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1
المؤلفون: David Maag, Eric F. Johnson, Donald J. Osterling, DeAnne F. Stolarik, Amanda M. Olson, Wenqing Gao, Julie L. Wilsbacher, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Larry R. Solomon, Luis E. Rodriguez, Yan Shi, Todd A. Hopkins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcfa08a35c000c13a490792d1596a75
https://doi.org/10.1158/1541-7786.22514481.v1 -
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المؤلفون: Andrew J. Souers, Wei Qiu, Thomas D. Penning, Darren C. Phillips, Xiaoqin Liu, Rick F. Clark, Joel D. Leverson, Amanda M. Olson, Chunqiu Lai, Daniel H. Albert, Gui-Dong Zhu, Yunsong Tong, Peter Kovar, Kenton L. Longenecker, Anthony Mastracchio, Morey L. Smith, Bailin Shaw, Alan S. Florjancic, Stephen K. Tahir, Donald J. Osterling
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Serine, In vivo, Oral administration, Chemistry, Kinase, Organic Chemistry, Drug Discovery, Toxicity, Cyclin-dependent kinase 9, Dosing, Pharmacology, Pharmacophore, Biochemistry
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3دورية أكاديمية
المؤلفون: William N Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Donald J Osterling, Wenqing Gao, Julie K Spence, Marina Pliushchev, Ramzi F Sweis, Fritz G Buchanan, Michael R Michaelides, Alexander R Shoemaker, Chris Tse, Gary G Chiang
المصدر: PLoS ONE, Vol 10, Iss 7, p e0131716 (2015)
وصف الملف: electronic resource
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المؤلفون: Niraj S. Trasi, Hitesh S. Purohit, Geoff G. Z. Zhang, Lynne S. Taylor, Wenqing Gao, DeAnne Stolarik, Gary J. Jenkins, Donald J. Osterling
المصدر: Molecular Pharmaceutics. 16:3617-3625
مصطلحات موضوعية: Male, Drug, Materials science, Chemistry, Pharmaceutical, media_common.quotation_subject, Administration, Oral, Biological Availability, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, Tacrolimus, law.invention, 03 medical and health sciences, Dogs, 0302 clinical medicine, X-Ray Diffraction, law, In vivo, Drug Discovery, Animals, Crystallization, Absorption (electromagnetic radiation), media_common, Water, 021001 nanoscience & nanotechnology, Amorphous solid, Solubility, Therapeutic Equivalency, Chemical engineering, Gastrointestinal Absorption, Area Under Curve, Molecular Medicine, Female, sense organs, 0210 nano-technology
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المؤلفون: Gary J. Jenkins, Donald J. Osterling, Lynne S. Taylor, Xiaochun Lou, Geoff G. Z. Zhang, DeAnne Stolarik, Wenqing Gao, Venecia R Wilson
المصدر: Journal of Controlled Release. 292:172-182
مصطلحات موضوعية: Male, Pharmaceutical Science, Antineoplastic Agents, 02 engineering and technology, 030226 pharmacology & pharmacy, Intestinal absorption, law.invention, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, law, Phase (matter), Nitriles, Phenylthiohydantoin, Animals, Crystallization, Solubility, Dissolution, Supersaturation, Chemistry, Biological Transport, Membranes, Artificial, 021001 nanoscience & nanotechnology, Amorphous solid, Drug Liberation, Intestinal Absorption, Chemical engineering, Benzamides, Absorption (chemistry), 0210 nano-technology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6145825f799fad5800cb4cf8ca6c0405
https://doi.org/10.1016/j .jconrel.2018.11.003 -
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المؤلفون: Geoff G. Z. Zhang, Kevin J. Edgar, Venecia R Wilson, Brittany L.B. Nichols, Xiaochun Lou, Gary J. Jenkins, Yifan Dong, Lynne S. Taylor, DeAnne Stolarik, Donald J. Osterling
المساهمون: Chemistry, Sustainable Biomaterials
المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reportsمصطلحات موضوعية: Male, PHARMACOKINETICS, IMPACT, BIOAVAILABILITY, Polymers, lcsh:Medicine, DISSOLUTION PERFORMANCE, 02 engineering and technology, 030226 pharmacology & pharmacy, CELLULOSE OMEGA-CARBOXYESTERS, law.invention, Rats, Sprague-Dawley, Drug Delivery Systems, 0302 clinical medicine, amorphous solid dispersion, law, crystallization kinetics, Pharmacology & Pharmacy, Solubility, Crystallization, lcsh:Science, media_common, chemistry.chemical_classification, Multidisciplinary, Polymer, 021001 nanoscience & nanotechnology, Benzamides, polymer-drug interaction, CRYSTALLIZATION, 0210 nano-technology, SUPERSATURATION, Hydrophobic and Hydrophilic Interactions, Drug, media_common.quotation_subject, Drug development, Absorption (skin), Article, drug-rich nanodroplet, 03 medical and health sciences, Pharmacokinetics, Polysaccharides, In vivo, Nitriles, Phenylthiohydantoin, WATER-SOLUBLE DRUG, Animals, lcsh:R, Water, IN-VITRO, Combinatorial chemistry, Rats, Bioavailability, chemistry, CLASSIFICATION-SYSTEM, lcsh:Q
