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1
المؤلفون: Emma K. Lendy, Bhavanam Sekhara Reddy, Satish Kovela, Emilio L. Cárdenas, Andrew D. Mesecar, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Deborah Downs, Kalapala Venketeswara Rao
المساهمون: Ghosh, A. K., Brindisi, M., Yen, Y. -C., Lendy, E. K., Kovela, S., Cardenas, E. L., Reddy, B. S., Rao, K. V., Downs, D., Huang, X., Tang, J., Mesecar, A. D.
المصدر: ChemMedChem. 14(5)
مصطلحات موضوعية: Isostere, Stereochemistry, BACE2 inhibitor, Drug Evaluation, Preclinical, Crystallography, X-Ray, Biochemistry, Article, chemistry.chemical_compound, Structure-Activity Relationship, Tmem27, Drug Discovery, Amyloid precursor protein, Ethylamines, Structure–activity relationship, Aspartic Acid Endopeptidases, Humans, Hypoglycemic Agents, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, type 2 diabete, Trifluoromethyl, Binding Sites, biology, Molecular Structure, Organic Chemistry, BACE2 inhibitors, structure-based design, type 2 diabetes, β-secretase 2, Molecular Docking Simulation, Memapsin 1, Enzyme, chemistry, Diabetes Mellitus, Type 2, Docking (molecular), biology.protein, Molecular Medicine, Thermodynamics, Amyloid Precursor Protein Secretases, Selectivity, Protein Binding
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2
المؤلفون: Andrew D. Mesecar, Emilio L. Cárdenas, Deborah Downs, Kanury V. S. Rao, Yu-Chen Yen, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Bhavanam Sekhara Reddy
المصدر: Chemical Science. 7:3117-3122
مصطلحات موضوعية: 0301 basic medicine, Cathepsin, Chemistry, General Chemistry, Type 2 diabetes, Pharmacology, Highly selective, medicine.disease, Combinatorial chemistry, 3. Good health, 03 medical and health sciences, Memapsin 1, 030104 developmental biology, β secretase, medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573b8d66f02273c2c3c567ed0e16a2b0
https://doi.org/10.1039/c5sc03718b -
3
المؤلفون: Margherita Brindisi, Arun K. Ghosh, Bhavanam Sekhara Reddy, Andrew D. Mesecar, Kalapala Venketeswara Rao, Deborah Downs, Jordan Tang, Satish Kovela, Emma K. Lendy, Emilio L. Cárdenas, Yu-Chen Yen, Xiangping Huang
المصدر: ChemMedChem. 14:513-513
مصطلحات موضوعية: Pharmacology, Stereochemistry, Chemistry, Organic Chemistry, Highly selective, Biochemistry, Design synthesis, Feature (computer vision), Drug Discovery, β secretase, Molecular Medicine, Structure–activity relationship, Cover (algebra), General Pharmacology, Toxicology and Pharmaceutics
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4
المؤلفون: Azar Dashti, Peng Zhai, Xinli Lin, Shili Wu, Xuejun C. Zhang, Deborah Downs, Yujun Pan, Xinjuan Wang, Yong-Tae Kim
المصدر: European Journal of Biochemistry. 269:5668-5677
مصطلحات موضوعية: chemistry.chemical_classification, Protease, medicine.medical_treatment, Peptide, Biology, Biochemistry, Inclusion bodies, Transmembrane protein, law.invention, Transmembrane domain, Enzyme, chemistry, law, mental disorders, medicine, Amyloid precursor protein, biology.protein, Recombinant DNA
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5
المؤلفون: Xuejun C. Zhang, Bret Hunter, Deborah Downs, Chi-Sun Wang, Simon Terzyan
المصدر: Protein Science. 9:1783-1790
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Sequence Data, Crystal structure, Crystallography, X-Ray, Biochemistry, Bile Acids and Salts, chemistry.chemical_compound, Enzyme activator, Catalytic Domain, Catalytic triad, Hydrolase, Humans, Amino Acid Sequence, Lipase, Molecular Biology, Sequence Homology, Amino Acid, biology, Chemistry, Active site, Enzyme Activation, Monomer, biology.protein, Oxyanion hole, Research Article
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6
المؤلفون: Jordan Tang, Hao Wu, Koena Ghosh, Peter Staib, Deborah Downs, Michel Monod, Arun K. Ghosh
المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(6)
