المؤلفون: Dawn M George, Raymond J Huntley, Kevin Cusack, David B Duignan, Michael Hoemann, Jacqueline Loud, Regina Mario, Terry Melim, Kelly Mullen, Gagandeep Somal, Lu Wang, Jeremy J Edmunds

المصدر: PLoS ONE, Vol 13, Iss 9, p e0203567 (2018)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC6128612?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/f9e4d7a1ef864cb18c1b355c36fdb091

المؤلفون: Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox

المصدر: Journal of Medicinal Chemistry. 64:417-429

مصطلحات موضوعية: Drug, media_common.quotation_subject, medicine.medical_treatment, Allosteric regulation, Administration, Oral, Arthritis, Pharmacology, Ligands, 01 natural sciences, Autoimmune Diseases, Arthritis, Rheumatoid, Mice, 03 medical and health sciences, Allosteric Regulation, In vivo, Drug Discovery, medicine, Animals, 030304 developmental biology, media_common, Biological Products, 0303 health sciences, Tumor Necrosis Factor-alpha, Chemistry, Drug discovery, medicine.disease, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cytokine, Drug Design, Molecular Medicine, Tumor necrosis factor alpha

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280

المؤلفون: Sami Osman, Christian Goess, Xiazi Qiu, David B. Duignan, Qin C. Ji, John P. Savaryn, Gary J. Jenkins

المصدر: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1180

مصطلحات موضوعية: Mice, Inbred BALB C, Chromatography, Chemistry, Clinical Biochemistry, Exotoxins, Reproducibility of Results, Leukotoxin-diol, Cell Biology, General Medicine, Plasma volume, Biochemistry, Analytical Chemistry, Single oral dose, Matrix (chemical analysis), Mice, Liquid chromatography–mass spectrometry, Tandem Mass Spectrometry, Potential biomarkers, Lc ms ms, Animals, Female, Pre concentration, Biomarkers, Stearic Acids, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8252d2289ab328e61a0d3c50faec6bed
https://pubmed.ncbi.nlm.nih.gov/34450476

المؤلفون: Anshul Gupta, Jennifer L. Liras, Stephen Fowler, W. George Lai, Jane R. Kenny, Jonathan A. Phillips, Jinping Gan, Niresh Hariparsad, David B. Duignan, Wen Li Kelly Chen

المصدر: Lab on a chip. 20(3)

مصطلحات موضوعية: Drug Industry, Computer science, Biomedical Engineering, Drug Evaluation, Preclinical, Bioengineering, Context (language use), 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Lab-On-A-Chip Devices, Animals, Humans, 030304 developmental biology, Pharmaceutical industry, ADME, 0303 health sciences, System development, business.industry, Drug discovery, General Chemistry, Human physiology, Microfluidic Analytical Techniques, Drug development, Risk analysis (engineering), Pharmaceutical Preparations, Proof of concept, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7999b04fd17f88b03091a6f0d36dc64
https://pubmed.ncbi.nlm.nih.gov/31932816

المؤلفون: Douglas A. Keller, Brian R. Berridge, Ananthsrinivas Chakilam, Yvonne Will, Monicah A. Otieno, Kristin M. Fabre, David B. Duignan, Yvonne P. Dragan, Lorna Ewart, Terry R. Van Vleet, Danilo A. Tagle, Claire G. Jeong, Jinping Gan, Peggy Guzzie-Peck, Jonathan A. Phillips, Jeetu Eswaraka, Sonia M. de Morais, David E. Watson, Radhakrishna Sura, William R Proctor

المصدر: Experimental Biology and Medicine. 242:1579-1585

مصطلحات موضوعية: 0301 basic medicine, Knowledge management, Drug Industry, business.industry, End user, Microfluidics, Liability, Drug Evaluation, Preclinical, Context (language use), General Biochemistry, Genetics and Molecular Biology, Biotechnology, 03 medical and health sciences, 030104 developmental biology, Resource (project management), Lab-On-A-Chip Devices, Paradigm shift, General partnership, Microchip Analytical Procedures, Commentary, Humans, business, Pace, Pharmaceutical industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128a14f0b4ce35a220ee4e7ecd5eeff
https://doi.org/10.1177/1535370217715441

المؤلفون: Wilson Noel S, Gagandeep Somal, Michael Z. Hoemann, Don Konopacki, Maria A. Argiriadi, Anil Vasudevan, David B. Duignan, Bruce Clapham, David Banach, Phil B. Cox, Andrew Burchat, David J. Calderwood

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5562-5567

مصطلحات موضوعية: 0301 basic medicine, Pyrimidine, Clinical Biochemistry, Pharmaceutical Science, Syk, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Syk Kinase, Potency, Furans, Protein Kinase Inhibitors, Molecular Biology, ADME, chemistry.chemical_classification, Kinase, Organic Chemistry, Arthritis, Experimental, Rats, Molecular Docking Simulation, Pyrimidines, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9516261e3731d757da98b64f609b1a0f
https://doi.org/10.1016/j.bmcl.2016.09.077

المؤلفون: Kevin P. Cusack, David B. Duignan, Jacqueline Loud, Michael Z. Hoemann, Lu Wang, Kelly D. Mullen, Regina Mario, Jeremy J. Edmunds, Dawn M. George, Gagandeep Somal, Raymond Huntley, Terry Melim

