-
1
المؤلفون: Tarik Khaznadar, Helen Susanne Price, Andy Billinton, Martin E. Swarbrick, David Andrew Stevens, Gerard Martin Paul Giblin, Melanie A. Kay, Anton D. Michel, Nicholas Maughan Clayton, David J. Spalding, Alan Naylor, Alex W. Wilson, Amanda C. Allan, Mark Patrick Healy, Iain P. Chessell, Kristin Bailey
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1892-1896
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, EP4 Receptor, Pharmaceutical Science, Inflammatory pain, Biochemistry, Partial agonist, Anti-inflammatory, 03 medical and health sciences, Acetic acid, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Drug Discovery, Neuropathic pain, medicine, Molecular Medicine, Inhibitory concentration 50, lipids (amino acids, peptides, and proteins), Molecular Biology, 030217 neurology & neurosurgery
-
2
المؤلفون: Mark P, Healy, Amanda C, Allan, Kristin, Bailey, Andy, Billinton, Iain P, Chessell, Nicholas M, Clayton, Gerard M P, Giblin, Melanie A, Kay, Tarik, Khaznadar, Anton D, Michel, Alan, Naylor, Helen, Price, David J, Spalding, David A, Stevens, Martin E, Swarbrick, Alexander W, Wilson
المصدر: Bioorganicmedicinal chemistry letters. 28(10)
مصطلحات موضوعية: Lipopolysaccharides, Blood Cells, Tumor Necrosis Factor-alpha, Anti-Inflammatory Agents, Drug Evaluation, Preclinical, Pain, Isoindoles, Dinoprostone, Rats, Inhibitory Concentration 50, Animals, Humans, Protein Isoforms, Receptors, Prostaglandin E, EP4 Subtype, Half-Life
-
3
المؤلفون: Meindert Danhof, Anne S. Y. Chain, David J. Spalding, O Della Pasqua, Dymphy R.H. Huntjens, Scott G. Summerfield, A Metcalf, A Strougo
المصدر: British Journal of Pharmacology. 153:1072-1084
مصطلحات موضوعية: Pharmacology, education.field_of_study, Chemistry, Population, Flurbiprofen, Intestinal absorption, NONMEM, Diclofenac, Pharmacokinetics, Pharmacodynamics, medicine, education, Rofecoxib, medicine.drug
-
4
المؤلفون: Gerard Martin Paul Giblin, Anton D. Michel, Adrian Hall, Riccardo Novelli, Matthew R. Johnson, Alan Naylor, Susan H. Brown, David J. Spalding, Nicholas Maughan Clayton, Mark Patrick Healy, Anita Chowdhury, Jennifer Sweeting, Iain P. Chessell, Tanya Coleman, Beverley Hammond, Ann Metcalf
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:732-735
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pain, Pharmaceutical Science, CHO Cells, Benzoates, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, In vivo, Oral administration, Cricetinae, mental disorders, Drug Discovery, Animals, Receptors, Prostaglandin E, Structure–activity relationship, Pyrroles, Receptor, Molecular Biology, Benzoic acid, Pyrrole, Inflammation, Organic Chemistry, Antagonist, Receptors, Prostaglandin E, EP1 Subtype, Rats, chemistry, Molecular Medicine
-
5
المؤلفون: Nicholas Maughan Clayton, Gerard Martin Paul Giblin, Mark Patrick Healy, Anton D. Michel, Riccardo Novelli, Beverley Hammond, Stephen John Atkinson, Sac P. Tang, Susan H. Brown, Matthew R. Johnson, Anita Chowdhury, Alan Naylor, David J. Spalding, Adrian Hall, Iain P. Chessell, Robert Gleave, Tanya Coleman
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3657-3662
