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1
المؤلفون: Diane M. Coe, Simon J. F. Macdonald, Davina Humphreys, Philip Alan Skone, Haydn Terence Jones, George Hardy, Iain M. McLay, Annette Miles-Williams, David House, Matilde Caivano, Iain Uings, Keith Biggadike, Margaret Clackers, Vicki Weller
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4846-4850
مصطلحات موضوعية: Agonist, Indazoles, Molecular model, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Catalytic Domain, Drug Discovery, medicine, Humans, Computer Simulation, Molecular Biology, biology, Aryl, Organic Chemistry, NF-kappa B, Active site, chemistry, Docking (molecular), biology.protein, Pyrazoles, Molecular Medicine, Glucocorticoid, medicine.drug
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2
المؤلفون: Philip Alan Skone, Iain Uings, Davina Humphreys, Diane M. Coe, George Hardy, Simon J. F. Macdonald, Doug J. Minick, Richard Loiseau, Haydn Terence Jones, Iain M. McLay, David House, Derek A. Demaine, Michael John Johnston, Graham G. A. Inglis, Margaret Clackers
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4737-4745
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Drug Discovery, medicine, Moiety, Binding site, Glucocorticoids, Molecular Biology, Binding Sites, Bicyclic molecule, Chemistry, Aryl, Organic Chemistry, Stereoisomerism, Amides, Models, Chemical, Drug Design, Pyrazoles, Molecular Medicine, Steroids, Glucocorticoid, medicine.drug
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3
المؤلفون: Melanie Washington, Davina Humphreys, Lesley Nisbet, Philip Alan Skone, Royston C. B. Copley, Simon J. F. Macdonald, Graham G. A. Inglis, Richard J. Upton, Mike D. Barker, Margaret Clackers, Victoria Vinader, Haydn Terence Jones, Michael John Johnston, Iain M. McLay, Derek A. Demaine, Stephen E. Shanahan, David House, Richard Loiseau, Dan Tape, Michael V. Haase, Francois Pacquet, Iain Uings
المصدر: Journal of Medicinal Chemistry. 49:4216-4231
مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, Agonist, medicine.medical_specialty, Tetrahydronaphthalenes, Transcription, Genetic, medicine.drug_class, Administration, Topical, Binding, Competitive, Partial agonist, Dexamethasone, Cell Line, Mice, Radioligand Assay, Structure-Activity Relationship, Transactivation, Receptors, Glucocorticoid, Glucocorticoid receptor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Hypersensitivity, Delayed, Receptor, Transrepression, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Stereoisomerism, Benzoxazines, Endocrinology, Docking (molecular), Molecular Medicine
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4
المؤلفون: Lee Andrew Harrison, Michael Dennis Dowle, Harry Finch, Robin Andrew Smith, Pritom Shah, K.Abhhilash Kumar, Gill Fleetwood, Simon Teanby Hodgson, George W. Hardy, Graham Murkitt, Simon J. F. Macdonald, Graham G. A. Inglis, Christopher R Molloy, Geoffrey D. Clarke, Augustin Amour, Rosalind E Godward, Tony Padfield, Davina Humphreys, M. R. Johnson, Mary Dixon, Tadeusz Skarzynski, Onkar M. P. Singh
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:895-898
مصطلحات موضوعية: Lactams, Human neutrophil, Metabolic Clearance Rate, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Dogs, Drug Stability, Piperidines, Pharmacokinetics, Cricetinae, Drug Discovery, Animals, Molecular Biology, Short duration, Serpins, Bacteria, Pancreatic Elastase, Chemistry, Serine Endopeptidases, Organic Chemistry, Elastase, Bacterial Infections, Rats, Bioavailability, Orally active, Pharmacodynamics, Molecular Medicine, Crystallization, Leukocyte Elastase, Intracellular
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5
المؤلفون: Graham G. A. Inglis, George Hardy, Philip Alan Skone, Simon J. F. Macdonald, Gemma Veitch, Diane M. Coe, Haydn Terence Jones, Iain M. McLay, Margaret Clackers, Derek A. Demaine, Richard Loiseau, Gordon G. Weingarten, Iain Uings, Keith Biggadike, Michael John Johnston, Deborah Needham, Mohamed Boudjelal, David House, Davina Humphreys
