart L. Rulten
المصدر: Cancer Research. 76:6084-6094
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Repair, medicine.medical_treatment, Genes, BRCA1, Synthetic lethality, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Biology, Q1, Piperazines, Olaparib, Mice, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Bone Marrow, Cell Line, Tumor, Drug Discovery, Temozolomide, medicine, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, PARP Inhibitor AZD2461, Chemotherapy, Cancer, Neoplasms, Experimental, medicine.disease, Xenograft Model Antitumor Assays, Rats, 3. Good health, Dacarbazine, 030104 developmental biology, medicine.anatomical_structure, Oncology, Tolerability, chemistry, PARP inhibitor, Phthalazines, Bone marrow, Poly(ADP-ribose) Polymerases, DNA Damage
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318c6f6c6cc972443af48c50dbf1283f
https://doi.org/10.1158/0008-5472.can-15-3240 -
2
المؤلفون: Iain Simpson, Craig A. Roberts, Carr Gregory Richard, David Alan Rudge, Gail L. Wrigley, James L. Feron, Johnson Paul David
المصدر: Tetrahedron Letters. 53:5049-5055
مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Organic Chemistry, chemistry.chemical_element, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Amide, Intramolecular force, Yield (chemistry), Drug Discovery, Molecule, Amine gas treating, Alkyl, Palladium
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المؤلفون: Andrew Peter Thomas, Anne-Kathrin Schott, Jennifer H. Pink, Jason Breed, Karen Roberts, David M. Andrews, Andrew G. Leach, Richard A. Norman, Derek Ogg, Andrew P. Garner, Jonathon P. Orme, David Alan Rudge, Kevin Michael Foote
المصدر: Journal of Medicinal Chemistry. 55:5003-5012
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Crystallography, X-Ray, Ligands, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, Fibroblast Growth Factor, Type 1, Phosphorylation, Binding site, Mice, Knockout, chemistry.chemical_classification, Binding Sites, Molecular Structure, Kinase, Pyrimidines, Enzyme, chemistry, Fibroblast growth factor receptor, Drug Design, Pyrazoles, Molecular Medicine, Dimerization, Tyrosine kinase, Protein ligand
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المؤلفون: David Alan Rudge
المصدر: Laboratory Automation & Information Management. 33:81-86
مصطلحات موضوعية: Scope (project management), Leadership and Management, Computer science, business.industry, Robotics, Automation, Solution phase, Identification (information), Robotic systems, Systems engineering, Robot, Artificial intelligence, Isolation (database systems), business, Simulation
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المؤلفون: James L. Feron, Greory R. Carr, Gail L. Wrigley, Iain Simpson, Craig A. Roberts, Johnson Paul David, David Alan Rudge
المصدر: ChemInform. 43
مصطلحات موضوعية: chemistry, Intramolecular force, Intramolecular cyclization, chemistry.chemical_element, General Medicine, Combinatorial chemistry, Palladium, Catalysis
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المؤلفون: David Anthony Roberts, A.C. Reid, S. T. Russell, C. P. Allott, Richard W. A. Luke, A.A. Oldham, Eric Fisher, R.J. Pearce, Michael Dennis, Robert Hugh Bradbury, J. S. Major, David Alan Rudge
المصدر: Bioorganic & Medicinal Chemistry Letters. 3:899-904
مصطلحات موضوعية: Angiotensin receptor, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Quinoline, Pharmaceutical Science, Pharmacology, Biochemistry, Angiotensin II, Guinea pig, chemistry.chemical_compound, Animal model, Pressor response, Drug Discovery, Pyridine, Molecular Medicine, Membrane binding, Molecular Biology
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المؤلفون: Kin Yip Tam, David Alan Rudge, Julie A. Tucker, Louise Moss, Barker Andrew John, Clifford David Jones, Peter B. Simpson, Alexandra McGregor, David M. Andrews, Michael A. Walker, Kevin Blades, Catherine Geh, Swain Michael Lingard, S J East, Keith M. Johnson, Heather M. McFarland, Mark A. Graham, Sarah A. Loddick, Paula Daunt
المصدر: Bioorganicmedicinal chemistry letters. 18(24)
مصطلحات موضوعية: ERG1 Potassium Channel, Pyrimidine, Clinical Biochemistry, hERG, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Cyclin-dependent kinase, Cell Line, Tumor, Drug Discovery, Imidazole, Humans, Protein Isoforms, Infusions, Intravenous, Molecular Biology, Protein Kinase Inhibitors, Cyclin-Dependent Kinase Inhibitor Proteins, biology, Chemistry, Chemistry, Physical, Organic Chemistry, Imidazoles, Biological activity, Amides, Ether-A-Go-Go Potassium Channels, Pyrimidines, Models, Chemical, Enzyme inhibitor, Drug Design, Lipophilicity, biology.protein, Molecular Medicine, CDK inhibitor, Neoplasm Transplantation
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المؤلفون: Linette Ruston, Tanya Coleman, Robin Smith, Teresa Klinowska, David Buttar, Maria-Elena Theoclitou, Andrew Peter Thomas, Paul R. Gavine, Nigel Brooks, Lorraine Mooney, David Alan Rudge, Gail L. Wrigley, Michael Dennis
المصدر: Cancer Research. 72:3912-3912
مصطلحات موضوعية: Cancer Research, medicine.drug_class, Fibroblast growth factor receptor 1, Cancer, Biology, Pharmacology, medicine.disease, Tyrosine-kinase inhibitor, chemistry.chemical_compound, Oncology, chemistry, In vivo, Fibroblast growth factor receptor, medicine, Efflux, Binding site, Benzamide
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::95e7e03c031e9772c57e9cb08d8ae421
https://doi.org/10.1158/1538-7445.am2012-3912