-
1دورية أكاديمية
المؤلفون: Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
المصدر: Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)
مصطلحات موضوعية: Glucocerebrosidase, Glucosylceramide synthase inhibitor, Glycosphingolipids, Parkinson's disease, Lysosomal biology, Preformed fibril model, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
-
2
المؤلفون: Philipp J. Kahle, Renee C Gentzel, Lei Ma, Jacob Marcus, Sean M. Smith, Dawn Toolan, Joel B. Schachter, Sarah Jinn
المصدر: Neurobiology of aging 106, 12-25 (2021). doi:10.1016/j.neurobiolaging.2021.05.012
مصطلحات موضوعية: Genetically modified mouse, Aging, Alpha-Synuclein, Parkinson's disease, Synucleinopathies, administration & dosage [alpha-Synuclein], Gene Expression, Mice, Transgenic, adverse effects [alpha-Synuclein], A30P, Biology, chemistry.chemical_compound, genetics [Parkinson Disease], medicine, Animals, Transgenic mice, ddc:610, metabolism [alpha-Synuclein], Alpha-synuclein, Parkinson's Disease, Microglia, Tyrosine hydroxylase, Dementia with Lewy bodies, General Neuroscience, pathology [Microglia], genetics [Synucleinopathies], Parkinson Disease, etiology [Synucleinopathies], medicine.disease, pathology [Parkinson Disease], Cell biology, Disease Models, Animal, medicine.anatomical_structure, pathology [Synucleinopathies], chemistry, alpha-Synuclein, genetics [alpha-Synuclein], Synuclein, etiology [Parkinson Disease], Neurology (clinical), Geriatrics and Gerontology, Developmental Biology
-
3
المؤلفون: Cornelis Blauwendraat, Sarah Jinn, Dawn Toolan, Andrew B. Singleton, Jacob Marcus, Robert E. Drolet, Sean M. Smith, David J. Stone, Cheryl A. Gretzula, Mike A. Nalls
المصدر: Human Molecular Genetics
مصطلحات موضوعية: Potassium Channels, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Genetics, Humans, Missense mutation, SNP, Genetic Predisposition to Disease, Phosphorylation, Molecular Biology, Gene, Genetics (clinical), 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Parkinson Disease, General Medicine, Molecular biology, Phenotype, alpha-Synuclein, General Article, Chromosomes, Human, Pair 4, Lysosomes, 030217 neurology & neurosurgery, Genome-Wide Association Study
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51249e3008ee1f9af30cb005c09f5cf
https://doi.org/10.1093/hmg/ddz136 -
4
المؤلفون: Marla L. Watt, Sarah Jinn, Nathan G. Hatcher, Lei Ma, Mali Cosden, Monika Kandebo, Christine Burlein, Christina Minnick, Mark E. Fraley, Cheryl A. Gretzula, Wei Lemaire, Rose B. Flick, Sean M. Smith, James Mulhearn, Gregory C. Adam, Jacob Marcus, Robert E. Drolet, Dawn Toolan, Lihang Yao
المصدر: Neurobiology of Disease, Vol 159, Iss, Pp 105507-(2021)
مصطلحات موضوعية: Glucocerebrosidase, Pathology, medicine.medical_specialty, Synucleinopathies, Lysosomal biology, Parkinson's disease, Preformed fibril model, Primary Cell Culture, Neurosciences. Biological psychiatry. Neuropsychiatry, In Vitro Techniques, medicine.disease_cause, Glycosphingolipids, Mice, Protein Aggregates, chemistry.chemical_compound, Lysosome, medicine, Animals, Glucosylceramide synthase inhibitor, Neurons, Alpha-synuclein, Benzoxazoles, Mutation, Chemistry, Dopaminergic Neurons, Neurodegeneration, Parkinson Disease, Biological activity, Glycosphingolipid, medicine.disease, Rats, carbohydrates (lipids), medicine.anatomical_structure, Neurology, Glucosyltransferases, alpha-Synuclein, Glucosylceramidase, lipids (amino acids, peptides, and proteins), Neuron, Lysosomes, RC321-571
-
5
المؤلفون: Andus Hon-Kit Wong, Robert E. Drolet, Galya Vassileva, Cheryl A. Gretzula, Paige Cramer, Jyoti Disa, Marija Tadin-Strapps, David J. Stone, Bhavya Voleti, Sarah Jinn, Dawn Toolan
المصدر: Proceedings of the National Academy of Sciences. 114:2389-2394
مصطلحات موضوعية: 0301 basic medicine, Autophagosome, Potassium Channels, Primary Cell Culture, Mitochondrion, Biology, Fibril, Models, Biological, Pathogenesis, Protein Aggregates, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Lysosome, Autophagy, medicine, Animals, Humans, Ion channel, Multidisciplinary, Dopaminergic Neurons, Autophagosomes, Parkinson Disease, Hydrogen-Ion Concentration, Biological Sciences, Mitochondria, Rats, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, alpha-Synuclein, Transmembrane Protein 175, Glucosylceramidase, Phosphorylation, Lysosomes, Neuroscience, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac18fc109c991ebfd1af11dfbf9d4505
