المؤلفون: Lili Xie, Charles R. Dean, Colin Osborne, Grazia Piizzi, Som Wattanasin, Jade Bojkovic, Francois Lenoir, Eugene Liu, Yipin Lu, Meir Glick, Donghui Yu, Tommasi Ruben A, Lawrence G. Hamann, Bing Wang, John Ryan Kerrigan, David Thomas Parker, Markus Dobler, Srijan Ranjitkar, JoAnn Dzink-Fox, Yunshan Peng, Leanne Lanieri, Hongming Wang, Xia Yang, David McKenney, Jill Nunez, Anup Patnaik, Maria-Dawn Lilly, Elizabeth R. Sprague

المصدر: Journal of Medicinal Chemistry. 60:5002-5014

مصطلحات موضوعية: 0301 basic medicine, 030106 microbiology, Drug Evaluation, Preclinical, Chemistry Techniques, Synthetic, Microbial Sensitivity Tests, Drug resistance, Crystallography, X-Ray, medicine.disease_cause, Amidohydrolases, Microbiology, Lipid A, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Resistance, Multiple, Bacterial, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Pseudomonas Infections, Enzyme Inhibitors, Cytotoxicity, Pathogen, Mice, Inbred BALB C, Hydroxamic acid, Chemistry, Pseudomonas aeruginosa, Hep G2 Cells, Anti-Bacterial Agents, Molecular Docking Simulation, Multiple drug resistance, 030104 developmental biology, Drug Design, Molecular Medicine, Female, K562 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094ae843eba8c8bf8c94ae8350980ced
https://doi.org/10.1021/acs.jmedchem.7b00377

المؤلفون: Feng Sun, David Thomas Parker, Friedrich Schuerch, Silvio Roggo, Xiaolin Li, Zachary Kevin Sweeney, Li Cao, Nicole Meier, Bernard Riss, Christian Guenat, Wei Li, Zhaobo Gao, Jiping Fu, Jibin Zhao, Subramanian Karur, Wang Ruidong, Andrew H. Weiss, Regis Denay, Alexey Rivkin, Su Xu, Harald Schroeder, Michael Paul Capparelli, Simon Ng, Quanbing Wu, Xin Xiong, Weikuan Li, Wosenu Mergo, Christopher Becker, Robert Lowell Simmons, Amy Lu, Gai Yu, Wenjian Xu, Peichao Lu, Nicolas Wenger, Christian Zürcher, Thomas Lochmann, Meiliana Tjandra, Alexandre Luneau, Hongyong Kim, Aregahegn Yifru, Yunshan Peng, Fabrice Gallou, Jianguang Zhou, Roger Aki Fujimoto, Michael Wang

المصدر: Bioorganicmedicinal chemistry. 26(4)

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, chemistry.chemical_compound, Cyclosporin a, Drug Discovery, Potency, Chelation, Molecular Biology, Cyclophilin, 010405 organic chemistry, Organic Chemistry, Chiral ligand, Transporter, Stereoisomerism, Dipeptides, Quinidine, 0104 chemical sciences, Claisen rearrangement, 030104 developmental biology, chemistry, Cyclization, Drug Design, Cyclosporine, Molecular Medicine, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e52dd8f35f84c5e846138d1c4df359
https://pubmed.ncbi.nlm.nih.gov/28919180

المؤلفون: David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto

المصدر: Journal of Medicinal Chemistry. 52:3523-3538

مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Carboxylic acid, Type II collagen, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Pharmacology, Crystallography, X-Ray, Inhibitory Concentration 50, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Protease Inhibitors, Collagen Type II, chemistry.chemical_classification, Sulfonamides, Biological activity, Rats, Cartilage, Enzyme, chemistry, Biochemistry, Collagenase, Molecular Medicine, Cattle, Proteoglycans, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180003a136c55f74b0ef18c43fb4d04e
https://doi.org/10.1021/jm801394m

المؤلفون: Guang-Pei Chen, Hui Liu, Calienni John Vincent, David Thomas Parker, Edwin Bernard Villhauer, Thomas J. Blacklock, Oljan Repic, Joginder S. Bajwa, Vivelo James Anthony, Joel Slade, Kapa Prasad

المصدر: Organic Process Research & Development. 11:825-835

مصطلحات موضوعية: Mesylate, Stereochemistry, Growth factor, medicine.medical_treatment, Organic Chemistry, Azetidine, Alkylation, Ring (chemistry), Reductive amination, Cyclobutane, chemistry.chemical_compound, chemistry, medicine, Physical and Theoretical Chemistry, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8680a9e056f9ffa4fdd95136e5c721f6
https://doi.org/10.1021/op700052u

المؤلفون: Joel Slade, David Thomas Parker, Oljan Repic, Raeann Wu, Scott Joseph, Michael J. Girgis

المصدر: Organic Process Research & Development. 11:721-725

مصطلحات موضوعية: medicine.drug_class, Organic Chemistry, Histone deacetylase inhibitor, Aqueous ethanol, Toluene, law.invention, chemistry.chemical_compound, chemistry, law, Yield (chemistry), SCALE-UP, medicine, Organic chemistry, Physical and Theoretical Chemistry, Crystallization, Stoichiometry, Phenylhydrazine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::db050e9dbc8bb27e8c0eb21a6432b334
https://doi.org/10.1021/op7000518

