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1دورية أكاديمية
المؤلفون: Giulia Di Marco, Francesca Vallese, Benjamin Jourde, Christian Bergsdorf, Mattia Sturlese, Agnese De Mario, Valerie Techer-Etienne, Dorothea Haasen, Berndt Oberhauser, Simone Schleeger, Giulia Minetti, Stefano Moro, Rosario Rizzuto, Diego De Stefani, Mara Fornaro, Cristina Mammucari
المصدر: Cell Reports, Vol 30, Iss 7, Pp 2321-2331.e6 (2020)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Francesco Hofmann, William R. Sellers, Clive McCarthy, Markus Wartmann, Peter Drueckes, Dorothea Haasen, Jutta Blank, Michael D. Jones, John E. Monahan, David A. Ruddy, Emily Buck, Joseph Schoepfer, Sabrina Wagner, Brent A. Appleton, Pascal Furet, Elisa Degenkolbe, Ralph Tiedt
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3613711d07dd229641d5f5262ca31848
https://doi.org/10.1158/0008-5472.22388450.v1 -
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المؤلفون: Nicolas Soldermann, Ian Lewis, Alexander Baxter Smith, Klemens Hoegenauer, Frédéric Zecri, Dorothea Haasen, Anette Von Matt, Gregory Hollingworth, Christoph Burkhart, Christina Hebach, Rainer Wilcken, Romain M. Wolf
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5657-5662
مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, 01 natural sciences, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Quinazoline, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Enzyme Assays, Phosphoinositide-3 Kinase Inhibitors, Organic Chemistry, Combinatorial chemistry, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, Lipophilicity, Quinazolines, Molecular Medicine, Selectivity
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المؤلفون: Simone Schleeger, Mara Fornaro, Christian Bergsdorf, Benjamin Jourde, Valerie Techer-Etienne, Mattia Sturlese, Diego De Stefani, Rosario Rizzuto, Stefano Moro, Agnese De Mario, Cristina Mammucari, Francesca Vallese, Giulia Minetti, Berndt Oberhauser, Dorothea Haasen, Giulia Di Marco
المصدر: Cell Reports
Cell Reports, Vol 30, Iss 7, Pp 2321-2331.e6 (2020)مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Molecular model, High-throughput screening, mitochondrial calcium uptake, Mitochondrial Membrane Transport Proteins, high-throughput screening, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Humans, active compounds, Mitochondrial calcium uptake, Inner mitochondrial membrane, lcsh:QH301-705.5, Cation Transport Proteins, chemistry.chemical_classification, molecular modeling, Calcium-Binding Proteins, Mitochondrial calcium uniporter, Small molecule, High-Throughput Screening Assays, Amino acid, Cell biology, small molecules, MCU, 030104 developmental biology, lcsh:Biology (General), mitochondrial calcium uniporter, chemistry, Docking (molecular), MICU1, HTS, 030217 neurology & neurosurgery, HeLa Cells
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المؤلفون: Christophe Antczak, Chantale T. Guy, Ulrich Schopfer, Dorothea Haasen, Florian Fuchs, Paul Selzer
المصدر: Assay and drug development technologies. 15(6)
مصطلحات موضوعية: 0301 basic medicine, Drug Industry, 010405 organic chemistry, business.industry, Drug discovery, Phenotypic screening, Drug Evaluation, Preclinical, The Renaissance, Success factors, Biology, 01 natural sciences, 0104 chemical sciences, Biotechnology, 03 medical and health sciences, 030104 developmental biology, Phenotype, Drug Discovery, Molecular Medicine, Animals, Humans, Marketing, business, Pharmaceutical industry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4586c94ef56922bcc05fbe1f503c18
https://pubmed.ncbi.nlm.nih.gov/28800248 -
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المؤلفون: Jutta Blank, David A. Ruddy, Elisa Degenkolbe, Dorothea Haasen, Pascal Furet, Joseph Schoepfer, Ralph Tiedt, Brent A. Appleton, Sabrina Wagner, Francesco Hofmann, Michael D. Jones, John Monahan, Markus Wartmann, Clive Mccarthy, Peter Drueckes, William R. Sellers, Emily Buck
المصدر: Cancer Research. 71:5255-5264
مصطلحات موضوعية: Models, Molecular, Cancer Research, Protein Conformation, DNA Mutational Analysis, Mutation, Missense, Aminopyridines, Antineoplastic Agents, Drug resistance, Biology, Crystallography, X-Ray, medicine.disease_cause, Receptor tyrosine kinase, Mice, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Point Mutation, Missense mutation, Receptors, Growth Factor, Protein Kinase Inhibitors, Cell Line, Transformed, Mutation, Mutation Spectra, Point mutation, Imatinib, DNA, Neoplasm, Proto-Oncogene Proteins c-met, Bridged Bicyclo Compounds, Heterocyclic, Molecular biology, Protein Structure, Tertiary, Enzyme Activation, Amino Acid Substitution, Oncology, Protein kinase domain, Drug Resistance, Neoplasm, Mutagenesis, Quinolines, biology.protein, Pyrazoles, Tyrosine, Protein Binding, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b39c282911cb88e005d88a37176fd51
