-
1
المؤلفون: Donald William Ludovici, Gilles Bignan, Carsten Schubert, Erwin Fraiponts, Karine Smans, Norbert Esser, Danielle Peeters, Michael H. Parker, Maxwell D. Cummings, Peter Vermeulen, Lieven Meerpoel, Sabine De Breucker, Tianbao Lu, Luc Van Nuffel, Richard Alexander, Bruce L. Grasberger, James R. Bischoff, Christian Rocaboy, Ron Gilissen, Christophe Meyer, Boudewijn Janssens, Peter J. Connolly
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2159-2164
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell type, Oral treatment, Clinical Biochemistry, Cancer therapy, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Oral administration, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Imidazoles, Cancer, Neoplasms, Experimental, medicine.disease, Bioavailability, Fatty Acid Synthase, Type I, Fatty acid synthase, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Pharmacodynamics, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor
-
2
المؤلفون: Scott L. Dax, Mingde Xia, Dennis J. Stone, Xiaoqing Xu, Bin Zhu, Donald William Ludovici, Matthews Jay M, Mark A. Youngman, Tasha L. Hutchinson, Michael R. Brandt, Christopher M. Flores, Mary Lou Lubin, Mark J. Macielag, Raymond W. Colburn, Ning Qin, Manomi A. Tennakoon
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2234-2237
مصطلحات موضوعية: Clinical Biochemistry, Cell, Glycine, TRPM Cation Channels, Pharmaceutical Science, Stereoisomerism, Pyrimidinones, Pharmacology, Biochemistry, Structure-Activity Relationship, Transient receptor potential channel, In vivo, Drug Discovery, TRPM8, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Behavior, Animal, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, In vitro, Rats, HEK293 Cells, medicine.anatomical_structure, Molecular Medicine, Antagonism
-
3
المؤلفون: Paul L. Boyer, H. Maarten Vinkers, Robert W. Kavash, Marie Pierre de Béthune, Eddy Arnold, Patrick K. Clark, Jan Heeres, Donald William Ludovici, Paul A. J. Janssen, Lucien Maria Henricus Koymans, Michael J. Kukla, Koen Andries, Mark A. Lichtenstein, Rudi Pauwels, Paul J. Lewi, Bart De Corte, Chih Y. Ho, Hong Ye, Marc René De Jonge, Kalyan Das, Arthur D. Clark, Frederik Frans Desire Daeyaert, Stephen H. Hughes
المصدر: Journal of medicinal chemistry
مصطلحات موضوعية: Models, Molecular, Anti-HIV Agents, Protein Conformation, Stereochemistry, Etravirine, Crystallography, X-Ray, Nucleoside Reverse Transcriptase Inhibitor, chemistry.chemical_compound, Protein structure, Drug Resistance, Viral, Nitriles, Drug Discovery, medicine, Diarylpyrimidines, Reverse-transcriptase inhibitor, biology, Chemistry, Wild type, HIV Reverse Transcriptase, Pyridazines, Discovery and development of non-nucleoside reverse-transcriptase inhibitors, Pyrimidines, Enzyme inhibitor, Mutation, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, medicine.drug
-
4
المؤلفون: Marc René De Jonge, Paul J. Lewis, A.D. Clark Jr, Frits Daeyaert, Stephen H. Hughes, Chih Ho, Koen Andries, Luc Koymans, Paul L. Boyer, Eddy Arnold, Donald William Ludovici, Robert W. Kavash, Jan Heeres, Paul A. J. Janssen, Maarten Vinkers, Bart De Corte, Kalyan Das, Marie-Pierre de Béthune, Mike Kukla, Rudi Pauwels
المصدر: Journal of Computer-Aided Molecular Design. 17:129-134
مصطلحات موضوعية: Mutation, Molecular model, Chemistry, Ligand, Stereochemistry, A protein, Plasma protein binding, medicine.disease_cause, Computer Science Applications, Protein structure, Drug Discovery, medicine, Molecule, Physical and Theoretical Chemistry, Binding site
-
5
المؤلفون: Bart De Corte, Hong Ye, Chih Y. Ho, Donald William Ludovici, Marc René De Jonge, Hilde Azijn, Paul J. Lewi, Michael J. Kukla, Paul Adriaan Jan Janssen, Mark A. Lichtenstein, Lucien Maria Henricus Koymans, Koen Jeanne Alfons Van Aken, Edward Arnold, Rudi Pauwels, Marie Pierre de Béthune, Frederik Frans Desire Daeyaert, Robert W. Kavash, Koen Andries, Jan Heeres, Kalyan Das
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:2235-2239