وصف الملف: 12 page(s); application/pdf
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المؤلفون: Philip J. Merta, Amanda M. Olson, Fritz G. Buchanan, Nirupama B. Soni, Donald J. Osterling, Alan S. Florjancic, Debra Ferguson, David Maag, Eric F. Johnson, Yunsong Tong, Alexander R. Shoemaker, Maricel Torrent, Kenneth D. Bromberg, Thomas D. Penning, Loren M. Lasko
المصدر: ACS Medicinal Chemistry Letters. 6:58-62
مصطلحات موضوعية: chemistry.chemical_classification, Molecular model, biology, Pyrimidine, Chemistry, Kinase, Organic Chemistry, Pharmacology, Biochemistry, Wee1, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, biology.protein, Pharmacophore, Cytotoxicity, Tricyclic
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المؤلفون: Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu
المصدر: Nature chemical biology. 13(4)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein subunit, Allosteric regulation, Antineoplastic Agents, macromolecular substances, Protein–protein interaction, 03 medical and health sciences, Histone H3, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Tumor Cells, Cultured, Gene silencing, Humans, Epigenetics, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, Polycomb Repressive Complex 2, Cell Biology, 030104 developmental biology, Enzyme, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein, Drug Screening Assays, Antitumor, PRC2, Protein Binding
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المؤلفون: Patrick A. Marcotte, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, David R. Reuter, Junling Li, Yanping Luo, Lori J. Pease, Chris Tse, Terrance J. Magoc, Ru-Qi Wei, Paul Tapang, Eric F. Johnson, Cherrie K. Donawho, Zehan Chen, Amanda M. Olson, Donald J. Osterling, Daniel H. Albert, Michael L. Curtin, Keith B. Glaser, Jennifer J. Bouska, Mai H. Bui, Robin R. Frey
المصدر: Journal of Pharmacology and Experimental Therapeutics. 343:617-627
مصطلحات موضوعية: Male, Time Factors, Aminopyridines, Antineoplastic Agents, Mice, SCID, Protein Serine-Threonine Kinases, Histones, Mice, chemistry.chemical_compound, Growth factor receptor, Aurora Kinases, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, Animals, Aurora Kinase B, Humans, Receptors, Platelet-Derived Growth Factor, Pharmacology, Mice, Inbred BALB C, Leukemia, Experimental, Dose-Response Relationship, Drug, Molecular Structure, biology, Phenylurea Compounds, Autophosphorylation, Xenograft Model Antitumor Assays, Molecular biology, Vascular endothelial growth factor, Vascular endothelial growth factor A, Receptors, Vascular Endothelial Growth Factor, src-Family Kinases, chemistry, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ff4def0b6e7aabec77986594da503f
https://doi.org/10.1124/jpet.112.197087 -
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المؤلفون: Cherrie K. Donawho, Jennifer J. Bouska, Chang Park, Yan Luo, Yan Shi, Xuesong Liu, Eric F. Johnson, Donald J. Osterling, Thomas D. Penning, Paul Ellis, Vincent L. Giranda, Jianchun Gong, Alexander R. Shoemaker, Viraj B. Gandhi, Gui-Dong Zhu, Amanda M. Olson
المصدر: Bioorganic & Medicinal Chemistry. 20:4635-4645
مصطلحات موضوعية: Models, Molecular, Pyridines, Clinical Biochemistry, Poly (ADP-Ribose) Polymerase-1, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Crystallography, X-Ray, Biochemistry, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Temozolomide, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, Cancer, Neoplasms, Experimental, medicine.disease, Xenograft Model Antitumor Assays, Mice, Inbred C57BL, Pyridazines, Enzyme, PARP inhibitor, Molecular Medicine, Female, Poly(ADP-ribose) Polymerases, medicine.drug
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