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المؤلفون: Duplaquet L; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA., So K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Biological and Biomedical Sciences Graduate Program, Harvard Medical School, Boston, MA 02115, USA., Ying AW; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pal Choudhuri S; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li X; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA., Xu GD; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Li Y; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA., Qiu X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Li R; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Singh S; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA., Wu XS; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA., Hamilton S; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chien VD; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Liu Q; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Qi J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Somerville TDD; Novartis BioMedical Research, Cambridge, MA 02139, USA., Heiling HM; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Mazzola E; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lee Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zoller T; Novartis BioMedical Research, Cambridge, MA 02139, USA., Vakoc CR; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Forrester WC; Novartis BioMedical Research, Cambridge, MA 02139, USA., Abrams T; Novartis BioMedical Research, Cambridge, MA 02139, USA., Long HW; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Niederst MJ; Novartis BioMedical Research, Cambridge, MA 02139, USA., Drapkin BJ; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kadoch C; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: cigall_kadoch@dfci.harvard.edu., Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: matthew_oser@dfci.harvard.edu.

المصدر: Cancer cell [Cancer Cell] 2024 Aug 12; Vol. 42 (8), pp. 1352-1369.e13. Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Small Cell Lung Carcinoma*/genetics , Small Cell Lung Carcinoma*/metabolism , Small Cell Lung Carcinoma*/pathology , Small Cell Lung Carcinoma*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Transcription Factors*/metabolism , Transcription Factors*/genetics , Gene Expression Regulation, Neoplastic*, Humans ; Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosomal Proteins, Non-Histone/genetics ; Octamer Transcription Factor-3/metabolism ; Octamer Transcription Factor-3/genetics

المؤلفون: Maurizio M; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Masid M; Ludwig Institute for Cancer Research, Department of Oncology, University of Lausanne and Lausanne University Teaching Hospital (CHUV), Lausanne, Switzerland.; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Woods K; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Caldelari R; Institute of Cell Biology, University of Bern, Bern, Switzerland., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Naguleswaran A; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Joly D; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., González-Fernández M; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Zemp J; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.; Institute of Cell Biology, University of Bern, Bern, Switzerland., Borteele M; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Hatzimanikatis V; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Heussler V; Institute of Cell Biology, University of Bern, Bern, Switzerland., Rottenberg S; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. sven.rottenberg@unibe.ch., Olias P; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. philipp.olias@vetmed.uni-giessen.de.; Institute of Veterinary Pathology, Justus Liebig University, Giessen, Germany. philipp.olias@vetmed.uni-giessen.de.

المصدر: Nature communications [Nat Commun] 2024 Jul 21; Vol. 15 (1), pp. 6145. Date of Electronic Publication: 2024 Jul 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Plasmodium falciparum*/genetics , Hepatocytes*/parasitology , Hepatocytes*/metabolism , Malaria, Falciparum*/parasitology , CRISPR-Cas Systems* , Theileria*/genetics, Humans ; Genomics/methods ; Heme/metabolism ; Host-Parasite Interactions/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Animals ; Gene Knockout Techniques

المؤلفون: Pablo JLB, Cornett SL, Wang LA, Jo S, Brünger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL Jr, Pan JQ

المصدر: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114327. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Misek SA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA., Fultineer A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Kalfon J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Noorbakhsh J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Boyle I; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Roy P; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Dempster J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Petronio L; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Huang K; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Saadat A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Green T; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Brown A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Beroukhim R; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. Rameen_Beroukhim@dfci.harvard.edu.; Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. Rameen_Beroukhim@dfci.harvard.edu., Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. boehm@mit.edu.; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. boehm@mit.edu.

