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1
المؤلفون: Krikor Bijian, Dominik Wernic, Anita K. Nivedha, Jie Su, Felicia Phei Lin Lim, Caitlin E. Miron, Hind Amzil, Nicolas Moitessier, Moulay A. Alaoui-Jamali
المصدر: Journal of medicinal chemistry. 65(4)
مصطلحات موضوعية: Antineoplastic Agents, Breast Neoplasms, Hydrogen Bonding, Substrate Specificity, Isoenzymes, Molecular Docking Simulation, Small Molecule Libraries, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Molecular Medicine, Humans, Female, Drug Screening Assays, Antitumor, Selenium Compounds, Protein Kinase Inhibitors, Protein Kinase C, Tumor Stem Cell Assay, Aurora Kinase A
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2
المؤلفون: Steven R. LaPlante, René Coulombe, Thao Trinh, Dominik Wernic, Rebekah J. Carson, Nathalie Rioux, Bruno Simoneau, Catherine Chabot, Youla S. Tsantrizos, Jianmin Duan, Simon Surprenant, Pierre R. Bonneau, Carl Thibeault, Stephen W. Mason, Serge Landry, Craig Fenwick, François Bilodeau, Araz Jakalian, Murray D. Bailey, Stephen H. Kawai, Clint James, Yves Bousquet, Bounkham Thavonekham, Michel Garneau, Eric Beaulieu, Sébastien Morin, Christiane Yoakim, Ted Halmos, Lee Fader, Jennifer Tsoung
المصدر: ACS Medicinal Chemistry Letters. 7:797-801
مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Organic Chemistry, Integrase inhibitor, Biology, Pharmacology, 01 natural sciences, Biochemistry, Desymmetrization, Virus, Chemical space, 0104 chemical sciences, Integrase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Pharmacokinetics, chemistry, Drug Discovery, Pyridine, biology.protein, Potency
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3
المؤلفون: Christian Brochu, James Gillard, Michael Bös, Martin Marquis, Richard Bethell, Gulrez Fazal, George Kukolj, Michel Garneau, Timothy A. Stammers, Paul C. Anderson, Dominik Wernic, Pierre L. Beaulieu, Stephen H. Kawai, Ginette McKercher, Marc-André Poupart, Jianmin Duan, Bounkham Thavonekham, Yves Bousquet, Michael G. Cordingley
المصدر: Journal of Medicinal Chemistry. 57:10130-10143
مصطلحات موضوعية: Indoles, Metabolite, Viral Nonstructural Proteins, Pharmacology, Antiviral Agents, Virus, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, NS5B, Hepatitis C, Hepatitis C, Chronic, RNA-Dependent RNA Polymerase, medicine.disease, Macaca mulatta, Rats, Acrylates, Mechanism of action, chemistry, Tolerability, Cinnamates, Molecular Medicine, medicine.symptom
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4
المؤلفون: Marc Pesant, Christian Brochu, Rebekah J. Carson, Bruno Simoneau, Patricia Schroeder, Murray D. Bailey, Pierre R. Bonneau, Michael G. Cordingley, Catherine Chabot, Michel Garneau, Anne-Marie Faucher, Michael Bös, René Coulombe, Mathieu Parisien, Stephen W. Mason, Araz Jakalian, Jianmin Duan, Marc-André Poupart, Dominik Wernic, Sébastien Morin, François Bilodeau, Serge Landry, Yves Bousquet, Eric Malenfant, Stephen H. Kawai, Punit Bhardwaj, Ma’an Amad, Lee Fader, Youla S. Tsantrizos, Richard Bethell, Christiane Yoakim, Steven R. LaPlante, Paul J. Edwards, Ted Halmos, Craig Fenwick
المصدر: ACS Medicinal Chemistry Letters. 5:422-427
مصطلحات موضوعية: biology, Organic Chemistry, Quinoline, Allosteric regulation, Substituent, Human immunodeficiency virus (HIV), Integrase inhibitor, Metabolic stability, medicine.disease_cause, Biochemistry, Combinatorial chemistry, Integrase, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, biology.protein, Potency
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5
المؤلفون: George Kukolj, Dominik Wernic, Michel Garneau, Jianmin Duan, Laibin Luo, Timothy A. Stammers, Chitra Telang, Josie De Marte, Pierre L. Beaulieu
المصدر: Bioorganicmedicinal chemistry letters. 25(2)
مصطلحات موضوعية: Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Self emulsifying, Administration, Oral, Pharmacology, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Ns5b polymerase, chemistry.chemical_compound, Drug Delivery Systems, Microsomes, Drug Discovery, medicine, Animals, Prodrugs, Polymerase inhibitor, Molecular Biology, NS5B, Nucleic Acid Synthesis Inhibitors, Chemistry, Organic Chemistry, Prodrug, Bioavailability, Rats, stomatognathic diseases, Solubility, Drug delivery, Molecular Medicine, Emulsions