المصدر: PLoS ONE, Vol 13, Iss 9, p e0203567 (2018)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Physiology, Glycobiology, Drug Evaluation, Preclinical, lcsh:Medicine, Pharmacology, Chemical synthesis, Biochemistry, Monocytes, Mass Spectrometry, Analytical Chemistry, White Blood Cells, Mice, 0302 clinical medicine, Spectrum Analysis Techniques, Animal Cells, Medicine and Health Sciences, Prodrugs, Receptor, lcsh:Science, Glucans, chemistry.chemical_classification, Liquid Chromatography, Multidisciplinary, Cyclodextrin, Molecular Structure, Chemistry, Organic Compounds, Chromatographic Techniques, Dextran Sulfate, Pro-Drugs, Drugs, Prodrug, Colitis, Body Fluids, Blood, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, 030220 oncology & carcinogenesis, Physical Sciences, Female, Anatomy, Cellular Types, Research Article, Colon, Immune Cells, Liquid Chromatography-Mass Spectrometry, Immunology, Research and Analysis Methods, Colony stimulating factor 1 receptor, 03 medical and health sciences, Therapeutic index, In vivo, Polysaccharides, medicine, Animals, Dextran, Cyclodextrins, Blood Cells, Macrophages, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, Cell Biology, medicine.disease, Gastrointestinal Tract, Disease Models, Animal, 030104 developmental biology, Alcohols, lcsh:Q, Digestive System

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4342c0d0784cf989301c8a18f47c3a
http://europepmc.org/articles/PMC6128612?pdf=render

المؤلفون: Youngjae Kim, Michelle Hart, Gary Gintant, Christopher M. Harris, Patricia N. Banfor, Jason A. Segreti, Scott W Mittelstadt, Peter Bousquet, David B. Duignan

المصدر: The Journal of pharmacology and experimental therapeutics. 359(1)

مصطلحات موضوعية: 0301 basic medicine, Bradycardia, Cardiac function curve, Male, medicine.medical_specialty, Sphingosine-1-phosphate receptor, Pharmacology, Biology, Piperazines, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Immune system, Sphingosine, Internal medicine, medicine, Animals, Sphingosine-1-phosphate, Enzyme Inhibitors, Receptor, Aldehyde-Lyases, Dose-Response Relationship, Drug, Myocardium, Heart, Fingolimod, Rats, 030104 developmental biology, Endocrinology, Lymphatic system, chemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, Lysophospholipids, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68005f0c0752bb145e9cc14f0a1cf53
https://pubmed.ncbi.nlm.nih.gov/27519818

المؤلفون: Jing Chen, Spiros Liras, Manthena V.S. Varma, Judith L. Treadway, Martha L. Minich, Laurel Sweet, John D. Knafels, Karen Atkinson, Nahor Haddish-Berhane, Angel Guzman-Perez, Benjamin D. Stevens, Alan Robertson, Sharad B. Murdande, David B. Duignan, Mark Ammirati, Timothy P. Rolph, William J. Zavadoski, Christopher S. Jones, Patricia Bourassa, Jeffrey A. Pfefferkorn, John Litchfield, Lili Yao, Kevin J. Filipski, Margit MacDougall, Levenia Baker, John C. Pettersen, Theresa D’Aquila, Ayman El-Kattan, Bo Feng, Francis Bourbonais, Meihua Tu, Robert J. Aiello, Gary Erik Aspnes, Jianwei Bian, David R. Derksen, Paul DaSilva-Jardine, Beijing Tan, James A. Landro, Over Cabrera, Rachel E. Kosa, Hud Lawrence Risley, Shenping Liu, Amanda L. Lapworth, Nicole Barucci

المصدر: Journal of Medicinal Chemistry. 55:1318-1333

مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, medicine.medical_specialty, Allosteric regulation, Enzyme Activators, Organic Anion Transporters, In Vitro Techniques, Hypoglycemia, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Insulin-Secreting Cells, Internal medicine, Glucokinase, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Glucose homeostasis, Tissue Distribution, Rats, Wistar, chemistry.chemical_classification, Chemistry, Activator (genetics), Imidazoles, Nicotinic Acids, Type 2 Diabetes Mellitus, Stereoisomerism, Haplorhini, medicine.disease, Small molecule, Rats, Enzyme, Endocrinology, Diabetes Mellitus, Type 2, Hepatocytes, Molecular Medicine, Allosteric Site, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4c2ff700899b62627c8e68d3696bfd
https://doi.org/10.1021/jm2014887

المؤلفون: Yurong Lai, Yi-an Bi, David B. Duignan, Na Li

المصدر: Molecular Pharmaceutics. 6:1180-1189

مصطلحات موضوعية: Cell Culture Techniques, Pharmaceutical Science, Biology, Immunoenzyme Techniques, Excretion, In vivo, Drug Discovery, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, Cells, Cultured, ADME, Multidrug resistance-associated protein 2, Bile Canaliculi, Transporter, Bile Salt Export Pump, Multidrug Resistance-Associated Protein 2, In vitro, Neoplasm Proteins, Rats, Cell biology, Biochemistry, Cell culture, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Hepatocytes, Molecular Medicine, ATP-Binding Cassette Transporters, Multidrug Resistance-Associated Proteins, Biomarkers, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca181e22967f5ef5c4f4fb0fc34e0c1b
https://doi.org/10.1021/mp900044x