المؤلفون: Elías Herrero-Galán, Inés Martínez-Martín, Cristina Sánchez-González, Natalia Vicente, Elena Bonzón-Kulichenko, Enrique Calvo, Carmen Suay-Corredera, Maria Rosaria Pricolo, Ángel Fernández-Trasancos, Diana Velázquez-Carreras, Claudio Badía Careaga, Mahmoud Abdellatif, Simon Sedej, Peter P. Rainer, David Giganti, Raúl Pérez-Jiménez, Jesús Vázquez, Jorge Alegre-Cebollada

المصدر: Redox Biology, Vol 52, Iss , Pp 102306- (2022)

مصطلحات موضوعية: Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722000787; https://doaj.org/toc/2213-2317

URL الوصول: https://doaj.org/article/a20413a909e945338b56d00461d948f8

المؤلفون: David Giganti, Kevin Yan, Carmen L. Badilla, Julio M. Fernandez, Jorge Alegre-Cebollada

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/bb0d9fa1d8914904b64c583908b5ecca

المؤلفون: Jef D. Boeke, Marcus B. Noyes, Brendan Camellato, David M. Ichikawa, Gregory W. Goldberg, Neta Agmon, Jeffrey M. Spencer, David Giganti

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, CRISPR-Cas9 genome editing, Streptococcus pyogenes, Science, General Physics and Astronomy, Computational biology, Biology, Protein Engineering, General Biochemistry, Genetics and Molecular Biology, Article, Substrate Specificity, 03 medical and health sciences, Negative selection, 0302 clinical medicine, stomatognathic system, CRISPR-Associated Protein 9, Cell Line, Tumor, mental disorders, parasitic diseases, Humans, Guide RNA, Amino Acid Sequence, Nucleotide Motifs, Selection (genetic algorithm), Synthetic biology, reproductive and urinary physiology, Zinc finger, Gene Editing, Multidisciplinary, Cas9, General Chemistry, Protein engineering, DNA, Directed evolution, Protospacer adjacent motif, 030104 developmental biology, Experimental evolution, Mutation, embryonic structures, Nucleic Acid Conformation, CRISPR-Cas Systems, Directed Molecular Evolution, 030217 neurology & neurosurgery, RNA, Guide, Kinetoplastida

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25762a6571ede1ec0d9d9c2b6abd77b8
https://doaj.org/article/3e675de09c284972a7413a9b4147d955

المؤلفون: Simon Sedej, Torsten Bloch Rasmussen, Fernando Domínguez, Jose Maria Garcia-Aznar, Jesús Vázquez, Ana Briceño, Jesús Piqueras-Flores, Jorge Alegre-Cebollada, Giovanna Giovinazzo, Elías Herrero-Galán, Enrique Calvo, Carmen Suay-Corredera, David Giganti, Mahmoud Abdellatif, Juan A. Bernal, Inmaculada Vivo-Ortega, Francisco Gutiérrez-Agüera, Natalia Vicente, Belén Bornstein, Esther Gonzalez-Lopez, Thomas Morris Hey, Enrique Lara-Pezzi, Diana Velázquez-Carreras, Peter P. Rainer, Ángel Fernández-Trasancos, Laura Lalaguna, Belén Prados, Inés Martínez-Martín, Raul Perez-Jimenez, Pablo García-Pavía, Juan Pablo Ochoa, Claudio Badía Careaga, Maria Rosaria Pricolo, Elena Bonzón-Kulichenko, Marta Cobo-Marcos, Cristina Sánchez-González

مصطلحات موضوعية: Gene isoform, education.field_of_study, biology, Population, Dilated cardiomyopathy, musculoskeletal system, medicine.disease, Cell biology, biology.protein, medicine, Myocyte, Missense mutation, Titin, Functional studies, education, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4c2571241a29bddee113f7f8e5cf49fd
https://doi.org/10.1101/2020.09.05.282913

