المؤلفون: Julie A. Douthwaite, Christopher A. Brown, John R. Ferdinand, Rahul Sharma, Jane Elliott, Molly A. Taylor, Nancy T. Malintan, Hannah Duvoisin, Thomas Hill, Oona Delpuech, Alexandra L. Orton, Haidee Pitt, Fred Kuenzi, Simon Fish, David J. Nicholls, Anna Cuthbert, Ian Richards, Giles Ratcliffe, Abhishek Upadhyay, Abigail Marklew, Craig Hewitt, Douglas Ross-Thriepland, Christopher Brankin, Matthieu Chodorge, Gareth Browne, Palwinder K. Mander, Ruud M. DeWildt, Shane Weaver, Penny A. Smee, Joost van Kempen, Jon G. Bartlett, Paula M. Allen, Emma L. Koppe, Charlotte A. Ashby, Julian D. Phipps, Nalini Mehta, David J. Brierley, David G. Tew, Melanie V. Leveridge, Stuart M. Baddeley, Ian G. Goodfellow, Clive Green, Chris Abell, Andy Neely, Ian Waddell, Steve Rees, Patrick H. Maxwell, Menelas N. Pangalos, Rob Howes, Roger Clark

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/b16f2bbb322448d5a5973467180ddaa4

المؤلفون: Andy Neely, Nancy T. Malintan, Menelas N. Pangalos, Haidee Pitt, Molly A. Taylor, Melanie Leveridge, Douglas Ross-Thriepland, Roger Clark, Simon Fish, Rahul Sharma, Anna Cuthbert, Ruud M. DeWildt, Stuart M. Baddeley, David J. Nicholls, Abigail Marklew, David J. Brierley, Palwinder K. Mander, Christopher A. Brown, Penny A. Smee, Jane Elliott, Hannah Duvoisin, Patrick H. Maxwell, Clive Green, Alexandra L. Orton, Giles Ratcliffe, Julie A. Douthwaite, Gareth Browne, Paula M. Allen, Rob Howes, Ian Richards, David G. Tew, Julian D. Phipps, Shane Weaver, Steve Rees, Ian Goodfellow, John R. Ferdinand, Oona Delpuech, Joost van Kempen, Matthieu Chodorge, Fred Kuenzi, Craig Hewitt, Emma Koppe, Ian D. Waddell, Abhishek Upadhyay, Thomas Hill, Charlotte Ashby, Nalini Mehta, Jon G. Bartlett, Christopher Brankin, Chris Abell

مصطلحات موضوعية: Computer science, Process (engineering), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Data mining, computer.software_genre, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::24e7691c6b13828a9439674e7cb3af4c
https://doi.org/10.21203/rs.3.rs-637020/v1

المؤلفون: David G. Tew

المصدر: Emerging topics in life sciences. 3(5)

مصطلحات موضوعية: 0301 basic medicine, business.industry, Computer science, Data science, General Biochemistry, Genetics and Molecular Biology, Therapeutic modalities, 03 medical and health sciences, Synthetic biology, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Health care, General Agricultural and Biological Sciences, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5082be756f7d7e3b692cde4a4d93dd69
https://pubmed.ncbi.nlm.nih.gov/33523174

المؤلفون: David W. McClymont, Derek Bell, David G. Tew, Marcelo Kern, Glen-Oliver F. Gowers, Soo Mei Chee, Tom Ellis, Lorna Suckling

المساهمون: Biotechnology and Biological Sciences Research Council (BBSRC), Engineering & Physical Science Research Council (EPSRC)

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Science, Saccharomyces cerevisiae, General Physics and Astronomy, 02 engineering and technology, Computational biology, Biology, Genome, General Biochemistry, Genetics and Molecular Biology, Article, Mass Spectrometry, Genome engineering, Metabolic engineering, 03 medical and health sciences, Synthetic biology, Genes, Synthetic, Genomic library, Genetic Testing, Betulinic Acid, lcsh:Science, Genetic Association Studies, Gene Library, Recombination, Genetic, Multidisciplinary, General Chemistry, 021001 nanoscience & nanotechnology, Directed evolution, biology.organism_classification, Triterpenes, 030104 developmental biology, Synthetic Biology, lcsh:Q, Nanopore sequencing, Chromosomes, Fungal, Directed Molecular Evolution, Genome, Fungal, 0210 nano-technology, Genetic Engineering, Pentacyclic Triterpenes, Biotechnology, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b024bb18d731eba3425107e5a221462b
http://hdl.handle.net/10044/1/77035

المؤلفون: David G. Tew, Marcelo Kern, Glen-Oliver F. Gowers, Simon J S Cameron, Tom Ellis, Derek Bell, Alvaro Perdones-Montero, Zoltan Takats, Soo Mei Chee

المساهمون: Biotechnology and Biological Sciences Research Council (BBSRC)

المصدر: Gowers, G-O F, Cameron, S J S, Perdones-Montero, A, Bell, D, Chee, S M, Kern, M, Tew, D, Ellis, T & Takats, Z 2019, ' Off-colony screening of biosynthetic libraries by rapid laser-enabled mass spectrometry ', ACS Synthetic Biology . https://doi.org/10.1021/acssynbio.9b00243

مصطلحات موضوعية: 0106 biological sciences, High-throughput screening, Metabolite, Biomedical Engineering, Computational biology, ambient mass spectrometry, Saccharomyces cerevisiae, Mass spectrometry, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Agar plate, Metabolic engineering, 03 medical and health sciences, Synthetic biology, chemistry.chemical_compound, Transformation, Genetic, 010608 biotechnology, Sample preparation, Betulinic Acid, 030304 developmental biology, 0303 health sciences, REIMS, General Medicine, Yeast, Triterpenes, Culture Media, High-Throughput Screening Assays, Agar, chemistry, Metabolic Engineering, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Synthetic Biology, Pentacyclic Triterpenes, high throughput screening, Chromatography, Liquid, Plasmids

