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المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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المؤلفون: George L. Trainor, Jun Dai, Arvind Mathur, Francis Y. Lee, Sunilkumar Mandal, Yingru Zhang, Richard Rampulla, Kiran Babu Gona, Patrice Gill, Raja Thiruvenkadam, Victor R. Guarino, Wen-Ching Han, Ding Ren Shen, Aaron Balog, Mary Ellen Cvijic, Dauh-Rurng Wu, Gregory D. Vite, Krista Menard, Anne Rose, Sathiah Kandula, Ashvinikumar V. Gavai, Weifang Shan, John T. Hunt, Asoka Ranasinghe, Kelly McGlinchey, Richard A. Westhouse, Claude A. Quesnelle, Derek J. Norris, Mei-Li Wen, Ronald E. White, Kamalraj Thiyagarajan
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1905-1909
مصطلحات موضوعية: Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Receptor, Solid tumor, Molecular Biology, Cell Proliferation, Benzodiazepinones, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Notch, Chemistry, Organic Chemistry, Biological activity, Neoplasms, Experimental, medicine.disease, Leukemia, Orally active, Microsomes, Liver, Molecular Medicine, Drug Screening Assays, Antitumor
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المؤلفون: Claude A. Quesnelle, Patrice Gill, Richard Rampulla, Ching Su, Gerry Everlof, George L. Trainor, Ke Chen, Vinod Arora, Richard A. Westhouse, Celia D’Arienzo, Andrew J. Tebben, Weifang Shan, John T. Hunt, Derek J. Norris, Louis J. Lombardo, Zheng Yang, Arvind Mathur, Mei-Li Wen, Yingru Zhang, Dauh-Rurng Wu, Wen-Ching Han, Krista Menard, Victor R. Guarino, Asoka Ranasinghe, Richard E. Olson, Ashvinikumar V. Gavai, Bruce S. Fischer, Phil S. Baran, Anne Rose, Lan Xiao, Ronald E. White, Mary Ellen Cvijic, Gregory D. Vite, Ding Ren Shen, Jere E. Meredith, Haiqing Wang, Francis Y. Lee, Aaron Balog
المصدر: ACS Medicinal Chemistry Letters. 6:523-527
مصطلحات موضوعية: business.industry, Organic Chemistry, Pharmacology, medicine.disease, Biochemistry, T Acute Lymphoblastic Leukemia, Leukemia, In vivo, Drug Discovery, medicine, Receptor, business, Solid tumor, Clinical evaluation, Triple-negative breast cancer
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المؤلفون: Dauh-Rurng Wu, Zheng Yang, Steven Sheriff, Muthoni G. Kamau, Lalgudi S. Harikrishnan, Dharmpal S. Dodd, Henry Yip, Christine Huang, Yingru Zhang, Yufen Zhao, Jianqing Li, Richard A. Westhouse, Richard Rampulla, Ashvinikumar V. Gavai, Haiying Zhang, Susan Wee, Dawn Sun, Gerry Everlof, Tram N. Huynh, Ching Su, Derek J. Norris, Arvind Mathur, Wayne Vaccaro, Peng Li, Huiping Zhang, Gregory D. Vite, Mussari Christopher P, John T. Hunt, Asoka Ranasinghe, David R. Tortolani, Nirmala Raghavan, Celia D’Arienzo, Daniel O'malley, Vijay T. Ahuja, Patrice Gill, Lisa Zhang, Claude A. Quesnelle, Tokarski John S, Michael A. Poss
المصدر: Cancer Research. 78:5789-5789
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Thermal shift assay, BRD4, Oncogene, Chemistry, Cancer, medicine.disease, Bromodomain, BET inhibitor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, In vivo, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad3948219544cdcb29d5e3baea4000aa
https://doi.org/10.1158/1538-7445.am2018-5789 -
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المؤلفون: Hongjian Zhang, Brian E. Fink, David R. Langley, Harold Mastalerz, Ming Chang, Punit Marathe, Simone Oppenheimer, Dolatrai M. Vyas, Ping Chen, Bogdan Sleczka, John S. Tokarski, Francis Y. Lee, Kenneth J. Leavitt, Johnson Walter Lewis, Wen-Ching Han, Tai W. Wong, Ashvinikumar V. Gavai, Guifen Zhang, Henry Wong, Gregory D. Vite, Tarrant James G, Derek J. Norris
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4947-4954
مصطلحات موضوعية: Insecta, Molecular model, Receptor, ErbB-2, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Adenosine Triphosphate, Piperidines, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Pyrroles, Epidermal growth factor receptor, Molecular Biology, chemistry.chemical_classification, biology, Triazines, Chemistry, Kinase, Organic Chemistry, In vitro, ErbB Receptors, Enzyme, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Signal transduction, Neoplasm Transplantation
