المؤلفون: Assini JM; Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, N6A 5B7, Canada; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada., Clark JR; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, N6A 5B7, Canada., Youssef A; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada., Xing C; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada., Doerfler AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Park SH; Department of Bioengineering, Rice University, Houston, USA., Saxena L; Department of Bioengineering, Rice University, Houston, USA., Yaseen AB; Department of Bioengineering, Rice University, Houston, USA., Børen J; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden., Gros R; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, N6A 5B7, Canada., Bao G; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada., Lagor WR; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA; Department of Bioengineering, Rice University, Houston, USA., Boffa MB; Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, N6A 5B7, Canada; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada. Electronic address: mlk@robarts.ca., Koschinsky ML; Robarts Research Institute, Schulich School of Medicine & Dentistry, London, Ontario, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, N6A 5B7, Canada. Electronic address: mboffa@uwo.ca.

المصدر: Atherosclerosis [Atherosclerosis] 2023 Nov; Vol. 384, pp. 117150. Date of Electronic Publication: 2023 May 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE

مواضيع طبية MeSH: Lipoprotein(a)*/genetics , Atherosclerosis*/genetics , Atherosclerosis*/metabolism, Male ; Humans ; Female ; Mice ; Animals ; Apolipoprotein B-100/genetics ; Mice, Transgenic ; Apolipoproteins B ; Apolipoproteins A ; Apoprotein(a) ; Cholesterol

المؤلفون: De Giorgi M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Park SH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Castoreno A; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Cao M; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley A; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Saxena L; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Chuecos MA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA., Walkey CJ; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Doerfler AM; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Furgurson MN; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Ljungberg MC; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Patel KR; Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA., Hyde S; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Chickering T; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Lefebvre S; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Wassarman K; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Miller P; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Qin J; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Schlegel MK; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Zlatev I; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Li RG; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Kim J; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Martin JF; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Bissig KD; Department of Pediatrics, Alice and Y. T. Chen Center for Genetics and Genomics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA., Jadhav V; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 29. Date of Electronic Publication: 2023 Jul 29.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Doerfler AM; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Park SH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Assini JM; Department of Biochemistry, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6A 5B7, Canada., Youssef A; Robarts Research Institute, Schulich School of Medicine and Dentistry, London, ON N6G 2V4, Canada., Saxena L; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Yaseen AB; Department of Bioengineering, Rice University, Houston, TX 77030, USA., De Giorgi M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Chuecos M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Hurley AE; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Li A; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Marcovina SM; Medpace Reference Laboratories, Cincinnati, OH 45227, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Boffa MB; Department of Biochemistry, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6A 5B7, Canada.; Robarts Research Institute, Schulich School of Medicine and Dentistry, London, ON N6G 2V4, Canada., Koschinsky ML; Robarts Research Institute, Schulich School of Medicine and Dentistry, London, ON N6G 2V4, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON N6A 5B7, Canada., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Bioengineering, Rice University, Houston, TX 77030, USA.

المصدر: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2022 Oct 13; Vol. 27, pp. 337-351. Date of Electronic Publication: 2022 Oct 13 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501 (Print) Linking ISSN: 23290501 NLM ISO Abbreviation: Mol Ther Methods Clin Dev Subsets: PubMed not MEDLINE

