المؤلفون: Xiaoming Zha (a), Doriano Lamba (b), Lili Zhanga (c), Yinghan Lou (a, Changxu Xua (c), Di Kanga (d), Li Chen (c), Yungen Xu (d), Luyong Zhang (a), Angela De Simone (e), Sarah Samez (b, Alessandro Pesaresi (b), Jure Stojan (g), Manuela G. Lopez (h), Javier Egea (h), Vincenza Andrisano (d), Manuela Bartolini (i)

المساهمون: Zha, Xiaoming, Lamba, Doriano, Zhang, Lili, Lou, Yinghan, Xu, Changxu, Kang, Di, Chen, Li, Xu, Yungen, Zhang, Luyong, De Simone, Angela, Samez, Sarah, Pesaresi, Alessandro, Stojan, Jure, Lopez, Manuela G., Egea, Javier, Andrisano, Vincenza, Bartolini, Manuela

المصدر: Journal of medicinal chemistry 59 (2016): 114–131. doi:10.1021/acs.jmedchem.5b01119
info:cnr-pdr/source/autori:Xiaoming Zha (a), Doriano Lamba (b), Lili Zhanga (c), Yinghan Lou (a,d), Changxu Xua (c), Di Kanga (d), Li Chen (c), Yungen Xu (d), Luyong Zhang (a), Angela De Simone (e), Sarah Samez (b,f), Alessandro Pesaresi (b), Jure Stojan (g), Manuela G. Lopez (h), Javier Egea (h), Vincenza Andrisano (d), and Manuela Bartolini (i)/titolo:Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography/doi:10.1021%2Facs.jmedchem.5b01119/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:114/pagina_a:131/intervallo_pagine:114–131/volume:59

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Drug Discovery, Pharmaceutical Science, multi-ligand-target-design, Pharmaceutical Science, Crystallography, X-Ray, Torpedo, 01 natural sciences, Mice, chemistry.chemical_compound, Models, Drug Discovery, Aspartic Acid Endopeptidases, Aspartic Acid Endopeptidase, Amyloid Precursor Protein Secretase, Cholinesterase Inhibitor, Benzofuran, Nootropic Agents, Mice, Inbred ICR, Crystallography, Behavior, Animal, biology, Medicine (all), Inbred ICR, Acetylcholinesterase, Tacrine, Molecular Medicine, Chemical and Drug Induced Liver Injury, Human, medicine.drug, Cell Survival, Stereochemistry, Alzheimer Disease, Amyloid Precursor Protein Secretases, Animals, Behavior, Animal, Benzofurans, Cell Line, Cholinesterase Inhibitors, X-Ray, Drug Design, Drug-Induced Liver Injury, Humans, Molecular, Structure-Activity Relationship, structure-base drug discovery, acetylcholinesterase, 03 medical and health sciences, In vivo, medicine, Structure–activity relationship, IC50, Cholinesterase, Nootropic Agent, 010405 organic chemistry, In vitro, 0104 chemical sciences, 030104 developmental biology, chemistry, biology.protein

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2982356effe2a416f4043399aeca380
https://doi.org/10.1021/acs.jmedchem.5b01119