يعرض 1 - 6 نتائج من 6 نتيجة بحث عن '"Davies, Dave E."', وقت الاستعلام: 1.74s تنقيح النتائج
  1. 1
    دورية أكاديمية

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  2. 2
    دورية أكاديمية
    2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR

    المؤلفون: Wyatt, Paul G., Allen, Michael J., Borthwick, Alan D., Davies, Dave E., Exall, Anne M., Hatley, Richard J.D., Irving, Wendy R., Livermore, David G., Miller, Neil D., Nerozzi, Fabrizio, Sollis, Steve L., Szardenings, Anna Katrin

    المصدر: In Bioorganic & Medicinal Chemistry Letters 16 May 2005 15(10):2579-2582

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  3. 3
    دورية أكاديمية

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  4. 4
    دورية أكاديمية
    Pyridyl-2,5-Diketopiperazinesas Potent, Selective, and Orally Bioavailable Oxytocin Antagonists:Synthesis, Pharmacokinetics, and In Vivo Potency.

    المؤلفون: Borthwick, Alan D., Liddle, John, Davies, Dave E., Exall, Anne M., Hamlett, Christopher, Hickey, Deirdre M., Mason, Andrew M., Smith, Ian E. D., Nerozzi, Fabrizio, Peace, Simon, Pollard, Derek, Sollis, Steve L., Allen, Michael J., Woollard, Patrick M., Pullen, Mark A., Westfall, Timothy D., Stanislaus, Dinesh J.

    المصدر: Journal of Medicinal Chemistry; Jan2012, Vol. 55 Issue 2, p783-796, 14p

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  5. 5
    دورية أكاديمية
    2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

    المؤلفون: Borthwick AD; Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K. alan.d.borthwick@gsk.com, Davies DE, Exall AM, Livermore DG, Sollis SL, Nerozzi F, Allen MJ, Perren M, Shabbir SS, Woollard PM, Wyatt PG

    المصدر: Journal of medicinal chemistry [J Med Chem] 2005 Nov 03; Vol. 48 (22), pp. 6956-69.

    نوع المنشور: Journal Article

    بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

    مواضيع طبية MeSH: Piperazines/*chemical synthesis , Receptors, Oxytocin/*antagonists & inhibitors, Administration, Oral ; Animals ; Antidiuretic Hormone Receptor Antagonists ; Biological Availability ; Crystallography, X-Ray ; Dogs ; Humans ; Molecular Structure ; Piperazines/pharmacokinetics ; Piperazines/pharmacology ; Radioligand Assay ; Rats ; Receptors, Oxytocin/chemistry ; Serum Albumin/chemistry ; Stereoisomerism ; Structure-Activity Relationship ; Uterine Contraction/drug effects ; Vasotocin/analogs & derivatives ; Vasotocin/pharmacology

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  6. 6
    دورية أكاديمية
    Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.

    المؤلفون: Borthwick AD; Department of Medicinal Chemistry CVU UK, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom. alan.d.borthwick@gsk.com, Davies DE, Ertl PF, Exall AM, Haley TM, Hart GJ, Jackson DL, Parry NR, Patikis A, Trivedi N, Weingarten GG, Woolven JM

    المصدر: Journal of medicinal chemistry [J Med Chem] 2003 Oct 09; Vol. 46 (21), pp. 4428-49.

    نوع المنشور: Comparative Study; Journal Article

    بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

    مواضيع طبية MeSH: Antiviral Agents/*chemical synthesis , Antiviral Agents/*pharmacology , Cytomegalovirus/*drug effects , Cytomegalovirus/*enzymology , Lactams/*chemical synthesis , Lactams/*pharmacology , Protease Inhibitors/*chemical synthesis , Protease Inhibitors/*pharmacology , Pyrroles/*chemical synthesis , Pyrroles/*pharmacology , Serine Endopeptidases/*metabolism, Animals ; Antiviral Agents/blood ; Biological Availability ; Brain/metabolism ; Cells, Cultured ; Dogs ; Drug Design ; Enzyme-Linked Immunosorbent Assay ; Eye/metabolism ; Ganciclovir/pharmacology ; Guinea Pigs ; Half-Life ; Humans ; Indicators and Reagents ; Kinetics ; Mass Spectrometry ; Models, Molecular ; Protease Inhibitors/blood ; Structure-Activity Relationship ; Substrate Specificity

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