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المؤلفون: Jianxia Shi, Xiaoning Zhao, Samer Chmait, Mary Dovlatyan, Silke Miller, Kristin L. Andrews, Geraldine Hill Della Puppa, James J. S. Treanor, Dianna Lester-Zeiner, Carl Davis, Essa Hu, Christopher Biorn, Jessica Able, Hang Chen, Jennifer R. Allen, Ji Ma
المصدر: ACS Medicinal Chemistry Letters. 5:700-705
مصطلحات موضوعية: Stereochemistry, Organic Chemistry, Phosphodiesterase, Biochemistry, Cocrystal, Bioavailability, chemistry.chemical_compound, chemistry, Morpholine, Drug Discovery, Pyridine, Potency, PDE10A, Receptor
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2
المؤلفون: Dianna Lester-Zeiner, Christopher Biorn, Essa Hu, Jianxia Shi, James J. S. Treanor, Sharon Zhao, Jennifer R. Allen, Amy Porter, Kristin L. Andrews, Samer Chmait, Shannon Rumfelt, Aaron C. Siegmund, Roxanne Kunz, Ning Chen, Hang Chen, Carl Davis, Ji Ma
المصدر: Journal of Medicinal Chemistry. 56:8781-8792
مصطلحات موضوعية: Male, Models, Molecular, Phosphodiesterase Inhibitors, Swine, Pharmacology, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Potency, Receptor, Cells, Cultured, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Phosphoric Diester Hydrolases, Phosphodiesterase, Ketones, Rats, Bioavailability, Enzyme, chemistry, Biochemistry, Drug Design, Molecular Medicine, Benzimidazoles, Efflux, PDE10A
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المؤلفون: Randall W. Hungate, Jennifer R. Allen, Roxanne Kunz, James J. S. Treanor, Ji Ma, Carl Davis, Jianxia Shi, Essa Hu, Ning Chen, Dianna Lester-Zeiner, Dah-Ren Hwang, Hang Chen, Klaus Michelsen
المصدر: ACS medicinal chemistry letters. 7(7)
مصطلحات موضوعية: medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Organic Chemistry, Phosphodiesterase, Binding potential, Pharmacology, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, In vivo, Positron emission tomography, 030220 oncology & carcinogenesis, TRACER, Drug Discovery, medicine, PDE10A, Pet tracer
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المؤلفون: Dah-Ren Hwang, Geraldine Hill Della Puppa, Jamie Wong, Essa Hu, Thomas Nixey, Silke Miller, Hang Chen, Jessica Able, Dianna Lester-Zeiner, James J. S. Treanor, Robert Cho, Santosh Talreja, Roxanne Kunz, Jianxia Shi, Ji Ma, David C. Immke, Jennifer R. Allen, Christopher Biorn, Amy Porter, Klaus Michelsen, Shannon Rumfelt, Stephen Hitchcock
المصدر: Journal of Medicinal Chemistry. 55:4776-4787
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Aminopyridines, Striatum, In Vitro Techniques, Tritium, Permeability, Cell Line, Rats, Sprague-Dawley, Dogs, Tandem Mass Spectrometry, In vivo, TRACER, Drug Discovery, Animals, Humans, Tissue Distribution, ATP Binding Cassette Transporter, Subfamily B, Member 1, Radionuclide Imaging, Phosphoric Diester Hydrolases, Drug discovery, Chemistry, Brain, Phosphodiesterase, Stereoisomerism, Surface Plasmon Resonance, Molecular biology, Small molecule, Rats, Pyridazines, Rapid identification, Quinolines, Pyrazoles, Molecular Medicine, PDE10A, Radiopharmaceuticals, Chromatography, Liquid, Protein Binding
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المؤلفون: Michelle Lindstrom, Timothy J. Carlson, Guifen Xu, Xiaoshan Min, Zhihua Ma, Frank Kayser, Shou-Hua Xiao, Dianna Lester-Zeiner, Christine Hedberg, Richard V. Connors, Zhulun Wang, Cesar Meleza, Yihong Li, Cris Guimaraes, Darin J. Gustin, Amy Porter
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2492-2496
مصطلحات موضوعية: Lactams, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Amidohydrolases, Amidase, Structure-Activity Relationship, Fatty acid amide hydrolase, Drug Discovery, medicine, Animals, Humans, Urea, Structure–activity relationship, Computer Simulation, Spiro Compounds, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Organic Chemistry, Rats, Enzyme, nervous system, Mechanism of action, Enzyme inhibitor, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), medicine.symptom, psychological phenomena and processes
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6
المؤلفون: Randall W. Hungate, Ming Huang, Gloria Biddlecome, Jason Brooks Human, Benny C. Askew, Jian J. Chen, Dianna Lester-Zeiner, Eileen Johnson, Wenyuan Qian, Barton H. Manning, Leyla Arik, Richard Loeloff, Toshihiro Aya, Kaustav Biswas, Hong Dong, Tanya Peterkin, Hong Sun, Gondi N. Kumar
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4764-4769
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Analgesic, Pain, Pharmaceutical Science, Bradykinin, Pharmacology, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Bradykinin B2 Receptor Antagonists, Drug Discovery, medicine, Animals, Humans, Sulfones, Bradykinin receptor, Receptor, Molecular Biology, Aryl, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Antagonist, Chronic pain, medicine.disease, Rats, Bradykinin B1 Receptor Antagonists, chemistry, Chronic Disease, Molecular Medicine, Rabbits
