المؤلفون: Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith

المصدر: Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)

مصطلحات موضوعية: Glucocerebrosidase, Glucosylceramide synthase inhibitor, Glycosphingolipids, Parkinson's disease, Lysosomal biology, Preformed fibril model, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996121002564; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/5bb119e476704557a1fe920f9ef43979

المؤلفون: Philipp J. Kahle, Renee C Gentzel, Lei Ma, Jacob Marcus, Sean M. Smith, Dawn Toolan, Joel B. Schachter, Sarah Jinn

المصدر: Neurobiology of aging 106, 12-25 (2021). doi:10.1016/j.neurobiolaging.2021.05.012

مصطلحات موضوعية: Genetically modified mouse, Aging, Alpha-Synuclein, Parkinson's disease, Synucleinopathies, administration & dosage [alpha-Synuclein], Gene Expression, Mice, Transgenic, adverse effects [alpha-Synuclein], A30P, Biology, chemistry.chemical_compound, genetics [Parkinson Disease], medicine, Animals, Transgenic mice, ddc:610, metabolism [alpha-Synuclein], Alpha-synuclein, Parkinson's Disease, Microglia, Tyrosine hydroxylase, Dementia with Lewy bodies, General Neuroscience, pathology [Microglia], genetics [Synucleinopathies], Parkinson Disease, etiology [Synucleinopathies], medicine.disease, pathology [Parkinson Disease], Cell biology, Disease Models, Animal, medicine.anatomical_structure, pathology [Synucleinopathies], chemistry, alpha-Synuclein, genetics [alpha-Synuclein], Synuclein, etiology [Parkinson Disease], Neurology (clinical), Geriatrics and Gerontology, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd63ea6b0e4145e8f82abc6da25eeae2
https://doi.org/10.1016/j.neurobiolaging.2021.05.012

المؤلفون: Cornelis Blauwendraat, Sarah Jinn, Dawn Toolan, Andrew B. Singleton, Jacob Marcus, Robert E. Drolet, Sean M. Smith, David J. Stone, Cheryl A. Gretzula, Mike A. Nalls

المصدر: Human Molecular Genetics

مصطلحات موضوعية: Potassium Channels, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Genetics, Humans, Missense mutation, SNP, Genetic Predisposition to Disease, Phosphorylation, Molecular Biology, Gene, Genetics (clinical), 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Parkinson Disease, General Medicine, Molecular biology, Phenotype, alpha-Synuclein, General Article, Chromosomes, Human, Pair 4, Lysosomes, 030217 neurology & neurosurgery, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51249e3008ee1f9af30cb005c09f5cf
https://doi.org/10.1093/hmg/ddz136

المؤلفون: Marla L. Watt, Sarah Jinn, Nathan G. Hatcher, Lei Ma, Mali Cosden, Monika Kandebo, Christine Burlein, Christina Minnick, Mark E. Fraley, Cheryl A. Gretzula, Wei Lemaire, Rose B. Flick, Sean M. Smith, James Mulhearn, Gregory C. Adam, Jacob Marcus, Robert E. Drolet, Dawn Toolan, Lihang Yao

المصدر: Neurobiology of Disease, Vol 159, Iss, Pp 105507-(2021)

مصطلحات موضوعية: Glucocerebrosidase, Pathology, medicine.medical_specialty, Synucleinopathies, Lysosomal biology, Parkinson's disease, Preformed fibril model, Primary Cell Culture, Neurosciences. Biological psychiatry. Neuropsychiatry, In Vitro Techniques, medicine.disease_cause, Glycosphingolipids, Mice, Protein Aggregates, chemistry.chemical_compound, Lysosome, medicine, Animals, Glucosylceramide synthase inhibitor, Neurons, Alpha-synuclein, Benzoxazoles, Mutation, Chemistry, Dopaminergic Neurons, Neurodegeneration, Parkinson Disease, Biological activity, Glycosphingolipid, medicine.disease, Rats, carbohydrates (lipids), medicine.anatomical_structure, Neurology, Glucosyltransferases, alpha-Synuclein, Glucosylceramidase, lipids (amino acids, peptides, and proteins), Neuron, Lysosomes, RC321-571

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cd5da06600d31f6c7bb67bb7f45f07
https://doi.org/10.1016/j.nbd.2021.105507

المؤلفون: Andus Hon-Kit Wong, Robert E. Drolet, Galya Vassileva, Cheryl A. Gretzula, Paige Cramer, Jyoti Disa, Marija Tadin-Strapps, David J. Stone, Bhavya Voleti, Sarah Jinn, Dawn Toolan

المصدر: Proceedings of the National Academy of Sciences. 114:2389-2394

مصطلحات موضوعية: 0301 basic medicine, Autophagosome, Potassium Channels, Primary Cell Culture, Mitochondrion, Biology, Fibril, Models, Biological, Pathogenesis, Protein Aggregates, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Lysosome, Autophagy, medicine, Animals, Humans, Ion channel, Multidisciplinary, Dopaminergic Neurons, Autophagosomes, Parkinson Disease, Hydrogen-Ion Concentration, Biological Sciences, Mitochondria, Rats, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, alpha-Synuclein, Transmembrane Protein 175, Glucosylceramidase, Phosphorylation, Lysosomes, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac18fc109c991ebfd1af11dfbf9d4505
https://doi.org/10.1073/pnas.1616332114

