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المؤلفون: James J. Mousseau, Matthew A. Perry, Mark W. Bundesmann, Gary M. Chinigo, Chulho Choi, Gary Gallego, Robert W. Hicklin, Susan Hoy, David C. Limburg, Neal W. Sach, Yuan Zhang
المصدر: ACS Catalysis. 12:600-606
مصطلحات موضوعية: General Chemistry, Catalysis
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المؤلفون: Cheryl Myers Hayward, Ruggeri Sally G, David C. Limburg, John G. Van Alsten, Ruizhi Li, Steve M. Guinness, John C. Lucas, Scott Bader, Steve Hoagland, Bryan Li, Raggon Jeffrey W, J. Christopher McWilliams
المصدر: Journal of Flow Chemistry. 10:145-156
مصطلحات موضوعية: Fluid Flow and Transfer Processes, Green chemistry, Aqueous solution, 010405 organic chemistry, Organic Chemistry, Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Chloride, 0104 chemical sciences, chemistry.chemical_compound, Ammonia, Benzylamine, Aminolysis, chemistry, Chemistry (miscellaneous), Nucleophilic aromatic substitution, medicine, SN2 reaction, medicine.drug
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المؤلفون: James J. Mousseau, Matthew A. Perry, Mark W. Bundesmann, Gary M. Chinigo, Chulho Choi, Gary M. Gallego, Robert W. Hicklin, Susan Hoy, David C. Limburg, Neal W. Sach, Yuan Zhang
المصدر: ACS Catalysis. 12:2472-2472
مصطلحات موضوعية: General Chemistry, Catalysis
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المؤلفون: Brett D. Hollingshead, Fabien Vincent, Tsung H. Lin, John I. Trujillo, Betsy Pierce, Andrew Fensome, Brian S. Gerstenberger, Martin E. Dowty, Matthew Frank Brown, Xin Yang, David C. Limburg, Martin Hegen, John D. Knafels, Felix Vajdos, Andrew C. Flick, Mary Ellen Banker, Raman Sharma, Li Xing, Jason Jussif, Catherine M. Ambler, Ivan Viktorovich Efremov, James D. Clark, Liying Zhang, Peter T. Symanowicz, Eddine Saiah, Jill Chrencik, Jean-Baptiste Telliez, Xiaojing Yang, Eric P. Arnold, Ariamala Gopalsamy, Zhao-Kui Wan, Matthew Merrill Hayward, David W. Lin
المصدر: Journal of Medicinal Chemistry. 61:8597-8612
مصطلحات موضوعية: 0301 basic medicine, Janus kinase 1, Chemistry, medicine.medical_treatment, Interleukin, Arthritis, Pharmacology, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cytokine, Interferon, Tyrosine kinase 2, 030220 oncology & carcinogenesis, Drug Discovery, medicine, STAT protein, Molecular Medicine, Janus kinase, medicine.drug
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المؤلفون: David C. Limburg, Andrew Fensome, Fabien Vincent, Betsy Pierce, Martin E. Dowty, Mary Ellen Banker, Raman Sharma, Xin Yang, Ariamala Gopalsamy, Roger S. Gifford, Brian S. Gerstenberger, Andrew C. Flick, Eric P. Arnold, Jason Jussif, Ivan Viktorovich Efremov, Xiaojing Yang, Martin Hegen, Zhao-Kui Wan, Felix Vajdos, Catherine M. Ambler, James D. Clark, Tsung H. Lin, John I. Trujillo, Li Xing
المصدر: Bioorganic & Medicinal Chemistry. 28:115481
مصطلحات موضوعية: Pyrimidine, Clinical Biochemistry, Rat model, Pharmaceutical Science, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, ADME, TYK2 Kinase, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Janus Kinase 1, Arthritis, Experimental, Combinatorial chemistry, Rats, 0104 chemical sciences, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, chemistry, Rats, Inbred Lew, Drug Design, Molecular Medicine, Female, Selectivity, Transferase inhibitor
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المؤلفون: Andrew, Fensome, Catherine M, Ambler, Eric, Arnold, Mary Ellen, Banker, Matthew F, Brown, Jill, Chrencik, James D, Clark, Martin E, Dowty, Ivan V, Efremov, Andrew, Flick, Brian S, Gerstenberger, Ariamala, Gopalsamy, Matthew M, Hayward, Martin, Hegen, Brett D, Hollingshead, Jason, Jussif, John D, Knafels, David C, Limburg, David, Lin, Tsung H, Lin, Betsy S, Pierce, Eddine, Saiah, Raman, Sharma, Peter T, Symanowicz, Jean-Baptiste, Telliez, John I, Trujillo, Felix F, Vajdos, Fabien, Vincent, Zhao-Kui, Wan, Li, Xing, Xiaojing, Yang, Xin, Yang, Liying, Zhang