مصطلحات موضوعية: Models, Molecular, Integrins, Endosome, media_common.quotation_subject, Integrin, Molecular Sequence Data, Apoptosis, Biochemistry, Cell Line, Research Communications, Fungal Proteins, chemistry.chemical_compound, Lysosome, Candida albicans, Genetics, medicine, Aspartic Acid Endopeptidases, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Internalization, Molecular Biology, media_common, RGD motif, biology, Virulence, Acridine orange, Candidiasis, Epithelial Cells, biology.organism_classification, Cell biology, Cytosol, medicine.anatomical_structure, chemistry, Host-Pathogen Interactions, biology.protein, Lysosomes, Oligopeptides, Biotechnology, Protein Binding
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7
المؤلفون: Azar Dashti, Chi-Sun Wang, Deborah Downs, Kenneth W. Jackson
المصدر: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1302:224-230
مصطلحات موضوعية: Apolipoprotein C-II, Molecular Sequence Data, Biophysics, medicine.disease_cause, Aminopeptidases, Biochemistry, Mass Spectrometry, Inclusion bodies, law.invention, chemistry.chemical_compound, Endocrinology, law, Escherichia coli, medicine, Animals, Humans, Methionyl Aminopeptidases, Amino Acid Sequence, Threonine, Apolipoproteins C, Polyacrylamide gel electrophoresis, Chromatography, High Pressure Liquid, Methionine, Base Sequence, Molecular biology, Recombinant Proteins, Enzyme Activation, Lipoprotein Lipase, Milk, chemistry, Sephadex, Chromatography, Gel, Recombinant DNA, Cattle, Electrophoresis, Polyacrylamide Gel, lipids (amino acids, peptides, and proteins)
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8
المؤلفون: Deborah Downs, John R. Cirrito, Wan Pin Chang, Arun K. Ghosh, Jordan Tang, Xiangping Huang, Gerald Koelsch, David M. Holtzman
مصطلحات موضوعية: Gerontology, Genetically modified mouse, Age-related cognitive decline, Aging, Transgene, Phthalic Acids, Mice, Transgenic, Pharmacology, Biochemistry, Drug Administration Schedule, Research Communications, Amyloid beta-Protein Precursor, Mice, mental disorders, Genetics, medicine, Animals, Cognitive decline, Molecular Biology, Sulfonamides, biology, Molecular Structure, business.industry, Extramural, medicine.disease, biology.protein, β secretase, Alzheimer's disease, Amyloid Precursor Protein Secretases, business, Amyloid precursor protein secretase, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315717bea6b55f6c9fa4870bd39d337d
https://europepmc.org/articles/PMC3023390/ -
9
المؤلفون: Kenneth W. Jackson, Deborah Downs, Tadashi Baba, Jordan Tang, Chi Sun Wang
المصدر: Biochemistry. 30:500-510
مصطلحات موضوعية: Molecular Sequence Data, Sequence alignment, Biology, Biochemistry, Bile Acids and Salts, chemistry.chemical_compound, Complementary DNA, Animals, Humans, Amino Acid Sequence, Disulfides, RNA, Messenger, Cloning, Molecular, Pancreas, Peptide sequence, Glycoproteins, chemistry.chemical_classification, Binding Sites, Base Sequence, Heparin, cDNA library, Nucleic acid sequence, DNA, Lipase, Sterol Esterase, Blotting, Northern, Bile salt-dependent lipase, Molecular biology, Peptide Fragments, Rats, Amino acid, Enzyme Activation, Milk, chemistry, biology.protein, Cyanogen bromide, Lysophospholipase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52ae5251abc9d6f3fe4dee4c8f905f0
https://doi.org/10.1021/bi00216a028 -
10
المؤلفون: P. Alaupovic, Eugen Koren, R E Gregg, Chi-Sun Wang, Deborah Downs, Carolyn Knight-Gibson, H B Brewer
المصدر: Journal of Lipid Research, Vol 32, Iss 1, Pp 9-19 (1991)
مصطلحات موضوعية: medicine.medical_specialty, Very low-density lipoprotein, Lipoprotein lipase, Apolipoprotein B, biology, Chemistry, Apolipoprotein A-II, nutritional and metabolic diseases, Cell Biology, QD415-436, medicine.disease, Biochemistry, B vitamins, Endocrinology, Tangier disease, Internal medicine, biology.protein, medicine, lipids (amino acids, peptides, and proteins), Hypoalphalipoproteinemia, Lipoprotein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5deb8a3485d2ba4a1171a57cc9ce2c9b
http://www.sciencedirect.com/science/article/pii/S0022227520422394
