المؤلفون: Takeda M, Theardy MS, Sorokin A, Coker O, Kanikarla P, Chen S, Yang Z, Nguyen P, Wei Y, Yao J, Wang X, Yan L, Jin Y, Cai Y, Paku M, Chen Z, Li KZ, Citron F, Tomihara H, Gao S, Deem AK, Zhao J, Wang H, Hanash S, DePinho RA, Maitra A, Draetta GF, Ying H, Kopetz S, Yao W

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Soeung M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Perelli L; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Chen Z; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Dondossola E; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Ho IL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Carbone F; Nerviano Medical Sciences, Milan 20014, Italy., Zhang L; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Khan H; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Le CN; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Zhu C; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Peoples MD; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Feng N; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Jiang S; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Zacharias NM; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Minelli R; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Shapiro DD; Division of Urology, William S. Middleton Memorial VA Hospital, Madison, WI 53705., Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Gao S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Cheng EH; Department of Pathology, Memorial Sloan Kettering Cancer Institute, New York City, NY 10065., Lucchetti D; Department of Translational Medicine and Surgery-Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome 00168, Italy.; Multiplex Spatial Profiling Center, Fondazione Policlinico Universitario 'A. Gemelli', Rome 00168, Italy., Walker CL; Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030., Carugo A; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; Department of Oncology, IRBM S.p.A., Rome 00071, Italy., Giuliani V; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Heffernan TP; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Tannir NM; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Msaouel P; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.; Translational Research to Advance Therapeutics and Innovation in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77025.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 May 23; Vol. 120 (21), pp. e2209639120. Date of Electronic Publication: 2023 May 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Renal Cell*/pathology , Kidney Neoplasms*/pathology , Sickle Cell Trait*/genetics , Sickle Cell Trait*/metabolism, Animals ; Humans ; Mice ; Hypoxia/genetics ; Hypoxia/metabolism ; Kidney/metabolism ; SMARCB1 Protein/genetics ; SMARCB1 Protein/metabolism

المؤلفون: Chen Z; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ZChen13@mdanderson.org., Ho IL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Soeung M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yen EY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yan L; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Srinivasan S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jiang S; Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Edward Chang Q; The Oncology Research for Biologics and Immunotherapy Translation (ORBIT), The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gay JP; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang Q; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lorenzi PL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Veillon LJ; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wei B; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Weinstein JN; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Deem AK; Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gao S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yao W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, University of Texas, Houston, TX, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, 48109, USA., Marszalek JR; Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. GDraetta@mdanderson.org.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. GDraetta@mdanderson.org., Ying H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. hying@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2023 Apr 17; Vol. 14 (1), pp. 2194. Date of Electronic Publication: 2023 Apr 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/pathology , Carcinoma, Pancreatic Ductal*/metabolism, Humans ; Reactive Oxygen Species/metabolism ; Phospholipid Ethers/metabolism ; Mitochondria/metabolism ; Phospholipids/metabolism ; Homeostasis

المؤلفون: Puca F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. GDraetta@mdanderson.org AViale@mdanderson.org FPuca@mdanderson.org CLyssiot@med.umich.edu., Yu F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Bartolacci C; Department of Internal Medicine Division of Hematology & Oncology, University of Cincinnati, Cincinnati, Ohio., Pettazzoni P; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Carugo A; The Translational Research to Advance Therapeutics and Innovation in Oncology Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Huang-Hobbs E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Liu J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zanca C; The Translational Research to Advance Therapeutics and Innovation in Oncology Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Carbone F; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas., Del Poggetto E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Gumin J; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Dasgupta P; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Seth S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; The Translational Research to Advance Therapeutics and Innovation in Oncology Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Srinivasan S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lang FF; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Sulman EP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lorenzi PL; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Shan M; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Tolstyka ZP; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Kachman M; Michigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, Michigan., Zhang L; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Gao S; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas., Deem AK; The Translational Research to Advance Therapeutics and Innovation in Oncology Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas., Genovese G; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Scaglioni PP; Department of Internal Medicine Division of Hematology & Oncology, University of Cincinnati, Cincinnati, Ohio., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. GDraetta@mdanderson.org AViale@mdanderson.org FPuca@mdanderson.org CLyssiot@med.umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. GDraetta@mdanderson.org AViale@mdanderson.org FPuca@mdanderson.org CLyssiot@med.umich.edu., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. GDraetta@mdanderson.org AViale@mdanderson.org FPuca@mdanderson.org CLyssiot@med.umich.edu.