المؤلفون: Natalia Comino, Alexandre Chenal, Beatriz Trastoy, Montse Tersa, Itxaso Anso, Lena Mäler, David Albesa-Jové, David Giganti, Ane Rodrigo-Unzueta, Jobst Liebau, Cecilia D’Angelo, Saioa Urresti, Mattia Ghirardello, J. Ignacio Delso, Javier O. Cifuente, Pedro Merino, Alberto Marina, Marcelo E. Guerin

المساهمون: Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto Biofisika, Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Microbiologie structurale, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Bizkaia Science and Technology Park, Instituto Vasco de Investigación y Desarrollo Agrario [Derio] (NEIKER), Stockholm University, Biochimie des Interactions Macromoléculaires / Biochemistry of Macromolecular Interactions, This work was supported by grants from the European Commission, New Medicine for Tuberculosis, Contract LSHP-CT-2005-018923, and More Medicines for Tuberculosis, Contract HEALTH-F3-2011-260872 (M.E.G.), MARIE CURIE Reintegration Contract 844905 (B.T.), MINECO/FEDER EU Contracts SAF2010-19096, BIO2013-49022-C2-2-R, and BFU2016-77427-C2-2-R, Severo Ochoa Excellence Accreditation SEV-2016-0644 (M.E.G.), MINECO/FEDER EU Contract PID2019-104090RB-100 (P.M.), and 'Juan de la Cierva Postdoctoral program' Contract IJCI-2014-19206 (B.T.)., The authors gratefully acknowledge Dr. Ahmed Haouz, Patrick Weber, and Prof. Pedro M. Alzari (Institut Pasteur, Paris, France) for help with robotic crystallization and X-ray crystallography data and Pedro Arrasate for technical assistance (Biofisika Institute, Leioa, Spain). This study made use of Diamond Light Source beamline B21 (Oxfordshire, U.K.) and ALBA synchrotron beamline BL13-XALOC, funded in part by the Horizon 2020 programme of the European Union, iNEXT (H2020 Contract 653706)., European Project: LSHP-CT-2005-018923,NM4TB, European Project: LSHP-CT, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochemistry
Biochemistry, 2020, 59 (32), pp.2934-2945. ⟨10.1021/acs.biochem.0c00376⟩
Biochemistry, American Chemical Society, 2020, 59 (32), pp.2934-2945. ⟨10.1021/acs.biochem.0c00376⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza

مصطلحات موضوعية: Models, Molecular, MESH: Models, molecular, Mannosyltransferase, Mannosides, endocrine system diseases, MESH: Mannosyltransferases / metabolism, Protein Conformation, MESH: Bacterial proteins / chemistry, Movement, [SDV]Life Sciences [q-bio], MESH: Movement, Mannosyltransferases, Biochemistry, Bacterial Proteins, Glycosyltransferase, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Bacterial proteins / metabolism, biology, Chemistry, technology, industry, and agriculture, MESH: Protein conformation, nutritional and metabolic diseases, 3. Good health, Cell biology, MESH: Mannose / metabolism, carbohydrates (lipids), biology.protein, lipids (amino acids, peptides, and proteins), MESH: Mannosyltransferases / chemistry, Mannose

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c988513a56fe950e468a525d3ea0f08a
https://ueaeprints.uea.ac.uk/id/eprint/85153/

المؤلفون: Guillaume Stirnemann, David Giganti, Marcelo E. Guerin

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, medicine.medical_treatment, Entropy, Gene Expression, Target peptide, Peptide, Protein Engineering, Enzyme catalysis, Substrate Specificity, 03 medical and health sciences, Protein structure, Endopeptidases, medicine, Connectin, Peptide sequence, Polyproteins, Protein Unfolding, chemistry.chemical_classification, Multidisciplinary, Protease, Chemistry, Protein engineering, Conformational entropy, Biological Sciences, Biomechanical Phenomena, Kinetics, 030104 developmental biology, Proteolysis, Biophysics, Biocatalysis, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438540b84215db109cbefd4f2100037
https://europepmc.org/articles/PMC6233122/

المؤلفون: Kevin Yan, Jorge Alegre-Cebollada, Carmen L. Badilla, Julio M. Fernandez, David Giganti