https://doi.org/10.1158/0008-5472.can-10-4433 -
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المؤلفون: Barbara Kistler, Franz Oswald, Jörg Wiedenmann, Michael Wolff, Dorothea Haasen, G. Ulrich Nienhaus, Ralf Heilker, Simone Krede
المصدر: Combinatorial Chemistry & High Throughput Screening. 13:3-15
مصطلحات موضوعية: MAPK/ERK pathway, Chemokine CXCL1, Recombinant Fusion Proteins, media_common.quotation_subject, Chromosomal translocation, CHO Cells, Biology, Transfection, Receptors, Interleukin-8B, Cell Line, Green fluorescent protein, Chemokine receptor, Cricetulus, Cricetinae, Drug Discovery, Animals, Humans, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Internalization, media_common, NFATC Transcription Factors, Interleukin-8, Organic Chemistry, NFAT, General Medicine, Molecular biology, High-Throughput Screening Assays, Computer Science Applications, Cell biology, Luminescent Proteins, Protein Transport, High-content screening, Calcium, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf76db1ba4d5cff2f45817d008f30280
https://doi.org/10.2174/138620710790218249 -
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المؤلفون: Ralf Heilker, Silke Hobbie, Domnic Martyres, Dorothea Haasen, Susanne Merk, Peter Seither
المصدر: SLAS Discovery. 13:40-53
مصطلحات موضوعية: Chemokine CCL11, Fluorescence-lifetime imaging microscopy, MAP Kinase Signaling System, Receptors, CCR2, Receptors, CCR3, media_common.quotation_subject, CCR3, Drug Evaluation, Preclinical, CHO Cells, In Vitro Techniques, Biology, Transfection, Biochemistry, Analytical Chemistry, Chemokine receptor, Cricetulus, Cricetinae, Fluorescence microscope, Animals, Humans, Internalization, Receptor, Chemokine CCL2, media_common, Chinese hamster ovary cell, Recombinant Proteins, Cell biology, High-content screening, Molecular Medicine, Receptors, Chemokine, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448ff2fcdfe0e9f25411dfb966f54d52
https://doi.org/10.1177/1087057107312128 -
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المؤلفون: Pascal Furet, Jasmin Wirth, Dorothee Arz, Robin Alec Fairhurst, Giorgio Caravatti, Patricia Imbach-Weese, Marc Gerspacher, Daniel Guthy, Thomas Zoller, Christine Fritsch, Joerg Trappe, Dorothea Haasen
المصدر: Bioorganicmedicinal chemistry letters. 25(17)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Class I Phosphatidylinositol 3-Kinases, Clinical Biochemistry, Pharmaceutical Science, Alpha (ethology), Molecular Dynamics Simulation, Phosphatidylinositols, Biochemistry, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, Amide, Drug Discovery, Moiety, Animals, Humans, Urea, Phosphatidylinositol, Molecular Biology, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Chemistry, Kinase, Organic Chemistry, In vitro, Thiazoles, Molecular Medicine
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المؤلفون: Susanne Merk, Ralf Heilker, Margareta Kroner, Jörg Wiedenmann, Michael Wolff, Dorothea Haasen, Udo Maier, Gerd Ulrich Nienhaus, Sandra Bordel, Martin J. Valler
المصدر: Combinatorial Chemistry & High Throughput Screening. 9:339-350
مصطلحات موضوعية: Time Factors, High-throughput screening, medicine.medical_treatment, Green Fluorescent Proteins, Drug Evaluation, Preclinical, CHO Cells, Green fluorescent protein, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Phosphatidylinositol Phosphates, Cricetinae, Drug Discovery, medicine, Animals, Humans, Phosphatidylinositol, Enzyme Inhibitors, Insulin-Like Growth Factor I, Receptor, Cells, Cultured, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, Dose-Response Relationship, Drug, biology, Chinese hamster ovary cell, Growth factor, Cell Membrane, Organic Chemistry, General Medicine, Receptor, Insulin, Computer Science Applications, Microscopy, Fluorescence, Biochemistry, chemistry, High-content screening, biology.protein, Biological Assay, Female, Proto-Oncogene Proteins c-akt
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a3fbae1bf5ea35cc3a5df1f8238536
https://doi.org/10.2174/138620706777452447