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1دورية أكاديمية
المؤلفون: David E Timm, Valorie Bowman, Russell Madsen, Charles Rauch
المصدر: PLoS ONE, Vol 13, Iss 3, p e0193205 (2018)
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Qi Chen, Michal Vieth, David E Timm, Christine Humblet, Dina Schneidman-Duhovny, Ilan E Chemmama, Andrej Sali, Wei Zeng, Jirong Lu, Ling Liu
المصدر: PLoS ONE, Vol 12, Iss 4, p e0175758 (2017)
وصف الملف: electronic resource
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المؤلفون: Dale Porter, Alessandra Ianari, Merissa Brousseau, Patrick McCarren, Foxy P. Robinson, Adam Skepner, Virendar K. Kaushik, Kathleen M. Mulvaney, Arthur J. Campbell, Martin J Drysdale, Zachary Mullin-Bernstein, Brian J. McMillan, Robert Hilgraf, Ritu Singh, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, David C. McKinney, Jamie A. Moroco, Michael F. Mesleh, David E. Timm, Besnik Bajrami, Florence F. Wagner
المصدر: J Med Chem
مصطلحات موضوعية: Models, Molecular, Protein-Arginine N-Methyltransferases, Spliceosome, Dose-Response Relationship, Drug, Molecular Structure, biology, Stereochemistry, fungi, Signal transducing adaptor protein, Methylation, Small molecule, Article, Pyridazines, Structure-Activity Relationship, chemistry.chemical_compound, Histone, chemistry, Covalent bond, Drug Discovery, biology.protein, Humans, Molecular Medicine, Lead compound, Adaptor Proteins, Signal Transducing, Cysteine
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4
المؤلفون: Stephanie L. Stout, Leonard L. Winneroski, Jorg Hendle, Warren J. Porter, Patrick J. C. May, Leonard N. Boggs, Thomas K. Baker, James P. Beck, Steven James Green, Anthony R. Borders, Erik James Hembre, Stephen L. Lowe, Christopher D Aluise, David L. McKinzie, Brian Morgan Watson, Brian Michael Mathes, Jon A. Erickson, Zhixiang Yang, Patrick J Cocke, Dustin J. Mergott, Brian A. Willis, Scott A. Monk, Pablo Garcia-Losada, David E. Timm, Richard A. Brier, Jose Eduardo Lopez
المصدر: Journal of medicinal chemistry. 64(12)
مصطلحات موضوعية: Male, Drug target, Elevated liver enzymes, Crystallography, X-Ray, 01 natural sciences, Heterocyclic Compounds, 2-Ring, Madin Darby Canine Kidney Cells, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Drug Stability, Drug Discovery, Animals, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Pyrroles, 030304 developmental biology, 0303 health sciences, Molecular Structure, Low dose, Madin Darby canine kidney cell, Brain, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Retinal toxicity, Liver metabolism, chemistry, Blood-Brain Barrier, Pyrazines, Cancer research, Microsomes, Liver, Molecular Medicine, Amyloid Precursor Protein Secretases, Penetrant (biochemical), Protein Binding
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5
المؤلفون: Ritu Singh, Michael F. Mesleh, Matthew J. Ranaghan, Virendar K. Kaushik, Dale Porter, Brian J. McMillan, Kathleen M. Mulvaney, Alessandra Ianari, David E. Timm, William R. Sellers, Besnik Bajrami, Patrick McCarren, Meghan O’Keefe, David C. McKinney, Merissa Brousseau, Zachary Mullin-Bernstein, Jamie A. Moroco, Adam Skepner
مصطلحات موضوعية: Spliceosome, chemistry.chemical_compound, Chemistry, Covalent bond, Stereochemistry, fungi, Signal transducing adaptor protein, Substrate (chemistry), Methylation, Lead compound, Small molecule, Cysteine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0b6860a9dce9163efa6957c5be29c743
https://doi.org/10.1101/2021.02.03.429644 -
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المؤلفون: Shireen Y. Elhabian, Hong Xu, David E. Timm
المصدر: Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 ISBN: 9783030597214
