نتائج البحث - "David G. Sanford"

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Abstract 1815: AVA6000, a novel Precision medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein (FAP) mediated cleavage

المؤلفون: Fiona McLaughlin, Sarah E. Poplawski, David G. Sanford, Andrew Saunders, Jack H. Lai, Matthew Vincent, William W. Bachovchin, Neil Bell

المصدر: Cancer Research. 82:1815-1815

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7bba1d7c8d926c7fe5ebafc367808385
https://doi.org/10.1158/1538-7445.am2022-1815

2

Abstract 3303: Pre-clinical characterization of the novel FAP targeting ligand PNT6555 for imaging and therapy of cancer

المؤلفون: Robin M. Hallett, Sarah E. Poplawski, Mark H. Dornan, Shin Hye Ahn, Shuang Pan, Wu Wengen, Liu Yuxin, David G. Sanford, Valerie S. Hergott, Quang-De Nguyen, Anthony P. Belanger, Jack H. Lai, William Bachovchin, Joe A. McCann

المصدر: Cancer Research. 82:3303-3303

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eccb075297d2b254485b642d843159eb
https://doi.org/10.1158/1538-7445.am2022-3303

3

Abstract 1866: Pharmacokinetics and biodistribution of formatted Affimer® biotherapeutics targeting PD-L1

المؤلفون: Floriane Laurent, Estelle Adam, David Gilfoyle, Vincent Matthew, Amrik Basran, Cyril Berthet, David G. Sanford, Agnieszka Kownacka, Emma Stanley, Alexandra Oudot, Barry Jones, Maureen West, Emma Jenkins, William W. Bachovchin, Jennifer Hillman, Céline Mothes

المصدر: Cancer Research. 81:1866-1866

مصطلحات موضوعية: Cancer Research, Tumor microenvironment, Biodistribution, biology, business.industry, Fragment crystallizable region, Immune checkpoint, Oncology, Antigen, Spect imaging, biology.protein, Cancer research, Medicine, Antibody, business, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::42f64401096da3a1e51b33147f4de200
https://doi.org/10.1158/1538-7445.am2021-1866

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DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

المؤلفون: Sarah E. Poplawski, David G. Sanford, Mitchell S. Wang, Eun Bin Go, Daniel A. Bachovchin, William W. Bachovchin, Yuxin Liu, Darren C. Johnson, Michael O Arciprete, Ramya Sridharan, Ashley J. Chui, Wengen Wu, Marian C. Okondo, Todd R. Golub, Jack H. Lai

المصدر: Nature Chemical Biology. 13:46-53

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3162659cf671c421e083a92883e1885
https://doi.org/10.1038/nchembio.2229

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5

Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

المؤلفون: Zhiping Jin, David G. Sanford, James L. Sudmeier, Youhua Li, Wengen Wu, Jack H. Lai, William W. Bachovchin, Yuhong Zhou, Yuxin Liu, Sarah E. Poplawski, Yong Wu

المصدر: Journal of Medicinal Chemistry. 56:3467-3477

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e907e97f60716ea508018b285471fdd
https://doi.org/10.1021/jm400351a

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6

4-Substituted boro-proline dipeptides: Synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities

المؤلفون: Beth A. Connolly, Wengen Wu, Gengli Yu, Peng Zhao, Lawrence J. Milo, Youhua Li, Yuxin Liu, David G. Sanford, Jack H. Lai, Iwona Woznica, James L. Sudmeier, Sarah E. Poplawski, William W. Bachovchin, Yuhong Zhou, Ying Shu

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5536-5540

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce763f7d14409d7b06b65cb9df8dbc3d
https://doi.org/10.1016/j.bmcl.2012.07.033

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7

Pro-Soft Val-boroPro: A Strategy for Enhancing in Vivo Performance of Boronic Acid Inhibitors of Serine Proteases

المؤلفون: William W. Bachovchin, David G. Sanford, Jack H. Lai, Sarah E. Poplawski, Wengen Wu, James L. Sudmeier

المصدر: Journal of Medicinal Chemistry. 54:2022-2028

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14647924b35e376ee591b2cabb0e44ac
https://doi.org/10.1021/jm100972f

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8

Dipeptide Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: Determinants of Potency and in Vivo Efficacy and Safety

المؤلفون: James L. Sudmeier, William W. Bachovchin, Youhua Li, Sarah E. Healey, Wengen Wu, Diane E. Peters, Amrita K. Chiluwal, Jack H. Lai, Yuhong Zhou, Yuxin Liu, Beth A. Connolly, Zhiping Jin, Matthew T. Dimare, Hlaing Hlaing Maw, David G. Sanford

المصدر: Journal of Medicinal Chemistry. 51:6005-6013

مصطلحات موضوعية: Blood Glucose, Male, inorganic chemicals, Serine Proteinase Inhibitors, Time Factors, Drug-Related Side Effects and Adverse Reactions, Dipeptidyl Peptidase 4, Drug Evaluation, Preclinical, Molecular Conformation, Administration, Oral, Incretin, Dipeptidyl peptidase, Cell Line, Substrate Specificity, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Peptide Library, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Cloning, Molecular, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Serine protease, Dipeptidyl-Peptidase IV Inhibitors, Dipeptide, Dose-Response Relationship, Drug, biology, Dipeptides, Glucose Tolerance Test, Boronic Acids, Rats, Mice, Inbred C57BL, Glucose, chemistry, Biochemistry, biology.protein, Molecular Medicine, Female, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba21303579948c1d60127e4e86a641fb
https://doi.org/10.1021/jm800390n

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9

Synthesis and Characterization of Constrained Peptidomimetic Dipeptidyl Peptidase IV Inhibitors: Amino-Lactam boroAlanines

المؤلفون: Sarah E. Poplawski, Yuhong Zhou, Yuxin Liu, Lawrence J. Milo, David G. Sanford, Gillian D. Henry, Jack H. Lai, James L. Sudmeier, Wengen Wu, William W. Bachovchin, Hlaing Hlaing Maw

المصدر: Journal of Medicinal Chemistry. 50:2391-2398

مصطلحات موضوعية: chemistry.chemical_classification, Molecular model, biology, Stereochemistry, Peptidomimetic, Biological activity, Chemical synthesis, Dipeptidyl peptidase, chemistry.chemical_compound, Enzyme, chemistry, Enzyme inhibitor, Drug Discovery, Lactam, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0919180ca538e2bd82283c77a3ef6eeb
https://doi.org/10.1021/jm061321+

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10

T Antigen Origin-Binding Domain of Simian Virus 40: Determinants of Specific DNA Binding

المؤلفون: James L. Sudmeier, Xuelian Luo, Zachary A. Gurard-Levin, Elizabeth M. Bradshaw, Peter A. Bullock, David G. Sanford, William W. Bachovchin

المصدر: Biochemistry. 43:6928-6936

مصطلحات موضوعية: HMG-box, DNA replication, Biology, Simian, biology.organism_classification, Biochemistry, Molecular biology, Virus, chemistry.chemical_compound, chemistry, Antigen, SV40 T-antigen, DNA, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::de23534d22da9a46f5ba0e77f2266f7a
https://doi.org/10.1021/bi030228+

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