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1
المؤلفون: Samuel L. Graham, Joseph G. Bruno, Scott D. Mosser, Harold G. Selnick, Sandra M. Sanabria-Bohórquez, Christopher A. Salvatore, Rebecca B. White, Melody Mcwherter, Hong Fan, Mangay Williams, Jacquelynn J. Cook, Kerry Riffel, Richard Hargreaves, Ian M. Bell, Craig A. Stump, Eric L. Moore, Liza Gantert, Steven N. Gallicchio, Mona Purcell, C. Blair Zartman, Amanda L. Kemmerer, Eric D. Hostetler, Donnette D. Staas, Stefanie A. Kane
المصدر: ACS Medicinal Chemistry Letters. 4:863-868
مصطلحات موضوعية: chemistry.chemical_classification, medicine.diagnostic_test, business.industry, medicine.drug_class, Organic Chemistry, Peptide, Calcitonin gene-related peptide, Receptor antagonist, Biochemistry, Combinatorial chemistry, Molecular biology, Calcitonin gene-related peptide receptor antagonist, chemistry, In vivo, Positron emission tomography, Calcitonin, TRACER, Drug Discovery, medicine, business
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2
المؤلفون: Samuel L. Graham, Christine Fandozzi, Eric L. Moore, Donnette D. Staas, Ian M. Bell, Nova Sain, Joseph G. Bruno, Steven N. Gallicchio, Harold G. Selnick, Christopher A. Salvatore, Mark O. Urban, Rebecca B. White, Matthew M. Zrada, Amy Calamari, C. Blair Zartman, Amanda L. Kemmerer, Joseph P. Vacca, Stefanie A. Kane, Craig A. Stump, Scott D. Mosser
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3941-3945
مصطلحات موضوعية: medicine.medical_specialty, Pyridines, Migraine Disorders, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Calcitonin gene-related peptide, Pharmacology, Biochemistry, Mice, chemistry.chemical_compound, Dogs, Species Specificity, Calcitonin Gene-Related Peptide Receptor Antagonists, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Spiro Compounds, Receptor, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, Antagonist, Macaca mulatta, Rats, Blockade, Disease Models, Animal, Endocrinology, Pharmacodynamics, Molecular Medicine, Acetamide, Receptors, Calcitonin Gene-Related Peptide
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3
المؤلفون: Antonella Converso, Greg O’Donnell, Jixin Wang, Ming-Tain Lai, Kelli Solly, Wei Lemaire, Michael F.A. Finley, Mark E. Layton, Michelle K. Clements, Richard L. Kraus, Donnette D. Staas, Jason Cassaday, Tony Kreamer, Xinnian Li, Sean P. Cook, Chris Daley
المصدر: Journal of biomolecular screening. 21(5)
مصطلحات موضوعية: 0301 basic medicine, Pain, Nav1.5, Pharmacology, 01 natural sciences, Biochemistry, Analytical Chemistry, Membrane Potentials, NAV1.5 Voltage-Gated Sodium Channel, 03 medical and health sciences, Paroxysmal extreme pain disorder, medicine, Humans, Molecular Targeted Therapy, Membrane potential, Neurons, biology, Chemistry, Sodium channel, NAV1.7 Voltage-Gated Sodium Channel, Area under the curve, Rectum, medicine.disease, 0104 chemical sciences, High-Throughput Screening Assays, 010404 medicinal & biomolecular chemistry, Electrophysiology, Kinetics, 030104 developmental biology, NAV1, Neuropathic pain, biology.protein, Molecular Medicine, Neuralgia, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e333e0768a580b7c4fb09601f949b433
https://pubmed.ncbi.nlm.nih.gov/26861708 -
4
المؤلفون: Joseph P. Vacca, Linghang Zhuang, Lori J. Gabryelski, Terry A. Lyle, William A. Schleif, Peter J. Felock, Boyoung Kim, Lixia Jin, I.-W. Chen, Donnette D. Staas, Chris Culberson, Steven D. Young, Daria J. Hazuda, Thorsten E. Fisher, John S. Wai, Peter D. Williams, Mark Embrey, Rama Mallai, Joan D. Ellis
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5595-5599
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Integrase inhibitor, Virus Replication, Biochemistry, Cell Line, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, HIV Integrase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, HIV, Benzene, biology.organism_classification, In vitro, Rats, Integrase, Enzyme, chemistry, Viral replication, Enzyme inhibitor, Pyrazines, Lentivirus, Microsomes, Liver, biology.protein, Molecular Medicine
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5
المؤلفون: Vanessa L. Sherman, M. Reza Anari, Catherine M. Wiscount, Julie A. Krueger, Christopher J. Kochansky, Bobby J. Lucas, Tran Lekhanh O, Joseph P. Vacca, Terry A. Lyle, Bradley K. Wong, Sanderson Philip E, Heidi L. Shimp, Peter D. Williams, Sean Yu, Donnette D. Staas, Kelly L. Savage, S. Dale Lewis, Rebecca B. White, Youwei Yan, Daniel R. McMasters
المصدر: Bioorganic & Medicinal Chemistry. 14:6900-6916
