-
1
المؤلفون: Fang Yi, Karyn O'neil, Alan Gibbs, Steven Jacobs, Diane M. Maguire, Michelle Conk, Colleen Kane
المصدر: Protein Engineering Design and Selection. 28:385-393
مصطلحات موضوعية: Models, Molecular, Scaffold protein, Recombinant Fusion Proteins, Molecular Sequence Data, Bioengineering, Protein Engineering, Biochemistry, Mice, In vivo, Albumins, Consensus Sequence, Protein A/G, Escherichia coli, Consensus sequence, Animals, Humans, Amino Acid Sequence, Molecular Biology, biology, Protein Stability, Albumin, Protein Structure, Tertiary, Epitope mapping, biology.protein, Protein G, Biotechnology, Binding domain
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f052b2cd61b19dace70ce7cb55f83f
https://doi.org/10.1093/protein/gzv040 -
2
المؤلفون: Tara Mezzasalma Haarlander, Karen Carroll, Sharon L. Burke, Shariff Bayoumy, Ingrid Christa Deckman, Cuifen Huo, Richard Alexander, Monica Singer, Matthew J. Todd, Yue-Mei Zhang, Kristi A. Leonard, Cindy Milligan, Robyn Williams, Kenneth J. Rhodes, Robert H. Scannevin, Keli Dzordzorme, John Spurlino, Brett A. Tounge, Diane M. Maguire, Paul F. Jackson, Celine Schalk-Hihi, Lawrence C. Kuo, Eric Devine, Frank A. Lewandowski
المصدر: The Journal of biological chemistry. 292(43)
مصطلحات موضوعية: 0301 basic medicine, Allosteric regulation, Drug action, Matrix metalloproteinase, Biology, Matrix Metalloproteinase Inhibitors, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Protein Domains, Zymogen, Catalytic Domain, Chlorocebus aethiops, medicine, Animals, Humans, Editors' Picks, Molecular Biology, Enzyme Precursors, Drug discovery, Experimental autoimmune encephalomyelitis, Cell Biology, medicine.disease, Matrix Metalloproteinases, Cell biology, 030104 developmental biology, Matrix Metalloproteinase 9, Enzyme inhibitor, Zymogen activation, COS Cells, biology.protein, Editors' Picks Highlights, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7e2f60e01bada9e1e4fd469d2a6f02
https://pubmed.ncbi.nlm.nih.gov/29079642 -
3
المؤلفون: Matthew J. Todd, Marina I. Nelen, Celine Schalk-Hihi, Jose C. Clemente, James K. Kranz, Christopher M. Flores, Lawrence C. Kuo, Diane M. Maguire, Erica L Nulton, Sui-Po Zhang
المصدر: SLAS Discovery. 17:629-640
مصطلحات موضوعية: Cannabinoid receptor, High-throughput screening, Arachidonic Acids, Plasma protein binding, Biochemistry, Glycerides, Substrate Specificity, Analytical Chemistry, Inhibitory Concentration 50, Catalytic Domain, High-Throughput Screening Assays, medicine, Humans, Enzyme Inhibitors, Enzyme Assays, chemistry.chemical_classification, biology, Hydrolysis, Active site, Monoacylglycerol Lipases, Monoacylglycerol lipase, Kinetics, Enzyme, Solubility, chemistry, Mechanism of action, biology.protein, Molecular Medicine, medicine.symptom, Endocannabinoids, Protein Binding, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05db4e32fcae5283a2c28027f6dc8703
https://doi.org/10.1177/1087057112441012 -
4
المؤلفون: Frank A. Lewandowski, Li Liu, Jose Clemente, Charles H. Reynolds, Bruce L. Grasberger, Renee L. DesJarlais, Mark J. Macielag, Celine Schalk-Hihi, Christopher M. Flores, Mcdonnell Mark E, Richard S. Alexander, Shariff Bayoumy, Hongchang Ma, Ingrid Deckman, Diane M. Maguire, Keli C. Dzordzorme, Robyn L. Miller, Tara Mezzasalma Haarlander, Carsten Schubert, Lawrence C. Kuo, James K. Kranz, Cindy Milligan
المصدر: Protein Science. 20:670-683
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Glyceride, Plasma protein binding, Biochemistry, Monoacylglycerol lipase, chemistry.chemical_compound, Monomer, Membrane, Catalytic cycle, Static electricity, biology.protein, Lipase, Molecular Biology
-
5
المؤلفون: Jennifer Lattanze, Tianbao Lu, Karen L. Milkiewicz, Bruce L. Grasberger, Theodore E. Carver, Louis V. LaFrance, Daniel J. Parks, Kannan Ramachandren, Varsha Gupta, Raul R. Calvo, Diane M. Maguire, Eugene C. Petrella, Maxwell D. Cummings
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:765-770
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Pharmaceutical Science, Fluorescence Polarization, Peptide, Biochemistry, Chemical synthesis, Benzodiazepines, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Proto-Oncogene Proteins, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Binding site, Molecular Biology, chemistry.chemical_classification, Benzodiazepine, Binding Sites, Organic Chemistry, Nuclear Proteins, Proto-Oncogene Proteins c-mdm2, Small molecule, chemistry, Lactam, Molecular Medicine, Tumor Suppressor Protein p53, Fluorescence anisotropy, Protein Binding
-
6Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
