نتائج البحث - "Diane Erdmann"

المساهمون: Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plateforme Technologique de RMN Biologique et HDX-MS - Biological NMR and HDX-MS Technological Platform, Institute of Chemistry for Life and Health Sciences (iCLeHS), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Stuttgart, The 800-MHz NMR spectrometer of the Institut Pasteur was partially funded by the Région Ile de France (SESAME 2014 NMRCHR grant no. 4014526). The project was financed by the French PPR Antiobioresistance ANR-20-PAMR-0011–TheraEPI (to P.B.A.)., We thank Prof. Srinivasan and Prof. Nelson from the Sidney Kimmel Comprehensive Cancer Center at the University of Medicine, Johns Hopkins (Baltimore, MD) for the kind gift of MBD2-His plasmid. We thank Ludovic Halby for the design of the synthetic pathway and for the fruitful discussions on the project conception., ANR-20-PAMR-0011,TherAEPI,Thérapies épigénétiques pour esquiver la résistance(2020)

المصدر: ACS Chemical Biology
ACS Chemical Biology, 2022, Published as part of the ACS Chemical Biology special issue “Epigenetics 2022”., 17 (6), pp.1415-1426. ⟨10.1021/acschembio.1c00959⟩

مصطلحات موضوعية: DNA-Binding Proteins, 5-Methylcytosine, Humans, Molecular Medicine, CpG Islands, DNA, General Medicine, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, DNA Methylation, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5acb0f8d3441c15e8b36496ba011807
https://hal-pasteur.archives-ouvertes.fr/pasteur-03688129

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5

Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

المؤلفون: Paola B. Arimondo, Frédéric Bonhomme, Benoit Arcangioli, Flore Nardella, Elie Hammam, Jiaqi Liang, Artur Scherf, Peter C. Dedon, Diane Erdmann, Peter R. Preiser, Sebastian Baumgarten, Ameya Sinha, Samia Miled

المساهمون: Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Singapore-MIT Alliance for Research and Technology (SMART), Massachusetts Institute of Technology (MIT), Nanyang Technological University [Singapour], Institut Jacques Monod (IJM (UMR_7592)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), École Technique Supérieure du Laboratoire [Paris] (ETSL), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Ecole doctorale Médicament -Toxicologie - Chimie - Imageries [Université de Paris] (ED 563), Université Paris Cité (UPCité), Dynamique du Génome - Dynamics of the genome, A. Sinha and J.L. acknowledge support from the Singapore‐MIT Alliance (SMA) Graduate Fellowship and MOE Tier 2 grant MOE2018-T2-2-131. Proteomics work was performed in part in the Center for Environmental Health Sciences BioCore, which is supported by Center grant P30‐ES002109 from the National Institute of Environmental Health Sciences. We also acknowledge Peiying Ho and Tan Tse Mien for providing support at SMART laboratories in Singapore. F.N. is supported by a Pasteur Cantarini fellowship. A. Sinha acknowledges financial support from the Singapore-MIT Alliance (SMA) Graduate Fellowships. P.B.A. acknowledges the DIM1Health 2019 grant from the Région Ile de France to the project EpiK for the LC/MS-MS equipment. This work was supported by the French Parasitology consortium ParaFrap (ANR-11-LABX0024) to A. Scherf, a Fondation Pasteur Swiss grant to A. Scherf, and an ANR grant (ANR-2019 EpiKillMal)., ANR-20-CE18-0006,EpiKillMal,Cibler la méthylation de l'ADN pour contrer la chimiorésistance du paludisme(2020), School of Biological Sciences, Singapore-MIT Alliance for Research and Technology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Paris (UP), Arimondo, Paola B, Cibler la méthylation de l'ADN pour contrer la chimiorésistance du paludisme - - EpiKillMal2020 - ANR-20-CE18-0006 - AAPG2020 - VALID

المصدر: mBio
mBio, 2021, 12, pp.e02558-21. ⟨10.1128/mBio.02558-21⟩
mBio, American Society for Microbiology, 2021, 12, pp.e02558-21. ⟨10.1128/mBio.02558-21⟩
mBio, Vol 12, Iss 6 (2021)