المؤلفون: Doerfler AM; Molecular Physiology and Biophysics Graduate Program (A.M.D., J.F.M., W.R.L.), University of California Los Angeles.; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles., Han J; Baylor College of Medicine, Houston, TX. Genome British Columbia Proteomics Centre (J.H., D.R.G.), University of California Los Angeles.; Division of Medical Sciences (J.H.), University of California Los Angeles., Jarrett KE; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.; Integrative Molecular and Biomedical Sciences Graduate Program (K.E.J., J.F.M., N.S., W.R.L.), University of California Los Angeles.; University of Victoria, BC, Canada. Division of Cardiology, Department of Medicine (K.E.J., T.Q.d.A.V.), University of California Los Angeles., Tang L; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.; Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, China (L.T.)., Jain A; Mass Spectrometry Proteomics Core (A.J., A.S., A.M.), University of California Los Angeles., Saltzman A; Mass Spectrometry Proteomics Core (A.J., A.S., A.M.), University of California Los Angeles., De Giorgi M; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles., Chuecos M; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.; Translational Biology and Molecular Medicine Graduate Program (M.C., J.F.M., N.S., W.R.L.), University of California Los Angeles., Hurley AE; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles., Li A; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.; Department of Bioengineering, Rice University, Houston, TX (A.L., W.R.L.)., Morand P; Department of Biological Chemistry (P.M., T.Q.d.A.V.), University of California Los Angeles., Ayala C; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles., Goodlett DR; Baylor College of Medicine, Houston, TX. Genome British Columbia Proteomics Centre (J.H., D.R.G.), University of California Los Angeles.; Department of Biochemistry and Microbiology (D.R.G.), University of California Los Angeles., Malovannaya A; Mass Spectrometry Proteomics Core (A.J., A.S., A.M.), University of California Los Angeles.; Verna and Marrs McLean Department of Biochemistry and Molecular Biology (A.M.), University of California Los Angeles.; Department of Molecular and Cellular Biology (A.M.), University of California Los Angeles.; Dan L Duncan Comprehensive Cancer Center (A.M.), University of California Los Angeles., Martin JF; Molecular Physiology and Biophysics Graduate Program (A.M.D., J.F.M., W.R.L.), University of California Los Angeles.; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.; Integrative Molecular and Biomedical Sciences Graduate Program (K.E.J., J.F.M., N.S., W.R.L.), University of California Los Angeles.; Translational Biology and Molecular Medicine Graduate Program (M.C., J.F.M., N.S., W.R.L.), University of California Los Angeles.; Program in Developmental Biology (J.F.M.), University of California Los Angeles.; Cardiovascular Research Institute (J.F.M., W.R.L.), University of California Los Angeles.; Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston (J.F.M.)., de Aguiar Vallim TQ; University of Victoria, BC, Canada. Division of Cardiology, Department of Medicine (K.E.J., T.Q.d.A.V.), University of California Los Angeles.; Department of Biological Chemistry (P.M., T.Q.d.A.V.), University of California Los Angeles.; Molecular Biology Institute (T.Q.d.A.V.), University of California Los Angeles.; Johnsson Comprehensive Cancer Center (T.Q.d.A.V.), University of California Los Angeles., Shroyer N; Translational Biology and Molecular Medicine Graduate Program (M.C., J.F.M., N.S., W.R.L.), University of California Los Angeles.; Department of Medicine, Section of Gastroenterology and Hepatology (N.S.), University of California Los Angeles., Lagor WR; Molecular Physiology and Biophysics Graduate Program (A.M.D., J.F.M., W.R.L.), University of California Los Angeles.; Department of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.; Integrative Molecular and Biomedical Sciences Graduate Program (K.E.J., J.F.M., N.S., W.R.L.), University of California Los Angeles.; Translational Biology and Molecular Medicine Graduate Program (M.C., J.F.M., N.S., W.R.L.), University of California Los Angeles.; Cardiovascular Research Institute (J.F.M., W.R.L.), University of California Los Angeles.; Department of Bioengineering, Rice University, Houston, TX (A.L., W.R.L.).

المصدر: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2022 Apr; Vol. 42 (4), pp. 381-394. Date of Electronic Publication: 2022 Feb 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Intestines* , Stem Cells*, Acyl Coenzyme A ; Animals ; Cholesterol ; Female ; Male ; Mice ; Sterols

المؤلفون: De Giorgi M; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Li A; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley A; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Barzi M; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA., Doerfler AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Cherayil NA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Smith HE; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Brown JD; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lin CY; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Bissig KD; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

المصدر: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2021 Apr 24; Vol. 21, pp. 656-669. Date of Electronic Publication: 2021 Apr 24 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501 (Print) Linking ISSN: 23290501 NLM ISO Abbreviation: Mol Ther Methods Clin Dev Subsets: PubMed not MEDLINE

المؤلفون: De Giorgi M; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Jarrett KE; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA; Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX, USA., Burton JC; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA; Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX, USA., Doerfler AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Hurley A; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Li A; Department of Bioengineering, Rice University, Houston, TX, USA., Hsu RH; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Furgurson M; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Patel KR; Department of Pathology, Texas Children's Hospital, Houston, TX, USA., Han J; Genome British Columbia Proteomics Centre, University of Victoria, Victoria, British Columbia, Canada., Borchers CH; Proteomics Centre, Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Gerald Bronfman Department of Oncology, Jewish General Hospital, Montreal, Quebec, Canada; Department of Data Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Moscow, Russia., Lagor WR; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA. Electronic address: lagor@bcm.edu.

