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1
المؤلفون: Laurie Seliger, Jian Wang, Ronald Pongrac, Helen J. Mason, Bruce Beyer, Andrew Henwood, John Krupinski, Ximao Wu, John E. Macor, Saeho Chong, Rongan Zhang, Pam Ferrer, Diane E. Normandin, Guixue Yu, Leonard P. Adam, William G. Humphrey, Bin He
المصدر: Journal of Medicinal Chemistry. 46:457-460
مصطلحات موضوعية: Male, medicine.medical_specialty, Sildenafil, Administration, Oral, Biological Availability, Blood Pressure, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Erectile Dysfunction, Pharmacokinetics, 3',5'-Cyclic-GMP Phosphodiesterases, Oral administration, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Adverse effect, Cyclic Nucleotide Phosphodiesterases, Type 5, biology, medicine.disease, In vitro, Rats, Pyridazines, Erectile dysfunction, Endocrinology, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Rabbits, Penis
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2
المؤلفون: John E. Macor, Ronald Pongrac, Zhong Sun, David P. Rotella, Yeheng Zhu, John Krupinski, Diane E. Normandin, Laurie Seliger
المصدر: Journal of Medicinal Chemistry. 43:1257-1263
مصطلحات موضوعية: Male, Purinones, Phosphodiesterase Inhibitors, medicine.drug_class, Sildenafil, Carboxamide, In Vitro Techniques, Pharmacology, Piperazines, Sildenafil Citrate, Structure-Activity Relationship, chemistry.chemical_compound, Erectile Dysfunction, 3',5'-Cyclic-GMP Phosphodiesterases, Drug Discovery, medicine, Animals, Potency, Sulfones, Adverse effect, Cyclic Nucleotide Phosphodiesterases, Type 5, biology, Chemistry, Imidazoles, Biological activity, medicine.disease, respiratory tract diseases, Erectile dysfunction, Purines, Enzyme inhibitor, cGMP-specific phosphodiesterase type 5, Quinazolines, cardiovascular system, biology.protein, Molecular Medicine, Rabbits, Penis
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3
المؤلفون: G. C. Rovnyak, Y. F. Kelly, Raj N. Misra, Karnail S. Atwal, Arthur V. Miller, Paul G. Sleph, Charles Z. Ding, Diane E. Normandin, Syed Z. Ahmed, Gary J. Grover
المصدر: Journal of Medicinal Chemistry. 42:3711-3717
مصطلحات موضوعية: Cardiotonic Agents, Potassium Channels, ATP-sensitive potassium channel, Stereochemistry, Vasodilator Agents, Myocardial Ischemia, Vasodilation, Guanidines, Sulfone, chemistry.chemical_compound, Glyburide, Drug Discovery, medicine, Animals, Potency, Benzopyrans, Cardioprotective Agent, Heart, Potassium channel, Rats, Mechanism of action, chemistry, Molecular Medicine, medicine.symptom, Cromakalim, Muscle Contraction
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4
المؤلفون: Gary J. Grover, Nicholas J. Lodge, Diane E. Normandin, Robert Cohen, Sarah C. Traeger, Catherine C Bryson, Keneth E. J. Dickinson, Paul G. Sleph, Karnail S. Atwal
المصدر: Journal of Medicinal Chemistry. 41:271-275
مصطلحات موضوعية: Cardiotonic Agents, Potassium Channels, ATP-sensitive potassium channel, Muscle Relaxation, Structure-Activity Relationship, Dogs, KATP Channels, Smooth muscle, Drug Discovery, medicine, Animals, Cardioprotective Agent, Potassium Channels, Inwardly Rectifying, Binding site, Binding affinities, Chemistry, Myocardium, Muscle, Smooth, Biological activity, Membrane, Mechanism of action, Biochemistry, Biophysics, Molecular Medicine, ATP-Binding Cassette Transporters, medicine.symptom, Protein Binding
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5
المؤلفون: S Dzwonczyk, Sarah C. Traeger, Diane E. Normandin, G. C. Rovnyak, Lee G. McLaughlin, Syed Z. Ahmed, Anne J. Baird, Charles Z. Ding, Dinos Santafianos, Karnail S. Atwal, and Paul G. Sleph, Francis N. Ferrara, Gary J. Grover, W. Griffith Humphreys
المصدر: Journal of Medicinal Chemistry. 40:24-34