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المؤلفون: Brian E. Fink, Bindu Goyal, Marco M. Gottardis, Gregory D. Vite, Raj N. Misra, Dan You, Thomas E. Spires, Derek J. Norris, Wen-Ching Han, Matthew V. Lorenzi, Ashvinikumar V. Gavai, John S. Tokarski, S. David Kimball, Hai-Yun Xiao
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1532-1536
مصطلحات موضوعية: Models, Molecular, endocrine system, 17-Hydroxysteroid Dehydrogenases, Molecular model, medicine.drug_class, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Carboxamide, Biochemistry, Steroid, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Testosterone, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Androstenedione, Alkaline Phosphatase, Azocines, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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المؤلفون: Bang-Chi Chen, Suhong Pang, Steven H. Spergel, Leslie Leith, David J. Shuster, John Wityak, Derek J. Norris, Jagabandhu Das, Rulin Zhao, Gary L. Schieven, Kim W. McIntyre, Joel C. Barrish, Rosemary Zhang, Kamelia Behnia, Ding Ren Shen, Sidney Pitt, Arthur M. Doweyko, Ping Chen, Henry F. De Fex
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:6061-6066
مصطلحات موضوعية: Male, Models, Molecular, Clinical Biochemistry, Anti-Inflammatory Agents, Administration, Oral, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Potency, Structure–activity relationship, Src family kinase, Enzyme Inhibitors, Thiazole, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, Amides, Arthritis, Experimental, In vitro, Rats, Disease Models, Animal, Thiazoles, src-Family Kinases, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Enzyme inhibitor, biology.protein, Molecular Medicine
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المؤلفون: John Wityak, Amrita Kamath, Louis J. Lombardo, Ping Chen, John T. Hunt, Ivan Inigo, Stephen Castaneda, Joel C. Barrish, Herbert E. Klei, Robert J. Schmidt, John S. Tokarski, Sidney Pitt, Derek J. Norris, Francis Y. Lee, Jagabandhu Das, Craig Fairchild, Kathy A. Johnston, Punit Marathe, Robert M. Borzilleri, Cornelius Lyndon A M, Suhong Pang, Mei-Li Wen, Russell Peterson, Gary L. Schieven, Kamelia Behnia, David Kan, Arthur M. Doweyko
المصدر: Journal of Medicinal Chemistry. 47:6658-6661
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Dasatinib, Antineoplastic Agents, Carboxamide, Pharmacology, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Adenosine Triphosphate, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Proto-Oncogene Proteins c-abl, Thiazole, ABL, biology, Chemistry, medicine.disease, Rats, Thiazoles, Pyrimidines, src-Family Kinases, Enzyme inhibitor, biology.protein, Molecular Medicine, K562 Cells, Chronic myelogenous leukemia, Proto-oncogene tyrosine-protein kinase Src, K562 cells, medicine.drug
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المؤلفون: Steven H. Spergel, Robert V. Moquin, Ding Ren Shen, Jagabundhu Das, Gary L. Schieven, Kamelia Behnia, James Lin, O. Kocy, Paul L. Stanley, Sydney Pitt, John Wityak, Ping Chen, Sara Thrall, David J. Shuster, Derek J. Norris, Suhong Pang, Edwin J. Iwanowicz, Steven B. Kanner, Henry F. De Fex, Joel C. Barrish, Henry H. Gu, Kim W. McIntyre, Mark R. Witmer, Saeho Chong, Arthur M. Doweyko
المصدر: Journal of Medicinal Chemistry. 47:4517-4529
مصطلحات موضوعية: chemistry.chemical_classification, Quantitative structure–activity relationship, Molecular model, Chemistry, In vivo, Stereochemistry, Drug Discovery, Molecular Medicine, Aromatic amine, Src family kinase, Chemical synthesis, In vitro, Proinflammatory cytokine
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المؤلفون: Robert M. Townsend, Zhongqi Shen, Catherine A. Fleener, Derek J. Norris, Scott H. Watterson, Henry H. Gu, Ping Chen, Diane Hollenbaugh, T. G. Murali Dhar, Joel C. Barrish, Shelley K. Ballentine, Edwin J. Iwanowicz, Katherine A. Rouleau
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3557-3560
مصطلحات موضوعية: Indoles, Guanine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Catalysis, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, medicine, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Small molecule, Kinetics, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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