المؤلفون: Barbara A. Kruk, Robert Cain, Richard D. Gregg, Suresh B. Singh, Dong Chengguo, Peter Lindblom, Linghang Zhuang, Liu Zhijie, Ya-Jun Zheng, Gerard McGeehan, David A. Claremon, Yi Zhao, Colin M. Tice, Deepak S. Lala

المصدر: Journal of Chemical Information and Modeling. 59:3422-3436

مصطلحات موضوعية: chemistry.chemical_classification, Virtual screening, Chemistry, General Chemical Engineering, In silico, General Chemistry, Plasma protein binding, Computational biology, Library and Information Sciences, Hydroxysteroid Dehydrogenases, Chemical space, Computer Science Applications, Enzyme, Docking (molecular), Hit rate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8a73b16847a98bc03cc59e741adf50f8
https://doi.org/10.1021/acs.jcim.9b00198

المؤلفون: Paul B. Noto, Shi Meng, Yi Zhao, Geeta Kandpal, Suresh B. Singh, Guozhou Chen, Katerina Leftheris, Deepak S. Lala, Ya-Jun Zheng, Gerard McGeehan, Andrew Marcus, Yuri Bukhtiyarov, Brian M. McKeever, Jing Zhou, Stephen D. Lotesta

المصدر: Bioorganic & Medicinal Chemistry. 24:1384-1391

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Partial agonist, Structure-Activity Relationship, 03 medical and health sciences, Mineralocorticoid receptor, Signaling proteins, Drug Discovery, Humans, Structure–activity relationship, Spiro Compounds, Molecular Biology, Mineralocorticoid Receptor Antagonists, Medicine(all), Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, Ligand binding domain, 0104 chemical sciences, Receptors, Mineralocorticoid, 030104 developmental biology, Dibenzoxazepines, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50e8c94d7a072154029fc306f7d9290
https://doi.org/10.1016/j.bmc.2016.02.014

المؤلفون: Suresh B. Singh, Yajun Zheng, Deepak S. Lala, Colin M. Tice, Yuri Bukhtiyarov

المصدر: 2017 Medicinal Chemistry Reviews ISBN: 9780996293242
2017 Medicinal Chemistry Reviews

مصطلحات موضوعية: Chemistry, RAR-related orphan receptor gamma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::adb5ea0dd4c9298185996371d7482b3e
https://doi.org/10.29200/acsmedchemrev-v52.ch11

المؤلفون: David A. Claremon, Herbert Nar, Yi Zhao, Deepak S. Lala, Paula Krosky, Gerard McGeehan, Frank Himmelsbach, Joan Guo, Shi Meng, Rong Guo, Linghang Zhuang, Annette Schuler-Metz, Bradford S. Hamilton

المصدر: European Journal of Pharmacology. 746:50-55

مصطلحات موضوعية: Male, Models, Molecular, medicine.medical_specialty, Pyridones, Drug Evaluation, Preclinical, Adipose tissue, Dehydrogenase, Type 2 diabetes, Pharmacology, Biology, Catalytic Domain, Diabetes mellitus, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Oxazines, medicine, Animals, Humans, Enzyme Inhibitors, medicine.disease, Small molecule, Macaca fascicularis, Endocrinology, Diabetes Mellitus, Type 2, Cortisone, Metabolic syndrome, hormones, hormone substitutes, and hormone antagonists, Intracellular, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726c31b488b43ee75b833fbc8907e260
https://doi.org/10.1016/j.ejphar.2014.10.053

المؤلفون: Bradford S. Hamilton, Frank Himmelsbach, Barbara A. Kruk, Joan Guo, Gerard McGeehan, Peter Lindblom, Rong Guo, Colin M. Tice, Brian M. McKeever, Linghang Zhuang, David A. Claremon, Judith A. Johnson, Katerina Leftheris, Lamont Howard, Salvacion Cacatian, Heike Schauerte, Annette Schuler-Metz, Richard Gregg, Reshma Panemangalore, Deepak S. Lala, Paula Krosky, Zhenrong Xu, Yuri Bukhtiyarov, Suresh B. Singh, Yuanjie Ye, Yi Zhao, Wei Zhao, Shi Meng

المصدر: Bioorganicmedicinal chemistry. 25(14)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Pyridones, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, 11β hsd1, Adipose tissue, Administration, Oral, 01 natural sciences, Biochemistry, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, Cytochrome P-450 Enzyme System, 11β-hydroxysteroid dehydrogenase type 1, Oral administration, In vivo, Internal medicine, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Oxazines, medicine, Animals, Molecular Biology, IC50, Cells, Cultured, Binding Sites, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Hydroxysteroid Dehydrogenases, 0104 chemical sciences, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Macaca fascicularis, 030104 developmental biology, Endocrinology, Adipose Tissue, Pharmacodynamics, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a3ef85dcc22b2889fcf6062c9a383
https://pubmed.ncbi.nlm.nih.gov/28528082

المؤلفون: Deepak S. Lala, Colin M. Tice, Paul B. Noto, Suresh B. Singh, Kristi Fan, Linghang Zhuang

المصدر: Journal of Medicinal Chemistry. 57:7182-7205

مصطلحات موضوعية: Models, Molecular, Benzylamines, Sulfonamides, Binding Sites, Hydrocarbons, Fluorinated, Molecular Structure, Anticholesteremic Agents, food and beverages, Crystallographic data, Context (language use), Biology, Pharmacology, Atherosclerosis, Crystallography, X-Ray, Orphan Nuclear Receptors, Druglikeness, Benzoates, Medicinal chemistry, Protein Structure, Tertiary, Drug Discovery, Humans, Protein Isoforms, Molecular Medicine, Liver X receptor, Liver X Receptors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec8a49b86e9fa596979673d722983ac
https://doi.org/10.1021/jm500442z