المصدر: Cancer discovery [Cancer Discov] 2021 Nov; Vol. 11 (11), pp. 2904-2923. Date of Electronic Publication: 2021 May 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Acyl-CoA Dehydrogenase*/metabolism , Glioblastoma*/enzymology , Glioblastoma*/genetics , Lipid Peroxidation* , Mitochondria*/metabolism, Apoptosis ; Fatty Acids/metabolism ; Humans ; Oxidative Stress

المؤلفون: Del Poggetto E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ho IL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA., Balestrieri C; Experimental Hematology Unit, San Raffaele Research Hospital, Milan 20132, Italy.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy., Yen EY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA., Zhang S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Citron F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shah R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA., Corti D; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Diaferia GR; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan 20139, Italy., Li CY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA., Loponte S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Carbone F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hayakawa Y; Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY 10032, USA., Valenti G; Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY 10032, USA., Jiang S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sapio L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jiang H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Dey P; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Gao S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rose-John S; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel 24098, Germany., Yao W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ying H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rhim AD; Department of Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Genovese G; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Heffernan TP; TRACTION, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Maitra A; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang TC; Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY 10032, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Carugo A; TRACTION, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Natoli G; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan 20139, Italy.; Humanitas University, Pieve Emanuele, Milan 20089, Italy., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

المصدر: Science (New York, N.Y.) [Science] 2021 Sep 17; Vol. 373 (6561), pp. eabj0486. Date of Electronic Publication: 2021 Sep 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Carcinogenesis* , Genes, ras*, Acinar Cells/*pathology , Carcinoma, Pancreatic Ductal/*pathology , Pancreas/*pathology , Pancreatitis/*physiopathology, Animals ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/physiopathology ; Cell Transformation, Neoplastic ; Cells, Cultured ; Cellular Reprogramming ; Chromatin/metabolism ; Early Growth Response Protein 1/genetics ; Early Growth Response Protein 1/metabolism ; Enzyme Precursors/metabolism ; Epigenesis, Genetic ; Epithelial Cells/pathology ; Epithelial Cells/physiology ; Female ; MAP Kinase Signaling System ; Male ; Metaplasia ; Mice ; Mutation ; Pancreas/metabolism ; Pancreatitis/genetics ; Pancreatitis/immunology ; Spheroids, Cellular ; Transcriptome

المؤلفون: Giuliani V; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. VGiuliani@mdanderson.org., Miller MA; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu CY; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Class CA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pharmaceutical Sciences, Butler University, Indianapolis, IN, USA., Bristow CA; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Suzuki E; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Gao G; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gay JP; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tomihara H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Kindai University Nara Hospital, Nara, JP, USA., Daniele JR; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Peoples MD; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bardenhagen JP; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Geck Do MK; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang QE; ORBIT, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vangamudi B; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Exo Therapeutics, Cambridge, MA, USA., Vellano C; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ying H; Department of Cellular and Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Deem AK; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Do KA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marszalek JR; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kovacs JJ; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kim M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fleming JB; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Division of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA., Guccione E; Department of Oncological Sciences and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai, New York, NY, USA., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Emilia Di Francesco M; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yap TA; Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Jones P; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Draetta G; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Carugo A; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chedin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Heffernan TP; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. TPHeffernan@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2021 Jul 30; Vol. 12 (1), pp. 4626. Date of Electronic Publication: 2021 Jul 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage*, Carcinoma, Pancreatic Ductal/*genetics , Pancreatic Neoplasms/*genetics , Protein-Arginine N-Methyltransferases/*genetics , RNA/*genetics , Repressor Proteins/*genetics, Animals ; Biocatalysis/drug effects ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/prevention & control ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/prevention & control ; Protein-Arginine N-Methyltransferases/metabolism ; RNA/metabolism ; RNA Interference ; Repressor Proteins/metabolism ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays/methods ; Mice

المؤلفون: Inoue A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Gastroenterological Surgery, Osaka General Medical Center, Osaka, Japan. Electronic address: inoue_akira@gh.opho.jp., Robinson FS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Minelli R; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Tomihara H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rizi BS; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kodama T; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Osaka University, Osaka, Japan., Srinivasan S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Harris AL; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zuniga AM; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Mullinax RA; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ma X; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Seth S; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Daniele JR; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Peoples MD; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Loponte S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Akdemir KC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Khor TO; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Feng N; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Roszik J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Sobieski MM; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Brunell D; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Stephan C; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Giuliani V; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Shingu T; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Deribe YL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Menter DG; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Heffernan TP; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Bristow CA; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kopetz S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ggenovese@mdanderson.org., Carugo A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: acarugo@mdanderson.org.

