المؤلفون: Bertrums EJM; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Department of Pediatric Oncology/Hematology, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands., de Kanter JK; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Derks LLM; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Verheul M; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Trabut L; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Roosmalen MJ; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Hasle H; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Antoniou E; Clinic of Pediatrics III, University Hospital of Essen, Essen, Germany.; AML-BFM Study Group, Essen, Germany., Reinhardt D; Clinic of Pediatrics III, University Hospital of Essen, Essen, Germany.; AML-BFM Study Group, Essen, Germany., Dworzak MN; St. Anna Children's Cancer Research Institute, Vienna, Austria.; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Mühlegger N; St. Anna Children's Cancer Research Institute, Vienna, Austria., van den Heuvel-Eibrink MM; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Utrecht University, Utrecht, the Netherlands., Zwaan CM; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands.; Department of Pediatric Oncology/Hematology, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands., Goemans BF; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands., van Boxtel R; Princess Máxima Centrum for pediatric oncology, Utrecht, the Netherlands. R.vanBoxtel@prinsesmaximacentrum.nl.; Oncode Institute, Utrecht, the Netherlands. R.vanBoxtel@prinsesmaximacentrum.nl.

المصدر: Nature communications [Nat Commun] 2024 Jul 17; Vol. 15 (1), pp. 6025. Date of Electronic Publication: 2024 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Suppressor Protein p53*/genetics , Li-Fraumeni Syndrome*/genetics , Germ-Line Mutation* , Neoplasms, Second Primary*/genetics, Humans ; Child ; Male ; Female ; Platinum Compounds/therapeutic use ; Adult ; Adolescent ; Whole Genome Sequencing ; Phylogeny ; Child, Preschool ; Antineoplastic Agents/therapeutic use ; Single-Cell Analysis

المؤلفون: Celotti M; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, 3521 AL Utrecht, the Netherlands. Electronic address: m.celotti@hubrecht.eu., Derks LLM; Oncode Institute, 3521 AL Utrecht, the Netherlands; Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands., van Es J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, 3521 AL Utrecht, the Netherlands., van Boxtel R; Oncode Institute, 3521 AL Utrecht, the Netherlands; Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands., Clevers H; Oncode Institute, 3521 AL Utrecht, the Netherlands., Geurts MH; Oncode Institute, 3521 AL Utrecht, the Netherlands; Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands. Electronic address: m.h.geurts-6@prinsesmaximacentrum.nl.

المصدر: STAR protocols [STAR Protoc] 2024 Jul 12; Vol. 5 (3), pp. 103189. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

المؤلفون: Derks LLM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Jaarbeursplein 6, 3521 AL Utrecht, the Netherlands., van Boxtel R; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Jaarbeursplein 6, 3521 AL Utrecht, the Netherlands. Electronic address: r.vanboxtel@prinsesmaximacentrum.nl.

المصدر: Cell stem cell [Cell Stem Cell] 2023 Nov 02; Vol. 30 (11), pp. 1421-1433. Date of Electronic Publication: 2023 Oct 12.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Regenerative Medicine* , Stem Cells*/pathology, Adult ; Humans ; Mutation/genetics ; Carcinogenesis/genetics ; Carcinogenesis/pathology

المؤلفون: Middelkamp S; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Manders F; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Peci F; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Roosmalen MJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., González DM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Bertrums EJM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Department of Pediatric Oncology, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands., van der Werf I; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Derks LLM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Groenen NM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Verheul M; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Trabut L; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Pleguezuelos-Manzano C; Oncode Institute, Utrecht, the Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, the Netherlands., Brandsma AM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Antoniou E; Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany., Reinhardt D; Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany., Bierings M; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Belderbos ME; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., van Boxtel R; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.

المصدر: Cell genomics [Cell Genom] 2023 Aug 23; Vol. 3 (9), pp. 100389. Date of Electronic Publication: 2023 Aug 23 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE

المؤلفون: Geurts MH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands. M.H.Geurts-6@prinsesmaximacentrum.nl.; Oncode Institute, 3521AL, Utrecht, the Netherlands. M.H.Geurts-6@prinsesmaximacentrum.nl.; Princess Maxima Center for Pediatric Oncology, 3584 CS, Utrecht, the Netherlands. M.H.Geurts-6@prinsesmaximacentrum.nl., Gandhi S; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Miller Institute for Basic Research in Science, University of California, Berkeley, CA, 94720, USA., Boretto MG; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Akkerman N; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Derks LLM; Oncode Institute, 3521AL, Utrecht, the Netherlands.; Princess Maxima Center for Pediatric Oncology, 3584 CS, Utrecht, the Netherlands., van Son G; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands.; Princess Maxima Center for Pediatric Oncology, 3584 CS, Utrecht, the Netherlands., Celotti M; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Harshuk-Shabso S; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Peci F; Oncode Institute, 3521AL, Utrecht, the Netherlands.; Princess Maxima Center for Pediatric Oncology, 3584 CS, Utrecht, the Netherlands., Begthel H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Hendriks D; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands.; Princess Maxima Center for Pediatric Oncology, 3584 CS, Utrecht, the Netherlands., Schürmann P; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Andersson-Rolf A; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., Chuva de Sousa Lopes SM; Anatomy and Embryology, Leiden University Medical Center, Einthovenweg, 2333 ZC, Leiden, the Netherlands., van Es JH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands.; Oncode Institute, 3521AL, Utrecht, the Netherlands., van Boxtel R; Oncode Institute, 3521AL, Utrecht, the Netherlands.; Princess Maxima Center for Pediatric Oncology, 3584 CS, Utrecht, the Netherlands., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT, Utrecht, the Netherlands. h.clevers@hubrecht.eu.; Oncode Institute, 3521AL, Utrecht, the Netherlands. h.clevers@hubrecht.eu.; Pharma Research Early Development, Basel, Switzerland. h.clevers@hubrecht.eu.

المصدر: Nature communications [Nat Commun] 2023 Aug 17; Vol. 14 (1), pp. 4998. Date of Electronic Publication: 2023 Aug 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: RNA, Guide, CRISPR-Cas Systems* , Adult Stem Cells*, Adult ; Humans ; Oncogenes ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Organoids

المؤلفون: Bollen Y; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Medical Cell Biophysics, TechMed Centre, University of Twente, Enschede, the Netherlands., Hageman JH; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Leenen P; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Derks LLM; Oncode Institute, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Ponsioen B; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Buissant des Amorie JR; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van den Bos M; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Terstappen LWMM; Medical Cell Biophysics, TechMed Centre, University of Twente, Enschede, the Netherlands., van Boxtel R; Oncode Institute, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.

المصدر: PLoS biology [PLoS Biol] 2022 Jan 28; Vol. 20 (1), pp. e3001527. Date of Electronic Publication: 2022 Jan 28 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Loci* , Recombinational DNA Repair*, DNA/*genetics , Deoxyribonuclease I/*metabolism , Organoids/*metabolism , Staining and Labeling/*methods, Alleles ; Base Sequence ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Colon/cytology ; Colon/metabolism ; DNA/metabolism ; DNA End-Joining Repair ; Deoxyribonuclease I/genetics ; Electroporation/methods ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Gene Knock-In Techniques ; Genetic Vectors ; Genome, Human ; Heterozygote ; Humans ; Organoids/cytology