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1
المؤلفون: Christine Guntermann, Janet Dawson, Anna Vulpetti, Andreas Billich, Rowan Stringer, Johannes Ottl, Samuel Hintermann, Henri Mattes, Eric Vangrevelinghe, Nigel Graham Cooke, Klemens Kaupmann, Romain M. Wolf, Juergen Wagner, Klemens Hoegenauer, Joerg Kallen, David Orain, David Carcache
المصدر: Journal of Medicinal Chemistry. 61:6724-6735
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Drug Inverse Agonism, Inflammation, 01 natural sciences, 03 medical and health sciences, Transcription (biology), In vivo, RAR-related orphan receptor gamma, Catalytic Domain, Drug Discovery, medicine, Animals, Inverse agonist, Transcription factor, 010405 organic chemistry, Drug discovery, Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, Rats, 0104 chemical sciences, Cell biology, Disease Models, Animal, 030104 developmental biology, Molecular Medicine, Female, medicine.symptom
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2
المؤلفون: Christine Guntermann, Juergen Wagner, David Orain, Andreas Billich, Joerg Kallen, Samuel Hintermann, Janet Dawson, Rowan Stringer, Henri Mattes, Klemens Kaupmann, David Carcache, Anna Vulpetti
المصدر: ChemMedChem. 11:2640-2648
مصطلحات موضوعية: 0301 basic medicine, Imidazopyridine, Drug Inverse Agonism, Pyridines, Receptors, Retinoic Acid, Stereochemistry, medicine.medical_treatment, Plasma protein binding, Pharmacology, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, 03 medical and health sciences, Pharmacokinetics, RAR-related orphan receptor gamma, Drug Discovery, medicine, Animals, Humans, Potency, Inverse agonist, General Pharmacology, Toxicology and Pharmaceutics, Transcription factor, Cells, Cultured, Binding Sites, Molecular Structure, Chemistry, Interleukin-17, Organic Chemistry, Imidazoles, Nuclear Receptor Subfamily 1, Group F, Member 3, Triazoles, Rats, 030104 developmental biology, Cytokine, Molecular Medicine, Protein Binding
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3Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist
المؤلفون: David Orain, Kurt Lingenhoehl, Sandrine Desrayaud, David Carcache, Joerg Kallen, Anne Picard, Stephan Urwyler, Phillip Floersheim, Engin Tasdelen, Manuel Koller, Celine Dubois, Samuel Haessig, Henri Mattes
المصدر: ChemMedChem. 12:197-201
مصطلحات موضوعية: 0301 basic medicine, Selurampanel, Administration, Oral, AMPA receptor, Molecular Dynamics Simulation, Pharmacology, Crystallography, X-Ray, Binding, Competitive, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Seizures, Drug Discovery, medicine, Animals, Potency, Receptors, AMPA, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Quinazolinones, chemistry.chemical_classification, Electroshock, Sulfonamides, Binding Sites, Organic Chemistry, Glutamate receptor, Antagonist, medicine.disease, Protein Structure, Tertiary, Sulfonamide, Disease Models, Animal, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine, 030217 neurology & neurosurgery
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4
المؤلفون: Xiaojun Ren, Jason Sarber, Keith Mansfield, Adam Bentley, Jimmy Flarakos, Upendra A. Argikar, Joyce Judge, Luis Ramos, Guiqing Liang, Xiao-Hui Chen, Adam Amaral, Paul Moench, Jim Glick, Alexandre Catoire, David Carcache, Panos Hatsis, Samuel Hintermann
المصدر: Analytical chemistry. 88(23)
مصطلحات موضوعية: 0301 basic medicine, Tissue homogenate, Accuracy and precision, Chromatography, Chemistry, Surface Properties, 010401 analytical chemistry, Extraction (chemistry), Analytical chemistry, Sampling (statistics), Tandem mass spectrometry, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Standard curve, 03 medical and health sciences, 030104 developmental biology, Tissue sections, Pharmaceutical Preparations, Liquid chromatography–mass spectrometry, Tandem Mass Spectrometry, Drug Discovery, Chromatography, Liquid
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5
المؤلفون: Ivo Vranesic, Peter Ertl, Manuel Koller, Grit Laue, Dirk Behnke, David Orain, Sandrine Desrayaud, David Carcache
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:6454-6459
مصطلحات موضوعية: Pyridones, Stereochemistry, Metabotropic glutamate receptor 5, Chemistry, Receptor, Metabotropic Glutamate 5, Organic Chemistry, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Receptors, Metabotropic Glutamate, Amides, Biochemistry, Inhibitory Concentration 50, chemistry.chemical_compound, Allosteric Regulation, Solubility, Drug Discovery, Aqueous solubility, Pyridine, Humans, Molecular Medicine, Pyrroles, Metabotropic glutamate receptor 2, Molecular Biology
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6
المؤلفون: Stephan Urwyler, Kurt Lingenhoehl, David Carcache, Yves Auberson, Joerg Kallen, Henri Mattes, Silvio Ofner, Markus Schmutz, Ivan-Toma Vranesic, Manuel Koller, David Orain
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3358-3361
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, AMPA receptor, Pharmacology, Crystallography, X-Ray, Binding, Competitive, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Receptors, AMPA, Receptor, Molecular Biology, Quinazolinones, Sulfonamides, Molecular Structure, Chemistry, Organic Chemistry, Sulfonamide (medicine), Glutamate receptor, Antagonist, Biological activity, Rats, Molecular Medicine, Anticonvulsants, medicine.drug
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7
المؤلفون: Sandrine Desrayaud, David Carcache, Ivan-Toma Vranesic, Ralf Glatthar, Joachim Blanz, Markus Fendt
المصدر: ACS Medicinal Chemistry Letters. 2:58-62
مصطلحات موضوعية: business.industry, medicine.drug_class, Metabolite, Organic Chemistry, Pharmacology, Rat brain, Receptor antagonist, Biochemistry, chemistry.chemical_compound, Orally active, chemistry, Pharmacokinetics, In vivo, Drug Discovery, Medicine, business, Receptor
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8
المؤلفون: David Carcache, Henri Mattes, Manuel Koller, Hans O. Kalkman
المصدر: Journal of Medicinal Chemistry. 53:5367-5382
مصطلحات موضوعية: Analgesics, Clinical Trials as Topic, Chemistry, Stereochemistry, Drug Evaluation, Preclinical, Alpha (ethology), AMPA receptor, Bench to bedside, Protein Subunits, Neuroprotective Agents, Drug Discovery, Animals, Humans, Molecular Medicine, Anticonvulsants, Receptors, AMPA, Antipsychotic Agents
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9
المؤلفون: François Loiseau, Julie Jeanneret-Gris, Pavel Bobal, David Carcache, Jean-Mary Simone, Reinhard Neier
المصدر: Monatshefte für Chemie - Chemical Monthly. 138:131-139
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Furan, Organic chemistry, General Chemistry
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10
المؤلفون: Jean-Mary Simone, François Loiseau, David Carcache, Pavel Bobal, Julie Jeanneret-Gris, Reinhard Neier
المصدر: Monatshefte für Chemie - Chemical Monthly. 138:141-147
مصطلحات موضوعية: General Chemistry