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المؤلفون: Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack
المصدر: Journal of Medicinal Chemistry. 64:1454-1480
مصطلحات موضوعية: Chemistry, Metabolite, Arthritis, Pharmacology, medicine.disease, Ligand (biochemistry), chemistry.chemical_compound, Immune system, Pharmacokinetics, In vivo, Drug Discovery, medicine, Molecular Medicine, Receptor, PK/PD models
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المؤلفون: John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Aryl, Sphingosine-1-phosphate receptor, Organic Chemistry, Ether, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Potency, PK/PD models, ED50
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المؤلفون: Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski
المصدر: Journal of Medicinal Chemistry. 62:2265-2285
مصطلحات موضوعية: Agonist, 0303 health sciences, medicine.drug_class, Sphingosine-1-phosphate receptor, Metabolite, Pharmacology, 01 natural sciences, Fingolimod, Partial agonist, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, 030304 developmental biology, medicine.drug
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المؤلفون: John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael, Yang, Zili, Xiao, Xiaoxia, Yang, Tracy L, Taylor, Kim W, McIntyre, Bethanne M, Warrack, Hong, Shi, Paul C, Levesque, Anthony M, Marino, Georgia, Cornelius, Arvind, Mathur, Ding Ren, Shen, Jian, Pang, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Huadong, Sun, Jenny, Xie, Luisa, Salter-Cid, Percy H, Carter, Alaric J, Dyckman
المصدر: Journal of medicinal chemistry. 64(3)
مصطلحات موضوعية: Lung Diseases, Male, Serine Endopeptidases, Drug Evaluation, Preclinical, Arthritis, Experimental, Autoimmune Diseases, Rats, Bridged Bicyclo Compounds, Chemotaxis, Leukocyte, Structure-Activity Relationship, Rats, Inbred Lew, Animals, Humans, Myocytes, Cardiac, Proprotein Convertases, Phosphorylation, Bronchoalveolar Lavage Fluid, Biotransformation, Half-Life
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المؤلفون: Bin Jiang, Sylwia Stachura, T. G. Murali Dhar, Carolyn A. Weigelt, Dauh Rurng Wu, Jingwu Duan, Luisa M. Salter–Cid, Javed Khan, Ding Ren Shen, Melissa Yarde, Qihong Zhao, Zhonghui Lu, Percy H. Carter, John S. Sack, Max Ruzanov
المصدر: Bioorganicmedicinal chemistry letters. 30(19)
مصطلحات موضوعية: Pyrrolidines, Drug Inverse Agonism, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Alcohol, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Sulfone, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Stability, In vivo, Drug Discovery, Moiety, Inverse agonist, Animals, Humans, Sulfones, Binding site, Molecular Biology, Pregnane X receptor, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Hep G2 Cells, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, Molecular Medicine
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المؤلفون: Alaric Dyckman, Jenny Xie, Lois D Lehman-McKeeman, Marn Ellen Cvijic, Ding Ren Shen, Dauh-Rurng Wu, Arvind Mathur, Georgia Cornelius, Anthony Marino, Paul Levesque, Hong Shi, Andres Hernandez, David Marcoux, Michael Yang, T. G. Murali Dhar, Hai-Yun Xiao, John Lodge Gilmore
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f19bf75ab5a1d51b52f15362ce3665
https://doi.org/10.1021/scimeetings.0c02440 -
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المؤلفون: Celia D’Arienzo, Ananta Karmakar, Marta Dabros, Michael Galella, Jingwu Duan, John S. Sack, Dhanya Kumar Raut, David S. Weinstein, Andrew T. Pudzianowski, Ding-Ren Shen, Sylwia Stachura, Joel C. Barrish, Arun Kumar Gupta, Huadong Sun, William R. Foster, Javed Khan, Melissa Yarde, Dan Camac, Lauren Haque, Qihong Zhao, Dauh-Rurng Wu, Carolyn A. Weigelt, Faye Wang, Percy H. Carter, Luisa Salter-Cid, Hemalatha Hemagiri, Jenny Xie, T. G. Murali Dhar, Zhonghui Lu, Virna Borowski, Hua Gong, John E. Somerville
