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المؤلفون: William L. Thompson, Rab K. Prinjha, Rosario Luque-Martin, Inmaculada Rioja, Menno P.J. de Winther, Sharon G. Bernard, Mathias Kalxdorf, Charlotte A. Ashby, Jan Van den Bossche, Catriona Sharp, Palwinder K. Mander, Annette E. Neele, Wouter J. de Jonge, Davina C. Angell, H. Christian Eberl, Johannes Freudenberg
المساهمون: Molecular cell biology and Immunology, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, Medical Biochemistry, Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research
المصدر: Luque-Martin, R, Angell, D C, Kalxdorf, M, Bernard, S, Thompson, W, Eberl, H C, Ashby, C, Freudenberg, J, Sharp, C, van den Bossche, J, de Jonge, W J, Rioja, I, Prinjha, R K, Neele, A E, de Winther, M P J & Mander, P K 2021, ' IFN-γ Drives human monocyte differentiation into highly proinflammatory macrophages that resemble a phenotype relevant to psoriasis ', Journal of Immunology, vol. 207, no. 2, pp. 555-568 . https://doi.org/10.4049/jimmunol.2001310
Journal of Immunology, 207(2), 555-568. American Association of Immunologists
Journal of immunology (Baltimore, Md., 207(2), 555-568. American Association of Immunologistsمصطلحات موضوعية: Proteomics, Immunology, Biology, Monocytes, Proinflammatory cytokine, Interferon-gamma, Immune system, Psoriasis, medicine, Humans, Immunology and Allergy, Macrophage, Cells, Cultured, Skin, Inflammation, Macrophage Colony-Stimulating Factor, Macrophages, Monocyte, Cell Differentiation, medicine.disease, Phenotype, In vitro, Cell biology, medicine.anatomical_structure, Monocyte differentiation, Biomarkers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc517f304ed2fe12bc5eeb2aa48c676
https://research.vumc.nl/en/publications/469e0fd3-afc0-42e4-9c7d-f61ecc14c6aa -
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المؤلفون: Stephen John Atkinson, Chun-wa Chung, Peter Ernest Soden, Laurie J. Gordon, Rab K. Prinjha, Nicholas Smithers, Rebecca C. Furze, Kathryn A. Giblin, Davina C. Angell, Marcus Bantscheff, Nigel J. Parr, Inmaculada Rioja, Jason Witherington, Gerard Drewes
المصدر: MedChemComm. 5:342-351
مصطلحات موضوعية: Pharmacology, Hydroxamic acid, Organic Chemistry, Pharmaceutical Science, hemic and immune systems, chemical and pharmacologic phenomena, Biology, Biochemistry, Small molecule, In vitro, Bromodomain, chemistry.chemical_compound, chemistry, Transcription (biology), Drug Discovery, Cancer cell, Molecular Medicine, Histone deacetylase, Epigenetics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3bdb6f43d6b09b952d7c8ccd1e8cfa40
https://doi.org/10.1039/c3md00285c -
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المؤلفون: Deborah Needham, Jason A. Holt, Stuart N. Farrow, Robert J. H. Austin, Keith Biggadike, Karen Leavens, Iain Uings, Davina C. Angell, Michael V. Haase, Joyce Lesley Matthews
المصدر: British Journal of Pharmacology. 169:1389-1403
مصطلحات موضوعية: Pharmacology, Regulation of gene expression, Gene expression profiling, Reporter gene, Transactivation, Cell culture, medicine, Biology, Glucocorticoid, Allergic inflammation, Transrepression, medicine.drug
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المؤلفون: Robert J. H. Austin, Christopher Patten, Eugene L. Stewart, Simon Taylor, Peter Brown, Christopher M. Yates, Davina C. Angell, Jason A. Holt, Rosemary Z. Sasse, Iain Uings, Ryan P. Trump, Jodi M. Maglich
المصدر: Journal of Medicinal Chemistry. 53:4531-4544
مصطلحات موضوعية: Male, Models, Molecular, Agonist, medicine.medical_specialty, Indazoles, Protein Conformation, medicine.drug_class, Pharmacology, Substrate Specificity, Mice, Receptors, Glucocorticoid, Therapeutic index, Glucocorticoid receptor, In vivo, Internal medicine, Drug Discovery, Glucocorticoid Receptor Agonists, medicine, Animals, Humans, Dose-Response Relationship, Drug, Chemistry, NF-kappa B, Fibroblasts, NFKB1, In vitro, Rats, Endocrinology, Docking (molecular), Drug Design, Molecular Medicine
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المؤلفون: Diane M. Coe, David House, Hawa Diallo, Davina C. Angell, Heather A. Barnett, Steve Keeling, Iain M. McLay, Andy Craven, Simon J. F. Macdonald, Tony W. J. Cooper, Torquil I. Jack, Keith Biggadike, Simon Taylor, Samuel Oliver, Iain Uings, James Gray, Natalie Wellaway
المصدر: Bioorganicmedicinal chemistry letters. 21(4)
مصطلحات موضوعية: Agonist, Indazoles, medicine.drug_class, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Steroid, chemistry.chemical_compound, Structure-Activity Relationship, Glucocorticoid receptor, Receptors, Glucocorticoid, Cell Line, Tumor, Drug Discovery, medicine, Humans, Computer Simulation, Molecular Biology, chemistry.chemical_classification, Indazole, Sulfonamides, Trifluoromethyl, Binding Sites, Organic Chemistry, Sulfonamide, chemistry, Lipophilicity, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Glucocorticoid, medicine.drug