يعرض 1 - 7 نتائج من 7 نتيجة بحث عن '"Deborah Stanford"', وقت الاستعلام: 1.10s تنقيح النتائج
  1. 1
    Structure-based Mechanism of CMP-2-keto-3-deoxymanno-octulonic Acid Synthetase

    المؤلفون: Pierre Lafite, Stephen E. J. Rigby, Deborah Stanford, Steven R. Rossington, David Leys, Marie Goldrick, Ian Roberts, Andrew V. Stachulski, Derren J. Heyes, Colin Levy, Nigel S. Scrutton

    المصدر: Journal of Biological Chemistry. 284:35514-35523

    مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Active site, Substrate (chemistry), Isothermal titration calorimetry, Cell Biology, Biochemistry, chemistry.chemical_compound, Enzyme, Biosynthesis, chemistry, biology.protein, Transferase, Molecular Biology, Ternary complex, DNA

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7e9f16df9e9dcff6d0aca4c090dd90ef
    https://doi.org/10.1074/jbc.m109.056630

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  2. 2
    Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable 'Back-Up' Compound for N-tert-Butyl Isoquine

    المؤلفون: Stephen Hindley, Paul M. O'Neill, Eghbaleh Asadollahy, Karen Rimmer, Alison E. Shone, Gemma L. Nixon, James L. Maggs, Stephen A. Ward, Richard A. Brigandi, Martin Bates, Patrick G. Bray, P. A. Winstanley, Paul A. Stocks, Jill Davies, Silvia Parapini, Livia Vivas, Domingo Gargallo, Stephanie L. Gresham, Hollie Lander, Giancarlo A. Biagini, B. Kevin Park, Donatella Taramelli, Ramesh Bambal, Federico M. Gomez-de-las-Heras, Charles B. Davis, Charlotte Hall, Neil G. Berry, Phil Roberts, Deborah Stanford

    المصدر: Journal of Medicinal Chemistry. 52:1828-1844

    مصطلحات موضوعية: Male, Cell Survival, Plasmodium berghei, Stereochemistry, Plasmodium falciparum, Drug Resistance, Amodiaquine, In Vitro Techniques, Chemical synthesis, Antimalarials, Mice, Structure-Activity Relationship, Dogs, Parasitic Sensitivity Tests, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Rats, Wistar, ADME, Chemistry, Chloroquine, Biological activity, Haplorhini, Plasmodium yoelii, In vitro, Malaria, Rats, Bioavailability, Aminoquinolines, Hepatocytes, Molecular Medicine, Female, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2075934bbaca76abf6a07eb93897a
    https://doi.org/10.1021/jm8012757

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  3. 3
    Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles

    المؤلفون: María Jesús, Gemma L. Ellis, Livia Vivas, Jill Davies, Emily Bongard, Alison E. Shone, Domingo Gargallo, Sarah C. Charnaud, Karen Rimmer, Richard Amewu, Paul M. O'Neill, Sunil Sabbani, Deborah Stanford, Peter Gibbons, Stephen A. Ward, Paul A. Stocks, Sonia Lozanom, Charlotte Hall

    المصدر: Journal of Medicinal Chemistry. 51:2170-2177

    مصطلحات موضوعية: Male, Salmonella typhimurium, Trioxane, Plasmodium berghei, Plasmodium falciparum, medicine.disease_cause, Chemical synthesis, Antimalarials, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, Parasitic Sensitivity Tests, In vivo, Chlorocebus aethiops, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Tetraoxanes, Cytotoxicity, Dose-Response Relationship, Drug, Molecular Structure, Stereoisomerism, Biological activity, In vitro, Rats, Disease Models, Animal, chemistry, Biochemistry, Molecular Medicine, Genotoxicity

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030b9ed2f11ed04356cc9e1c48588770
    https://doi.org/10.1021/jm701435h

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  4. 4
    Convenient syntheses of deoxypyranose sugars from glucuronolactone

    المؤلفون: Deborah Stanford, Andrew V. Stachulski

    المصدر: Tetrahedron Letters. 48:2361-2364

    مصطلحات موضوعية: chemistry.chemical_classification, Anomer, Glycal, Stereochemistry, Organic Chemistry, Hydroxy group, Glucuronic acid, Biochemistry, chemistry.chemical_compound, chemistry, Pyranose, Dihydroxylation, Neosidomycin, Drug Discovery, Glucuronolactone

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::346efd8018a819d6f1e4e284dbdbbc56
    https://doi.org/10.1016/j.tetlet.2007.01.127

    View record from ScienceDirect
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  5. 5
    Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases

    المؤلفون: Derren J, Heyes, Colin, Levy, Pierre, Lafite, Ian S, Roberts, Marie, Goldrick, Andrew V, Stachulski, Steven B, Rossington, Deborah, Stanford, Stephen E J, Rigby, Nigel S, Scrutton, David, Leys

    المصدر: The Journal of biological chemistry. 284(51)

    مصطلحات موضوعية: Evolution, Molecular, Enzyme Catalysis and Regulation, Structural Homology, Protein, Cytidine Triphosphate, Escherichia coli, DNA-Directed DNA Polymerase, DNA-Directed RNA Polymerases, Crystallography, X-Ray, Nucleotidyltransferases, Protein Structure, Tertiary

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ad751422a9d2155221cafed80a652dd8
    https://pubmed.ncbi.nlm.nih.gov/19815542

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  6. 6
    دورية أكاديمية
    Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compound for N-tert-Butyl Isoquine.

    المؤلفون: Paul M. O’Neill, Alison E. Shone, Deborah Stanford, Gemma Nixon, Eghbaleh Asadollahy, B. Kevin Park, James L. Maggs, Phil Roberts, Paul A. Stocks, Giancarlo Biagini, Patrick G. Bray, Jill Davies, Neil Berry, Charlotte Hall, Karen Rimmer, Peter A. Winstanley, Stephen Hindley, Ramesh B. Bambal, Charles B. Davis, Martin Bates

    المصدر: Journal of Medicinal Chemistry; Apr2009, Vol. 52 Issue 7, p1828-1844, 17p

    Find this issue from the American Chemical Society
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  7. 7
    دورية أكاديمية
    Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles.

    المؤلفون: Gemma L. Ellis, Richard Amewu, Sunil Sabbani, Paul A. Stocks, Alison Shone, Deborah Stanford, Peter Gibbons, Jill Davies, Livia Vivas, Sarah Charnaud, Emily Bongard, Charlotte Hall, Karen Rimmer, Sonia Lozanom, María Jesús, Domingo Gargallo, Stephen A. Ward, Paul M. O’Neill

    المصدر: Journal of Medicinal Chemistry; Mar2008, Vol. 51 Issue 7, p2170-2177, 8p

    Find this issue from the American Chemical Society
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