نتائج البحث - "David C, Dalgarno"

1

دورية أكاديمية

High-throughput prediction of protein conformational distributions with subsampled AlphaFold2

المؤلفون: Gabriel Monteiro da Silva, Jennifer Y. Cui, David C. Dalgarno, George P. Lisi, Brenda M. Rubenstein

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/7f2e13d81e424a5eb5b8c27b36adc5cd

Find this article in full text from Springer Verlag.

Find this article in full text from ProQuest

Full Text Finder

2

دورية أكاديمية

Author Correction: High-throughput prediction of protein conformational distributions with subsampled AlphaFold2

المؤلفون: Gabriel Monteiro da Silva, Jennifer Y. Cui, David C. Dalgarno, George P. Lisi, Brenda M. Rubenstein

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/0eb397448ffd43329fab78f7c063809e

Find this article in full text from Springer Verlag.

Find this article in full text from ProQuest

Full Text Finder

3

Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer

المصدر: Bioorganic & Medicinal Chemistry Letters. 80:129084

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36257c29b5ae4b54e2d345df53177fd7
https://doi.org/10.1016/j.bmcl.2022.129084

View record from ScienceDirect

4

Abstract 3342: Discovery of potent and selective next-generation EGFR inhibitors with activity against single, double, and triple mutant EGFR variants including T790M and C797S

المؤلفون: Wei-Sheng Huang, Sara Nadworny, Narayana Narasimhan, Charles J. Eyermann, David C. Dalgarno, Victor M. Rivera, William C. Shakespeare

المصدر: Cancer Research. 82:3342-3342

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3b478b2d980afa91a4eec642fa30c3f7
https://doi.org/10.1158/1538-7445.am2022-3342

5

Abstract 1292: Preclinical characterization of THE-630, a next-generation inhibitor for KIT-mutant gastrointestinal stromal tumors (GIST)

المؤلفون: David C. Dalgarno, Mengrou Lu, Justin R. Pritchard, Victor Rivera, William C. Shakespeare, Wei-Sheng Huang

المصدر: Cancer Research. 81:1292-1292

مصطلحات موضوعية: Cancer Research, Stromal cell, Oncology, GiST, Mutant, Cancer research, Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ce5390064913679f2b251b3b095dfe80
https://doi.org/10.1158/1538-7445.am2021-1292

6

دورية أكاديمية

Novel Protein Kinase Inhibitors: SMART Drug Design Technology

المؤلفون: Tomi K. Sawyer, Regine S. Bohacek, Chester A. Metcalf III, William C. Shakespeare, Yihan Wang, Raji Sundaramoorthi, Terence Keenan, Surinder Narula, Manfred Weigele, David C. Dalgarno

المصدر: BioTechniques, Vol 34, Iss 6S, Pp S2-S15 (2003)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

URL الوصول: https://doaj.org/article/2a7a4be570f14a5eb30fe9249ca4314e

PDF full text from Publisher

Full Text Finder

7

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase

المصدر: Journal of medicinal chemistry. 59(10)

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Brigatinib, Cell Survival, Phosphines, Molecular Conformation, Administration, Oral, Antineoplastic Agents, Mice, SCID, Bioinformatics, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Organophosphorus Compounds, hemic and lymphatic diseases, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Anaplastic lymphoma kinase, Animals, Humans, Anaplastic Lymphoma Kinase, Lung cancer, Protein Kinase Inhibitors, ADME, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Kinase, Chemistry, Receptor Protein-Tyrosine Kinases, Neoplasms, Experimental, medicine.disease, Lymphoma, Rats, 030104 developmental biology, Enzyme, Pyrimidines, Protein kinase domain, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Female, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625d183379f1d6b062d2872fda27b944
https://pubmed.ncbi.nlm.nih.gov/27144831

Find this issue from the American Chemical Society

8

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 22(22)

مصطلحات موضوعية: 0301 basic medicine, Alectinib, Cancer Research, Lung Neoplasms, Brigatinib, medicine.drug_class, Pyridines, Antineoplastic Agents, Biology, 03 medical and health sciences, 0302 clinical medicine, Organophosphorus Compounds, Crizotinib, hemic and lymphatic diseases, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, ROS1, Anaplastic lymphoma kinase, Humans, Anaplastic Lymphoma Kinase, Sulfones, Protein Kinase Inhibitors, Ceritinib, ALK Gene Rearrangement, Receptor Protein-Tyrosine Kinases, Hep G2 Cells, U937 Cells, ALK inhibitor, 030104 developmental biology, Pyrimidines, Oncology, Biochemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, Pyrazoles, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a954184cf0503cf7aa96ae269a34c3cb
https://pubmed.ncbi.nlm.nih.gov/27780853

9

Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery

المؤلفون: Stephan G. Zech, Feng Li, Rachel M. Squillace, R. Mathew Thomas, David C. Dalgarno, David Miller, Yihan Wang, Matthew T. Greenfield, Xiaotian Zhu, William C. Shakespeare, Yongjin Xu, Jiwei Qi, Lois Parillon, Tianjun Zhou, Anna Kohlmann, Juan J. Miret

المصدر: Journal of medicinal chemistry. 59(2)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Choline kinase, Phosphorylcholine, Fragment-based lead discovery, Antineoplastic Agents, Apoptosis, medicine.disease_cause, Crystallography, X-Ray, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Choline Kinase, Humans, Enzyme Inhibitors, Phosphocholine, Cell Proliferation, chemistry.chemical_classification, Oncogene, Dose-Response Relationship, Drug, Cell growth, Small molecule, High-Throughput Screening Assays, 030104 developmental biology, Enzyme, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Carcinogenesis, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f08ea23a5fe9e235b1147b5ff77d60c
https://pubmed.ncbi.nlm.nih.gov/26700752

Find this issue from the American Chemical Society

10

Crizotinib‐Resistant Mutants of EML4‐ALK Identified Through an Accelerated Mutagenesis Screen

المؤلفون: Sen Zhang, Tim Clackson, David C. Dalgarno, Victor M. Rivera, Xiaotian Zhu, William C. Shakespeare, Scott Wardwell, Narayana I. Narasimhan, Lauren Moran, Qurish K. Mohemmad, Jeffrey A. Keats, Rana Anjum, Yaoyu Ning, Juan J. Miret, Yihan Wang, Frank Wang

المصدر: Chemical Biology & Drug Design

مصطلحات موضوعية: Lung Neoplasms, Pyridines, medicine.drug_class, EML4-ALK, Mutagenesis (molecular biology technique), Biology, medicine.disease_cause, Biochemistry, resistance, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, medicine, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Lung cancer, Protein Kinase Inhibitors, Pharmacology, crizotinib, Mutation, Crizotinib, Kinase, Organic Chemistry, Receptor Protein-Tyrosine Kinases, medicine.disease, ENU mutagenesis, Molecular biology, Research Letters, gatekeeper, ALK inhibitor, Pyrimidines, Protein kinase domain, Drug Resistance, Neoplasm, Cancer research, Pyrazoles, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f1b2a369ba7aad684338c137f1aa03
https://doi.org/10.1111/j.1747-0285.2011.01239.x

View record at Wiley

تنقيح النتائج