المصدر: Nature communications [Nat Commun] 2024 Jun 07; Vol. 15 (1), pp. 4892. Date of Electronic Publication: 2024 Jun 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Germ-Line Mutation*, Humans ; Gene Editing/methods ; RNA, Guide, CRISPR-Cas Systems/genetics ; Germ Cells/metabolism ; Genetic Variation ; Neoplasms/genetics ; False Negative Reactions ; Genome, Human ; Cell Line, Tumor ; Cell Line

المؤلفون: Chandrasekaran SN; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cimini BA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Goodale A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Miller L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kost-Alimova M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jamali N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fritchman B; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Skepner A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Melanson M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kalinin AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arevalo J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haghighi M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Caicedo JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kuhn D; Merck Healthcare KGaA, Darmstadt, Germany., Hernandez D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Berstler J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shafqat-Abbasi H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Swalley SE; Biogen Inc., Cambridge, MA, USA., Garg S; Merck Healthcare KGaA, Darmstadt, Germany., Singh S; Broad Institute of MIT and Harvard, Cambridge, MA, USA. shantanu@broadinstitute.org., Carpenter AE; Broad Institute of MIT and Harvard, Cambridge, MA, USA. anne@broadinstitute.org.

المصدر: Nature methods [Nat Methods] 2024 Jun; Vol. 21 (6), pp. 1114-1121. Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE

مواضيع طبية MeSH: Image Processing, Computer-Assisted*/methods, Humans ; Microscopy/methods

المؤلفون: Kennedy PH; Laboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA, USA.; Center of Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA., Alborzian Deh Sheikh A; Laboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA, USA.; Center of Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA., Balakar M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jones AC; Department of Pharmacology, University of California San Diego, San Diego, CA, USA.; Biomedical Sciences Graduate Program, University of California San Diego, San Diego, CA, USA., Olive ME; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hegde M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Matias MI; Laboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA, USA.; Center of Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA., Pirete N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burt R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Levy J; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Little T; Laboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA, USA.; Center of Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA., Hogan PG; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA.; Program in Immunology, University of California San Diego, San Diego, CA, USA.; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Newton AC; Department of Pharmacology, University of California San Diego, San Diego, CA, USA., Gottschalk RA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., de Boer CG; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Alarcón S; La Jolla Institute for Immunology, La Jolla, CA, USA.; AUGenomics, San Diego, CA, USA., Newby GA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Myers SA; Laboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA, USA. sam@lji.org.; Center of Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA. sam@lji.org.; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA. sam@lji.org.; Department of Pharmacology, University of California San Diego, San Diego, CA, USA. sam@lji.org.; Program in Immunology, University of California San Diego, San Diego, CA, USA. sam@lji.org.; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA. sam@lji.org.

المصدر: Nature methods [Nat Methods] 2024 Jun; Vol. 21 (6), pp. 1033-1043. Date of Electronic Publication: 2024 Apr 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE

مواضيع طبية MeSH: Protein Processing, Post-Translational*, Phosphorylation ; Humans ; NFATC Transcription Factors/metabolism ; NFATC Transcription Factors/genetics ; Signal Transduction ; HEK293 Cells ; Proteomics/methods ; High-Throughput Screening Assays/methods ; T-Lymphocytes/metabolism ; Jurkat Cells ; NF-kappa B/metabolism

المؤلفون: Luo Q; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Raulston EG; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Prado MA; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Wu X; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Gritsman K; Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA., Whalen KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Yan K; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Booth CAG; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Xu R; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., van Galen P; Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shimony S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Hematology, Rabin Medical Center, Tel Aviv Faculty of Medicine, Tel Aviv, Israel., Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Lane AA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. andrew_lane@dfci.harvard.edu.

المصدر: Nature [Nature] 2024 Jun; Vol. 630 (8015), pp. 198-205. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/genetics , Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Leukemia*/drug therapy , Leukemia*/enzymology , Leukemia*/genetics , Leukemia*/metabolism , p21-Activated Kinases*/antagonists & inhibitors , p21-Activated Kinases*/metabolism , Signal Transduction*, Animals ; Humans ; Mice ; Cell Line ; Cytarabine/pharmacology ; Cytarabine/therapeutic use ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxidative Phosphorylation/drug effects ; Phosphorylation ; Xenograft Model Antitumor Assays