المؤلفون: Jing Zhou, Suresh B. Singh, Colin M. Tice, Rebecca Van Orden, Guozhou Chen, Geeta Kandpal, Shi Meng, Cheng-Guo Dong, Yuri Bukhtiyarov, Paul B. Noto, Stephen D. Lotesta, Wei Zhao, Lamont Howard, Katerina Leftheris, Andrew P. Marcus, Kristi Fan, Andrew W. Hardy, Deepak S. Lala, Paula Krosky, Linghang Zhuang, Brian M. McKeever, Gerard McGeehan, Kerri Lipinski, Ya-Jun Zheng, Joan Guo, Yi Zhao, Richard Gregg, David A. Claremon, Zhongren Wu

المصدر: Bioorganicmedicinal chemistry letters. 26(20)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Amyloid beta, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Pharmacology, digestive system, Biochemistry, DNA-binding protein, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Downregulation and upregulation, Oral administration, Internal medicine, Drug Discovery, polycyclic compounds, medicine, Animals, RNA, Messenger, Liver X receptor, Molecular Biology, Liver X Receptors, biology, Chemistry, Organic Chemistry, Brain, Rats, Up-Regulation, 030104 developmental biology, Endocrinology, ABCA1, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Penetrant (biochemical), 030217 neurology & neurosurgery, ATP Binding Cassette Transporter 1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dfa607065920889aae5780297b0a05
https://pubmed.ncbi.nlm.nih.gov/27599745

المؤلفون: Deepak S. Lala, Paula Krosky, Kerri Lipinski, Colin M. Tice, Ya-Jun Zheng, Lamont Howard, Richard Gregg, Paul B. Noto, Yi Zhao, Kristi Fan, David A. Claremon, Zhongren Wu, Andrew W. Hardy, Rebecca Van Orden, Jing Zhou, Gerard McGeehan, Joan Guo, Cheng-Guo Dong, Stephen D. Lotesta, Geeta Kandpal, Jun Shimada, Zhijie Liu, Katerina Leftheris, Shi Meng, Suresh B. Singh, Guozhou Chen, Linghang Zhuang, Brian M. McKeever, Peter Lindblom, Yuri Bukhtiyarov, Wei Zhao

المصدر: Journal of medicinal chemistry. 59(7)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Benzylamines, Stereochemistry, medicine.drug_class, Context (language use), Plasma protein binding, Crystallography, X-Ray, Piperazines, 03 medical and health sciences, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Structure–activity relationship, Humans, Sulfones, Binding site, Liver X receptor, Liver X Receptors, Binding Sites, Chemistry, Drug discovery, Orphan Nuclear Receptors, 030104 developmental biology, Pyrimidines, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72847825e5e910bcb4d0f464f422727e
https://pubmed.ncbi.nlm.nih.gov/26990539

المؤلفون: Karen Elaine Sexton, Venkataraman Thanabal, Ann McCarthy, Leroy Lu, Erli Zhang, Maria N. Nguyen, Downs Victoria Leigh, Paul R. Keller, Mark L. Boys, Richard Gowan, Patrick I. McConnell, Edmund L. Ellsworth, Neil Raheja, Richard B. Gilbertsen, Hena Mostafa, Filzen Gary Frederick, N. A. Payne, Feng Bian, Huifen Chen, John D. Knafels, Samarendra N. Maiti, Elena M. Drummond, Stephen Douglas Barrett, Zhi Wang, Larry D. Bratton, Diane Alessi, Deepak S. Lala, Stephen Fakhoury, Sneha Patel, Barry C. Finzel, Susan Ciotti, Iula Donna Michele, Fang Sun, Paul Angell, Xiao Dan Ren, David Pocalyko, Rone Eisma, Kramer James Bernard, Catherine R. Kostlan, Christopher L. Chio

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3392-3397

مصطلحات موضوعية: Models, Molecular, Pyridines, Stereochemistry, Clinical Biochemistry, Receptor, Transforming Growth Factor-beta Type I, Dose dependence, Pharmaceutical Science, Protein Serine-Threonine Kinases, Pyrazole, Biochemistry, Cicatrix, chemistry.chemical_compound, Drug Discovery, Gene expression, Animals, Potency, Phosphorylation, Receptor, Protein Kinase Inhibitors, Molecular Biology, Skin, biology, Kinase, Chemistry, Organic Chemistry, Transforming growth factor beta, Rats, Protein kinase domain, Cancer research, biology.protein, Molecular Medicine, Receptors, Transforming Growth Factor beta

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632fe42ba8bb00febbc77151eb92bc8f
https://doi.org/10.1016/j.bmcl.2012.04.013

المؤلفون: Annette Schuler-Metz, David A. Claremon, Deepak S. Lala, Paula Krosky, Bradford S. Hamilton, Corinna Schoelch, Gerard McGeehan

المصدر: European journal of pharmacology. 789

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Hypothalamo-Hypophyseal System, Time Factors, Pyridones, Pituitary-Adrenal System, 030209 endocrinology & metabolism, Adrenocorticotropic hormone, Biology, Androgen Excess, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dehydroepiandrosterone sulfate, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Oxazines, medicine, Animals, Enzyme Inhibitors, Testosterone, Pharmacology, Macaca fascicularis, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Female, Cortisone, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, Hypothalamic–pituitary–adrenal axis, medicine.drug, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c8aea406d39f13787726a2fd27d99d
https://pubmed.ncbi.nlm.nih.gov/27393460