المؤلفون: Brigitte Wiedmann, Michael Wang, Andrew H. Weiss, Silvio Roggo, David Thomas Parker, Robert Elling, Jiping Fu, Zachary Kevin Sweeney, Markus Furegati, Kwan Leung, Robert Lowell Simmons, Aregahegn Yifru, Subramanian Karur, Yunshan Peng, Shengtian Yang, Roger Aki Fujimoto, Lili Xie, Alexey Rivkin, Michael Paul Capparelli, Linda Xiao, Imad Hanna, Charlotte Miault, Simon Ng, Christopher Becker, Wosenu Mergo, Theresa Kasprzyk, Dallas Bednarczyk, Peichao Lu, Mark Knapp, Meiliana Tjandra, Bo Zhou, Xiaolin Li, Wenjian Xu

المصدر: Journal of medicinal chemistry. 57(20)

مصطلحات موضوعية: Organic Anion Transporters, Cyclosporins, Chemistry Techniques, Synthetic, Hepacivirus, Pharmacology, Crystallography, X-Ray, Virus Replication, Antiviral Agents, Cyclophilins, Structure-Activity Relationship, Dogs, Pharmacokinetics, Cyclosporin a, Drug Discovery, polycyclic compounds, Potency, Animals, Humans, Cyclophilin, Alisporivir, Chemistry, Liver-Specific Organic Anion Transporter 1, Multidrug resistance-associated protein 2, Transporter, Hepatitis C, Multidrug Resistance-Associated Protein 2, Rats, Biochemistry, Cyclosporine, Molecular Medicine, Multidrug Resistance-Associated Proteins, Hydrophobic and Hydrophilic Interactions, Cyclophilin D, Immunosuppressive Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a61abf4dfcb20880ae50fd15ffdba9f
https://pubmed.ncbi.nlm.nih.gov/25310383

المؤلفون: Karl Dean, Apurva Chaudhary, Dana Wambser, Oljan Repic, Martin Mueller, Hui Liu, Joginder S. Bajwa, Helmut Boehnke, Kathryn Rene Bracken, Paul G. Lee, Thomas J. Blacklock, Vivelo James Anthony, Joseph Carosi, Kapa Prasad, Michael J. Girgis, Joel Slade, Guang-Pei Chen, David Thomas Parker

المصدر: Organic Process Research & Development. 10:78-93

مصطلحات موضوعية: chemistry.chemical_classification, medicine.drug_class, Stereochemistry, Magnesium, Organic Chemistry, Enantioselective synthesis, chemistry.chemical_element, Carboxamide, Amino acid, chemistry.chemical_compound, Peptide deformylase, chemistry, Hydrogenolysis, Pyridine, medicine, Benzyl group, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::235d589a0750f7d99f4094c42ae298b3
https://doi.org/10.1021/op050165y

المؤلفون: Michael J. Girgis, David Thomas Parker, Parker David John, Joginder S. Bajwa, Hui Liu, Oljan Repic, Joel Slade, Thomas J. Blacklock, Vivelo James Anthony

المصدر: Organic Process Research & Development. 9:608-620

مصطلحات موضوعية: chemistry.chemical_classification, Hydroxamic acid, Stereochemistry, Carboxylic acid, Organic Chemistry, Diastereomer, Ether, Medicinal chemistry, chemistry.chemical_compound, Hydroxylamine, chemistry, Bromide, Physical and Theoretical Chemistry, Racemization, Cis–trans isomerism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::65e7b5f41692ea0178d06de135825474
https://doi.org/10.1021/op050066k

المؤلفون: Naveen Pathak, Ki-Yean Nam, Xiaolu Zhang, Nina C. Gonnella, Richard Melton, Shu-Ih Hu, James Koehn, David Thomas Parker, Vishwas Ganu

المصدر: Journal of Molecular Biology. 301:513-524

مصطلحات موضوعية: chemistry.chemical_classification, HNCA experiment, Hydroxamic acid, Stereochemistry, Nuclear magnetic resonance spectroscopy, Stromelysin 1, chemistry.chemical_compound, Enzyme, chemistry, Structural Biology, Collagenase, medicine, Molecular Biology, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed3ec780e45b90201ba2ea4b3a6d818d
https://doi.org/10.1006/jmbi.2000.3988

المؤلفون: David Thomas Parker, Tonia Parker, Joe Somers, Clive Gideon Diefenbacher, Ben Mugrage

المصدر: Tetrahedron Letters. 41:2047-2050

مصطلحات موضوعية: chemistry.chemical_compound, Diclofenac, Chemistry, Benzyl alcohol, Organic Chemistry, Drug Discovery, medicine, Trimethyl phosphite, Organic chemistry, Alkylation, Biochemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4cbe3b93df17a1598bb312866c9580b
https://doi.org/10.1016/s0040-4039(00)00111-8