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1
المؤلفون: Maria Joshi, Fuxin Qian, Xiaoli Zhang, Xinqiang Li, Marlena Walls, David T. Winn, Amogh Boloor, David Alan Campbell, Ping Wei, Yuliang Zhang, Denise Hanway, Gabriel Mendez, Juan Manuel Betancort, Michael E. Hepperle
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5708-5711
مصطلحات موضوعية: Proteases, Genotype, Peptidomimetic, viruses, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, Viral Proteins, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Peptide synthesis, Humans, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, NS3, Protease, biology, Organic Chemistry, Intracellular Signaling Peptides and Proteins, virus diseases, biochemical phenomena, metabolism, and nutrition, Boronic Acids, Hepatitis C, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Mutant Proteins, Carrier Proteins, Boronic acid
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2
المؤلفون: David Campbell, James Schmeits, Shu-Hui Chen, Denise Hanway, David T. Winn, Wensheng Liao, Ruzhang Liu, Juan M. Betancort, Junjuan Liu, David P. Carney, Quansheng Xu, Xinqiang Li, Eric M. Gordon
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4437-4440
مصطلحات موضوعية: Pyrrolidines, Time Factors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Catalysis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Nitriles, Drug Discovery, Diabetes Mellitus, Humans, Enzyme Inhibitors, Molecular Biology, Dipeptidyl peptidase-4, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, Molecular Structure, Bicyclic molecule, biology, Organic Chemistry, In vitro, Protein Structure, Tertiary, Thiazoles, Enzyme, Models, Chemical, chemistry, Enzyme inhibitor, Drug Design, Lactam, biology.protein, Thiazolidines, Molecular Medicine, Selectivity, Azabicyclo Compounds
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3
المؤلفون: David T. Winn, Ge Li, Juan Manuel Betancort, Qiang Li, Yang Wu, Wensheng Liao, Shu-Hui Chen, Ruzhang Liu, David Campbell
المصدر: Tetrahedron. 64:4363-4369
مصطلحات موضوعية: chemistry.chemical_compound, Bicyclic molecule, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Thiazolidine, Lactam, Epimer, Biochemistry
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4
المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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5
المؤلفون: David T. Winn, Kristy A. Martin, Anthony W. Czarnik, Lewis E. Fikes, Mark A. Mortellaro, Robert W. Sweger, Scott Clary, Morgan P. Johnson
المصدر: Journal of the American Chemical Society. 117:10443-10448
مصطلحات موضوعية: chemistry.chemical_classification, Colloid and Surface Chemistry, Nucleophile, Cyclodextrin, Chemistry, Stereochemistry, Alpha (ethology), Reactivity (chemistry), General Chemistry, Beta (finance), Biochemistry, Catalysis
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6
المؤلفون: David T. Winn, Anthony W. Czarnik, Mark A. Mortellaro, Sungyeap Hong
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2041-2044
مصطلحات موضوعية: chemistry.chemical_classification, Primary (chemistry), Cyclodextrin, Chemistry, Organic Chemistry, Clinical Biochemistry, technology, industry, and agriculture, Pharmaceutical Science, Oxime, Biochemistry, carbohydrates (lipids), Hydrolysis, chemistry.chemical_compound, Reagent, Drug Discovery, polycyclic compounds, Molecular Medicine, Organic chemistry, lipids (amino acids, peptides, and proteins), Molecular Biology
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7
المؤلفون: David J. Mangelsdorf, Richard A. Heyman, Marcus F. Boehm, Michael R. McClurg, Jonathan J. Hebert, Charles Pathirana, Steven K. White, David T. Winn, Mark E. Goldman
المصدر: Journal of Medicinal Chemistry. 37:408-414
مصطلحات موضوعية: Retinoid X receptor alpha, Chemistry, Retinoic acid, Retinoid receptor, Retinoid X receptor, Retinoid X receptor gamma, Retinoic acid receptor, chemistry.chemical_compound, Biochemistry, Retinoic acid receptor alpha, embryonic structures, Drug Discovery, Molecular Medicine, Retinoid X receptor beta
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8
المؤلفون: Keith B. Marschke, James P. Edwards, Mark E. Goldman, Robert I. Higuchi, Lawrence G. Hamann, Thomas R. Caferro, Pooley Charlotte L F, Lin Zhi, David T. Winn, Todd K. Jones
المصدر: ChemInform. 30
مصطلحات موضوعية: Transcriptional activity, Trifluoromethyl, Nonsteroidal, General Medicine, Molecular biology, Androgen Receptor Agonists, In vitro, Androgen receptor, chemistry.chemical_compound, chemistry, Dihydrotestosterone, medicine, Whole cell, medicine.drug
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9
المؤلفون: John W. Kozarich, Melissa S. Wong, David T. Winn, Tyzoon K. Nomanbhoy, Stacy R. Fuller, Jonathan S. Rosenblum, Kevin R. Shreder, Min Wu, Yi Hu, Senaiet Alemayehu, Zhizhou Yu, Sergio Corral
المصدر: Bioorganicmedicinal chemistry letters. 15(19)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Norleucine, Pharmaceutical Science, Biochemistry, Chemical synthesis, Substrate Specificity, Residue (chemistry), chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Molecular Biology, Alkyl, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Dipeptides, Boronic Acids, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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10
المؤلفون: Babak Samii, Eric Okerberg, Baohong Zhang, Matthew P. Patricelli, Jonathan J. Burbaum, David T. Winn, Kelly Blackford, Kevin R. Shreder, Jiangyue Wu
مصطلحات موضوعية: chemistry.chemical_classification, Proteomics, Multidisciplinary, Binding Sites, Serine Endopeptidases, Active site, Electrophoresis, Capillary, Peptide, Biology, Biological Sciences, Peptide Mapping, DNA sequencing, Mice, chemistry, Biochemistry, Functional proteomics, Proteome, biology.protein, Profiling (information science), Animals, Binding site, Peptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f9604a603b6a31527077e043fd8769
https://europepmc.org/articles/PMC555687/