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1
المؤلفون: Hyun Lee, Isabel Ojeda, Jinhong Ren, Samuel H. Light, Wayne F. Anderson, Dhanapalan Nagarathnam, Michael E. Johnson, Jason Vargas, George Minasov, Salvatore Nocadello, Amy J. Rice
المصدر: Antiviral Research
مصطلحات موضوعية: 0301 basic medicine, Microcephaly, Proteases, Serine Proteinase Inhibitors, Protein Conformation, medicine.medical_treatment, viruses, 030106 microbiology, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Article, Zika virus, 03 medical and health sciences, Inhibitory Concentration 50, Virology, Drug Discovery, medicine, Pharmacology, Serine protease, NS3, Protease, biology, Zika Virus, Surface Plasmon Resonance, biology.organism_classification, medicine.disease, Flavivirus, Kinetics, 030104 developmental biology, Viral replication, biology.protein, Serine Proteases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab38484eeac867b299bd934cab0b52f
https://europepmc.org/articles/PMC5627664/ -
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المؤلفون: Jinfa Du, Eisuke Murakami, Jian Liu, Haiying Bao, Michael J. Sofia, Dhanapalan Nagarathnam, Peiyuan Wang, Christine Espiritu, Phillip A. Furman
المصدر: Nucleosides, Nucleotides and Nucleic Acids. 31:277-285
مصطلحات موضوعية: Stereochemistry, Hepatitis C virus, Cyclopentanes, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, medicine.disease_cause, Antiviral Agents, Biochemistry, Ns5b polymerase, Cell Line, chemistry.chemical_compound, Organophosphorus Compounds, Genetics, medicine, Humans, Prodrugs, Nucleotide, Polymerase, chemistry.chemical_classification, biology, Diastereomer, Phosphoramidate, General Medicine, Prodrug, Deoxyuridine, Uridine, chemistry, biology.protein, Molecular Medicine
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3
المؤلفون: Holly M. Micolochick Steuer, Donghui Bao, Wonsuk Chang, Bruce S. Ross, Angela M. Lam, Shalini Bansal, Dhanapalan Nagarathnam, Michael J. Otto, P. Ganapati Reddy, Meg Keilman, Byoung-Kwon Chun, Congrong Niu, Hai-Ren Zhang, Rachakonda Suguna, Christine Espiritu, Phillip A. Furman, Jinfa Du, Michael J. Sofia
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7376-7380
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Prodrugs, Nucleotide, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Nucleosides, Prodrug, Nucleotidyltransferase, In vitro, Cyclic P-Oxides, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Nucleotides, Cyclic, Nucleoside
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4
المؤلفون: Jinfa Du, Angela M. Lam, Shalini Bansal, Rachakonda Suguna, Congrong Niu, Meg Keilman, Michael J. Otto, Donghui Bao, Bruce S. Ross, Peiyuan Wang, Dhanapalan Nagarathnam, Wonsuk Chang, Holly M. Micolochick Steuer, Michael J. Sofia, Hai-Ren Zhang, Phillip A. Furman, P. Ganapati Reddy, Christine Espiritu
المصدر: Journal of Medicinal Chemistry. 53:7202-7218
مصطلحات موضوعية: Hepatitis C virus, Protide, Hepacivirus, In Vitro Techniques, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Cell Line, Structure-Activity Relationship, Dogs, In vivo, Drug Resistance, Viral, Drug Discovery, medicine, Animals, Humans, Prodrugs, Nucleotide, chemistry.chemical_classification, virus diseases, Esters, Stereoisomerism, Biological activity, Phosphoramidate, Prodrug, digestive system diseases, Rats, Macaca fascicularis, Liver, Biochemistry, chemistry, Mutation, Hepatocytes, Molecular Medicine, Replicon, Sofosbuvir, Uridine Monophosphate, Nucleoside
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المؤلفون: David N. Frick, Dhanapalan Nagarathnam, Congrong Niu, Angela M. Lam, Donald F. Smee, Holly M. Micolochick Steuer, Meg Keilman, Justin G. Julander, Julie A. Heck, Christine Espiritu, Haiying Bao, Nigel Bourne, Phillip A. Furman, Veronique Zennou, Eisuke Murakami, Michael J. Otto, Bruce S. Ross, Peiyuan Wang, Michael J. Sofia, John D. Morrey
المصدر: Antimicrobial Agents and Chemotherapy. 54:3187-3196
مصطلحات موضوعية: Genotype, viruses, Hepatitis C virus, RNA-dependent RNA polymerase, Hepacivirus, Viral Nonstructural Proteins, Biology, Virus Replication, medicine.disease_cause, Antiviral Agents, Virus, chemistry.chemical_compound, Cell Line, Tumor, medicine, Humans, Phosphoric Acids, Prodrugs, Pharmacology (medical), Replicon, Enzyme Inhibitors, NS5B, Pharmacology, Nucleoside analogue, RNA, RNA-Dependent RNA Polymerase, Amides, Virology, Infectious Diseases, chemistry, Viral replication, RNA, Viral, Deoxyuracil Nucleotides, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d48d4b55418bd4222aa888d9f782047
https://doi.org/10.1128/aac.00399-10 -
