نتائج البحث - "Deog Joong Kim"

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دورية أكاديمية

RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

المؤلفون: John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt, Jennifer R. Diamond

المصدر: BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)

مصطلحات موضوعية: RX-5902, Triple-negative breast cancer, p68, β-Catenin, PD-1 inhibitor, Immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-020-07500-1; https://doaj.org/toc/1471-2407

URL الوصول: https://doaj.org/article/1dcda43bbcb945d6ae883320daa5d648

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Data from First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

المؤلفون: Jennifer R. Diamond, John J. Tentler, S. Gail Eckhardt, Todd M. Pitts, Jihye Kim, Aik Choon Tan, Sarah J. Hartman, Brian Gittleman, Ely Benaim, Young B. Lee, Christina George, Deog Joong Kim, Julie G. Frank, Anastasia Ionkina, Betelehem W. Yacob, Naomi Currimjee, Kyrie L. Dailey, Stacey M. Bagby, Anna Capasso

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3570a4b7073fb17fadee2a9d11204b79
https://doi.org/10.1158/1535-7163.c.6538611.v1

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Supplementary Figure S1 from First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

المؤلفون: Jennifer R. Diamond, John J. Tentler, S. Gail Eckhardt, Todd M. Pitts, Jihye Kim, Aik Choon Tan, Sarah J. Hartman, Brian Gittleman, Ely Benaim, Young B. Lee, Christina George, Deog Joong Kim, Julie G. Frank, Anastasia Ionkina, Betelehem W. Yacob, Naomi Currimjee, Kyrie L. Dailey, Stacey M. Bagby, Anna Capasso

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5d27faa7abc00285d7541d06c04edd
https://doi.org/10.1158/1535-7163.22507179.v1

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RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

المؤلفون: Richard J. Honeywell, Young Bok Lee, Godefridus J. Peters, Christine B. Peterson, Julie Poore, Dzjemma Sarkisjan, Callie Heaton, Ely Benaim, Elisa Giovannetti, Btissame El Hassouni, Beatrice Balboni, Deog Joong Kim

المساهمون: VU University medical center, Medical oncology laboratory, Medical oncology, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer biology and immunology

المصدر: Expert Opinion on Investigational Drugs, 28(4), 311-322. Taylor and Francis Ltd.
Balboni, B, el Hassouni, B, Honeywell, R J, Sarkisjan, D, Giovannetti, E, Poore, J, Heaton, C, Peterson, C, Benaim, E, Lee, Y B, Kim, D J & Peters, G J 2019, ' RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment ', Expert Opinion on Investigational Drugs, vol. 28, no. 4, pp. 311-322 . https://doi.org/10.1080/13543784.2019.1583742

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de49d19ad4125048d6f79e1a3e85708a
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063098464&origin=inward

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RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

المؤلفون: Young Bok Lee, John J. Tentler, Ely Benaim, Brian Gittleman, Julie E. Lang, Stacey M. Bagby, S. Gail Eckhardt, Jennifer R. Diamond, Anna Capasso, Betelehem W. Yacob, Deog Joong Kim, Sarah J. Hartman, Todd M. Pitts, Andrew Eisen, Roberta Pelanda

المصدر: BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)

مصطلحات موضوعية: 0301 basic medicine, Granzyme B production, Cancer Research, Myeloid, medicine.medical_treatment, Apoptosis, Triple Negative Breast Neoplasms, Piperazines, Mice, 0302 clinical medicine, Tumor Cells, Cultured, Tumor Microenvironment, Immune Checkpoint Inhibitors, beta Catenin, Mice, Inbred BALB C, RX-5902, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, p68, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Drug Therapy, Combination, Female, Immunotherapy, Humanized mouse models, Nivolumab, Research Article, β-Catenin, Mice, Nude, lcsh:RC254-282, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Immune system, Triple-negative breast cancer, Quinoxalines, Genetics, medicine, Animals, Humans, Cell Proliferation, Tumor microenvironment, business.industry, Tumor-infiltrating lymphocytes, Xenograft Model Antitumor Assays, Immune checkpoint, PD-1 inhibitor, 030104 developmental biology, Cancer research, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60907b1468b02ce996f4be0c49304637
https://doi.org/10.1186/s12885-020-07500-1

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Rx-3117 (Fluorocyclopentenyl-cytosine)-mediated down-regulation of dna methyltransferase 1 leads to protein expression of tumor-suppressor genes and increased functionality of the proton-coupled folate carrier

المؤلفون: Larry H. Matherly, Young Bok Lee, Joris R. Julsing, Dzjemma Sarkisjan, Btissame El Hassouni, Godefridus J. Peters, Deog Joong Kim, Ietje Kathmann, Richard J. Honeywell

المساهمون: Medical oncology, Medical oncology laboratory, Clinical pharmacology and pharmacy, CCA - Cancer biology and immunology, AGEM - Digestive immunity

المصدر: Sarkisjan, D, Julsing, J R, El Hassouni, B, Honeywell, R J, Kathmann, I, Matherly, L H, Lee, Y B, Kim, D J & Peters, G J 2020, ' Rx-3117 (Fluorocyclopentenyl-cytosine)-mediated down-regulation of dna methyltransferase 1 leads to protein expression of tumor-suppressor genes and increased functionality of the proton-coupled folate carrier ', International Journal of Molecular Sciences, vol. 21, no. 8, 2717 . https://doi.org/10.3390/ijms21082717
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, 21(8):2717. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2717, p 2717 (2020)

مصطلحات موضوعية: 0301 basic medicine, DNA (Cytosine-5-)-Methyltransferase 1, 5-aza-2′-deoxycytidine, Methyltransferase, Cytidine, DNA methyltransferase, Catalysis, Article, methotrexate, RX-3117, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Gene expression, Humans, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Dose-Response Relationship, Drug, Chemistry, Tumor Suppressor Proteins, Organic Chemistry, Promoter, General Medicine, DNA Methylation, Molecular biology, Computer Science Applications, Demethylating agent, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Hypomethylating agent, Gene Expression Regulation, 030220 oncology & carcinogenesis, DNA methylation, DNMT1, Proton-Coupled Folate Transporter, hypomethylation, proton-coupled folate receptor