مصطلحات موضوعية: Indole test, Potassium Channels, Nitrile, ATP-sensitive potassium channel, Stereochemistry, Biological Availability, Heart, Rats, Sulfone, Benzopyran, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, chemistry, Glyburide, Drug Discovery, Animals, Molecular Medicine, Benzopyrans, Cardioprotective Agent, Selectivity, Cromakalim
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6
المؤلفون: Nicholas J. Lodge, Diane E. Normandin
المصدر: The Journal of Urology. :1758-1761
مصطلحات موضوعية: medicine.hormone, medicine.medical_specialty, Carbachol, business.industry, Urology, Potassium channel, Endothelins, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Nifedipine, Prostate, Internal medicine, medicine, Serotonin, business, Phenylephrine, Histamine, medicine.drug
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7
المؤلفون: and Anne J. Baird, Charles Z. Ding, Karnail S. Atwal, S Dzwonczyk, Paul G. Sleph, Diane E. Normandin, Gary J. Grover, Francis N. Ferrara
المصدر: Journal of Medicinal Chemistry. 39:304-313
مصطلحات موضوعية: Agonist, Cardiotonic Agents, Potassium Channels, ATP-sensitive potassium channel, medicine.drug_class, Stereochemistry, Vasodilator Agents, Myocardial Ischemia, Guanidines, Chemical synthesis, Methoxamine, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Glyburide, Nitriles, Drug Discovery, medicine, Animals, Vasoconstrictor Agents, Structure–activity relationship, Benzopyrans, Molecular Structure, Myocardial Contraction, Potassium channel, Rats, Benzopyran, chemistry, Mechanism of action, Molecular Medicine, medicine.symptom, Lead compound
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b8421479d907e3b763e4fc1aebb5de
https://doi.org/10.1021/jm950646f -
8
المؤلفون: Gary J. Grover, Raymond B. Darbenzio, Joseph C. Sewter, Thomas A. Hess, Paul G. Sleph, Diane E. Normandin, Nicholas J. Lodge, Albert J. D'Alonzo
المصدر: European Journal of Pharmacology. 294:271-280
مصطلحات موضوعية: Male, Agonist, Cromakalim, medicine.medical_specialty, Cardiotonic Agents, Potassium Channels, Refractory Period, Electrophysiological, medicine.drug_class, Myocardial Ischemia, Hemodynamics, Aorta, Thoracic, Blood Pressure, Vasodilation, In Vitro Techniques, Pharmacology, Guanidines, Rats, Inbred WKY, Muscle, Smooth, Vascular, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Species Specificity, Heart Conduction System, Heart Rate, In vivo, Lactate dehydrogenase, medicine.artery, Internal medicine, Animals, Medicine, Benzopyrans, Pyrroles, Aorta, business.industry, Heart, Rats, Electrophysiology, Mean blood pressure, Endocrinology, chemistry, cardiovascular system, business, Anti-Arrhythmia Agents
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9
المؤلفون: Steven Dzwonczyk, Gary J. Grover, Diane M. McMullen, Paul G. Sleph, Suzanne Moreland, Charles S. Parham, Diane E. Normandin
المصدر: Journal of Cardiovascular Pharmacology. 26:289-294
مصطلحات موضوعية: Pharmacology, Aorta, Chemotherapy, business.industry, medicine.medical_treatment, Calcium channel, Coronary heart disease, Smooth muscle, In vivo, Anesthesia, medicine.artery, Ic50 values, medicine, Cardiology and Cardiovascular Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bfa3bcf1e779dc4bab4331ebe7712b70
https://doi.org/10.1097/00005344-199508000-00015 -
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المؤلفون: Kenneth E.J. Dickinson, J. Buote, Denis E. Ryono, John Lloyd, Diane E. Normandin, J.E. Bird, Tamara Dejneka, Suzanne Moreland, E.R. Spitzmiller, Carol L. Delaney, Thomas L. Waldron, S. Skwish
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:195-200
مصطلحات موضوعية: Angiotensin receptor, medicine.medical_specialty, Lagomorpha, Angiotensin II receptor type 1, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Quinoline, Pharmaceutical Science, Pharmacology, biology.organism_classification, Biochemistry, Chemical synthesis, Angiotensin II, In vitro, chemistry.chemical_compound, Endocrinology, In vivo, Internal medicine, Drug Discovery, medicine, Molecular Medicine, Molecular Biology