لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Johnson TW; Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States. ted.w.johnson@pfizer.com, Tanis SP, Butler SL, Dalvie D, Delisle DM, Dress KR, Flahive EJ, Hu Q, Kuehler JE, Kuki A, Liu W, McClellan GA, Peng Q, Plewe MB, Richardson PF, Smith GL, Solowiej J, Tran KT, Wang H, Yu X, Zhang J, Zhu H

المصدر: Journal of medicinal chemistry [J Med Chem] 2011 May 12; Vol. 54 (9), pp. 3393-417. Date of Electronic Publication: 2011 Apr 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: HIV Integrase Inhibitors/*chemical synthesis , HIV-1/*drug effects , Heterocyclic Compounds, 3-Ring/*chemical synthesis , Naphthyridines/*chemical synthesis, Administration, Oral ; Animals ; Biological Availability ; Cell Membrane Permeability ; Cells, Cultured ; Dogs ; Drug Design ; HIV Integrase Inhibitors/pharmacokinetics ; HIV Integrase Inhibitors/pharmacology ; HIV-1/enzymology ; Hepatocytes/metabolism ; Heterocyclic Compounds, 3-Ring/pharmacokinetics ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; Liver/metabolism ; Molecular Conformation ; Naphthyridines/pharmacokinetics ; Naphthyridines/pharmacology ; Structure-Activity Relationship

المؤلفون: Dragovich PS; Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, USA., Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Reich SH, Prins TJ, Marakovits JT, Littlefield ES, Zhou R, Tikhe J, Ford CE, Wallace MB, Meador JW 3rd, Ferre RA, Brown EL, Binford SL, Harr JE, DeLisle DM, Worland ST

المصدر: Journal of medicinal chemistry [J Med Chem] 1998 Jul 16; Vol. 41 (15), pp. 2806-18.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , Antiviral Agents*/metabolism , Antiviral Agents*/pharmacology , Cysteine Proteinase Inhibitors*/chemical synthesis , Cysteine Proteinase Inhibitors*/chemistry , Cysteine Proteinase Inhibitors*/metabolism , Cysteine Proteinase Inhibitors*/pharmacology , Drug Design* , Oligopeptides*/chemical synthesis , Oligopeptides*/chemistry , Oligopeptides*/metabolism , Oligopeptides*/pharmacology , Viral Proteins*, Cysteine Endopeptidases/*metabolism , Rhinovirus/*drug effects, 3C Viral Proteases ; Animals ; Binding Sites ; Cell Line, Transformed ; Crystallography, X-Ray ; Cysteine Endopeptidases/chemistry ; Drug Stability ; HeLa Cells ; Humans ; Protein Conformation ; Rats ; Rats, Sprague-Dawley ; Rhinovirus/enzymology ; Structure-Activity Relationship

المؤلفون: Dragovich PS; Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, USA., Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Reich SH, Marakovits JT, Prins TJ, Zhou R, Tikhe J, Littlefield ES, Bleckman TM, Wallace MB, Little TL, Ford CE, Meador JW 3rd, Ferre RA, Brown EL, Binford SL, DeLisle DM, Worland ST

المصدر: Journal of medicinal chemistry [J Med Chem] 1998 Jul 16; Vol. 41 (15), pp. 2819-34.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , Antiviral Agents*/metabolism , Antiviral Agents*/pharmacology , Cysteine Proteinase Inhibitors*/chemical synthesis , Cysteine Proteinase Inhibitors*/chemistry , Cysteine Proteinase Inhibitors*/metabolism , Cysteine Proteinase Inhibitors*/pharmacology , Drug Design* , Oligopeptides*/chemical synthesis , Oligopeptides*/chemistry , Oligopeptides*/metabolism , Oligopeptides*/pharmacology , Viral Proteins*, Cysteine Endopeptidases/*metabolism , Rhinovirus/*drug effects, 3C Viral Proteases ; Binding Sites ; Cell Line, Transformed ; Crystallography, X-Ray ; Cysteine Endopeptidases/chemistry ; Drug Evaluation, Preclinical ; Humans ; Rhinovirus/enzymology ; Structure-Activity Relationship