المؤلفون: Pou S; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Winter RW; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Dodean RA; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Liebman K; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Li Y; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Mather MW; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Nepal B; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Nilsen A; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Handford MJ; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Riscoe TM; Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Laxson S; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Kirtley PJ; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States., Aleshnick M; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States., Zakharov LN; Center for Advanced Materials Characterization in Oregon (CAMCOR), 1443 E. 13th Avenue, Eugene, Oregon 97403, United States., Kelly JX; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Smilkstein MJ; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Wilder BK; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States., Kortagere S; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Vaidya AB; Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States., Alday PH; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Doggett JS; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Riscoe MK; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2024 Jul 12; Vol. 10 (7), pp. 2419-2442. Date of Electronic Publication: 2024 Jun 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/pharmacokinetics , Plasmodium falciparum*/drug effects , Quinolones*/pharmacology , Quinolones*/chemistry , Quinolones*/pharmacokinetics, Animals ; Mice ; Malaria/drug therapy ; Malaria/prevention & control ; Humans ; Prodrugs/pharmacology ; Prodrugs/chemistry ; Prodrugs/pharmacokinetics ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/prevention & control ; Female ; Structure-Activity Relationship

المؤلفون: Karunakaran D; Pharmaceutical Sciences Group, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA, USA., Mutyam SK; Pharmaceutical Sciences Group, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA, USA., Fu M; Pharmaceutical Sciences Group, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA, USA., Chen J; Pharmaceutical Sciences Group, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA, USA., Pham KHN; Pharmaceutical Sciences Group, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA, USA., Pou S; VA Medical Center, Experimental Chemotherapy Lab, 3710 SW, US Veterans Hospital Road, Portland, OR, USA., Winter RW; VA Medical Center, Experimental Chemotherapy Lab, 3710 SW, US Veterans Hospital Road, Portland, OR, USA., Nilsen A; VA Medical Center, Experimental Chemotherapy Lab, 3710 SW, US Veterans Hospital Road, Portland, OR, USA., Dodean RA; VA Medical Center, Experimental Chemotherapy Lab, 3710 SW, US Veterans Hospital Road, Portland, OR, USA., Smilkstein MJ; VA Medical Center, Experimental Chemotherapy Lab, 3710 SW, US Veterans Hospital Road, Portland, OR, USA; Oregon Health & Science University, Department of Molecular Microbiology & Immunology, 3181 SW Sam Jackson Boulevard, Portland, OR, USA., Riscoe MK; VA Medical Center, Experimental Chemotherapy Lab, 3710 SW, US Veterans Hospital Road, Portland, OR, USA; Oregon Health & Science University, Department of Molecular Microbiology & Immunology, 3181 SW Sam Jackson Boulevard, Portland, OR, USA., Shankar G; Pharmaceutical Sciences Group, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA, USA. Electronic address: gita.shankar@sri.com.

المصدر: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Jul 01; Vol. 198, pp. 106795. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials*/administration & dosage , Antimalarials*/pharmacokinetics, Animals ; Injections, Intramuscular ; Male ; Rats ; Rats, Sprague-Dawley ; Delayed-Action Preparations/administration & dosage ; Prodrugs/administration & dosage ; Prodrugs/pharmacokinetics ; Malaria/drug therapy

المؤلفون: Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Ortiz D; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Fargo CM; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Zhang X; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Li Y; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Sanchez M; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Kumar A; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Yeluguri M; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Dodean RA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Caridha D; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Madejczyk MS; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Martin M; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Jin X; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Blount C; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Chetree R; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pannone K; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Dinh HT; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., DeLuca J; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Evans M; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Nadeau R; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vuong C; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Leed S; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Dennis WE; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Roncal N; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pybus BS; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Lee PJ; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Roth A; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Reynolds KA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Kelly JX; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Landfear SM; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8323-8345. Date of Electronic Publication: 2024 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemistry , Antiprotozoal Agents*/therapeutic use , Antiprotozoal Agents*/chemical synthesis , Antiprotozoal Agents*/pharmacokinetics , Leishmania donovani*/drug effects , Leishmania mexicana*/drug effects, Animals ; Structure-Activity Relationship ; Mice ; Drug Discovery ; Humans ; Female ; Leishmaniasis/drug therapy ; Mice, Inbred BALB C