المؤلفون: Rhonda Roberts, Renee C. Gentzel, Jason M. Uslaner, Amy Jo Koser, Sean M. Smith, John J. Renger, Monika Kandebo, Dawn Toolan, James C. Hershey

المصدر: Neuropharmacology. 99:256-263

مصطلحات موضوعية: Male, medicine.medical_specialty, Enkephalin, Phosphodiesterase Inhibitors, Gene Expression, Nerve Tissue Proteins, Striatum, Substance P, Pharmacology, Catalepsy, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Internal medicine, Dopamine receptor D2, medicine, Haloperidol, Animals, Rats, Wistar, Early Growth Response Protein 1, Neurons, Arc (protein), Dose-Response Relationship, Drug, Phosphoric Diester Hydrolases, Receptors, Dopamine D2, Chemistry, Gene Expression Profiling, Antagonist, Enkephalins, medicine.disease, Corpus Striatum, Substantia Nigra, Cytoskeletal Proteins, Endocrinology, Quinolines, Dopamine Antagonists, Pyrazoles, PDE10A, Proto-Oncogene Proteins c-fos, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ff51c080ece26eeb0c8c932c078f94
https://doi.org/10.1016/j.neuropharm.2015.05.024

المؤلفون: Vanita Puri, John Swestock, Pravien Abeywickrema, Lei Ma, Jenny Wai, Michelle R. Machacek, Georgia B. McGaughey, Sean M. Smith, Deping Wang, Shawn J. Stachel, John C. Reid, Melissa Egbertson, Donnie Eddins, Debbie Perlow, Dawn Toolan, Jason M. Uslaner, Gopal Parthasarathy, Hua-Poo Su

المصدر: Bioorganicmedicinal chemistry letters. 28(6)

مصطلحات موضوعية: Gene isoform, Indoles, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Computational biology, 010402 general chemistry, 01 natural sciences, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Catalytic Domain, Drug Discovery, Animals, Cognitive Dysfunction, Novel object recognition, Molecular Biology, Acetic Acid, Indole test, Chemotype, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, fungi, Organic Chemistry, Active site, Cognition, Multiple species, Cyclic Nucleotide Phosphodiesterases, Type 2, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Selectivity, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3bdb613b1ea0252fa0ce46b392a31b
https://pubmed.ncbi.nlm.nih.gov/29534798

المؤلفون: Sarah L. Huszar, John D. Schreier, Michael J. Breslin, Joshua D. Vardigan, Sean M. Smith, Lihang Yao, Monika Kandebo, Christopher D. Cox, Christopher E. Cannon, John J. Renger, Jason M. Uslaner, Paul J. Coleman, Izzat T. Raheem, Donnie Eddins, Dawn Toolan

المصدر: Neuropharmacology. 64:215-223

مصطلحات موضوعية: Male, MAPK/ERK pathway, Phosphodiesterase Inhibitors, Pyridines, Memory, Episodic, Nerve Tissue Proteins, AMPA receptor, Pharmacology, CREB, Executive Function, Random Allocation, Cellular and Molecular Neuroscience, Animals, Molecular Targeted Therapy, Phosphorylation, Rats, Wistar, Nootropic Agents, Neurons, Behavior, Animal, Dose-Response Relationship, Drug, biology, Phosphoric Diester Hydrolases, Phosphodiesterase, Macaca mulatta, Corpus Striatum, Rats, Pyrimidines, Second messenger system, Synaptic plasticity, Schizophrenia, biology.protein, PDE10A, Signal transduction, Cognition Disorders, Psychology, Protein Processing, Post-Translational, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9174a94ad0f64839758180d258f7a8b1
https://doi.org/10.1016/j.neuropharm.2012.06.013

المؤلفون: Jacob Marcus, Ruben Declercq, Mali Cosden, Cristian Salinas, John J. Renger, Mark Forman, Ernest J. McEachern, Sean M. Smith, Daniel Jonathan, David J. Vocadlo, Dawn Toolan, Fred Hess, Joseph Duffy, Wenping Li, Arie Struyk, Harold G. Selnick, Hostetler D. Eric, Michelle Pearson, Joel B. Schachter, Xiaohai Wang, Darryle Schoepp

المصدر: Alzheimer's & Dementia. 12

مصطلحات موضوعية: 0301 basic medicine, Epidemiology, business.industry, Health Policy, O-GlcNAcase, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Cancer research, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e24b62cfbc2344cee50f66cbb91f6ed7
https://doi.org/10.1016/j.jalz.2016.06.469

المؤلفون: Punam Sandhu, Joseph L. Duffy, Maria S. Michener, Sean M. Smith, Joan D. Ellis, Mary J. Savage, Ernest J. McEachern, Chandni Valiathan, Brittany Walker, Jeanine E. Ballard, Arie Struyk, David J. Vocadlo, Junghoon Lee, Dawn Toolan, Thomas McAvoy, Daniel P. Dreyer, Nicole Trainor, Jacob Marcus

المصدر: Alzheimer's & Dementia. 12

مصطلحات موضوعية: 0301 basic medicine, Epidemiology, business.industry, Health Policy, O-GlcNAcase, Pharmacology, medicine.disease, Progressive supranuclear palsy, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, Developmental Neuroscience, Pharmacokinetics, medicine, Neurology (clinical), Geriatrics and Gerontology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed7b11ee409914010230b3cf244ada5d
https://doi.org/10.1016/j.jalz.2016.06.2125