https://doi.org/10.1073/pnas.1616332114 -
6
المؤلفون: Rhonda Roberts, Renee C. Gentzel, Jason M. Uslaner, Amy Jo Koser, Sean M. Smith, John J. Renger, Monika Kandebo, Dawn Toolan, James C. Hershey
المصدر: Neuropharmacology. 99:256-263
مصطلحات موضوعية: Male, medicine.medical_specialty, Enkephalin, Phosphodiesterase Inhibitors, Gene Expression, Nerve Tissue Proteins, Striatum, Substance P, Pharmacology, Catalepsy, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Internal medicine, Dopamine receptor D2, medicine, Haloperidol, Animals, Rats, Wistar, Early Growth Response Protein 1, Neurons, Arc (protein), Dose-Response Relationship, Drug, Phosphoric Diester Hydrolases, Receptors, Dopamine D2, Chemistry, Gene Expression Profiling, Antagonist, Enkephalins, medicine.disease, Corpus Striatum, Substantia Nigra, Cytoskeletal Proteins, Endocrinology, Quinolines, Dopamine Antagonists, Pyrazoles, PDE10A, Proto-Oncogene Proteins c-fos, medicine.drug
-
7
المؤلفون: Vanita Puri, John Swestock, Pravien Abeywickrema, Lei Ma, Jenny Wai, Michelle R. Machacek, Georgia B. McGaughey, Sean M. Smith, Deping Wang, Shawn J. Stachel, John C. Reid, Melissa Egbertson, Donnie Eddins, Debbie Perlow, Dawn Toolan, Jason M. Uslaner, Gopal Parthasarathy, Hua-Poo Su
المصدر: Bioorganicmedicinal chemistry letters. 28(6)
مصطلحات موضوعية: Gene isoform, Indoles, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Computational biology, 010402 general chemistry, 01 natural sciences, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Catalytic Domain, Drug Discovery, Animals, Cognitive Dysfunction, Novel object recognition, Molecular Biology, Acetic Acid, Indole test, Chemotype, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, fungi, Organic Chemistry, Active site, Cognition, Multiple species, Cyclic Nucleotide Phosphodiesterases, Type 2, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Selectivity, 030217 neurology & neurosurgery
-
8
المؤلفون: Sarah L. Huszar, John D. Schreier, Michael J. Breslin, Joshua D. Vardigan, Sean M. Smith, Lihang Yao, Monika Kandebo, Christopher D. Cox, Christopher E. Cannon, John J. Renger, Jason M. Uslaner, Paul J. Coleman, Izzat T. Raheem, Donnie Eddins, Dawn Toolan
المصدر: Neuropharmacology. 64:215-223
مصطلحات موضوعية: Male, MAPK/ERK pathway, Phosphodiesterase Inhibitors, Pyridines, Memory, Episodic, Nerve Tissue Proteins, AMPA receptor, Pharmacology, CREB, Executive Function, Random Allocation, Cellular and Molecular Neuroscience, Animals, Molecular Targeted Therapy, Phosphorylation, Rats, Wistar, Nootropic Agents, Neurons, Behavior, Animal, Dose-Response Relationship, Drug, biology, Phosphoric Diester Hydrolases, Phosphodiesterase, Macaca mulatta, Corpus Striatum, Rats, Pyrimidines, Second messenger system, Synaptic plasticity, Schizophrenia, biology.protein, PDE10A, Signal transduction, Cognition Disorders, Psychology, Protein Processing, Post-Translational, Antipsychotic Agents
-
9
المؤلفون: Jacob Marcus, Ruben Declercq, Mali Cosden, Cristian Salinas, John J. Renger, Mark Forman, Ernest J. McEachern, Sean M. Smith, Daniel Jonathan, David J. Vocadlo, Dawn Toolan, Fred Hess, Joseph Duffy, Wenping Li, Arie Struyk, Harold G. Selnick, Hostetler D. Eric, Michelle Pearson, Joel B. Schachter, Xiaohai Wang, Darryle Schoepp
المصدر: Alzheimer's & Dementia. 12
مصطلحات موضوعية: 0301 basic medicine, Epidemiology, business.industry, Health Policy, O-GlcNAcase, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Cancer research, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
-
10
المؤلفون: Punam Sandhu, Joseph L. Duffy, Maria S. Michener, Sean M. Smith, Joan D. Ellis, Mary J. Savage, Ernest J. McEachern, Chandni Valiathan, Brittany Walker, Jeanine E. Ballard, Arie Struyk, David J. Vocadlo, Junghoon Lee, Dawn Toolan, Thomas McAvoy, Daniel P. Dreyer, Nicole Trainor, Jacob Marcus
المصدر: Alzheimer's & Dementia. 12
مصطلحات موضوعية: 0301 basic medicine, Epidemiology, business.industry, Health Policy, O-GlcNAcase, Pharmacology, medicine.disease, Progressive supranuclear palsy, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, Developmental Neuroscience, Pharmacokinetics, medicine, Neurology (clinical), Geriatrics and Gerontology, business