المؤلفون: Pou S; Medical Research Service, VA Healthcare System, Portland, Oregon, USA., Winter RW; Medical Research Service, VA Healthcare System, Portland, Oregon, USA., Liebman KM; Medical Research Service, VA Healthcare System, Portland, Oregon, USA., Dodean RA; Medical Research Service, VA Healthcare System, Portland, Oregon, USA., Nilsen A; Medical Research Service, VA Healthcare System, Portland, Oregon, USA.; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA., DeBarber A; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA., Doggett JS; Medical Research Service, VA Healthcare System, Portland, Oregon, USA.; Division of Infectious Diseases, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA., Riscoe MK; Medical Research Service, VA Healthcare System, Portland, Oregon, USA.; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA.

المصدر: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2024 May 15; Vol. 67 (5), pp. 186-196. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7610510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1344 (Electronic) Linking ISSN: 03624803 NLM ISO Abbreviation: J Labelled Comp Radiopharm Subsets: MEDLINE

مواضيع طبية MeSH: Quinolones*/chemical synthesis , Quinolones*/chemistry , Deuterium*/chemistry , Chemistry Techniques, Synthetic*, Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Antimalarials/pharmacology

المؤلفون: Pou S; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Dodean RA; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Frueh L; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Liebman KM; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Gallagher RT; Department of Chemistry, Portland State University, 1719 SW 10 Avenue, Portland, Oregon 97201, United States., Jin H; Medicinal Chemistry Core, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Jacobs RT; Medicines for Malaria Venture, ICC, route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva 15, Switzerland., Nilsen A; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Medicinal Chemistry Core, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Stuart DR; Department of Chemistry, Portland State University, 1719 SW 10 Avenue, Portland, Oregon 97201, United States., Doggett JS; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Riscoe MK; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States., Winter RW; VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

المصدر: Organic process research & development [Org Process Res Dev] 2021 Aug 20; Vol. 25 (8), pp. 1841-1852. Date of Electronic Publication: 2021 Aug 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9890443 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1083-6160 (Print) Linking ISSN: 10836160 NLM ISO Abbreviation: Org Process Res Dev Subsets: PubMed not MEDLINE

المؤلفون: Alday PH; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., McConnell EV; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Boitz Zarella JM; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Dodean RA; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States., Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Kelly JX; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Doggett JS; Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2021 Jul 09; Vol. 7 (7), pp. 1877-1884. Date of Electronic Publication: 2021 Mar 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Parasites* , Toxoplasma* , Toxoplasmosis*/drug therapy, Acridones ; Animals ; Mice

المؤلفون: Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Li Y; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Yeluguri M; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Dodean RA; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Reynolds KA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Kelly JX; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Jun 24; Vol. 64 (12), pp. 8739-8754. Date of Electronic Publication: 2021 Jun 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*therapeutic use , Prodigiosin/*analogs & derivatives , Prodigiosin/*therapeutic use , Pyrroles/*therapeutic use, Animals ; Antimalarials/chemical synthesis ; Antimalarials/toxicity ; Female ; Hep G2 Cells ; Humans ; Mice ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Plasmodium yoelii/drug effects ; Prodigiosin/toxicity ; Pyrroles/chemical synthesis ; Pyrroles/toxicity ; Stereoisomerism ; Structure-Activity Relationship

المؤلفون: Silva MG; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. marta_silva@wsu.edu., Bastos RG; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA., Stone Doggett J; Oregon Health and Science University, 3181 SW Sam Jackson Blvd., Portland, Oregon, 97239, USA., Riscoe MK; Oregon Health and Science University, 3181 SW Sam Jackson Blvd., Portland, Oregon, 97239, USA., Pou S; VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, 97239, USA., Winter R; VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, 97239, USA., Dodean RA; VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, 97239, USA., Nilsen A; Oregon Health and Science University, 3181 SW Sam Jackson Blvd., Portland, Oregon, 97239, USA.; VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, 97239, USA., Suarez CE; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. carlos.suarez@usda.gov.; Animal Disease Research Unit, Agricultural Research Service, USDA, WSU, Pullman, WA, USA. carlos.suarez@usda.gov.