المساهمون: National Science Foundation (Estados Unidos), National Institutes of Health (Estados Unidos), Ministerio de Economía, Industria y Competitividad (España), Fundación ProCNIC, Unión Europea. Comisión Europea

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications

مصطلحات موضوعية: Models, Molecular, Sarcomeres, 0301 basic medicine, Protein Folding, animal structures, Science, General Physics and Astronomy, Sequence (biology), Immunoglobulin domain, macromolecular substances, Microscopy, Atomic Force, Sarcomere, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Isomerism, medicine, Animals, Connectin, Cysteine, Disulfides, Elasticity (economics), lcsh:Science, Protein Unfolding, Multidisciplinary, biology, Chemistry, Triad (anatomy), General Chemistry, musculoskeletal system, Elasticity, 030104 developmental biology, medicine.anatomical_structure, embryonic structures, cardiovascular system, biology.protein, Biophysics, Titin, lcsh:Q, Rabbits, Immunoglobulin Domains, Oxidation-Reduction, Isomerization, tissues, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768fe1c50c3f4bf44031cb5bd5975ce6
https://hdl.handle.net/20.500.12105/6695

المؤلفون: Chad M. Warren, Nazha Hamdani, R. John Solaro, Wolfgang A. Linke, Edward C. Eckels, David Giganti, Julio M. Fernandez, Jorge Alegre-Cebollada, Jaime Andrés Rivas-Pardo, Pallav Kosuri

المساهمون: Physiology, ICaR - Heartfailure and pulmonary arterial hypertension

المصدر: Cell, 156(6), 1235-1246. Cell Press
Alegre-Cebollada, J, Kosuri, P, Giganti, D, Eckels, E, Rivas-Pardo, J A, Hamdani, N, Warren, C M, Solaro, R J, Linke, W A & Fernandez, J M 2014, ' S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding ', Cell, vol. 156, no. 6, pp. 1235-1246 . https://doi.org/10.1016/j.cell.2014.01.056

مصطلحات موضوعية: Models, Molecular, Protein Folding, animal structures, Obscurin, Immunoglobulin domain, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Protein structure, Humans, Myotilin, Connectin, Myocytes, Cardiac, Cysteine, S-Glutathionylation, Glutaredoxins, Biochemistry, Genetics and Molecular Biology(all), musculoskeletal system, Elasticity, Biomechanical Phenomena, Protein Structure, Tertiary, Cell biology, Actinin, alpha 2, Biochemistry, cardiovascular system, biology.protein, Titin, Protein folding, Protein Processing, Post-Translational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d9e30fd87b889b426586e22df51814

المؤلفون: David Giganti, Anthony Bouillon, Lina Tawk, Fabienne Robert, Mariano Martinez, Elodie Crublet, Patrick Weber, Christine Girard-Blanc, Stéphane Petres, Ahmed Haouz, Jean-François Hernandez

المصدر: Nature, Nature Communications. 5(1):1-11

الإتاحة: https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms5833.html

المؤلفون: Henrieta Škovierová, Maria Rosalia Pasca, Stewart T. Cole, Anna Milano, Giulia Degiacomi, Giovanna Riccardi, Petronela Dianišková, Laurent R. Chiarelli, Marco Bellinzoni, Vadim Makarov, Ana Luisa de Jesus Lopes Ribeiro, Giulia Manina, Jozef Marák, David Giganti, Edda De Rossi, Anna Paola Lucarelli, Katarína Mikušová, Pedro M. Alzari, Ahmed Haouz, Silvia Buroni, Aurora Piazza, Elena A. Salina, João Neres

المصدر: Molecular Microbiology. 77:1172-1185

مصطلحات موضوعية: 0303 health sciences, biology, 030306 microbiology, medicine.drug_class, Mycobacterium smegmatis, Flavin mononucleotide, biology.organism_classification, Antimycobacterial, Microbiology, 3. Good health, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Nitroreductase, Protein structure, chemistry, Biochemistry, Docking (molecular), medicine, Molecular Biology, Gene knockout, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ee045b7d01f84c834a86fc2231e813b4
https://doi.org/10.1111/j.1365-2958.2010.07277.x