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المؤلفون: Malcolm Boyce, Aili L. Lazaar, Donald C. Carpenter, Joanne Bal, Teresa Heslop, Bruce E. Miller, Nigel Dallow, Alison Churchill, Ruth J. Mayer, Navin Goyal
المصدر: British journal of clinical pharmacology. 83(12)
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Proteases, Time Factors, Administration, Oral, Cathepsin G, Pharmacology, Cathepsin C, Drug Administration Schedule, Desquamation, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Pharmacokinetics, Drug Safety, Proteinase 3, medicine, Humans, Pharmacology (medical), Protease Inhibitors, Whole blood, Skin, Cross-Over Studies, biology, Dose-Response Relationship, Drug, Epithelial Cells, Dipeptides, Middle Aged, Healthy Volunteers, 030104 developmental biology, Treatment Outcome, chemistry, 030220 oncology & carcinogenesis, Neutrophil elastase, Immunology, biology.protein, medicine.symptom
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المؤلفون: Ruth J. Mayer, Michael Salmon, Miriam Burman, Donald C. Carpenter, Jakob Busch-Petersen, John Yonchuk, David J. Kilian, James J. Foley, Gerald E. Hunsberger, Ruth Tal-Singer
المصدر: The Journal of pharmacology and experimental therapeutics. 362(2)
مصطلحات موضوعية: 0301 basic medicine, Male, CHO Cells, Pharmacology, Receptors, Interleukin-8B, 03 medical and health sciences, 0302 clinical medicine, Cricetulus, Piperidines, Cricetinae, Animals, Humans, CXC chemokine receptors, Interleukin 8, Sulfones, Receptor, Dose-Response Relationship, Drug, Chemistry, Interleukin-8, Antagonist, Chemotaxis, Rats, CXCL1, CXCL2, 030104 developmental biology, Biochemistry, Competitive antagonist, Rats, Inbred Lew, 030220 oncology & carcinogenesis, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653c1590be6e82e88b8bc4de3ebcf433
https://pubmed.ncbi.nlm.nih.gov/28611093 -
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المؤلفون: Michael S. McQueney, Roy A. Johanson, Elizabeth A. Capper-Spudich, Josephine H. Fox, Patricia L. Podolin, John J. Peterson, Robert W. Marquis, Edit Kurali, T. Gregg Davis, Dennis S. Yamashita, Stephen M. LoCastro, Gerald J. Terfloth, Brian R. Smith, Donald C. Carpenter, Edward Long, Xiaoyang Dong, Brian Bolognese
المصدر: The Journal of Immunology. 180:7989-8003
مصطلحات موضوعية: Male, Encephalomyelitis, Autoimmune, Experimental, Pyridines, Encephalomyelitis, T cell, Immunology, Cysteine Proteinase Inhibitors, Lymphocyte Activation, Mice, Antigen, Leucine, Cell Line, Tumor, MHC class I, medicine, Splenocyte, Animals, Humans, Immunology and Allergy, Collagen Type II, Cells, Cultured, Benzofurans, Mice, Knockout, biology, Chemistry, Experimental autoimmune encephalomyelitis, Histocompatibility Antigens Class II, Azepines, medicine.disease, Arthritis, Experimental, Cathepsins, Molecular biology, Raji cell, Antigens, Differentiation, B-Lymphocyte, Mice, Inbred C57BL, medicine.anatomical_structure, Mice, Inbred DBA, Cell culture, biology.protein, Cattle, Female, Protein Processing, Post-Translational, Spleen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88df259ac244132f833d3d9196e414fd
https://doi.org/10.4049/jimmunol.180.12.7989 -
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المؤلفون: Henry M. Sarau, Michael Salmon, Trevor T. Hansel, Ruth Tal-Singer, Rupert Vessey, Rachel C. Tennant, Donald C. Carpenter, Grant C. Nicholson, Peter J. Barnes, Onn Min Kon
المصدر: Pulmonary Pharmacology & Therapeutics. 20:52-59
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, CCR2, Chemokine, Neutrophils, Receptor expression, Lipopolysaccharide Receptors, CD16, GPI-Linked Proteins, Monocytes, Receptors, Interleukin-8B, Chemokine Receptor Antagonist, Pulmonary Disease, Chronic Obstructive, Chemokine receptor, Antigens, CD, medicine, Humans, Pharmacology (medical), CXC chemokine receptors, Cell Shape, CD11b Antigen, Dose-Response Relationship, Drug, biology, Chemistry, Monocyte, Interleukin-8, Receptors, IgG, Biochemistry (medical), Reproducibility of Results, Flow Cytometry, Chemokine CXCL11, Up-Regulation, Cell biology, medicine.anatomical_structure, biology.protein, Chemokines, CXC
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المؤلفون: Hugh M Davis, Wenyu Zhang, Donald C. Carpenter, Jocelyn M Stahl, Don E Griswold, Weslia P Hynicka