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Human immunodeficiency virus (HIV), Pharmaceutical Science, medicine.disease_cause, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Nitriles, Drug Discovery, medicine, Anti-hiv drugs, Inhibitory concentration 50, Structure–activity relationship, Molecular Biology, Diarylpyrimidines, biology, Chemistry, Organic Chemistry, virus diseases, biology.organism_classification, Virology, HIV Reverse Transcriptase, Reverse transcriptase, Pyrimidines, Mutation, Lentivirus, HIV-1, Reverse Transcriptase Inhibitors, Molecular Medicine
-
6
المؤلفون: Danielle Peeters, Michael H. Parker, Donald William Ludovici, Christophe Meyer, Richard Alexander, Bruce L. Grasberger, S. de Breucker, Christian Rocaboy, Norbert Esser, Lieven Meerpoel, Tianbao Lu, Ronaldus Arnodus Hendrika Joseph Gilissen, Maxwell D. Cummings, Peter J. Connolly, James R. Bischoff, Gilles Bignan, Erwin Fraiponts, Boudewijn Janssens, Karine Smans, Carsten Schubert
المصدر: European Journal of Cancer. 50:141-142
مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Stereochemistry, Domain (software engineering)
-
7
المؤلفون: Lieven Meerpoel, Gilles Bignan, Luc Van Nuffel, Peter Vermeulen, Ron Gilissen, Tianbao Lu, Max Cummings, Christophe Meyer, Bruce L. Grasberger, Peter J. Connolly, Michael H. Parker, Erwin Fraiponts, Richard Alexander, Karine Smans, Boudewijn Janssens, Danielle Peeters, Norbert Esser, Donald William Ludovici, Carsten Schubert, James R. Bischoff, Sabine De Breucker
المصدر: Cancer Research. 74:4747-4747
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, Cell growth, Chemistry, Cancer, Pharmacology, medicine.disease, medicine.disease_cause, Fatty acid synthase, Enzyme, Oncology, Apoptosis, Cancer cell, medicine, biology.protein, Carcinogenesis, IC50
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbc77f2de582fc793cad2cd350548d6d
https://doi.org/10.1158/1538-7445.am2014-4747 -
8
المؤلفون: Lieven Meerpoel, James R. Bischoff, Carsten Schubert, Boudewijn Janssen, Geert Van Hecke, Erwin Fraiponts, Karine Smans, Luc Van Nuffel, Sabine De Breucker, Tianbao Lu, Michael H. Parker, Danielle Peeters, Yolanda T. Chong, Bruce L. Grasberger, Peter Vermeulen, Christophe Meyer, Ralph Graeser, Gilles Bignan, Suzana Vidic, Norbert Esser, Donald William Ludovici, Ron Gilissen, Peter J. Connolly
المصدر: Cancer Research. 74:801-801
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, biology, Chemistry, Cancer, medicine.disease, Molecular biology, Fatty acid synthase, Endocrinology, Oncology, Growth factor receptor, In vivo, Cell culture, Internal medicine, Cancer cell, LNCaP, medicine, biology.protein, Lipid raft
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4a8ba06d36370068648ff2c8bc5179
https://doi.org/10.1158/1538-7445.am2014-801 -
9
المؤلفون: Carsten Schubert, Ron Gilissen, Bruce L. Grasberger, Christophe Meyer, Peter J. Connolly, Sabine De Breucker, Luc Van Nuffel, Norbert Esser, James R. Bischoff, Michael H. Parker, Donald William Ludovici, Erwin Fraiponts, Boudewijn Janssens, Danielle Peeters, Karine Smans, Tianbao Lu, Peter Vermeulen, Lieven Meerpoel, Gilles Bignan
المصدر: Cancer Research. 74:2535-2535
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, In vitro, Palmitic acid, chemistry.chemical_compound, Fatty acid synthase, Enzyme, Oncology, Biochemistry, Biosynthesis, chemistry, In vivo, Cell culture, biology.protein, IC50
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5984cccf305d5033564ca0577f95f99e
https://doi.org/10.1158/1538-7445.am2014-2535 -
10
المؤلفون: Hilde Azijn, Michael J. Kukla, Bart De Corte, Hong Ye, Kalyan Das, Lucien Maria Henricus Koymans, Koen Jeanne Alfons Van Aken, Paul Adriaan Jan Janssen, Chih Y. Ho, Robert W. Kavash, Rudi Pauwels, Jan Heeres, Marie-Pierre de Béthune, Edward Arnold, Frederik Frans Desire Daeyaert, Paul J. Lewi, Marc René De Jonge, Henry E.L. Moereels, Donald William Ludovici, Koen Andries
المصدر: Bioorganicmedicinal chemistry letters. 11(17)
مصطلحات موضوعية: Stereochemistry, Anti-HIV Agents, Clinical Biochemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, medicine.disease_cause, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Anti-hiv drugs, medicine, Molecular Biology, Diarylpyrimidines, Triazines, Organic Chemistry, virus diseases, Reverse transcriptase, HIV Reverse Transcriptase, chemistry, Drug Design, HIV-1, Molecular Medicine, Reverse Transcriptase Inhibitors