مصطلحات موضوعية: Models, Molecular, Proline, Protein Conformation, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Tripeptide, In Vitro Techniques, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Drug Discovery, medicine, Humans, Potency, Trypsin, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Dipeptide, biology, Organic Chemistry, Stereoisomerism, Protein Structure, Tertiary, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Discovery and development of direct thrombin inhibitors, medicine.drug
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6
المؤلفون: Linda T. Ecto, Carolyn Bahnck, Theresa M. Booth, Amy L. Himmelberger, John S. Wai, Renee Hrin, Rowena D. Ruzek, Donnette D. Staas, Jessica A. Flynn, Jay A. Grobler, Kara A. Stillmock, Joseph P. Vacca, Marc V. Witmer, Peter D. Williams, Daniel J. DiStefano, Shankar Venkatraman, Terry A. Lyle, Michael D. Miller, Daria J. Hazuda, Bradley P. Feuston, Geetha Dornadula, H. Marie Loughran
المصدر: Bioorganicmedicinal chemistry letters. 20(22)
مصطلحات موضوعية: Anti-HIV Agents, Clinical Biochemistry, Ribonuclease H, Human immunodeficiency virus (HIV), Pharmaceutical Science, medicine.disease_cause, Biochemistry, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Naphthyridines, RNase H, Cytotoxicity, Molecular Biology, biology, Chemistry, Organic Chemistry, Active site, Molecular biology, Reverse transcriptase, Integrase, Viral replication, biology.protein, HIV-1, Molecular Medicine, HeLa Cells
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7
المؤلفون: Donnette D. Staas, Daniel V. Paone
المصدر: Expert opinion on therapeutic patents. 19(12)
مصطلحات موضوعية: Drug Industry, Migraine Disorders, Population, Triptans, Pharmacology, Calcitonin gene-related peptide, Olcegepant, Piperazines, Patents as Topic, Calcitonin gene-related peptide receptor antagonist, Calcitonin Gene-Related Peptide Receptor Antagonists, Drug Discovery, medicine, Animals, Humans, education, education.field_of_study, Telcagepant, business.industry, Imidazoles, General Medicine, Azepines, Dipeptides, medicine.disease, Migraine, Calcitonin, Drug Design, Quinazolines, business, medicine.drug, Receptors, Calcitonin Gene-Related Peptide
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8
المؤلفون: Lori J. Gabryelski, Mark Embrey, Thorsten E. Fisher, Alysha M. Day, Linda T. Ecto, John S. Wai, Christopher J. Kochansky, Donnette D. Staas, Carl F. Homnick, Catherine M. Wiscount, Kara A. Stillmock, Michael D. Miller, Joseph P. Vacca, Tran Lekhanh O, Daria J. Hazuda, Peter J. Felock, Vanessa L. Sherman, Terry A. Lyle, M. Reza Anari, ZiQiang Wang, Daniel J. DiStefano, Peter D. Williams, William A. Schleif, Marc V. Witmer
المصدر: Bioorganicmedicinal chemistry letters. 18(16)
مصطلحات موضوعية: Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Integrase inhibitor, Administration, Oral, Biological Availability, HIV Integrase, Virus Replication, Biochemistry, Chemical synthesis, Antiviral Agents, Pyridazine, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Molecular Biology, chemistry.chemical_classification, biology, Integrases, Organic Chemistry, Nucleotidyltransferase, In vitro, Integrase, Rats, Enzyme, chemistry, Models, Chemical, Enzyme inhibitor, Drug Design, Mutation, biology.protein, Molecular Medicine
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9
المؤلفون: Lori J. Gabryelski, Daria J. Hazuda, Thorsten E. Fisher, M. Reza Anari, Terry A. Lyle, Joseph P. Vacca, John S. Wai, Steven D. Young, Boyoung Kim, Matthew M. Zrada, William A. Schleif, Donnette D. Staas, Christopher J. Kochansky, Peter J. Felock
المصدر: Bioorganicmedicinal chemistry letters. 17(23)
مصطلحات موضوعية: Stereochemistry, T-Lymphocytes, Clinical Biochemistry, Pharmaceutical Science, Integrase inhibitor, HIV Integrase, Biochemistry, Cell Line, Tumor, Drug Discovery, Humans, HIV Integrase Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, Nucleotidyltransferase, Integrase, Enzyme, Viral replication, Enzyme inhibitor, Pyrazines, Lentivirus, biology.protein, Molecular Medicine
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10
المصدر: ChemInform. 34
مصطلحات موضوعية: chemistry.chemical_classification, Sulfonamides, Chemistry, Organic Chemistry, Imine, Synthon, Enantioselective synthesis, Diastereomer, Stereoisomerism, Fluorine, General Medicine, Chemical synthesis, Amino acid, chemistry.chemical_compound, Sulfinamide, Reagent, Amide, Organic chemistry, Stereoselectivity, Imines, Reformatsky reaction, Amino Acids, Alkyl, Amine derivatives