المؤلفون: da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MDNC

المصدر: Drug Design, Development and Therapy, Vol Volume11, Pp 1095-1105 (2017)

مصطلحات موضوعية: Chagas disease, arylimidamides, experimental chemotherapy, in vivo assays., Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.dovepress.com/phenotypic-evaluation-and-in-silico-admet-properties-of-novel-arylimid-peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881

URL الوصول: https://doaj.org/article/ae5fc12ce25542cc8990e21aa28a08b9

المؤلفون: Bernardino da Silva P, Titilola D. Kalejaiye, Soeiro Mnc, De Koning Hp, Cristina Fonseca-Berzal, de Araújo Js, Alfonso García-Rubia, Carmen Gil, Louis Maes, Sebastián-Pérez

المساهمون: European Commission, Red de Investigación Cooperativa en Enfermedades Tropicales (España), Ministerio de Educación, Cultura y Deporte (España), García-Rubia, Alfonso, Sebastián-Pérez, Víctor, Maes, Louis, Koning, Harry de, Gil,Carmen, García-Rubia, Alfonso [0000-0003-4002-910X], Sebastián-Pérez, Víctor [0000-0002-8248-4496], Maes, Louis [0000-0002-2324-9509], Koning, Harry de [0000-0002-9963-1827], Gil,Carmen [0000-0002-3882-6081]

المصدر: Antimicrobial agents and chemotherapy
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Chagas disease, Phenotypic screening, Trypanosoma cruzi, Pharmacology, 03 medical and health sciences, Mice, Structure-Activity Relationship, Parasitic Sensitivity Tests, parasitic diseases, medicine, Autophagy, Animals, Pharmacology (medical), Experimental Therapeutics, Nifurtimox, Biology, Imidazole, Cells, Cultured, 030304 developmental biology, 0303 health sciences, biology, Antiparasitic Agents, 030306 microbiology, Drug discovery, Chemistry, Pharmacology. Therapy, Imidazoles, Phosphodiesterase, medicine.disease, biology.organism_classification, 3. Good health, Infectious Diseases, Mechanism of action, Benznidazole, 3',5'-Cyclic-AMP Phosphodiesterases, Human medicine, medicine.symptom, medicine.drug

وصف الملف: application/pdf; pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2d4bb19f519061243c6ae35705c32c
http://hdl.handle.net/10261/186793

المؤلفون: Dos Santos VP; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., Cerutti CI; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., Alencar MJC; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., Queiroz AB; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., Ferreira LM; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., Fidelis C; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., de Araújo JS; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil., Alves CAS; Universidade Federal da Bahia - UFBA, Hospital Universitário Professor Edgard Santos - HUPES, Salvador, BA, Brasil.

المصدر: Jornal vascular brasileiro [J Vasc Bras] 2023 Jul 17; Vol. 22, pp. e20230014. Date of Electronic Publication: 2023 Jul 17 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sociedade Brasileira de Angiologia e Cirurgia Vascular Country of Publication: Brazil NLM ID: 101262256 Publication Model: eCollection Cited Medium: Internet ISSN: 1677-7301 (Electronic) Linking ISSN: 16775449 NLM ISO Abbreviation: J Vasc Bras Subsets: PubMed not MEDLINE

المؤلفون: de Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Peres RB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Bernardino da Silva P; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Sterk GJ; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Maes L; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium., Caljon G; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium., Leurs R; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., de Koning HP; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom., Kalejaiye TD; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom., Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Feb 17; Vol. 65 (3). Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents*/therapeutic use , Chagas Disease*/drug therapy , Leishmania mexicana* , Trypanosoma cruzi*, Humans ; Phosphoric Diester Hydrolases

المؤلفون: de Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., França da Silva C; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Batista DDGJ; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Nefertiti A; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Fiuza LFA; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Fonseca-Berzal CR; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.; Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain., Bernardino da Silva P; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Sijm M; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands., Kalejaiye TD; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Maes L; Laboratory for Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Sterk GJ; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands., Leurs R; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands., Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Aug 20; Vol. 64 (9). Date of Electronic Publication: 2020 Aug 20 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Chagas Disease*/drug therapy , Nitroimidazoles*/therapeutic use , Pyrazolones*/pharmacology , Pyrazolones*/therapeutic use , Trypanocidal Agents*/pharmacology , Trypanocidal Agents*/therapeutic use , Trypanosoma cruzi*, Animals ; Mice ; Phosphodiesterase Inhibitors/therapeutic use

المؤلفون: De Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Peres RB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Cardoso-Santos C; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Kalejaiye TD; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK., Munday JC; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK., De Heuvel E; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Sterk GJ; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Augustyns K; Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium., Salado IG; Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium., Matheeussen A; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium., De Esch I; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., De Koning HP; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK., Leurs R; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Maes L; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium., Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

المصدر: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Apr 01; Vol. 75 (4), pp. 958-967.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Chagas Disease*/drug therapy , Trypanocidal Agents*/pharmacology , Trypanocidal Agents*/therapeutic use , Trypanosoma cruzi*, Humans ; Phosphodiesterase Inhibitors/pharmacology ; Phosphodiesterase Inhibitors/therapeutic use