المصدر: Journal of medicinal chemistry. 50(26)
مصطلحات موضوعية: Agonist, Models, Molecular, Transcriptional Activation, Tetrahydronaphthalenes, Transcription, Genetic, Stereochemistry, medicine.drug_class, Cell Line, Transactivation, chemistry.chemical_compound, Structure-Activity Relationship, Glucocorticoid receptor, Receptors, Glucocorticoid, Drug Discovery, medicine, Humans, Isoquinoline, Receptor, Transrepression, Binding Sites, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Molecular Mimicry, NF-kappa B, Biological activity, Stereoisomerism, Drug Partial Agonism, Mammary Tumor Virus, Mouse, Molecular Medicine, Glucocorticoid, medicine.drug
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6
المؤلفون: Victoria Vinader, Davina Humphreys, Philip Alan Skone, Iain M. McLay, John Martin Pritchard, Derek A. Demaine, Michael John Johnston, Stephen E. Shanahan, Haydn Terence Jones, Mark Salter, Francois Pacquet, Iain Uings, Simon J. F. Macdonald, Mike D. Barker, Margaret Clackers
المصدر: Journal of medicinal chemistry. 48(14)
مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, Molecular model, Tetrahydronaphthalenes, Transcription, Genetic, Stereochemistry, Anti-Inflammatory Agents, Ligands, Partial agonist, Chemical synthesis, Cell Line, Transactivation, Mice, Structure-Activity Relationship, Glucocorticoid receptor, Receptors, Glucocorticoid, Cell Line, Tumor, Drug Discovery, Animals, Humans, biology, Chemistry, Mouse mammary tumor virus, Active site, Stereoisomerism, biology.organism_classification, Docking (molecular), biology.protein, Molecular Medicine
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7
المؤلفون: Alan J. Wonacott, Rosalind E Godward, Gill Fleetwood, Robin Andrew Smith, Pritom Shah, Simon J. F. Macdonald, Martin R. Johnson, Christopher R Molloy, George Hardy, Simon Teanby Hodgson, Lee Andrew Harrison, Augustin Amour, Michael Dennis Dowle, Onkar M. P. Singh, Graham G. A. Inglis, Mary Dixon, Davina Humphreys, Geoffrey D. Clarke
المصدر: Journal of medicinal chemistry. 45(18)
مصطلحات موضوعية: Male, Models, Molecular, Pyrrolidines, Lactams, Swine, Crystallography, X-Ray, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Structure–activity relationship, Animals, Combinatorial Chemistry Techniques, Humans, Pyrroles, Enzyme Inhibitors, Pancreatic elastase, Sulfonamides, biology, Molecular Structure, Chemistry, Elastase, Stereoisomerism, In vitro, Rats, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Leukocyte Elastase
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8
المؤلفون: Christopher R Molloy, Simon Teanby Hodgson, Robin A.J. Smith, Tadeusz Skarzynski, Onkar M. P. Singh, Rosalind E Godward, Julie E. Spooner, Harry Finch, Mary Dixon, K.Abhhilash Kumar, David J. Belton, Graham G. A. Inglis, Pritom Shah, Simon J. F. Macdonald, Graham Murkitt, Martin R. Johnson, Edward McDonald, Lee Andrew Harrison, Davina Humphreys, Gill Fleetwood, Geoffrey D. Clarke, George W. Hardy, Michael Dennis Dowle
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1249
مصطلحات موضوعية: Human neutrophil, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Elastase, Pharmaceutical Science, Biochemistry, Pyrrolidine, chemistry.chemical_compound, Orally active, chemistry, Drug Discovery, Molecular Medicine, Theology, Molecular Biology
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9دورية أكاديمية
المؤلفون: Keith Biggadike, Mohamed Boudjelal, Margaret Clackers, Diane M. Coe, Derek A. Demaine, George W. Hardy, Davina Humphreys, Graham G. A. Inglis, Michael J. Johnston, Haydn T. Jones, David House, Richard Loiseau, Deborah Needham, Philip A. Skone, Iain Uings, Gemma Veitch, Gordon G. Weingarten, Iain M. McLay, Simon J. F. Macdonald
المصدر: Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 26, p6519-6534, 16p
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