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Bisulfite sequencing, Protozoan Proteins, Epitranscriptomic, Epigenome, RNA, Transfer, homeostasis, Malaria, Falciparum, RNA Processing, Post-Transcriptional, Genetics, 0303 health sciences, biology, 030302 biochemistry & molecular biology, Biological sciences [Science], Translation (biology), epitranscriptomic, QR1-502, 3. Good health, [SDV] Life Sciences [q-bio], [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Codon usage bias, DNA methylation, RNA, Protozoan, Research Article, TRNA modification, Plasmodium falciparum, malaria, Microbiology, DNA methyltransferase, 03 medical and health sciences, Cytosine, Stress, Physiological, RNA cytosine methylation, Virology, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, tRNA, 030304 developmental biology, RNA, DNMT2, Methyltransferases, stress response, DNA Methylation, biology.organism_classification, Malaria, tRNA cytosine methylation, tRNA modification

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e3a86021f8eaea1577cc48a37cba1e
https://hal-pasteur.archives-ouvertes.fr/pasteur-03427780/file/mBio.02558-21.pdf

6

Procainamide-SAHA fused inhibitors of hHDAC6 tackle multi-drug resistant malaria parasites

المؤلفون: Elie Hammam, Roger Peronet, Artur Scherf, Salah Mecheri, Camille Roesch, Ludovic Halby, Corentin Bon, Irina Dobrescu, Ambre Tafit, Paola B. Arimondo, Aurélie Claes, Diane Erdmann, Johanna Viluma, Véronique Cadet-Daniel, Melissa Mairet-Khedim, Benoit Witkowski, Flore Nardella

المساهمون: Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Ecole doctorale Médicament -Toxicologie - Chimie - Imageries [Université de Paris] (ED 563), Université Paris Cité (UPCité), Malaria Molecular Epidemiology, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This work was supported by the Innovation program by Institut Pasteur-Institut Carnot (S-CR18089-02B15 DARRI CONSO INNOV 46-19, S-PI15006-10A INNOV 05-2019 ARIMONDO IARP 2019-PC), Pasteur Transversal Research Program (PTR 233-2019 HALBY), Pasteur Swiss Foundation grant, and ANR AAPG 2020-EpiKillMal, ANR-20-CE18-0006,EpiKillMal,Cibler la méthylation de l'ADN pour contrer la chimiorésistance du paludisme(2020), Nardella, Flore, Cibler la méthylation de l'ADN pour contrer la chimiorésistance du paludisme - - EpiKillMal2020 - ANR-20-CE18-0006 - AAPG2020 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Paris (UP), Malaria Molecular Epidemiology (MMEU)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2021, 64 (14), pp.10403-10417. ⟨10.1021/acs.jmedchem.1c00821⟩
Journal of Medicinal Chemistry, American Chemical Society, In press, ⟨10.1021/acs.jmedchem.1c00821⟩

مصطلحات موضوعية: medicine.medical_treatment, DNA Methyltransferase Inhibitor, Parasitemia, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Pharmacology, Histone Deacetylase 6, Hydroxamic Acids, 01 natural sciences, HDAC6 inhibitors, Drug Discovery, Malaria, Falciparum, Cytotoxicity, 0303 health sciences, DNA methylation, antimalarial, Molecular Structure, biology, Chemistry, Drug Resistance, Multiple, 3. Good health, in vivo, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, parasite, Molecular Medicine, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, Plasmodium falciparum, malaria, Dihydroartemisinin, Procainamide, Antimalarials, Structure-Activity Relationship, 03 medical and health sciences, parasitic diseases, medicine, Gametocyte, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Histone deacetylase, 030304 developmental biology, drug resistance, Dose-Response Relationship, Drug, biology.organism_classification, medicine.disease, 0104 chemical sciences, Histone Deacetylase Inhibitors, Multiple drug resistance, 010404 medicinal & biomolecular chemistry, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Malaria

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https://hal.science/hal-03264653/document

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7

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites

المؤلفون: Salah Mecheri, Benoit Witkowski, Flore Nardella, Artur Scherf, Elie Hammam, Ludovic Halby, Roger Peronet, Didier Menard, Véronique Cadet-Daniel, Diane Erdmann, Paola B. Arimondo

