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1
المؤلفون: David S. Nirschl, Mark F. Russo, William Neil, G. Greg Zipp, Gregory A. Nemeth
المصدر: SLAS technology. 23(5)
مصطلحات موضوعية: Automation, Laboratory, Internet, Source code, Barcode reader, business.industry, Computer science, media_common.quotation_subject, Sample (material), Barcode, Chemistry Techniques, Analytical, Computer Science Applications, law.invention, High-Throughput Screening Assays, Medical Laboratory Technology, Workflow, law, Container (abstract data type), Data system, Instrumentation (computer programming), business, Computer hardware, media_common
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871a773efb562807e6cb2cb3407d55d5
https://pubmed.ncbi.nlm.nih.gov/30016131 -
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المؤلفون: Qian Xiang, Dietmar A. Seiffert, Wu Yang, Tianan Fang, Joseph E. Myers, Joanne M. Smallheer, Patrick Y.S. Lam, Jeon Yoon T, Zhen Lou, Joanna Zheng, Joseph M. Luettgen, Jeffrey M. Bozarth, Steven Sheriff, Yufeng Wang, William R. Ewing, Zilun Hu, Indawati De Lucca, Donald J. P. Pinto, Michael J. Orwat, James R. Corte, Charles G. Clark, Karen A. Rossi, Alan R. Rendina, Timothy W. Harper, Ruth R. Wexler, David S. Nirschl, Baomin Xin, Yiming Wu
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:126604
مصطلحات موضوعية: Models, Molecular, Macrocyclic Compounds, Serine Proteinase Inhibitors, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Factor XIa, Ligands, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, Hydrolase, Humans, Moiety, Molecular Biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Ligand (biochemistry), Combinatorial chemistry, Enhanced bioavailability, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, Structure based, Linker
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3
المؤلفون: Mahboubeh Kheirabadi, Martin D. Eastgate, Kenneth M. Boy, David K. Leahy, Percy H. Carter, Gardner S. Creech, Jennifer X. Qiao, David S. Nirschl
المصدر: The Journal of organic chemistry. 83(8)
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Leaving group, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Amino acid, chemistry.chemical_compound, chemistry, Thioether, Nucleophile, Logic gate, Peptide synthesis, Side chain, Amine gas treating
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المؤلفون: Joel C. Barrish, Aberra Fura, Guoxiang Shen, Jingwu Duan, David S. Nirschl, Jonathan Lippy, Stephen T. Wrobleski, Rosemary Zhang, Lidia M. Doweyko, Bingwei V. Yang, Lauren Haque, Murray McKinnon, Shuqun Lin, Luisa Salter-Cid, Sidney Pitt, William J. Pitts, Percy H. Carter, John S. Sack, Gary L. Schieven, Bin Jiang, John Hynes, Gregory D. Brown, John S. Tokarski, Zhonghui Lu, Javed Khan, Steven G. Nadler
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5721-5726
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Clinical Biochemistry, Substituent, Administration, Oral, Pharmaceutical Science, Enzyme-Linked Immunosorbent Assay, Biochemistry, Pyrrolopyridazine, Pyridazine, Interferon-gamma, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Functional selectivity, Animals, Humans, Pyrroles, Tissue Distribution, Protein Kinase Inhibitors, Molecular Biology, Whole blood, Mice, Inbred BALB C, Molecular Structure, Organic Chemistry, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, Pyridazines, chemistry, Tyrosine kinase 2, Molecular Medicine, Amine gas treating, Janus kinase
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5Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode
المؤلفون: William R. Ewing, Carrie Xu, Heng Liu, Brian J. Murphy, Neil Flynn, Tao Wang, Douglas B. Moore, Lori Kunselman, Bruce A. Ellsworth, Elizabeth A. Jurica, Kimberly A. Foster, Atsu Apedo, Yuan Tian, Yang Hong, Arvind Mathur, Bradley A. Zinker, Biji Jacob, Kristin N. Williams, Min Zhou, Brad D. Maxwell, Gary Cao, Andres S. Hernandez, Qin Sun, Hong Cai, Jean M. Whaley, Elizabeth A. Dierks, Joel C. Barrish, Dora M. Schnur, Ximao Wu, Doree F. Sitkoff, Mary Ellen Cvijic, Richard Rampulla, Chunshan Xie, David S. Nirschl, Reshma Panemangalore, Michael B. Hicks, Jeffrey A. Robl, Jason J. Wilkes