MICCAI (5)مصطلحات موضوعية: 030307 microscopy, 0303 health sciences, Microscope, High magnification, Computer science, Cryo-electron microscopy, business.industry, Process (computing), Magnification, Pattern recognition, Grid, law.invention, 03 medical and health sciences, Data acquisition, law, Artificial intelligence, Electron microscope, Focus (optics), business, Throughput (business), 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::14707d7957d3c20567c88bcac00b15d7
https://doi.org/10.1007/978-3-030-59722-1_6 -
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المؤلفون: Philip J. Ebert, Gary L. Heady, Bruce W. Konicek, Melinda D. Willard, Stephanie L. Stout, Julie Stewart, David E. Timm, Yi Zeng, Victoria L. Peek, Suzane L. Um, Isabella H. Wulur, Beverly L. Falcon, Andrew Capen, Kelly M. Credille, Yong Wang, Jennifer R. Stephens, Sau-Chi Betty Yan, Richard A. Walgren, Bharvin K. R. Patel
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, NTRK fusion, Merestinib, Entrectinib, medicine.disease_cause, Receptor tyrosine kinase, Fusion gene, 03 medical and health sciences, 0302 clinical medicine, type II kinase inhibitor, medicine, LY2801653, Receptor, merestinib, Mutation, biology, Kinase, Chemistry, NTRK inhibitor, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Research Paper, Neurotrophin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d248b4902618ce5f3d208e81ce69d6
https://doi.org/10.18632/oncotarget.24488 -
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المؤلفون: José Francisco Soriano, Javier Agejas, Rosario Gonzalez, Ramón Rodríguez, Timothy B. Durham, Howard Barff Broughton, Juan F. Espinosa, Paloma Vidal, Ana B. Bueno, Robert Dean Dally, Hsiu-Chiung Yang, Alicia Marcos, David E. Timm, Gema Sanz, James R. McCarthy, Patric James Hahn
المصدر: Journal of Medicinal Chemistry. 60:9807-9820
مصطلحات موضوعية: Models, Molecular, Steric effects, Magnetic Resonance Spectroscopy, Stereochemistry, Isostere, Morpholines, Peptide, Crystallography, X-Ray, 01 natural sciences, Pyrrolidine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Ethylamines, Animals, Aspartic Acid Endopeptidases, Humans, Molecule, Protease Inhibitors, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Brain, Active site, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Cyclization, Drug Design, biology.protein, Molecular Medicine, Piperidine, Amyloid Precursor Protein Secretases, Peptides
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المؤلفون: David E. Timm, Leonard N. Boggs, Brian Michael Mathes, Yuan Shi, Mario Barberis, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Pablo Garcia-Losada, Jose Miguel Minguez, Leonard L. Winneroski, Jon A. Erickson, Richard A. Brier, Anthony R. Borders, Stephanie L. Stout, Porter Warren J, Zoran Rankovic, Jose Eduardo Lopez, Erik James Hembre, James E. Audia, Jorg Hendle, James P. Beck, Steven James Green, Brian Morgan Watson, Patrick C. May, Robert D. Boyer
المصدر: Bioorganic & Medicinal Chemistry. 28:115194
مصطلحات موضوعية: Cyclopropanes, Models, Molecular, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Ligands, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Alzheimer Disease, mental disorders, Drug Discovery, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Molecular Biology, Biological evaluation, Hydrolase inhibitor, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Biological activity, Ligand (biochemistry), Molecular Medicine, Organic synthesis, Amyloid Precursor Protein Secretases
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المؤلفون: Thierry Masquelin, Gary G. Deng, Prabhakar Kondaji Jadhav, Balagopalakrishna Chavali, David E. Timm, Najia Jin, Stephanie L. Stout, Mark J. Nilges, William F. Matter
المصدر: Applied Magnetic Resonance
مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Peptide, Small molecule, Article, Atomic and Molecular Physics, and Optics, chemistry.chemical_compound, Nuclear magnetic resonance, Enzyme, chemistry, Mechanism of action, Myeloperoxidase, biology.protein, Native state, medicine, medicine.symptom, Heme, Peroxidase