المصدر: Gastroenterology [Gastroenterology] 2021 Jul; Vol. 161 (1), pp. 196-210. Date of Electronic Publication: 2021 Mar 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Antineoplastic Combined Chemotherapy Protocols/*administration & dosage , Ataxia Telangiectasia Mutated Proteins/*antagonists & inhibitors , Biomarkers, Tumor/*genetics , Colorectal Neoplasms/*drug therapy , Karyopherins/*antagonists & inhibitors , Protein Kinase Inhibitors/*administration & dosage , Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors , Tumor Suppressor Protein p53/*genetics, Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Databases, Genetic ; HCT116 Cells ; HT29 Cells ; Humans ; Indoles/administration & dosage ; Karyopherins/metabolism ; Mice ; Morpholines/administration & dosage ; Piperazines/administration & dosage ; Pyridines/administration & dosage ; Pyrimidines/administration & dosage ; Receptors, Cytoplasmic and Nuclear/metabolism ; Sulfonamides/administration & dosage ; Xenograft Model Antitumor Assays ; Exportin 1 Protein

المؤلفون: Tomihara H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Carbone F; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Perelli L; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Huang JK; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Soeung M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston, Houston, Texas., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston, Houston, Texas., Robinson FS; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lissanu Deribe Y; Department of Thoracic and Cardio Surgery-Research, The University of Texas MD Anderson Cancer Center, Houston, Texas., Feng N; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Takeda M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Inoue A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Poggetto ED; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Maitra A; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas., Msaouel P; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Tannir NM; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Heffernan TP; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Bristow CA; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Carugo A; Therapeutics Discovery Division, TRACTION Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas. ggenovese@mdanderson.org ACarugo@mdanderson.org., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. ggenovese@mdanderson.org ACarugo@mdanderson.org.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas.

المصدر: Cancer research [Cancer Res] 2021 Jan 15; Vol. 81 (2), pp. 332-343. Date of Electronic Publication: 2020 Nov 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial-Mesenchymal Transition*, Antineoplastic Agents/*pharmacology , DNA-Binding Proteins/*metabolism , Gene Expression Regulation, Neoplastic/*drug effects , HSP90 Heat-Shock Proteins/*antagonists & inhibitors , Isoxazoles/*pharmacology , Pancreatic Neoplasms/*drug therapy , Resorcinols/*pharmacology , Transcription Factors/*metabolism, Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Female ; Humans ; Mice ; Mice, Nude ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Prognosis ; Transcription Factors/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Citron F; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Perelli L; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Deem AK; Institute for Applied Cancer Science, Therapeutics Discovery and Development Division, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Genovese G; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address: ggenovese@mdanderson.org., Viale A; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA. Electronic address: aviale@mdanderson.org.

المصدر: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2020 Oct; Vol. 161, pp. 102174. Date of Electronic Publication: 2020 Sep 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use , Coronavirus Infections/*drug therapy , Cytokine Release Syndrome/*prevention & control , Immunologic Factors/*therapeutic use , Leukotrienes/*metabolism , Pneumonia, Viral/*drug therapy, Acetates/therapeutic use ; Adrenal Cortex Hormones/therapeutic use ; Arachidonic Acid/metabolism ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Cyclopropanes ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/metabolism ; Cytokine Release Syndrome/virology ; Humans ; Hydroxyurea/analogs & derivatives ; Hydroxyurea/therapeutic use ; Indoles ; Pandemics ; Phenylcarbamates ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Quinolines/therapeutic use ; SARS-CoV-2 ; Severity of Illness Index ; Sulfides ; Sulfonamides ; Tosyl Compounds/therapeutic use

المؤلفون: Loponte S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. SLoponte@mdanderson.org., Lovisa S; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. SLovisa@mdanderson.org., Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. AKDeem@mdanderson.org., Carugo A; TRACTION platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. ACarugo@mdanderson.org., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. aviale@mdanderson.org.

المصدر: Cancers [Cancers (Basel)] 2019 Oct 16; Vol. 11 (10). Date of Electronic Publication: 2019 Oct 16.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE