-
1
المؤلفون: Lili Xie, Charles R. Dean, Colin Osborne, Grazia Piizzi, Som Wattanasin, Jade Bojkovic, Francois Lenoir, Eugene Liu, Yipin Lu, Meir Glick, Donghui Yu, Tommasi Ruben A, Lawrence G. Hamann, Bing Wang, John Ryan Kerrigan, David Thomas Parker, Markus Dobler, Srijan Ranjitkar, JoAnn Dzink-Fox, Yunshan Peng, Leanne Lanieri, Hongming Wang, Xia Yang, David McKenney, Jill Nunez, Anup Patnaik, Maria-Dawn Lilly, Elizabeth R. Sprague
المصدر: Journal of Medicinal Chemistry. 60:5002-5014
مصطلحات موضوعية: 0301 basic medicine, 030106 microbiology, Drug Evaluation, Preclinical, Chemistry Techniques, Synthetic, Microbial Sensitivity Tests, Drug resistance, Crystallography, X-Ray, medicine.disease_cause, Amidohydrolases, Microbiology, Lipid A, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Resistance, Multiple, Bacterial, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Pseudomonas Infections, Enzyme Inhibitors, Cytotoxicity, Pathogen, Mice, Inbred BALB C, Hydroxamic acid, Chemistry, Pseudomonas aeruginosa, Hep G2 Cells, Anti-Bacterial Agents, Molecular Docking Simulation, Multiple drug resistance, 030104 developmental biology, Drug Design, Molecular Medicine, Female, K562 Cells
-
2
المؤلفون: Feng Sun, David Thomas Parker, Friedrich Schuerch, Silvio Roggo, Xiaolin Li, Zachary Kevin Sweeney, Li Cao, Nicole Meier, Bernard Riss, Christian Guenat, Wei Li, Zhaobo Gao, Jiping Fu, Jibin Zhao, Subramanian Karur, Wang Ruidong, Andrew H. Weiss, Regis Denay, Alexey Rivkin, Su Xu, Harald Schroeder, Michael Paul Capparelli, Simon Ng, Quanbing Wu, Xin Xiong, Weikuan Li, Wosenu Mergo, Christopher Becker, Robert Lowell Simmons, Amy Lu, Gai Yu, Wenjian Xu, Peichao Lu, Nicolas Wenger, Christian Zürcher, Thomas Lochmann, Meiliana Tjandra, Alexandre Luneau, Hongyong Kim, Aregahegn Yifru, Yunshan Peng, Fabrice Gallou, Jianguang Zhou, Roger Aki Fujimoto, Michael Wang
المصدر: Bioorganicmedicinal chemistry. 26(4)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, chemistry.chemical_compound, Cyclosporin a, Drug Discovery, Potency, Chelation, Molecular Biology, Cyclophilin, 010405 organic chemistry, Organic Chemistry, Chiral ligand, Transporter, Stereoisomerism, Dipeptides, Quinidine, 0104 chemical sciences, Claisen rearrangement, 030104 developmental biology, chemistry, Cyclization, Drug Design, Cyclosporine, Molecular Medicine, Derivative (chemistry)
-
3
المؤلفون: David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto
المصدر: Journal of Medicinal Chemistry. 52:3523-3538
مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Carboxylic acid, Type II collagen, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Pharmacology, Crystallography, X-Ray, Inhibitory Concentration 50, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Protease Inhibitors, Collagen Type II, chemistry.chemical_classification, Sulfonamides, Biological activity, Rats, Cartilage, Enzyme, chemistry, Biochemistry, Collagenase, Molecular Medicine, Cattle, Proteoglycans, medicine.drug
-
4
المؤلفون: Guang-Pei Chen, Hui Liu, Calienni John Vincent, David Thomas Parker, Edwin Bernard Villhauer, Thomas J. Blacklock, Oljan Repic, Joginder S. Bajwa, Vivelo James Anthony, Joel Slade, Kapa Prasad
المصدر: Organic Process Research & Development. 11:825-835
مصطلحات موضوعية: Mesylate, Stereochemistry, Growth factor, medicine.medical_treatment, Organic Chemistry, Azetidine, Alkylation, Ring (chemistry), Reductive amination, Cyclobutane, chemistry.chemical_compound, chemistry, medicine, Physical and Theoretical Chemistry, Receptor
-
5
المؤلفون: Joel Slade, David Thomas Parker, Oljan Repic, Raeann Wu, Scott Joseph, Michael J. Girgis