المصدر: Journal of Immunological Methods. 240:125-132
مصطلحات موضوعية: Lipopolysaccharides, Male, Integrins, Granulocyte activation, Lipopolysaccharide, Neutrophils, Pyridines, Immunology, Receptors, Leukotriene B4, Macrophage-1 Antigen, Inflammation, Granulocyte, Binding, Competitive, Leukotriene B4, Leukotriene D4, Flow cytometry, chemistry.chemical_compound, Adjuvants, Immunologic, medicine, Humans, Immunology and Allergy, Whole blood, biology, medicine.diagnostic_test, Flow Cytometry, N-Formylmethionine Leucyl-Phenylalanine, medicine.anatomical_structure, Acrylates, chemistry, Integrin alpha M, biology.protein, Biomarker (medicine), medicine.symptom
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المؤلفون: Joseph P. Foley, Donald C. Carpenter, Oliver J. Harrison, Gregory A. Logan, Patrick T. Walsh, Brian Bolognese, Edward Long, Patricia L. Podolin
المصدر: American journal of physiology. Lung cellular and molecular physiology. 304(5)
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, CD4-Positive T-Lymphocytes, Physiology, medicine.medical_treatment, Pulmonary disease, Gene Expression, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Lymphocyte Depletion, Mice, Pulmonary Disease, Chronic Obstructive, Physiology (medical), Medicine, Cigarette smoke, Animals, Caspase 7, Immunosuppression Therapy, COPD, business.industry, Caspase 3, Interleukin-17, Smoking, Lung volume measurement, T-cell depletion, Immunosuppression, Cell Biology, Cigarette smoke exposure, medicine.disease, Mice, Inbred C57BL, Pulmonary Alveoli, Disease Models, Animal, Neutrophil Infiltration, Immunology, Lymphocyte activation, Cyclosporine, Female, Tobacco Smoke Pollution, business, Lung Volume Measurements
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fea2c57006f0c7ee64934a4639ae52c
https://pubmed.ncbi.nlm.nih.gov/23292810 -
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المؤلفون: Betsy M. Ohlsson-Wilhelm, Donald C. Carpenter, Katharine A. Muirhead, Brian D. Gray, Margaret Anne Baker
المصدر: Journal of Controlled Release. 40:89-100
مصطلحات موضوعية: In vivo, Chemistry, Pharmaceutical Science, Biological activity, Prodrug, Pharmacology, Cytotoxicity, Controlled release, Intracellular, In vitro, Conjugate
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المؤلفون: Jeffrey K. Kerns, Widdowson Katherine L, Patricia L. Podolin, Paul M. Keller, Benoit Riflade, Neysa Nevins, Attiq Rahman, Dennis S. Yamashita, Qi Jin, Bondinell William E, Thaddeus A. Tomaszek, Xiaoyang Dong, Laura Mitchell, Hong Nie, Donald C. Carpenter
المصدر: Bioorganicmedicinal chemistry letters. 21(15)
مصطلحات موضوعية: Niacinamide, Stereochemistry, Cathepsin L, Clinical Biochemistry, Cathepsin K, Substituent, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cathepsin O, Drug Discovery, Structure–activity relationship, Humans, Computer Simulation, Protease Inhibitors, Molecular Biology, Cathepsin S, Alanine, Binding Sites, Nicotinamide, biology, Chemistry, Organic Chemistry, Stereoisomerism, Azepines, Cathepsins, biology.protein, Molecular Medicine, Selectivity
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المؤلفون: Jackie C. Bloomer, Ruth Tal-Singer, Kevin Smart, Aili L. Lazaar, Donald C. Carpenter, Hiran Cooray, Bruce E. Miller, Sunil Mistry, Paul Connolly
المصدر: BMC Pharmacology & Toxicology
مصطلحات موضوعية: musculoskeletal diseases, Danirixin, Adult, Male, Adolescent, Neutrophils, Chemokine CXCL1, Pharmacology, Receptors, Interleukin-8B, Chemokine receptor, Young Adult, Pharmacokinetics, Double-Blind Method, Piperidines, Medicine, Humans, Pharmacology (medical), CXC chemokine receptors, Sulfones, Receptor, Aged, CD11b Antigen, Dose-Response Relationship, Drug, business.industry, Chronic obstructive pulmonary disease, Anti-Inflammatory Agents, Non-Steroidal, Antagonist, Age Factors, hemic and immune systems, GSK1325756, respiratory system, Middle Aged, biological factors, Extravasation, Healthy Volunteers, respiratory tract diseases, Pharmacodynamics, Food, Immunology, CXCR2 antagonist, Antagonism, business, Omeprazole, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe2a31799f8eb48241832cd8640cee5