المؤلفون: Tianbao Lu, Jennifer Lattanze, Ingrid Deckman, Marie Zhang, Bruce L. Grasberger, Carl L. Manthey, and Christopher J. Molloy, John C. Spurlino, Diane M. Maguire, Eugene C. Petrella, Kannan Ramachandren, Holly K. Koblish, Shuyuan Zhao, Bruce E. Tomczuk, Gwendolyn R. Bylebyl, Louis V. LaFrance, Carsten Schubert, Daniel J. Parks, Karen L. Milkiewicz, Carol F. Franks, Theodore E. Carver, Roger F. Bone, Anna C. Maroney, Maxwell D. Cummings, Raul R. Calvo, W. Michael Avondale Pantoliano
المصدر: Journal of Medicinal Chemistry. 48:909-912
مصطلحات موضوعية: Models, Molecular, Molecular model, Crystallography, X-Ray, Cocrystal, Benzodiazepines, Structure-Activity Relationship, Transactivation, Proto-Oncogene Proteins c-mdm2, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Binding site, Transcription factor, chemistry.chemical_classification, DNA ligase, Binding Sites, Molecular Structure, Molecular Mimicry, Nuclear Proteins, Stereoisomerism, chemistry, Biochemistry, Biophysics, Molecular Medicine, Tumor Suppressor Protein p53
-
7
المؤلفون: Carl R. Illig, Ingrid Deckman, Troy Randle, Kenneth J. Wilson, Frank A. Lewandowski, Bruce L. Grasberger, Renee L. DesJarlais, M. Jonathan Rudolph, James B. Hoffman, Marie Zhang, Carl L. Manthey, David Green, Zhao Zhou, Diane M. Maguire, Nalin L. Subasinghe, Christopher J. Molloy, Celia Sharp, Roger F. Bone, John C. Spurlino, Richard Soll
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:491-495
مصطلحات موضوعية: Serine Proteinase Inhibitors, Alkylation, Stereochemistry, Clinical Biochemistry, Heteroatom, Amidines, Pharmaceutical Science, Thiophenes, Biochemistry, Chemical synthesis, Amidine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Thiophene, medicine, Molecular Biology, Alkyl, Urokinase, chemistry.chemical_classification, biology, Organic Chemistry, Urokinase-Type Plasminogen Activator, Combinatorial chemistry, Thiazoles, chemistry, Enzyme inhibitor, Lithium Compounds, biology.protein, Molecular Medicine, Indicators and Reagents, Plasminogen activator, Protein Binding, medicine.drug
-
8
المؤلفون: Troy Randle, Ingrid Deckman, Frank A. Lewandowski, Christopher J. Molloy, Celia Sharp, Marie Zhang, Renee L. DesJarlais, Carl L. Manthey, Roger F. Bone, Nalin L. Subasinghe, Zhau Zhou, David Green, M. Jonathan Rudolph, John C. Spurlino, Bruce L. Grasberger, Carl R. Illig, Diane M. Maguire, Richard Soll, Carl Crysler, James B. Hoffman, Kenneth J. Wilson
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1379-1382
مصطلحات موضوعية: Antimetabolites, Angiogenesis, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Biochemistry, Metastasis, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Molecular Biology, chemistry.chemical_classification, Serine protease, Binding Sites, biology, Organic Chemistry, Active site, medicine.disease, Urokinase-Type Plasminogen Activator, In vitro, Urokinase receptor, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
-
9
المؤلفون: John C. Spurlino, Renee L. DesJarlais, Bruce L. Grasberger, Richard Soll, David Green, Nalin L. Subasinghe, Zhao Zhou, Christopher J. Molloy, Frank A. Lewandowski, Celia Sharp, James B. Hoffman, Kenneth J. Wilson, Troy Randall, Marie Zhang, Diane M. Maguire, Roger F. Bone, Carl R. Illig, M. Jonathan Rudolph
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:915-918
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Amidines, Drug Evaluation, Preclinical, Pharmaceutical Science, Thiophenes, Biochemistry, Chemical synthesis, Amidine, Plasminogen Activators, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Thiophene, medicine, Molecular Biology, chemistry.chemical_classification, Serine protease, Urokinase, biology, Organic Chemistry, Urokinase-Type Plasminogen Activator, Thiazoles, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Amine gas treating, medicine.drug
-
10
المؤلفون: Karen L. Milkiewicz, Jennifer Lattanze, Bruce L. Grasberger, Maxwell D. Cummings, Diane M. Maguire, Anna C. Maroney, Daniel J. Parks, Pierre Raboisson, Louis V. LaFrance, Raul R. Calvo, Holly K. Koblish, Shuyuan Zhao, Juan J. Marugan, Carol F. Franks, Theodore E. Carver, Carsten Schubert, Tianbao Lu
المصدر: Bioorganicmedicinal chemistry letters. 16(12)
مصطلحات موضوعية: Drug, Models, Molecular, Cell Membrane Permeability, Alkylation, Stereochemistry, medicine.drug_class, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Benzodiazepines, Mice, Structure-Activity Relationship, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Pentanoic Acids, Molecular Biology, IC50, media_common, Cell Proliferation, Benzodiazepine, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Proto-Oncogene Proteins c-mdm2, Bioavailability, Drug Design, Molecular Medicine, Tumor Suppressor Protein p53, Lead compound, Protein Binding