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المؤلفون: Jean-Marc Lapierre, Cathy O. Bull, Ronald E. Savage, Sudharshan Eathiraj, David Vensel, Sapna Makhija, Eugene Kelleher, Neil Westlund, Jeff Szwaya, Yanbin Liu, Steffi Koerner, Magdi Moussa, Susan Cornell-Kennon, Akihisa Matsuda, Darin Kizer, Nivedita Namdev, Hui Wu, Shin Iimura, Brian Schwartz, Erika Volckova
المصدر: Journal of Medicinal Chemistry. 59:6455-6469
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Allosteric regulation, Administration, Oral, Aminopyridines, AKT1, Antineoplastic Agents, AKT2, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Animals, Humans, Moiety, Protein Kinase Inhibitors, Protein kinase B, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Imidazoles, Neoplasms, Experimental, Endometrial Neoplasms, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, embryonic structures, Molecular Medicine, Phosphorylation, Female, Drug Screening Assays, Antitumor, Carcinoma, Endometrioid, Proto-Oncogene Proteins c-akt
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2
المؤلفون: Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Karen Bresciano, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Terence Hall, Jason Hill, Eoin Kelleher, Sampada Khanapurkar, Darin Kizer, Steffi Koerner, Jeff Link, Yanbin Liu, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Khanh Nguyen, Robert Nicewonger, Rocio Palma, Jeff Szwaya, Manish Tandon, Uma Uppalapati, David Vensel, Laurie P. Volak, Erika Volckova, Neil Westlund, Hui Wu, Rui-Yang Yang, Thomas C. K. Chan
المصدر: Journal of Medicinal Chemistry. 55:5291-5310
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Pyridines, Administration, Oral, Biological Availability, AKT1, Antineoplastic Agents, Plasma protein binding, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein kinase B, Adaptor Proteins, Signal Transducing, Cell Proliferation, Effector, Chemistry, Imidazoles, Ribosomal Protein S6 Kinases, 70-kDa, Small molecule, Biochemistry, Microsomes, Liver, Molecular Medicine, Proto-Oncogene Proteins c-akt, Protein Binding
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3
المؤلفون: Rocio Palma, Alan Beresford, Mary-Margaret O’Donnell, Donglai Yang, Alex Porte, David Vensel, Manish Tandon, Mark A. Ashwell
المصدر: Bioorganicmedicinal chemistry letters. 14(7)
مصطلحات موضوعية: Stereochemistry, In silico, Clinical Biochemistry, Pharmaceutical Science, Ligands, Biochemistry, Chemical synthesis, Piperazines, Gepirone, Serotonin Agents, Cytochrome P-450 Enzyme System, Drug Discovery, Cytochrome P-450 CYP3A, medicine, Molecule, Humans, Molecular Biology, chemistry.chemical_classification, biology, CYP3A4, Ligand, Chemistry, Organic Chemistry, Cytochrome P450, General Medicine, Metabolism, In vitro, Enzyme, Drug Design, Receptor, Serotonin, 5-HT1A, biology.protein, Molecular Medicine, medicine.drug, Human cytochrome
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المؤلفون: Yi Yu, David Vensel, Cathy Bull, Deirdre Lowe, Hui Wu, Chang-Rung Chen, Daniel T. Dransfield, Xuibin Gu, Susan Cornell-Kennon, Nivedita Namdev, Steffi Koerner, Laurie P. Volak, Mark A. Ashwell, Jason Hill, Jianqiang Wang, Yanbin Liu, Magdi Moussa
المصدر: Molecular Cancer Therapeutics. 12:B270-B270
مصطلحات موضوعية: Non-receptor tyrosine kinase, Cancer Research, biology, Kinase, Chemistry, B-cell receptor, Oncology, Biochemistry, hemic and lymphatic diseases, Trk receptor, Cancer research, biology.protein, Bruton's tyrosine kinase, Phosphorylation, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::981ed3e69453ba2a562f23a373c4c480
https://doi.org/10.1158/1535-7163.targ-13-b270 -
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المؤلفون: Laurie P. Volak, David Mckearn, Ronald E. Savage, David Vensel, Karen R. Bresciano, Jean-Marc Lapierre, Terence Hall, Inese Smukste
المصدر: Molecular Cancer Therapeutics. 12:C83-C83
مصطلحات موضوعية: Volume of distribution, Cancer Research, CYP2D6, Oncology, Pharmacokinetics, CYP3A4, CYP3A, Cmax, Pharmacology, Biology, Bioavailability, ADME
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bdbd69b7d65267c9f93aa5e27de51283
https://doi.org/10.1158/1535-7163.targ-13-c83 -
6
المؤلفون: Syed M. Ali, Chris Brassard, Audra Dalton, Darin Kizer, Jean-Marc Lapierre, Yanbin Liu, Magdi Moussa, Rocio Palma, Manish Tandon, David Vensel, Erika Volckova, Jianqiang Wang, Neil Westlund, Hui Wu, Rui-Yang Yang, Craig Bates, Mayank Bhavsar, Cathy Bull, Sudharshan Eathiraj, Robert Nicewonger, Ron Savage, Carol Waghorne, Jennifer Castro, Enkeleda Nakuci, Chang-Rung Chen, Dennis S. France, Thomas C.K. Chan, Mark A. Ashwell
المصدر: Cancer Research. 72:3905-3905
مصطلحات موضوعية: Cancer Research, Kinase, In silico, Cancer, Pharmacology, Biology, medicine.disease, In vitro, Oncology, Biochemistry, In vivo, Fibroblast growth factor receptor, medicine, Structure–activity relationship, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f3f2f570d6e9677ed33340d22c18292f
https://doi.org/10.1158/1538-7445.am2012-3905 -
7
المؤلفون: Thomas C.K. Chan, Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Jason Hill, Steffi Koerner, Eoin Kelleher, Darin Kizer, Yanbin Liu, Jeff Link, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Robert Nicewonger, Uma Uppalapati, Rocio Palma, Jeff Szwaya, Manish Tandon, David Vensel, Laurie Volak, Erika Volckova, Neil Westland, Hui Wu, Rui-Yang Yang
المصدر: Cancer Research. 72:LB-1
مصطلحات موضوعية: Cancer Research, Effector, Chemistry, AKT1, Cancer, Pharmacology, medicine.disease, Small molecule, In vitro, Oncology, In vivo, medicine, Protein kinase B, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34014a12fe34271da22ab4f26b260726
https://doi.org/10.1158/1538-7445.am2012-lb-1
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