المصدر: Journal of lipid research [J Lipid Res] 2020 Dec; Vol. 61 (12), pp. 1675-1686. Date of Electronic Publication: 2020 Oct 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res

مواضيع طبية MeSH: Hydroxymethylglutaryl CoA Reductases*/metabolism , Hydroxymethylglutaryl CoA Reductases*/genetics , Endoplasmic Reticulum Stress*/genetics , Liver*/metabolism , Terpenes*/metabolism, Animals ; Mice ; Hepatocytes/metabolism ; Gene Deletion ; Apoptosis ; CRISPR-Cas Systems ; Mevalonic Acid/metabolism ; Mice, Knockout ; Dolichols/metabolism

المؤلفون: Li A; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Tanner MR; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Lee CM; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley AE; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., De Giorgi M; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Jarrett KE; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Davis TH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Doerfler AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA. Electronic address: gang.bao@rice.edu., Beeton C; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: beeton@bcm.edu., Lagor WR; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: william.lagor@bcm.edu.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2020 Jun 03; Vol. 28 (6), pp. 1432-1441. Date of Electronic Publication: 2020 Apr 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Clustered Regularly Interspaced Short Palindromic Repeats*, CRISPR-Associated Protein 9/*immunology , Dependovirus/*genetics , Gene Editing/*methods , Genetic Vectors/*genetics, Animals ; Biomarkers ; CRISPR-Associated Protein 9/adverse effects ; Gene Expression ; Gene Order ; Hepatocytes/metabolism ; Humans ; Immunization ; Immunologic Memory ; Immunophenotyping ; Mice ; RNA, Guide, CRISPR-Cas Systems ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Transgenes

المؤلفون: Doerfler AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston Texas, USA., Walkey CJ, Lagor WR

المصدر: Current opinion in cardiology [Curr Opin Cardiol] 2020 May; Vol. 35 (3), pp. 242-248.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Lippincott Williams and Wilkins Country of Publication: United States NLM ID: 8608087 Publication Model: Print Cited Medium: Internet ISSN: 1531-7080 (Electronic) Linking ISSN: 02684705 NLM ISO Abbreviation: Curr Opin Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells*, Cardiovascular Diseases/*therapy, Animals ; Gene Editing ; Humans

المؤلفون: Li A; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lee CM; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley AE; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Jarrett KE; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.; Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA., De Giorgi M; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Lu W; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Balderrama KS; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Doerfler AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA., Deshmukh H; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Ray A; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.; Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.

المصدر: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2018 Dec 06; Vol. 12, pp. 111-122. Date of Electronic Publication: 2018 Dec 06 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501 (Print) Linking ISSN: 23290501 NLM ISO Abbreviation: Mol Ther Methods Clin Dev Subsets: PubMed not MEDLINE

المؤلفون: Jarrett KE; From the Department of Molecular Physiology and Biophysics (K.E.J., M.D.G., A.H., A.M.D., W.R.L.).; Integrative Molecular and Biomedical Sciences Graduate Program (K.E.J.), Baylor College of Medicine, Houston, TX., Lee C; Department of Bioengineering, Rice University, Houston, TX (C.L., A.L., G.B.)., De Giorgi M; From the Department of Molecular Physiology and Biophysics (K.E.J., M.D.G., A.H., A.M.D., W.R.L.)., Hurley A; From the Department of Molecular Physiology and Biophysics (K.E.J., M.D.G., A.H., A.M.D., W.R.L.)., Gillard BK; Houston Methodist Research Institute, TX (B.K.G., H.J.P.).; Weill Cornell Medicine, New York (B.K.G., H.J.P.)., Doerfler AM; From the Department of Molecular Physiology and Biophysics (K.E.J., M.D.G., A.H., A.M.D., W.R.L.)., Li A; Department of Bioengineering, Rice University, Houston, TX (C.L., A.L., G.B.)., Pownall HJ; Houston Methodist Research Institute, TX (B.K.G., H.J.P.).; Weill Cornell Medicine, New York (B.K.G., H.J.P.)., Bao G; Department of Bioengineering, Rice University, Houston, TX (C.L., A.L., G.B.)., Lagor WR; From the Department of Molecular Physiology and Biophysics (K.E.J., M.D.G., A.H., A.M.D., W.R.L.).

المصدر: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2018 Sep; Vol. 38 (9), pp. 1997-2006.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Clustered Regularly Interspaced Short Palindromic Repeats* , Disease Models, Animal* , Genetic Vectors*, Atherosclerosis/*genetics , Receptors, LDL/*genetics, Adenoviridae ; Animals ; Atherosclerosis/blood ; CRISPR-Associated Protein 9/genetics ; Female ; Gene Editing ; Gene Expression ; Hypercholesterolemia/blood ; Hypercholesterolemia/genetics ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proprotein Convertase 9/blood ; Proprotein Convertase 9/genetics ; Receptors, LDL/blood