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المؤلفون: Mark G. Bock, Charles Gluchowski, Sriram Tyagarajan, Quanrong Shen, Tsing-Bau Chen, Mohammad R. Marzabadi, Carlos Forray, Dhanapalan Nagarathnam, Wai C. Wong, Stacey O'Malley, Barbara Francis, Dhar T G Murali, Douglas J. Pettibone, Jerry DiSalvo, Roger M. Freidinger, Miao Shou Wu, Raymond S.L. Chang, Bharat Lagu
المصدر: European Journal of Pharmacology. 409:301-312
مصطلحات موضوعية: Male, Tetrahydronaphthalenes, Adrenergic receptor, Stereochemistry, Urinary Bladder, Pyrimidinones, Biology, Phenylephrine, Dogs, Receptors, Adrenergic, alpha-1, Prazosin, medicine, Animals, Humans, Receptor, Adrenergic alpha-Antagonists, Caudal artery, Pharmacology, Hydrobromide, Imidazoles, Prostate, Antagonist, In vitro, Rats, medicine.anatomical_structure, Adrenergic alpha-1 Receptor Antagonists, Adrenergic alpha-Agonists, medicine.drug
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المؤلفون: Robert J. Bendesky, Wai C. Wong, Theodore P. Broten, Fengqi Zhang, Dake Tian, Carlos Forray, James Fang, Sriram Tyagarajan, Dhanapalan Nagarathnam, and Kamlesh P. Vyas, Shou Wu Miao, George Chiu, Mohammad R. Marzabadi, T. G. Murali Dhar, Charles Gluchowski, Kathryn Schneck, Paul J. Kling, Raymond S.L. Chang, Bharat Lagu, Jack Zhang, Wanying Sun, Stacey O'Malley, Tsing B. Chen, Richard W. Ransom, Terry W. Schorn, Charles M. Harrell, John M. Wetzel
المصدر: Journal of Medicinal Chemistry. 42:4764-4777
مصطلحات موضوعية: Male, medicine.drug_class, Drug Evaluation, Preclinical, Nitro compound, Blood Pressure, Carboxamide, Pyrimidinones, In Vitro Techniques, Pharmacology, Binding, Competitive, Chemical synthesis, Rats, Sprague-Dawley, Radioligand Assay, Dogs, Urethra, In vivo, Receptors, Adrenergic, alpha-1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Receptor, Adrenergic alpha-Antagonists, chemistry.chemical_classification, Prostate, Antagonist, Stereoisomerism, In vitro, Rats, chemistry, Biochemistry, Drug Design, Adrenergic alpha-1 Receptor Antagonists, Molecular Medicine
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المؤلفون: Carlos Forray, Tsing B. Chen, Raymond S. L. Chang, Stacey O'Malley, Dhanapalan Nagarathnam, George Chiu, Dake Tian, Miao Shou Wu, Wai C. Wong, Bharat Lagu, Richard W. Ransom, Mohammad R. Marzabadi, Kanyin Zhang, Kamlesh P. Vyas, Charles Gluchowski, James Fang, Wanying Sun, Fengqi Zhang
المصدر: Journal of Medicinal Chemistry. 42:4794-4803
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Metabolite, Carboxamide, Phenylpiperazine, Chemical synthesis, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, Moiety, Receptor, Lead compound
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المؤلفون: Miao Shou Wu, Stacey O'Malley, Kamlesh P. Vyas, Paul J. Kling, Raymond S.L. Chang, Wanying Sun, Wai C. Wong, Richard W. Ransom, Kanyin Zhang, John M. Wetzel, Jian Peng, Charles Gluchowski, Theodore P. Broten, Dhanapalan Nagarathnam, Carlos Forray, Fengqi Zhang, Dake Tian, Bharat Lagu, Tsing B. Chen, Mohammad R. Marzabadi
المصدر: Journal of Medicinal Chemistry. 42:4804-4813
مصطلحات موضوعية: Male, medicine.drug_class, Stereochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Carboxamide, In Vitro Techniques, Binding, Competitive, Chemical synthesis, Structure-Activity Relationship, Dogs, Smooth muscle, Receptors, Adrenergic, alpha-1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Adrenergic alpha-Antagonists, Chemistry, Prostate, Antagonist, Stereoisomerism, Recombinant Proteins, Rats, Pyrimidines, α1a adrenoceptor, Drug Design, Benzene derivatives, Adrenergic alpha-1 Receptor Antagonists, Molecular Medicine, Enantiomer
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المؤلفون: Dhanapalan Nagarathnam, Terry W. Schorn, Wai C. Wong, John M. Wetzel, Carlos Forray, Raymond S.L. Chang, William E. Heydorn, George Chiu, Theodore P. Broten, C. Gluchowski, Xingfang Hong, T. A. Branchek, Shou Wu Miao, James Fang, Mohammad R. Marzabadi
المصدر: Journal of Medicinal Chemistry. 41:5320-5333
مصطلحات موضوعية: Male, Dihydropyridines, medicine.medical_specialty, Drug Evaluation, Preclinical, Prostatic Hyperplasia, Nitro compound, Blood Pressure, In Vitro Techniques, Pharmacology, Binding, Competitive, Chemical synthesis, Cell Line, Structure-Activity Relationship, Dogs, Piperidines, Prostate, In vivo, Receptors, Adrenergic, alpha-1, Internal medicine, Drug Discovery, medicine, Animals, Humans, Adrenergic alpha-Antagonists, chemistry.chemical_classification, Chemistry, Dihydropyridine, Antagonist, Muscle, Smooth, Stereoisomerism, Hyperplasia, medicine.disease, Recombinant Proteins, In vitro, Rats, medicine.anatomical_structure, Endocrinology, Adrenergic alpha-1 Receptor Antagonists, Molecular Medicine, Muscle Contraction, medicine.drug