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6
المصدر: Current Biology. 12(16):1368-1378
مصطلحات موضوعية: Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, Proteolysis, Mitosis, Cell Cycle Proteins, Biology, Cleavage (embryo), Models, Biological, Chromosomes, General Biochemistry, Genetics and Molecular Biology, Fungal Proteins, Polyploidy, Endopeptidases, medicine, Animals, Humans, Sister chromatids, Amino Acid Sequence, Enzyme Inhibitors, Separase, Cell Nucleus, Genetics, Molecular Structure, Cohesin, medicine.diagnostic_test, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, Phosphoproteins, Neoplasm Proteins, Cell biology, Enzyme Activation, Securin, Establishment of sister chromatid cohesion, Trans-Activators, RNA Interference, Peptides, General Agricultural and Biological Sciences, Sequence Alignment, HeLa Cells, Protein Binding
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7
المؤلفون: Dominik Wernic, Gulrez Fazal, Vida Gorys, Montse Llinas-Brunet, Ghiro Elise, Diane Thibeault, Marc-André Poupart, Jean Rancourt, Murray D. Bailey, Daniel Lamarre, Ted Halmos, Roger Maurice, Martin Poirier, Sylvie Goulet
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:2267-2270
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Protein Conformation, Swine, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Peptide, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, Cathepsin B, Structure-Activity Relationship, chemistry.chemical_compound, Non-competitive inhibition, Drug Discovery, Peptide synthesis, Animals, Chymotrypsin, Humans, Proline, Molecular Biology, Serine protease, chemistry.chemical_classification, Pancreatic Elastase, biology, Tetrapeptide, Chemistry, Serine Endopeptidases, Organic Chemistry, Kinetics, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Leukocyte Elastase, Oligopeptides
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8
المؤلفون: Pierre Lavallee, Dominik Wernic, Jean-Simon Duceppe, Pierre L. Beaulieu, James Gillard, Christian Beaulieu, Murray D. Bailey
المصدر: The Journal of Organic Chemistry. 64:6622-6634
مصطلحات موضوعية: chemistry.chemical_compound, Hydrolysis, Orally active, Enzyme catalyzed, Chemistry, medicine.drug_class, Succinic acid, Stereochemistry, Organic Chemistry, medicine, Stereoselectivity, Renin inhibitor
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9
المؤلفون: Jean Rancourt, Kirrane Thomas M, Rajiv Sharma, Martin Poirier, John R. Proudfoot, Susan Lukas, Montse Llinas-Brunet, Usha R. Patel, Dominik Wernic, Alisa K. Kabcenell, Pierre L. Beaulieu, Neil Moss, Scott Jakes, Vida Gorys, Jean Gauthier, Mario G. Cardozo, Liang Tong, Eugene R. Hickey, Dale R. Cameron, Jean-Marie Ferland, Raj Betageri, Richard H. Ingraham, James Gillard, Ghiro Elise
المصدر: Journal of Medicinal Chemistry. 42:1757-1766
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Dipeptide, Stereochemistry, Peptide, Dipeptides, Crystallography, X-Ray, Ligands, Ligand (biochemistry), SH2 domain, src Homology Domains, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Drug Discovery, Molecular Medicine, Moiety, Structure–activity relationship, Phosphorylation, Tyrosine kinase, Protein Binding
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10
المؤلفون: Martin Poirier, Marc-André Poupart, Diane Thibeault, Sylvie Goulet, Steven R. LaPlante, Montse Llinas-Brunet, Ted Halmos, Roger Maurice, Dominik Wernic, Gulrez Fazal, Murray D. Bailey, Daniel Lamarre
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:1713-1718
مصطلحات موضوعية: Serine Proteinase Inhibitors, Stereochemistry, viruses, medicine.medical_treatment, Molecular Sequence Data, Clinical Biochemistry, Pharmaceutical Science, Peptide, Hepacivirus, Biochemistry, Substrate Specificity, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Peptide synthesis, medicine, Amino Acid Sequence, Molecular Biology, Serine protease, chemistry.chemical_classification, NS3, Protease, biology, Serine Endopeptidases, Organic Chemistry, NS2-3 protease, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Oligopeptides