المصدر: Parasites & vectors [Parasit Vectors] 2020 Dec 03; Vol. 13 (1), pp. 606. Date of Electronic Publication: 2020 Dec 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*pharmacology , Babesia/*drug effects , Babesiosis/*parasitology , Horse Diseases/*parasitology , Quinolones/*pharmacology , Theileria/*drug effects , Theileriasis/*parasitology, Animals ; Babesia/growth & development ; Babesia/physiology ; Babesiosis/drug therapy ; Erythrocytes/parasitology ; Horse Diseases/drug therapy ; Horses ; Leukocytes, Mononuclear/parasitology ; Theileria/growth & development ; Theileria/physiology ; Theileriasis/drug therapy

المؤلفون: Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Dodean RA; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Li Y; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Pou S; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Pybus B; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Melendez V; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Read L; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Bane CE; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vesely B; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Kreishman-Deitrick M; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Black C; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Li Q; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Sciotti RJ; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Olmeda R; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Luong TL; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Gaona H; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Potter B; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Sousa J; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Marcsisin S; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Caridha D; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Xie L; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vuong C; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Zeng Q; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Zhang J; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Zhang P; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Lin H; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Butler K; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Roncal N; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Gaynor-Ohnstad L; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Leed SE; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Nolan C; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Ceja FG; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Rasmussen SA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Rosenthal PJ; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, United States., Mu J; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, United States., Bayles BR; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.; Global Public Health Program, Dominican University of California, San Rafael, California 94901, United States., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Reynolds KA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Smilkstein MJ; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Riscoe MK; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Kelly JX; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Jun 11; Vol. 63 (11), pp. 6179-6202. Date of Electronic Publication: 2020 May 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Acridones/*chemistry , Antimalarials/*chemistry, Acridones/pharmacokinetics ; Acridones/pharmacology ; Acridones/therapeutic use ; Administration, Oral ; Animals ; Antimalarials/pharmacokinetics ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Cell Survival/drug effects ; Disease Models, Animal ; Female ; Half-Life ; Hep G2 Cells ; Humans ; Life Cycle Stages/drug effects ; Malaria/drug therapy ; Malaria/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/isolation & purification ; Structure-Activity Relationship

المؤلفون: Smilkstein MJ; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA. smilkste@ohsu.edu., Pou S; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA., Krollenbrock A; Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA., Bleyle LA; Bioanalytical Shared Resource Core Pharmacokinetics, Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L334, Portland, OR, 97239, USA., Dodean RA; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA.; Department of Chemistry, Portland State University, PO Box 751, Portland, OR, 97207, USA., Frueh L; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA., Hinrichs DJ; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA., Li Y; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA., Martinson T; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, OR, 97006, USA., Munar MY; Oregon State University/Oregon Health and Science University College of Pharmacy, 2730 SW Moody Avenue, CL5CP, Portland, OR, 97201, USA., Winter RW; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA.; Department of Chemistry, Portland State University, PO Box 751, Portland, OR, 97207, USA., Bruzual I; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA., Whiteside S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave N., Suite 500, Seattle, WA, USA., Nilsen A; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA., Koop DR; Bioanalytical Shared Resource Core Pharmacokinetics, Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L334, Portland, OR, 97239, USA., Kelly JX; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA.; Department of Chemistry, Portland State University, PO Box 751, Portland, OR, 97207, USA., Kappe SHI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave N., Suite 500, Seattle, WA, USA., Wilder BK; Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, OR, 97006, USA., Riscoe MK; VA Portland Health Care System Research and Development Service, 3710 SW US Veterans Hospital Road, RD-33, Portland, OR, 97239, USA.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.

المصدر: Malaria journal [Malar J] 2019 Aug 27; Vol. 18 (1), pp. 291. Date of Electronic Publication: 2019 Aug 27.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*adverse effects , Antimalarials/*pharmacokinetics , Plasmodium yoelii/*drug effects , Quinolones/*adverse effects , Quinolones/*pharmacokinetics, Animals ; Female ; Mice ; Prodrugs/adverse effects ; Prodrugs/pharmacokinetics