مصطلحات موضوعية: Stereochemistry, Isostere, Carboxylic acid, Clinical Biochemistry, Biological Availability, Pain, Pharmaceutical Science, Ether, Cyclopentanes, Ligands, Benzoates, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Cyclohexanes, Drug Discovery, Animals, Receptors, Prostaglandin E, Pyrroles, Molecular Biology, Pyrrole, Inflammation, chemistry.chemical_classification, Analgesics, Organic Chemistry, Receptors, Prostaglandin E, EP1 Subtype, Rats, Bioavailability, chemistry, Benzyl group, Molecular Medicine, Derivative (chemistry)
-
6
المصدر: British Journal of Pharmacology. 148:396-404
مصطلحات موضوعية: Pharmacology, Naproxen, biology, Blood proteins, Thromboxane B2, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, medicine, biology.protein, Cyclooxygenase, Ex vivo, medicine.drug
-
7
المؤلفون: Maria del Carmen Osuna, David J. Spalding, Ann Hersey, Beverley Hammond, P. Jeffrey, Alexander J. Stevens, Scott G. Summerfield, Sac-Pham Tang, Leanne Cutler
المصدر: Journal of Pharmacology and Experimental Therapeutics. 316:1282-1290
مصطلحات موضوعية: Male, Membrane permeability, Central nervous system, Biology, Pharmacology, Blood–brain barrier, Permeability, Mice, Dogs, Species Specificity, In vivo, medicine, Animals, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Brain, Transporter, Penetration (firestop), Rats, medicine.anatomical_structure, Solubility, Blood-Brain Barrier, biology.protein, Biophysics, Molecular Medicine, Efflux, Dialysis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72277d0934e7ea9036431fd70fee9638
https://doi.org/10.1124/jpet.105.092916 -
8
المؤلفون: C. Bountra, M J Sheehan, David J. Spalding, Alan Naylor, Paul John Beswick, C.D. Eldred, Sue D. Collins, R.P.C. Cousins, Nick M. Clayton
المصدر: Medicinal Chemistry Research. 13:88-98
مصطلحات موضوعية: Chemistry, Organic Chemistry, Pharmacology toxicology, medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Adenosine, medicine.drug
-
9
المؤلفون: Andrew K. Takle, Gail Hutley, Neil Stuart Garton, Terry Panchal, Thomas George Christopher Hayhow, Emmanuel Hubert Demont, Delphine Brissy, Mark James Bamford, Irene Farre-Gutierrez, Joanna Brookfield, Nicholas Bailey, Richard L. Elliott, David J. Spalding, Antoinette Naylor, Hui-Xian Seow
المصدر: Bioorganicmedicinal chemistry letters. 19(13)
مصطلحات موضوعية: Stereochemistry, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biochemistry, Chemical synthesis, chemistry.chemical_compound, H(+)-K(+)-Exchanging ATPase, Structure-Activity Relationship, Dogs, Pharmacokinetics, In vivo, Oral administration, Drug Discovery, Pyridine, Animals, Humans, Molecular Biology, biology, Organic Chemistry, Proton Pump Inhibitors, Hydrogen-Ion Concentration, Rats, Orally active, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Gastric acid
-
10
المصدر: European journal of pain (London, England). 13(5)
مصطلحات موضوعية: Male, Pain Threshold, Naproxen, Time Factors, Endpoint Determination, Freund's Adjuvant, Drug Evaluation, Preclinical, Pain, Pharmacology, Placebo, Sensitivity and Specificity, Dinoprostone, Rats, Sprague-Dawley, Diclofenac, Pharmacokinetics, Threshold of pain, medicine, Animals, Cyclooxygenase Inhibitors, Rofecoxib, Pain Measurement, Inflammation, Behavior, Animal, business.industry, Membrane Proteins, Rats, Ketorolac, Thromboxane B2, Disease Models, Animal, Anesthesiology and Pain Medicine, Cyclooxygenase 2, Anesthesia, Hyperalgesia, Cyclooxygenase 1, medicine.symptom, Inflammation Mediators, business, Biomarkers, medicine.drug