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المؤلفون: Kevin W. Johnson, Peter Fuller, Sujal V. Deshmukh, Fang He, Peter Goldenblatt, Lauren Dorosh, Hongbo Zeng, Jason D. Brubaker, Luis E. Torres, Tony Siu, Fiona Elwood, Charles A. Lesburg, Sangita B. Patel, Duan Liu, Elma Kadic, Christopher J. Dinsmore, Xavier Fradera, Lynsey Shaffer, Jonathan R. Young, Lily Y. Moy, Feng Shi, Carla Alpert, Joel A. Klappenbach, Joshua Close, Rafael Fernandez, Hongshi Yu, Nathan Bays, Dawn M. Mampreian
المصدر: Journal of Medicinal Chemistry. 60:9676-9690
مصطلحات موضوعية: 0301 basic medicine, Halogenation, Stereochemistry, medicine.drug_class, Carboxamide, Pyrazole, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Ligand efficiency, Chemistry, Drug discovery, Janus Kinase 1, Ligand (biochemistry), Rats, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Pyran, Pyrazoles, Molecular Medicine
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المؤلفون: Hugh Nuthall, Lily Y. Moy, Candia M. Kenific, Sean P. Ahearn, Damaris Diaz, Elizabeth Helen Kelley, Bethany Hughes, Armetta D. Hill, Adam J. Schell, Nadya Smotrov, Valentina V. Jeliazkova-Mecheva, Chris Moxham, Hua Zhou, Sanjiv J. Shah, Andrew Rosenau, Alexey Rivkin, Sam Kattar, Joey L. Methot, Richard G. Ball, William Brown, Mark S. Shearman, Chaomin Li, Christian Fischer, Alexander A. Szewczak, Sujal V. Deshmukh, Dawn M. Mampreian, Thomas A. Miller, Benito Munoz
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:3495-3500
مصطلحات موضوعية: Genetically modified mouse, Clinical Biochemistry, hERG, Biological Availability, Pharmaceutical Science, Mice, Transgenic, Pharmacology, Biochemistry, Mice, chemistry.chemical_compound, Pharmacokinetics, Alzheimer Disease, Amide, Drug Discovery, medicine, Animals, Moiety, Molecular Biology, biology, Chemistry, Organic Chemistry, medicine.disease, Rats, Bioavailability, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase
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المؤلفون: Richard E. Middleton, Valentina V. Jeliazkova-Mecheva, Damaris Diaz, Candia M. Kenific, George N. Nikov, Sanjiv J. Shah, Adam J. Schell, Bethany Hughes, Nadja Smotrov, Alexander A. Szewczak, Melanie Bouthillette, Hugh Nuthall, Deborah Walker, W. Colby Brown, Mark S. Shearman, Hua Zhou, Benito Munoz, Christian Fischer, Dan F. Savage, Joey L. Methot, Jonathan C. Cruz, Susan L. Zultanski, Nathan Bays, Dawn M. Mampreian
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4083-4087
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Amyloid precursor protein, Animals, Structure–activity relationship, Inhibitory concentration 50, γ secretase, Enzyme Inhibitors, Molecular Biology, Gamma secretase, Amyloid beta-Peptides, Molecular Structure, biology, Aryl, Organic Chemistry, Triazoles, Rats, Enzyme Activation, chemistry, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Protein Binding
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المصدر: Tetrahedron Letters. 49:1155-1159
مصطلحات موضوعية: chemistry.chemical_compound, Piperazine, Bicyclic molecule, Chemistry, Stereochemistry, Imidazolidinone, Organic Chemistry, Drug Discovery, Aminal, Iminium, Biochemistry, Ion, Cyclobutane
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المؤلفون: Melissa Chenard, Christopher Hamblett, Astrid M. Kral, J. Paul Secrist, Andreas Harsch, Jonathan C. Cruz, Joon Jung, Thomas A. Miller, Brian B. Haines, Joey L. Methot, Candia M. Kenific, Judith C. Fleming, Bethany Hughes, Dawn M. Mampreian, Richard E. Middleton, William K. Dahlberg, Hongmei Wang, Nicole Ozerova, Alexander A. Szewczak
المصدر: Bioorganicmedicinal chemistry letters. 18(23)
مصطلحات موضوعية: Niacinamide, ERG1 Potassium Channel, Stereochemistry, medicine.drug_class, Clinical Biochemistry, hERG, Pharmaceutical Science, Mice, Nude, Antineoplastic Agents, Biochemistry, Histone Deacetylases, Polar surface area, Histones, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Combinatorial Chemistry Techniques, Humans, Protein Isoforms, Spiro Compounds, Molecular Biology, chemistry.chemical_classification, Nicotinamide, biology, Molecular Structure, Histone deacetylase 2, Organic Chemistry, Histone deacetylase inhibitor, Aromatic amine, HCT116 Cells, Xenograft Model Antitumor Assays, Ether-A-Go-Go Potassium Channels, Histone Deacetylase Inhibitors, chemistry, Enzyme inhibitor, Benzamides, biology.protein, Molecular Medicine, Histone deacetylase
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المصدر: ChemInform. 39
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Bicyclic molecule, Aminal, Iminium, General Medicine, Medicinal chemistry, Ion
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المؤلفون: Jonathan C. Cruz, Nicole Ozerova, Richard E. Middleton, Joey L. Methot, Sujal V. Deshmukh, Christopher Hamblett, Andreas Harsch, Anna M. Hitz, Judith C. Fleming, Naim Nazef, Bethany Hughes, Melissa Chenard, Astrid M. Kral, David L. Sloman, Thomas A. Miller, William K. Dahlberg, J. Paul Secrist, Matthew G. Stanton, Ralph T. Mosley, Hongmei Wang, Dawn M. Mampreian, Alex A. Szewczak
المصدر: Bioorganicmedicinal chemistry letters. 17(19)
مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biological Availability, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Benzamide, Molecular Biology, Nicotinamide, biology, Organic Chemistry, Histone deacetylase inhibitor, In vitro, Rats, Histone Deacetylase Inhibitors, Isoenzymes, 6-Aminonicotinamide, chemistry, Enzyme inhibitor, Area Under Curve, Drug Design, Benzamides, biology.protein, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Half-Life, Protein Binding
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المؤلفون: Amir H. Hoveyda, Dawn M. Mampreian
المصدر: ChemInform. 35
مصطلحات موضوعية: Dipeptide, Alkylation, Chemistry, Organic Chemistry, Enantioselective synthesis, Cycloparaffins, General Medicine, Alkenes, Ligands, Nitro Compounds, Biochemistry, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, Zinc, Reagent, Organometallic Compounds, Organic chemistry, Indicators and Reagents, Physical and Theoretical Chemistry, Amines, Phosphine, Copper, Conjugate
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المؤلفون: Jing Wu, Dawn M. Mampreian, Amir H. Hoveyda
المصدر: Journal of the American Chemical Society. 127:4584-4585
مصطلحات موضوعية: chemistry.chemical_classification, Addition reaction, Nitro compound, Enantioselective synthesis, Stereoisomerism, General Medicine, General Chemistry, Nitro Compounds, Combinatorial chemistry, Biochemistry, Catalysis, Amino acid, Stereocenter, chemistry.chemical_compound, Colloid and Surface Chemistry, chemistry, Reagent, Alkanes, Organometallic Compounds, Organic chemistry, Copper, Phosphine, Conjugate
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