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36c732fe13fcda1beca3a900b4c9e3f
https://pure.qub.ac.uk/en/publications/offcolony-screening-of-biosynthetic-libraries-by-rapid-laserenabled-mass-spectrometry(b04a12e0-c8a0-4202-8283-e8d8ca5d1f47).html

المؤلفون: Deborah K. Shoemark, Joseph L. Beesley, Colin M. Edge, Derek N. Woolfson, Dominic Alibhai, Judith Mantell, Jordan M. Fletcher, David G. Tew, Angela Bridges, Paul Verkade, Harriet E. V. Bray, James F. Ross, William M. Dawson, Richard B. Sessions, Lorna Hodgson

المصدر: Ross, J F, Bridges, A, Fletcher, J M, Shoemark, D, Alibhai, D, Bray, H E V, Beesley, J L, Dawson, W M, Hodgson, L R, Mantell, J, Verkade, P, Edge, C M, Sessions, R B, Tew, D & Woolfson, D N 2017, ' Decorating Self-Assembled Peptide Cages with Proteins ', ACS Nano, vol. 11, no. 8, pp. 7901-7914 . https://doi.org/10.1021/acsnano.7b02368

مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Materials science, Protein design, General Physics and Astronomy, BrisSynBio, Nanotechnology, Peptide, Nanoreactor, Self assembled, Supramolecular assembly, 03 medical and health sciences, Synthetic biology, General Materials Science, protein design, supramolecular assembly, Coiled coil, chemistry.chemical_classification, coiled coil, Bristol BioDesign Institute, fungi, General Engineering, Proteins, protein cage, self-assembly, Combinatorial chemistry, 030104 developmental biology, chemistry, Synthetic Biology, synthetic biology, Self-assembly, nanoreactor, Peptides, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45c13bd41eb10f9d7499c298e21c096
https://doi.org/10.1021/acsnano.7b02368

المؤلفون: Doug E. Fuerst, David G. Tew, Sarah L. Lovelock, Helena K. Philpott, Pamela Thomas

المصدر: Philpott, H, Thomas, P, Tew, D, Fuerst, D & Lovelock, S 2018, ' A Versatile Biosynthetic Approach to Amide Bond Formation ', Green Chemistry, vol. 20, no. 15, pp. 3426-3431 . https://doi.org/10.1039/C8GC01697F

مصطلحات موضوعية: chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Carboxylic acid, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Pollution, Combinatorial chemistry, Cofactor, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Amide, Yield (chemistry), biology.protein, Environmental Chemistry, Peptide bond, Amine gas treating

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75013d607da270ad494a9a1f48f378f
http://www.mendeley.com/research/versatile-biosynthetic-approach-amide-bond-formation

المؤلفون: Susan L. Dyos, Emma Hiley, Angela A. Dunne, Mary A. Morse, Fiona Flett, Martin Rüdiger, Edward Hollingsworth, Namir J. Hassan, Martin Hibbs, Jonathan P. Hutchinson, David G. Tew, Amanda Emmons, David J. Powell, Jeremy D. A. Kitson, Sheraz Gul

المصدر: Biochemical Journal. 419:65-73

مصطلحات موضوعية: Blotting, Western, Cell, Chromosomal translocation, Protein Serine-Threonine Kinases, Spodoptera, Biology, Models, Biological, Biochemistry, Cell Line, law.invention, NF-kappa B p52 Subunit, law, medicine, Animals, Humans, Phosphorylation, Molecular Biology, Gene, Insect cell, Kinase, NF-kappa B, Cell Biology, Kinase inhibition, Molecular biology, I-kappa B Kinase, Cell biology, medicine.anatomical_structure, Recombinant DNA, Biological Assay, Nucleus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4f87f33b575ebe8700adca9d63259f
https://doi.org/10.1042/bj20081646

المؤلفون: Mehul Patel, Andrea H. Epperly, Gale Jennifer Paul, Pamela L. Golden, Hu Li, Frank T. Coppo, Daphne C. Clancy, Yue H. Li, Todd L. Graybill, David G. Tew, Francis X. Tavares, Joyce A. Boucheron, Stephen A. Thomson, Karen A. Evans, James E. Weiel, Maria Cichy-Knight, Sara H. Thrall

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4068-4071

مصطلحات موضوعية: Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Glycogen Phosphorylase, Liver Form, Inhibitory Concentration 50, Structure-Activity Relationship, Glycogen phosphorylase, Solid-phase synthesis, Drug Discovery, Glycosyltransferase, Animals, Humans, Urea, Structure–activity relationship, ortho-Aminobenzoates, Amino Acids, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Rats, Amino acid, Enzyme, Liver, Models, Chemical, chemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9449c506d8423976e067252798e47af0
https://doi.org/10.1016/j.bmcl.2008.05.102

المؤلفون: Mehul Patel, Sara H. Thrall, Thomas D. Meek, Wu-Schyong Liu, Joshua West, David G. Tew

المصدر: Biochemistry. 44:16753-16765

مصطلحات موضوعية: Enzyme complex, Base Sequence, Chemistry, Stereochemistry, Kinetics, Substrate (chemistry), Hydrogen-Ion Concentration, Reductase, Deuterium, Biochemistry, Catalysis, Alcohol Oxidoreductases, Streptococcus pneumoniae, Product inhibition, Kinetic isotope effect, 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase, lipids (amino acids, peptides, and proteins), Cloning, Molecular, DNA Primers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3dbf3f9d7ab5aa116f320d22b29746
https://doi.org/10.1021/bi050947j