المؤلفون: Lawson H; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Holt-Martyn JP; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Dembitz V; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Department of Physiology and Immunology and Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia., Kabayama Y; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Wang LM; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Bellani A; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Atwal S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Saffoon N; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Durko J; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., van de Lagemaat LN; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., De Pace AL; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Tumber A; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Corner T; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Salah E; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Arndt C; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Brewitz L; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Bowen M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Dubusse L; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., George D; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Allen L; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Guitart AV; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.; Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale INSERM U1035, Bordeaux, France., Fung TK; Leukemia and Stem Cell Biology Group, Comprehensive Cancer Centre, King's College London, London, UK.; Department of Haematological Medicine, King's College Hospital, King's College London, London, UK., So CWE; Leukemia and Stem Cell Biology Group, Comprehensive Cancer Centre, King's College London, London, UK.; Department of Haematological Medicine, King's College Hospital, King's College London, London, UK., Schwaller J; University Children's Hospital Basel (UKBB), Department of Biomedicine, University of Basel, Basel, Switzerland., Gallipoli P; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., O'Carroll D; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk., Kranc KR; The Institute of Cancer Research, London, UK. kamil.kranc@icr.ac.uk.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK. kamil.kranc@icr.ac.uk.

المصدر: Nature cancer [Nat Cancer] 2024 Jun; Vol. 5 (6), pp. 916-937. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor-Proline Dioxygenases*/antagonists & inhibitors , Hypoxia-Inducible Factor-Proline Dioxygenases*/metabolism , Prolyl-Hydroxylase Inhibitors*/pharmacology , Prolyl-Hydroxylase Inhibitors*/therapeutic use , Disease Progression*, Humans ; Animals ; Mice ; Apoptosis/drug effects ; Proto-Oncogene Proteins/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Cell Line, Tumor ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Protein Stability/drug effects ; Bridged Bicyclo Compounds, Heterocyclic

المؤلفون: Vacante F; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Rodor J; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Lalwani MK; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Mahmoud AD; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Bennett M; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., De Pace AL; Institute for Regeneration and Repair, Centre for Regenerative Medicine (A.D.P., D.O.), University of Edinburgh, Scotland., Miller E; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Van Kuijk K; Pathology, Maastricht Medical Center, the Netherlands (K.V.K., J.d., J.C.S., A.H.B.)., de Bruijn J; Pathology, Maastricht Medical Center, the Netherlands (K.V.K., J.d., J.C.S., A.H.B.)., Gijbels M; Pathology CARIM, Cardiovascular Research Institute Maastricht, GROW-School for Oncology and Developmental Biology, Maastricht University, the Netherlands (M. Gijbels)., Williams TC; Insitute of Genetics and Molecular Medicine (T.C.W.), University of Edinburgh, Scotland., Clark MB; Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, The University of Melbourne, Australia (M.B.C.)., Scanlon JP; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Doran AC; Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (A.C.D)., Montgomery R; miRagen Therapeutics, lnc, Boulder, Colorado (R.M.)., Newby DE; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Giacca M; Medical Biochemistry, Experimental Vascular Biology, Amsterdam UMC, University of Amsterdam, the Netherlands (M. Gijbels).; King's College London, England (M. Giacca)., O'Carroll D; Institute for Regeneration and Repair, Centre for Regenerative Medicine (A.D.P., D.O.), University of Edinburgh, Scotland., Hadoke PWF; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Denby L; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland., Sluimer JC; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland.; Pathology, Maastricht Medical Center, the Netherlands (K.V.K., J.d., J.C.S., A.H.B.)., Baker AH; Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland.; Pathology, Maastricht Medical Center, the Netherlands (K.V.K., J.d., J.C.S., A.H.B.).

المصدر: Circulation research [Circ Res] 2021 Apr 30; Vol. 128 (9), pp. 1258-1275. Date of Electronic Publication: 2021 Feb 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: Cell Dedifferentiation*, Atherosclerosis/*etiology , MicroRNAs/*metabolism , Muscle, Smooth, Vascular/*physiology , RNA, Long Noncoding/*physiology, Animals ; Atherosclerosis/pathology ; Cell Movement ; Cell Proliferation ; Clustered Regularly Interspaced Short Palindromic Repeats ; Coronary Vessels/cytology ; Down-Regulation ; Gene Knockdown Techniques ; Gene Silencing ; Humans ; Lipid Metabolism ; Mice ; Muscle, Smooth, Vascular/cytology ; Oligonucleotides, Antisense ; Phenotype ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Transcriptome