المصدر: Organic Process Research & Development. 11:721-725
مصطلحات موضوعية: medicine.drug_class, Organic Chemistry, Histone deacetylase inhibitor, Aqueous ethanol, Toluene, law.invention, chemistry.chemical_compound, chemistry, law, Yield (chemistry), SCALE-UP, medicine, Organic chemistry, Physical and Theoretical Chemistry, Crystallization, Stoichiometry, Phenylhydrazine
-
6
المؤلفون: Brigitte Wiedmann, Michael Wang, Andrew H. Weiss, Silvio Roggo, David Thomas Parker, Robert Elling, Jiping Fu, Zachary Kevin Sweeney, Markus Furegati, Kwan Leung, Robert Lowell Simmons, Aregahegn Yifru, Subramanian Karur, Yunshan Peng, Shengtian Yang, Roger Aki Fujimoto, Lili Xie, Alexey Rivkin, Michael Paul Capparelli, Linda Xiao, Imad Hanna, Charlotte Miault, Simon Ng, Christopher Becker, Wosenu Mergo, Theresa Kasprzyk, Dallas Bednarczyk, Peichao Lu, Mark Knapp, Meiliana Tjandra, Bo Zhou, Xiaolin Li, Wenjian Xu
المصدر: Journal of medicinal chemistry. 57(20)
مصطلحات موضوعية: Organic Anion Transporters, Cyclosporins, Chemistry Techniques, Synthetic, Hepacivirus, Pharmacology, Crystallography, X-Ray, Virus Replication, Antiviral Agents, Cyclophilins, Structure-Activity Relationship, Dogs, Pharmacokinetics, Cyclosporin a, Drug Discovery, polycyclic compounds, Potency, Animals, Humans, Cyclophilin, Alisporivir, Chemistry, Liver-Specific Organic Anion Transporter 1, Multidrug resistance-associated protein 2, Transporter, Hepatitis C, Multidrug Resistance-Associated Protein 2, Rats, Biochemistry, Cyclosporine, Molecular Medicine, Multidrug Resistance-Associated Proteins, Hydrophobic and Hydrophilic Interactions, Cyclophilin D, Immunosuppressive Agents
-
7
المؤلفون: Karl Dean, Apurva Chaudhary, Dana Wambser, Oljan Repic, Martin Mueller, Hui Liu, Joginder S. Bajwa, Helmut Boehnke, Kathryn Rene Bracken, Paul G. Lee, Thomas J. Blacklock, Vivelo James Anthony, Joseph Carosi, Kapa Prasad, Michael J. Girgis, Joel Slade, Guang-Pei Chen, David Thomas Parker
المصدر: Organic Process Research & Development. 10:78-93
مصطلحات موضوعية: chemistry.chemical_classification, medicine.drug_class, Stereochemistry, Magnesium, Organic Chemistry, Enantioselective synthesis, chemistry.chemical_element, Carboxamide, Amino acid, chemistry.chemical_compound, Peptide deformylase, chemistry, Hydrogenolysis, Pyridine, medicine, Benzyl group, Physical and Theoretical Chemistry
-
8
المؤلفون: Michael J. Girgis, David Thomas Parker, Parker David John, Joginder S. Bajwa, Hui Liu, Oljan Repic, Joel Slade, Thomas J. Blacklock, Vivelo James Anthony
المصدر: Organic Process Research & Development. 9:608-620
مصطلحات موضوعية: chemistry.chemical_classification, Hydroxamic acid, Stereochemistry, Carboxylic acid, Organic Chemistry, Diastereomer, Ether, Medicinal chemistry, chemistry.chemical_compound, Hydroxylamine, chemistry, Bromide, Physical and Theoretical Chemistry, Racemization, Cis–trans isomerism
-
9
المؤلفون: Naveen Pathak, Ki-Yean Nam, Xiaolu Zhang, Nina C. Gonnella, Richard Melton, Shu-Ih Hu, James Koehn, David Thomas Parker, Vishwas Ganu
المصدر: Journal of Molecular Biology. 301:513-524
مصطلحات موضوعية: chemistry.chemical_classification, HNCA experiment, Hydroxamic acid, Stereochemistry, Nuclear magnetic resonance spectroscopy, Stromelysin 1, chemistry.chemical_compound, Enzyme, chemistry, Structural Biology, Collagenase, medicine, Molecular Biology, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy, medicine.drug
-
10
المصدر: Tetrahedron Letters. 41:2047-2050
مصطلحات موضوعية: chemistry.chemical_compound, Diclofenac, Chemistry, Benzyl alcohol, Organic Chemistry, Drug Discovery, medicine, Trimethyl phosphite, Organic chemistry, Alkylation, Biochemistry, medicine.drug