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المؤلفون: Axel Behrens, Clive Da Costa, Min Wu, David Joseph Guerin, Emma Nye, Jonathan O'Connell, Adan Pinto-Fernandez, Eva M. Riising, Jeffrey D Kearns, Tim Hammonds, Andrew P. Turnbull, Crystal McKinnon, E. Josue Ruiz, Claire Heride, Christopher J. Dinsmore, Malte Gersch, Ian Rosewell, Thomas M. Charlton, Linxiang Lan, Neil P. Jones, Andreas Damianou, Hannah C. Scott, Benedikt M. Kessler, Sylvie Urbé, Michael J. Clague, Natalia Moncaut, Wojciech W. Krajewski, Stephanos Ioannidis, David Komander, Marie Katz, Sunkyu Kim, George Vere
مصطلحات موضوعية: Chemistry, Cancer research, Small molecule, Squamous cell lung carcinoma
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::205d91672bd258cadd1c178b2544807d
https://doi.org/10.7554/elife.71596.sa2 -
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المؤلفون: Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
المصدر: eLife, Vol 10 (2021)
eLifeمصطلحات موضوعية: Lung Neoplasms, Gene Expression, medicine.disease_cause, Imaging, Mice, 0302 clinical medicine, Biology (General), Cancer Biology, Human Biology & Physiology, 0303 health sciences, Chemistry, Stem Cells, General Neuroscience, Lung squamous cell carcinoma, Genome Integrity & Repair, Treatment options, General Medicine, Small molecule, 3. Good health, DNA-Binding Proteins, medicine.anatomical_structure, c-MYC, 030220 oncology & carcinogenesis, Medicine, Lung tumours, Ubiquitin Thiolesterase, Genetics & Genomics, Research Article, Human, Squamous cell lung carcinoma, Model organisms, QH301-705.5, Science, Chemical biology, USP28, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, squamous cell lung cancer, Biochemistry and Chemical Biology, medicine, Ubiquitin specific protease, Animals, Humans, Neoplasms, Squamous Cell, Survival rate, 030304 developmental biology, Lung, General Immunology and Microbiology, Tumour Biology, Disease Models, Animal, Cancer research, Carcinogenesis, Gene Deletion, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb8f4f7baf6b379b1145b3efa1b3fa6
https://elifesciences.org/articles/71596 -
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المؤلفون: Michael D. Altman, Christopher J. Dinsmore, John F. Reilly, Jonathan R. Young, Chaomin Li, Sangita B. Patel, Deborah Walker, Craig Rosenstein, David Joseph Guerin, Timothy Allison, Harold Hatch, Stephen M. Soisson, Sujal V. Deshmukh, Bart Lutterbach, Bo Sheng Pan, Danielle Falcone, Michael H. Reutershan, Keith W. Rickert, Matthew H. Katcher, Wei Lu, Melissa Chenard, Kevin J. Wilson, Alan B. Northrup, Alexander A. Szewczak, Matthew H. Daniels
المصدر: Journal of Medicinal Chemistry. 56:2294-2310
مصطلحات موضوعية: chemistry.chemical_compound, C-Met, Protein structure, CYP3A4, chemistry, Cell culture, Kinase, Stereochemistry, Drug discovery, Drug Discovery, Molecular Medicine, Potency, Selectivity
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المؤلفون: Jason D. Katz, Bart Lutterbach, Harold Hatch, Robert J. Mathvink, Wenxian Wang, Xianlu Qu, Kaiko Kunii, C. Gary Marshall, Bo-Sheng Pan, Keith W. Rickert, Craig Rosenstein, Alexander A. Szewczak, Jonathan R. Young, Kevin J. Lumb, David Joseph Guerin, Sangita B. Patel, Gaozhen Hang, Qinwen Zeng, Sujal V. Deshmukh, Deborah Walker, Danielle Falcone, Stephen M. Soisson, Lenora Davis, Rachael Holmes, Kerrie Spencer, William K. Dahlberg, Wei Lu, James P. Jewell, Ana Esther Ortega Gabarda, Naim Nazef, Michael D. Altman, Christopher J. Dinsmore, John F. Reilly, Jongwon Lim
المصدر: Journal of Medicinal Chemistry. 54:4092-4108
مصطلحات موضوعية: Models, Molecular, C-Met, Pyridines, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Phosphorylation, Sulfonamides, biology, Chemistry, Cyclin-dependent kinase 4, Kinase, Receptor Protein-Tyrosine Kinases, Cancer, Haplorhini, medicine.disease, Transmembrane protein, Rats, Benzocycloheptenes, Biochemistry, Mutation, Cancer research, biology.protein, Pyrazoles, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Signal transduction, Tyrosine kinase, Neoplasm Transplantation, Protein Binding
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المؤلفون: David Joseph Guerin, Danielle Falcone, Ekundayo Osimboni
المصدر: Tetrahedron Letters. 55:2646-2648
مصطلحات موضوعية: chemistry.chemical_classification, Xantphos, Aryl, Organic Chemistry, Hydantoin, chemistry.chemical_element, Biochemistry, Catalysis, Amino acid, chemistry.chemical_compound, chemistry, Drug Discovery, Glycine, Organic chemistry, Amination, Palladium
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المؤلفون: David Joseph Guerin, Danielle Falcone, Ekundayo Osimboni
المصدر: ChemInform. 45
مصطلحات موضوعية: chemistry.chemical_classification, Carbamate, Xantphos, medicine.medical_treatment, Aryl, Synthon, chemistry.chemical_element, General Medicine, Catalysis, Amino acid, chemistry.chemical_compound, chemistry, Glycine, medicine, Organic chemistry, Palladium
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المؤلفون: Kevin J. Lumb, David Joseph Guerin, Stephen M. Soisson, Jennifer M. Shipman, Kevin J. Wilson, Rachael E. Ford, Jun Lu, Sanjeev Munshi, John C. Reid, Jonathon R. Young, Sangita B. Patel, Maria Kornienko, Elizabeth Stanton, Timothy J. Allison, Dawn L. Hall, Paul L. Darke, Keith W. Rickert, Noel Byrne
المصدر: The Journal of biological chemistry. 286(13)
مصطلحات موضوعية: Conformational change, Receptor Protein-Tyrosine Kinases, C-Mer Tyrosine Kinase, Biology, Spodoptera, Crystallography, X-Ray, Biochemistry, Receptor tyrosine kinase, Protein Structure, Secondary, Cell Line, Structure-Activity Relationship, Protein structure, Proto-Oncogene Proteins, Animals, Humans, Phosphorylation, Molecular Biology, Protein Kinase Inhibitors, c-Mer Tyrosine Kinase, Autophosphorylation, Cell Biology, Small molecule, Protein Structure, Tertiary, Protein kinase domain, Drug Design, Protein Structure and Folding, biology.protein, Biophysics, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ed4ab62eb2cae926d37593e2d4a5ac
https://pubmed.ncbi.nlm.nih.gov/21247903
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