المساهمون: Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie biologique épigénétique - Epigenetic Chemical Biology, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), ED 515 - Complexité du vivant, Sorbonne Université (SU), Malaria Molecular Epidemiology, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This work was supported by a European Research Council Advanced Grant (PlasmoSilencing 670301), a Fondation Pasteur Swiss grant and the French Parasitology consortium ParaFrap (ANR-11-LABX0024) to A.S., as well as DARRI Carnot Pasteur MS 2019 Projet INNOV-5-19 to A.S. and P.B.A., DIM1 Health Ile de France 2019 to P.B.A., and PTR Institut Pasteur 2019 (TaME) to L.H. and F.N, We thank Dr. T. Ishino (Department of Medical Zoology, Mie University School of Medicine, Edobashi, Tsu, Japan) for her kind gift of the P. berghei ANKA GFP-expressing strain.(26) We thank Agnès Zettor and Fabrice Agou of the PF-CCB (Institut Pasteur) for the solubility analysis and Eric Legrand (Biology of Host-Parasite Interactions, Institut Pasteur, Paris) for his technical assistance., ANR-11-LABX-0024/11-LABX-0024,ParaFrap,Alliance française contre les maladies parasitaires(2011), European Project: 670301,H2020,ERC-2014-ADG,PlasmoSilencing(2015), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Ecole Doctorale Complexité du Vivant (ED515), Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), ANR-11-LABX-0024,ParaFrap,Alliance française contre les maladies parasitaires(2011), MECHERI, Salah, Laboratoires d'excellence - Alliance française contre les maladies parasitaires - - ParaFrap2011 - ANR-11-LABX-0024 - LABX - VALID, Exoribonuclease-mediated degradation of nascent RNA in Malaria Parasites: A Novel Mechanism in Virulence Gene Silencing - PlasmoSilencing - - H20202015-11-01 - 2020-10-31 - 670301 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Paris (UP)

المصدر: ACS Central Science
ACS Central Science, ACS Publications, In press, ⟨10.1021/acscentsci.9b00874⟩
ACS Central Science, 2020, 6 (1), pp.16-21. ⟨10.1021/acscentsci.9b00874⟩
ACS Central Science, Vol 6, Iss 1, Pp 16-21 (2019)
ACS Central Science, ACS Publications, 2020, 6 (1), pp.16-21. ⟨10.1021/acscentsci.9b00874⟩

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd68c668eba5b8ce8c8e319f7a42410
https://hal-pasteur.archives-ouvertes.fr/pasteur-02385718

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8

XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii

المؤلفون: Carine Vergne-Vaxelaire, Anne Zaparucha, Jean-Louis Petit, Véronique de Berardinis, Aurélie Fossey-Jouenne, Adrien Debard, Diane Erdmann, Jérémy Domergue

المساهمون: Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), The authors gratefully acknowledge Dr. Eugenio P. Patallo (Institut für Biochemie, TU Dresden, 01062 Dresden, Germany) for sending a sample of 7‑chloro tryptophan. They would like to thank Olek Maciejak and Marie‑Jeanne Clément (SABNP, INSERM U 1204—Université d’Evry Val‑d’Essonne, Université Paris‑Saclay, France) for assistance in 1H and 13C NMR experiments, the Region Ile de France for financial support of the 600 MHz NMR spectrometer, Dr. Alain Perret, Christine Pelle and Peggy Sirvain for protein supply, Virginie Pellouin for technical support., Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)

المصدر: AMB Express
AMB Express, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
AMB Express, Springer Nature, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
AMB Express, Vol 9, Iss 1, Pp 1-11 (2019)

مصطلحات موضوعية: Stereochemistry, lcsh:Biotechnology, [SDV]Life Sciences [q-bio], lcsh:QR1-502, Biophysics, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Applied Microbiology and Biotechnology, lcsh:Microbiology, Regioselectivity, lcsh:TP248.13-248.65, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, [CHIM]Chemical Sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Indole test, Flavin-dependent halogenases, 010405 organic chemistry, Chemistry, Tryptophan, Symbiotic bacterium, Halogenation, 0104 chemical sciences, enzyme, Electrophilic halogenation, Biocatalysis, Original Article, Indole derivatives, Xenorhabdus szentirmaii

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6688ca807a2fbd3e4c82d689fc7181f7
https://doi.org/10.1186/s13568-019-0898-y

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9

[Untitled]

المؤلفون: Sean Murphy, Diane Erdmann

المصدر: Designs, Codes and Cryptography. 10:325-339

مصطلحات موضوعية: Average-case complexity, Discrete mathematics, Distribution (number theory), Applied Mathematics, Maximum length sequence, Probability distribution, Pseudorandom binary sequence, Algorithm, Stream cipher, Time complexity, Computer Science Applications, Statistical hypothesis testing, Mathematics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0a5ac874a2b5adcf39ef506e93f96bba
https://doi.org/10.1023/a:1008295603824

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