نتائج البحث - "Dirk-Jan van den Berg"

المساهمون: Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Center for Liver, Digestive and Metabolic Diseases (CLDM), Nanomedicine & Drug Targeting, National cerebral and cardiovascular center research institute, Leiden University, Janssen Pharmaceutica [Beerse], University of Groningen [Groningen], Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Leiden Amsterdam Center for Drug Research (LACDR)

المصدر: Pharmaceutical Research, 34(2), 333-351. SPRINGER/PLENUM PUBLISHERS
Pharmaceutical Research
Pharmaceutical Research, 34(2), 333–351
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2017, 34 (2), pp.333-351. ⟨10.1007/s11095-016-2065-3⟩

مصطلحات موضوعية: Male, CISTERNA-MAGNA, [SDV]Life Sciences [q-bio], Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, 0302 clinical medicine, Cerebrospinal fluid, BARRIER PERMEABILITY, Extracellular fluid, Pharmacology (medical), Tissue Distribution, ComputingMilieux_MISCELLANEOUS, media_common, Morphine, Brain, P-GLYCOPROTEIN, Human brain, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, 3. Good health, medicine.anatomical_structure, Target site, Molecular Medicine, human prediction, pharmacokinetics, Biotechnology, Research Paper, Drug, media_common.quotation_subject, Central nervous system, BULK FLOW, Computational biology, Biology, Blood–brain barrier, RAT-BRAIN, Models, Biological, 03 medical and health sciences, central nervous system (CNS), PHARMACOKINETIC MODEL, Pharmacokinetics, translational model, medicine, Animals, Humans, Rats, Wistar, Acetaminophen, PLASMA-PROTEIN BINDING, Organic Chemistry, CENTRAL-NERVOUS-SYSTEM, CEREBROSPINAL-FLUID SYSTEM, Models, Theoretical, blood-brain barrier, Rats, CHOROID-PLEXUS, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f99545027cafeb7a51e50259063b93
https://hdl.handle.net/11370/3aa40e39-3c25-4321-922d-9c635d2c8422

Find this article in full text from Springer Verlag.

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6

Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain

المؤلفون: Piet H. van der Graaf, Gunnar Flik, Elizabeth C. M. de Lange, Dirk-Jan van den Berg, Willem van den Brink, Belén Gonzalez-Amoros, Nanda Koopman, Jeroen Elassais-Schaap, Thomas Hankemeier, Robin Hartman

المصدر: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, 8(2), 107-117

مصطلحات موضوعية: Agonist, Male, Quinpirole, medicine.drug_class, Pharmacology, Article, Plasma, Pharmacokinetics, Dopamine, Dopamine receptor D2, medicine, Animals, Metabolomics, Pharmacology (medical), PK/PD models, Chemistry, Research, Brain, Articles, Rats, Drug development, Pharmaceutical Preparations, Blood-Brain Barrier, Modeling and Simulation, Pharmacodynamics, Dopamine Agonists, Biomarkers, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699691bfd20a5b484a5140db6eff93a2
https://hdl.handle.net/1887/74180

7

LUF7244, an allosteric modulator/activator of K

المؤلفون: Muge, Qile, Henriette D M, Beekman, David J, Sprenkeler, Marien J C, Houtman, Willem B, van Ham, Anna, Stary-Weinzinger, Stanislav, Beyl, Steffen, Hering, Dirk-Jan, van den Berg, Elizabeth C M, de Lange, Laura H, Heitman, Ad P, IJzerman, Marc A, Vos, Marcel A G, van der Heyden

المصدر: British Journal of Pharmacology

مصطلحات موضوعية: Models, Molecular, ERG1 Potassium Channel, Sulfonamides, Pyridines, Research Papers, Disease Models, Animal, Dogs, HEK293 Cells, Allosteric Regulation, Torsades de Pointes, Phenethylamines, Animals, Humans, Myocytes, Cardiac, Atrioventricular Block, Anti-Arrhythmia Agents, Cells, Cultured, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::66ac4c668312463df84314187799a0a6
https://pubmed.ncbi.nlm.nih.gov/31339551

View record at Wiley

8

LUF7244, an allosteric modulator/activator of K v11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

المؤلفون: Marien J C Houtman, Laura H. Heitman, Marc A. Vos, Elizabeth C. M. de Lange, Stanislav Beyl, Ad P. IJzerman, Steffen Hering, David J Sprenkeler, Muge Qile, Willem B. van Ham, Marcel A.G. van der Heyden, Henriette D.M. Beekman, Anna Stary-Weinzinger, Dirk-Jan van den Berg

المصدر: British Journal of Pharmacology, 176(19), 3871-3885
British Journal of Pharmacology
British Journal of Pharmacology, 176(19), 3871. Wiley-Blackwell