المصدر: Journal of medicinal chemistry. 60(4)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Blood Glucose, Male, Models, Molecular, Pyrrolidines, medicine.drug_class, Stereochemistry, Carboxylic acid, 01 natural sciences, Pyrrolidine, Cell Line, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Glucagon-Like Peptide 1, Free fatty acid receptor 1, Drug Discovery, medicine, Radioligand, Animals, Humans, Hypoglycemic Agents, Insulin, Cells, Cultured, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Ligand binding assay, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 030104 developmental biology, Diabetes Mellitus, Type 2, Molecular Medicine, Pharmacophore
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المؤلفون: John H. Dodd, John L. Gilmore, Joel C. Barrish, Hai Yun Xiao, Jack S. Sack, Martin J. Corbett, James E. Sheppeck, Mark D. Cunningham, Mary F. Malley, John E. Somerville, Lorraine I. McKay, Jack Z. Gougoutas, Steven G. Nadler, David S. Nirschl, Sium Habte, T. G. Murali Dhar, Arthur M. Doweyko
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:5442-5447
مصطلحات موضوعية: Agonist, Indazoles, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Glucocorticoid, Amide, Drug Discovery, medicine, Humans, Potency, Molecular Biology, Indazole, Binding Sites, Nonsteroidal, Molecular Structure, Organic Chemistry, In vitro toxicology, Amides, chemistry, Nuclear receptor, Molecular Medicine, Steroids, Glucocorticoid, Protein Binding, medicine.drug
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المصدر: ACS Combinatorial Science. 14:520-526
مصطلحات موضوعية: Process (engineering), Chemistry, Chemistry, Pharmaceutical, Six Sigma, General Chemistry, General Medicine, Process changes, Efficiency, Organizational, Medicinal chemistry, Lean manufacturing, Bottleneck, Pharmaceutical Preparations, Drug Discovery, Humans, Lower cost, Productivity
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المؤلفون: William J. Pitts, Alaric J. Dyckman, Scott H. Watterson, Robert V. Moquin, Kim W. McIntyre, Zheng Yang, Jagabandhu Das, Katy Van Kirk, James R. Burke, David B. Wang-Iverson, Hollie Booth-Lute, James Kempson, Laishun Chen, Charles M. Langevine, Joel C. Barrish, Guchen Yang, Xiaoxia Yang, John H. Dodd, David S. Nirschl, Murray McKinnon, Steven H. Spergel, Mark A. Pattoli, Michael Galella, Kurt R. Gregor, Junquing Guo
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7006-7012
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Acetamides, Drug Discovery, Animals, Humans, Inhibitory concentration 50, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Drug discovery, Organic Chemistry, Inflammatory Bowel Diseases, In vitro, I-kappa B Kinase, Rats, Enzyme Activation, chemistry, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Acetamide, Tricyclic
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المؤلفون: William H. Bullock, Kurt J. Edinger, David S. Nirschl, Thomas Swann, Jeffrey Kiplinger, Mark A. Hermsmeier, Steven L. Hoffman, Harold N. Weller, Jiang Zhao, Paul Lefebvre, Katalin Ebinger
المصدر: Journal of Combinatorial Chemistry. 12:877-882
مصطلحات موضوعية: animal structures, Preparative hplc, Chromatography, Chemistry, Chromatography, Supercritical Fluid, General Chemistry, High-performance liquid chromatography, Small molecule, Small Molecule Libraries, Orthogonality, Drug Design, Supercritical fluid chromatography, Selectivity, Chromatography, High Pressure Liquid
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المؤلفون: Ying Han, Katalin Ebinger, Lauren E. Vandevier, Jennifer W. Maloney, David S. Nirschl, Harold N. Weller
المصدر: Tetrahedron Letters. 51:629-632
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Microwave irradiation, Benzenesulfonyl chloride, Organic chemistry, Biochemistry, Amine derivatives