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:85-93
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Receptors, Steroid, Propanols, Receptors, Retinoic Acid, Clinical Biochemistry, Pharmaceutical Science, Benzothiazine, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, Animals, Humans, Inverse agonist, Liver X receptor, Receptor, Molecular Biology, Liver X Receptors, Orphan receptor, Mice, Inbred BALB C, Sulfonamides, Pregnane X receptor, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Pregnane X Receptor, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Retinoic acid receptor, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine
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المؤلفون: Marta Dabros, Paul Levesque, Elizabeth M. Heimrich, Arvind Mathur, Percy H. Carter, Richard Rampulla, Anuradha Gupta, Lois D. Lehman-McKeeman, Huadong Sun, David Marcoux, Ding Ren Shen, Xiaoxia Yang, Xia D. Zhou, Hai-Yun Xiao, Dauh-Rurng Wu, Louis J. Lombardo, Hong Shi, Zheng Yang, Mary Ellen Cvijic, Alaric J. Dyckman, Kim W. McIntyre, Luisa Salter-Cid, Celia D’Arienzo, Anthony M. Marino, Bala Pragalathan, Georgia Cornelius, Jenny Xie, T. G. Murali Dhar, Tracy L. Taylor, Rochelle Thomas
المصدر: MedChemComm. 8:725-729
مصطلحات موضوعية: 0301 basic medicine, Drug, Agonist, medicine.drug_class, Metabolite, media_common.quotation_subject, Pharmaceutical Science, Pharmacology, Biochemistry, Partial agonist, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, medicine, media_common, chemistry.chemical_classification, S1p1 receptor, Organic Chemistry, Prodrug, Fingolimod, 030104 developmental biology, chemistry, Molecular Medicine, medicine.drug, Tricyclic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d2e68634039d58468401fb206f57908e
https://doi.org/10.1039/c6md00539j -
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المؤلفون: Ding Ren Shen, Mary Ellen Cvijic, Hai-Yun Xiao, Alaric J. Dyckman, Yu-Wen Li, Bala Pragalathan, Joel C. Barrish, Georgia Cornelius, Peng Li, Tracy L. Taylor, Zili Xiao, Lois D. Lehman-McKeeman, Jianlin Feng, Dauh-Rurng Wu, John L. Gilmore, Percy H. Carter, David Marcoux, Zheng Yang, Arvind Mathur, Elizabeth M. Heimrich, Kim W. McIntyre, Bethanne M. Warrack, Anuradha Gupta, Yang Michael G, Luisa Salter-Cid, Praveen Balimane, Virna Borowski, Jenny Xie, T. G. Murali Dhar, Alda Fernandes, Anthony M. Marino
المصدر: Journal of Medicinal Chemistry. 59:11138-11147
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Alkene, S1p1 receptor, Stereochemistry, Combinatorial chemistry, Brain Cell, 03 medical and health sciences, chemistry.chemical_compound, Hydroboration, 030104 developmental biology, 0302 clinical medicine, Lysophosphatidylcholine, chemistry, Drug Discovery, Molecular Medicine, Methanol, 030217 neurology & neurosurgery
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المؤلفون: John S. Sack, Sylwia Stachura, Bin Jiang, Sridhar Vanteru, Percy H. Carter, Lisa Zhang, Max Ruzanov, Javed Khan, Zhonghui Lu, Jenny Xie, Jingwu Duan, Qihong Zhao, Ding-Ren Shen, Luisa Salter-Cid, T. G. Murali Dhar, Dauh-Rurng Wu, Arvind Mathur, David J. Shuster, Virna Borowski, Arun Kumar Gupta, Carolyn A. Weigelt, Michael Galella, William R. Foster, Melissa Yarde
مصطلحات موضوعية: chemistry.chemical_classification, Sulfonyl, Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Organic Chemistry, 01 natural sciences, Biochemistry, Pyrrolidine, 0104 chemical sciences, Sulfonamide, Sulfone, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Oral administration, Drug Discovery, Inverse agonist, Selectivity
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291851fb8201f5b23025040c19f28f3e
https://europepmc.org/articles/PMC6421587/
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