المصدر: Journal of medicinal chemistry. 61(19)
مصطلحات موضوعية: TYK2 Kinase, Molecular Structure, Antitubercular Agents, Janus Kinase 1, Mycobacterium tuberculosis, Arthritis, Experimental, Rats, Pyrimidines, Rats, Inbred Lew, Animals, Pyrazoles, Tuberculosis, Female, Protein Kinase Inhibitors
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المؤلفون: Cara M. M. Williams, Bruce Allen Lefker, David C. Limburg, Stephen W. Wright, Julia Shin, Paul D. Bonin, Parag Sahasrabudhe, Simeon Ramsey, Jiang Wu, Kieran F. Geoghegan
المصدر: MedChemComm. 5:1871-1878
مصطلحات موضوعية: Pharmacology, Chemistry, Organic Chemistry, Pharmaceutical Science, Chemical probe, Drug action, Computational biology, Biochemistry, Combinatorial chemistry, law.invention, Bromodomain, law, Drug Discovery, Recombinant DNA, Molecular Medicine, Potency
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4f190a8af45764d22c2e32c175e6988a
https://doi.org/10.1039/c4md00259h -
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المؤلفون: Ann E. Hallinan, Jeffery S. Carter, David G. Brown, John J. Talley, Timothy Maziasz, Karl W. Aston, Bruce C. Hamper, Matthew J. Graneto, Koszyk Francis, Jaime L. Masferrer, Ludwig Cindy L, Jane L. Wang, David C. Limburg
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7164-7168
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Carboxylic Acids, Serum protein, Pharmaceutical Science, Computational biology, Biochemistry, Part iii, Structure-Activity Relationship, chemistry.chemical_compound, Prostaglandin-Endoperoxide Synthase, MicroDose, Drug Discovery, Humans, Benzopyrans, Molecular Biology, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, biology, Chemistry, Organic Chemistry, Benzopyran, biology.protein, Molecular Medicine, Cyclooxygenase, Half-Life
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المؤلفون: Jeff Carter, David C. Limburg, Jane Wang, James K. Gierse, Gabriel Mbalaviele, Michael L. Vazquez
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1604-1609
مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_treatment, Clinical Biochemistry, Thiazines, Pharmaceutical Science, Biochemistry, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Prostaglandin-E Synthases, biology, ATP synthase, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Molecular biology, Enzyme assay, Cyclic S-Oxides, Intramolecular Oxidoreductases, Cell culture, Oxicam, biology.protein, Microsome, Molecular Medicine, lipids (amino acids, peptides, and proteins), Selectivity, medicine.drug, Prostaglandin E
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المؤلفون: Joseph P. Steiner, Hansjorg Sauer, Gregory S. Hamilton, Michael D Fuller, Raj Soni, Bert E. Thomas, David C. Limburg, Hong Guo, Agnes Holmes, Yi Chen, Douglas E. Wilkinson, Pamela Howorth, Dawn Spicer, Douglas T. Ross, Yong Qian Wu, Heather Valentine
المصدر: Bioorganic & Medicinal Chemistry. 11:4815-4825
مصطلحات موضوعية: Male, Models, Molecular, Proline, Tyrosine 3-Monooxygenase, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Inbred Strains, Tacrolimus Binding Protein 1A, Isomerase, Ligands, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Structure–activity relationship, Molecular Biology, Pipecolic acid, Aza Compounds, Dose-Response Relationship, Drug, Organic Chemistry, Biological activity, Corpus Striatum, In vitro, Neuroprotective Agents, FKBP, chemistry, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Pipecolic Acids, Molecular Medicine