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المؤلفون: Burgess Laurence E, Leyla Arik, Chester Chenguang Yuan, Nianhe Han, Randall W. Hungate, Derin C. D'amico, David A. Mareska, Feng-Yin Hsieh, Eileen Johnson, Hong Sun, Qingyian Liu, Barton H. Manning, Bobby Riahi, Christopher H. Fotsch, Gloria Biddlecome, Mark H. Norman, Augustus Kamassah, Ming Huang, Richard Loeloff, Gondi N. Kumar, Andras Toro, Jian J. Chen, Jason Brooks Human, Hideo Suzuki, Robert D. Groneberg, Benny C. Askew, Aiwen Li, Gordon Ng, James Zhan, Kaustav Biswas, Dianna Lester-Zeiner, Hong Dong, David E. Clarke
المصدر: Journal of Medicinal Chemistry. 50:2200-2212
مصطلحات موضوعية: Male, medicine.drug_class, Pain, Bradykinin, Blood Pressure, Carboxamide, CHO Cells, In Vitro Techniques, Receptor, Bradykinin B1, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, In vivo, Cricetinae, Microsomes, Drug Discovery, medicine, Animals, Humans, Moiety, Structure–activity relationship, Benzopyrans, Chromans, Receptor, Inflammation, Analgesics, Sulfonamides, Stereoisomerism, Amides, In vitro, Rats, Bradykinin B1 Receptor Antagonists, chemistry, Biochemistry, Hyperalgesia, Molecular Medicine, Calcium, Rabbits, medicine.symptom
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المؤلفون: Hu Ye, Tim Kazules, Ji Ma, Dianna Lester-Zeiner, Essa Hu, Santosh Talreja, Carl Davis, Charlie Glaus, Oliver R. Thiel, Ning Chen, Geraldine Hill Della Puppa, James J. S. Treanor, Shannon Rumfelt, Hui Hannah Dou, Roxanne Kunz, David C. Immke, Jessica Able, Jennifer R. Allen, Silke Miller, Xiaoning Zhao, Hang Chen, Jianxia Shi, Jamie Wong, Toni Williamson, Christopher Biorn, Amy Porter, Klaus Michelsen, Ada Chen
المصدر: The Journal of pharmacology and experimental therapeutics. 352(2)
مصطلحات موضوعية: Male, Fluorine Radioisotopes, Phosphodiesterase Inhibitors, Pharmacology, Mass Spectrometry, Rats, Sprague-Dawley, Radioligand Assay, Species Specificity, medicine, Distribution (pharmacology), Animals, Humans, Tissue Distribution, medicine.diagnostic_test, Molecular Structure, Chemistry, Drug discovery, Phosphoric Diester Hydrolases, Antagonist, Phosphodiesterase, Brain, Stereoisomerism, Surface Plasmon Resonance, Small molecule, Drug development, Positron emission tomography, Positron-Emission Tomography, Pyrazines, Molecular Medicine, Benzimidazoles, Female, PDE10A, Chromatography, Liquid, Papio, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2114c0263395e74897b10174822cf2a
https://pubmed.ncbi.nlm.nih.gov/25502803 -
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المؤلفون: Kaustav Biswas, Ning Chen, Ji Ma, Xiaoning Zhao, Randall W. Hungate, Carl Davis, Jessica Able, Madelyn Cueva, James J. S. Treanor, Matthew P. Bourbeau, Samer Chmait, Paul E. Harrington, Dianna Lester-Zeiner, Roxanne Kunz, Jianxia Shi, Hang Chen, Jennifer R. Allen, Amy Porter, Kristin L. Andrews, Essa Hu, Jean Danao, Santosh Talreja, Thomas Kornecook
المصدر: Journal of medicinal chemistry. 57(15)
مصطلحات موضوعية: Male, Primates, Stereochemistry, Phosphodiesterase Inhibitors, Protein Conformation, Administration, Oral, Biological Availability, Motor Activity, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Morpholine, Drug Discovery, Potency, Animals, Humans, Phosphoric Diester Hydrolases, Phosphodiesterase, Brain, Tetrahydropyran, Piperazine, chemistry, Pyrazines, Molecular Medicine, Benzimidazoles, PDE10A, Piperidine, Antipsychotic Agents
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المؤلفون: David A. Mareska, Dianna Lester-Zeiner, Randall W. Hungate, Eileen Johnson, Toshi Aya, Leyla Arik, Bobby Riahi, Mark H. Norman, Augustus Kamassah, Jian J. Chen, Gloria Biddlecome, Judy Wang, Christopher H. Fotsch, Paul J. Reider, Jason Brooks Human, Benny C. Askew, Derin C. D'amico, Andras Toro, Burgess Laurence E, Carlo van Staden, Vellarkad N. Viswanadhan, Laird Ellen, Darren Martin Harvey, David E. Clarke, Gordon Ng, James Zhan, Kaustav Biswas, Christopher A. Willoughby, Hideo Suzuki, Robert D. Groneberg
المصدر: Journal of medicinal chemistry. 50(4)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.drug_class, Entropy, Molecular Conformation, Bradykinin, Inflammation, CHO Cells, Pharmacology, In Vitro Techniques, Crystallography, X-Ray, Capillary Permeability, chemistry.chemical_compound, Structure-Activity Relationship, Cricetulus, Species Specificity, Cricetinae, Drug Discovery, Chlorocebus aethiops, medicine, Animals, Humans, Chromans, Pleurisy, Lagomorpha, biology, Anti-Inflammatory Agents, Non-Steroidal, Antagonist, Biological activity, Stereoisomerism, Receptor antagonist, biology.organism_classification, In vitro, Extravasation, Rats, Bradykinin B1 Receptor Antagonists, chemistry, Molecular Medicine, Rabbits, medicine.symptom