المؤلفون: Dos Santos VP; Universidade Federal da Bahia - UFBA, Instituto de Humanidades Artes e Ciências Professor Milton Santos, Salvador, BA, Brasil., Alves CAS; Universidade Federal da Bahia - UFBA, Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, BA, Brasil., Queiroz AB; Universidade Federal da Bahia - UFBA, Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, BA, Brasil., Barberino MGMA; Universidade Federal da Bahia - UFBA, Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, BA, Brasil., Fidelis RJR; Universidade Federal da Bahia - UFBA, Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, BA, Brasil., Fidelis C; Universidade Federal da Bahia - UFBA, Faculdade de Medicina da Bahia, Salvador, BA, Brasil., de Araújo JS; Universidade Federal da Bahia - UFBA, Faculdade de Medicina da Bahia, Salvador, BA, Brasil.

المصدر: Jornal vascular brasileiro [J Vasc Bras] 2019 Nov 08; Vol. 18, pp. e20190063. Date of Electronic Publication: 2019 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sociedade Brasileira de Angiologia e Cirurgia Vascular Country of Publication: Brazil NLM ID: 101262256 Publication Model: Electronic Cited Medium: Internet ISSN: 1677-7301 (Electronic) Linking ISSN: 16775449 NLM ISO Abbreviation: J Vasc Bras Subsets: PubMed not MEDLINE

المؤلفون: Ribeiro VT; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil., Asevedo EA; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil., de Paiva Vasconcelos LTC; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil., Filho MAO; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil., de Araújo JS; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil., de Macedo GR; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil., de Sousa Júnior FC; Pharmacy Department, Universidade Federal do Rio Grande do Norte, R. Gen. Gustavo Cordeiro de Faria, Natal, Rio Grande do Norte, 59012-570, Brazil., Dos Santos ES; Chemical Engineering Department, Universidade Federal do Rio Grande do Norte, Av. Sen. Salgado Filho, 3000, Natal, Rio Grande do Norte, 59078-970, Brazil. everaldo@eq.ufrn.br.

المصدر: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2019 Aug; Vol. 103 (16), pp. 6495-6504. Date of Electronic Publication: 2019 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression* , Transcriptional Activation*, Antigens, Protozoan/*biosynthesis , Escherichia coli/*metabolism , Leishmania/*genetics , Recombinant Proteins/*biosynthesis, Antigens, Protozoan/genetics ; Escherichia coli/genetics ; Genomic Instability/drug effects ; Isopropyl Thiogalactoside/metabolism ; Plasmids ; Recombinant Proteins/genetics ; Temperature

المؤلفون: Simões-Silva MR; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro,Brazil., De Araújo JS; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro,Brazil., Peres RB; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro,Brazil., Da Silva PB; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro,Brazil., Batista MM; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro,Brazil., De Azevedo LD; Laboratório de Síntese Orgânica, Instituto de Tecnologia em Fármacos - Farmanguinhos, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-900 Rio de Janeiro, Rio de Janeiro,Brazil., Bastos MM; Laboratório de Síntese Orgânica, Instituto de Tecnologia em Fármacos - Farmanguinhos, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-900 Rio de Janeiro, Rio de Janeiro,Brazil., Bahia MT; Laboratório de Doenças Parasitárias, Escola de Medicina & Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Universitário,Morro do Cruzeiro s/no, 35400-000 Ouro Preto, Minas Gerais,Brazil., Boechat N; Laboratório de Síntese Orgânica, Instituto de Tecnologia em Fármacos - Farmanguinhos, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-900 Rio de Janeiro, Rio de Janeiro,Brazil., Soeiro MNC; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,Av. Brasil 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro,Brazil.

المصدر: Parasitology [Parasitology] 2019 Jul; Vol. 146 (8), pp. 1006-1012. Date of Electronic Publication: 2019 Mar 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cambridge University Press Country of Publication: England NLM ID: 0401121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8161 (Electronic) Linking ISSN: 00311820 NLM ISO Abbreviation: Parasitology Subsets: MEDLINE

مواضيع طبية MeSH: Drug Repositioning*, Chagas Disease/*drug therapy , Imatinib Mesylate/*pharmacology , Nitroimidazoles/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Animals ; Cell Line ; Drug Therapy, Combination ; Fibroblasts ; Mice

المؤلفون: de Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., García-Rubia A; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain., Sebastián-Pérez V; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain., Kalejaiye TD; Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom., Bernardino da Silva P; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Fonseca-Berzal CR; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.; Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain., Maes L; Laboratory for Microbiology, Parasitology, and Hygiene, University of Antwerp, Antwerp, Belgium., De Koning HP; Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom., Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br carmen.gil@csic.es., Gil C; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain soeiro@ioc.fiocruz.br carmen.gil@csic.es.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Mar 27; Vol. 63 (4). Date of Electronic Publication: 2019 Mar 27 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: 3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors , Antiparasitic Agents/*pharmacology , Chagas Disease/*drug therapy , Imidazoles/*pharmacology , Trypanosoma cruzi/*drug effects, Animals ; Autophagy/drug effects ; Cells, Cultured ; Drug Discovery ; Imidazoles/chemical synthesis ; Mice ; Parasitic Sensitivity Tests ; Structure-Activity Relationship