المؤلفون: Becanovic, K, Norremolle, A, Neal, SJ, Kay, C, Collins, JA, Arenillas, D, Lilja, T, Gaudenzi, G, Manoharan, S, Doty, CN, Beck, J, Lahiri, N, Portales-Casamar, E, Warby, SC, Connolly, C, DeSouza, RAG, Tabrizi, SJ, Hermanson, O, Langbehn, DR, Hayden, MR, Wasserman, WW, Leavitt, BR

المصدر: Nature neuroscience. 18(6):807

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:131352832

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Caron NS; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Anderson C; Centre for Molecular Medicine and Therapeutics, Vancouver, BC, Canada., Black HF; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Sanders SS; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Lemarié FL; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Doty CN; Centre for Molecular Medicine and Therapeutics, Vancouver, BC, Canada., Hayden MR; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

المصدر: Journal of Huntington's disease [J Huntingtons Dis] 2021; Vol. 10 (3), pp. 355-365.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101589965 Publication Model: Print Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/genetics, Alleles ; Animals ; Humans ; Huntingtin Protein/genetics ; Immunoblotting ; Mice

المؤلفون: Southwell AL; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Kordasiewicz HB; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA., Langbehn D; Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Skotte NH; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Parsons MP; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada., Villanueva EB; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Caron NS; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Østergaard ME; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA., Anderson LM; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Xie Y; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Cengio LD; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Findlay-Black H; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Doty CN; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada., Fitsimmons B; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA., Swayze EE; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA., Seth PP; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA., Raymond LA; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada., Frank Bennett C; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA., Hayden MR; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada. mrh@cmmt.ubc.ca.

المصدر: Science translational medicine [Sci Transl Med] 2018 Oct 03; Vol. 10 (461).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Cognition*, Huntingtin Protein/*metabolism , Huntington Disease/*metabolism , Huntington Disease/*physiopathology, Animals ; Anxiety/complications ; Anxiety/pathology ; Anxiety/physiopathology ; Atrophy/pathology ; Behavior, Animal/drug effects ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism ; Female ; Humans ; Huntington Disease/complications ; Huntington Disease/pathology ; Limbic System/pathology ; Male ; Mutant Proteins/metabolism ; Oligonucleotides, Antisense/pharmacology ; Primates

المؤلفون: Southwell AL; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Skotte NH; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Villanueva EB; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Østergaard ME; IONIS Pharmaceuticals, Carlsbad, CA, USA., Gu X; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Kordasiewicz HB; IONIS Pharmaceuticals, Carlsbad, CA, USA., Kay C; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Cheung D; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Xie Y; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Waltl S; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Dal Cengio L; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Findlay-Black H; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Doty CN; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Petoukhov E; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Iworima D; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Slama R; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada., Ooi J; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research and the Department of Medicine, National University of Singapore, Singapore 138648., Pouladi MA; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research and the Department of Medicine, National University of Singapore, Singapore 138648.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597., Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Swayze EE; IONIS Pharmaceuticals, Carlsbad, CA, USA., Seth PP; IONIS Pharmaceuticals, Carlsbad, CA, USA., Hayden MR; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

المصدر: Human molecular genetics [Hum Mol Genet] 2017 Mar 15; Vol. 26 (6), pp. 1115-1132.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Huntingtin Protein/*genetics , Huntington Disease/*genetics , Mutation/*genetics, Alleles ; Animals ; Disease Models, Animal ; Exons/genetics ; Heterozygote ; Humans ; Huntington Disease/pathology ; Mice ; Mice, Transgenic ; Phenotype

المؤلفون: Kay C; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Collins JA; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Skotte NH; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Southwell AL; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Warby SC; Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada., Caron NS; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Doty CN; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Nguyen B; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Griguoli A; Neurogenetics Unit and Rare Disease Centre, IRCCS Neuromed Pozzilli (IS), Pozzilli, Italy., Ross CJ; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Squitieri F; Neurogenetics Unit and Rare Disease Centre, IRCCS Neuromed Pozzilli (IS), Pozzilli, Italy., Hayden MR; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mrh@cmmt.ubc.ca.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2015 Nov; Vol. 23 (11), pp. 1759-1771. Date of Electronic Publication: 2015 Jul 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Therapy/*methods , Huntington Disease/*genetics , Huntington Disease/*therapy , Nerve Tissue Proteins/*genetics, Alleles ; Gene Expression ; Gene Targeting ; Haplotypes/genetics ; Heterozygote ; Humans ; Huntingtin Protein ; INDEL Mutation/genetics ; Oligonucleotides, Antisense/genetics ; Polymorphism, Single Nucleotide ; RNA, Messenger/genetics ; Trinucleotide Repeat Expansion/genetics ; White People/genetics

المؤلفون: Mattis VB; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Tom C; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Akimov S; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Saeedian J; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Østergaard ME; ISIS Pharmaceuticals, Carlsbad, CA, USA., Southwell AL; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada and., Doty CN; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada and., Ornelas L; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Sahabian A; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Lenaeus L; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Mandefro B; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Sareen D; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA., Arjomand J; CHDI Foundation, Princeton, NJ, USA., Hayden MR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada and., Ross CA; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Svendsen CN; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, 8400 AHSP, Los Angeles, CA 90048, USA clive.svendsen@cshs.org.

المصدر: Human molecular genetics [Hum Mol Genet] 2015 Jun 01; Vol. 24 (11), pp. 3257-71. Date of Electronic Publication: 2015 Mar 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Brain-Derived Neurotrophic Factor/*physiology , Glutamic Acid/*physiology , Huntington Disease/*metabolism , Induced Pluripotent Stem Cells/*metabolism , Neural Stem Cells/*physiology, Age of Onset ; Animals ; Apoptosis ; Cell Survival ; Cells, Cultured ; Humans ; Huntington Disease/pathology ; Mice

المؤلفون: Southwell AL; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Skotte NH; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Kordasiewicz HB; ISIS Pharmaceuticals, Carlsbad, California, USA., Østergaard ME; ISIS Pharmaceuticals, Carlsbad, California, USA., Watt AT; ISIS Pharmaceuticals, Carlsbad, California, USA., Carroll JB; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, Washington, USA., Doty CN; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Villanueva EB; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Petoukhov E; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Vaid K; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Xie Y; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Freier SM; ISIS Pharmaceuticals, Carlsbad, California, USA., Swayze EE; ISIS Pharmaceuticals, Carlsbad, California, USA., Seth PP; ISIS Pharmaceuticals, Carlsbad, California, USA., Bennett CF; ISIS Pharmaceuticals, Carlsbad, California, USA., Hayden MR; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mrh@cmmt.ubc.ca.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2014 Dec; Vol. 22 (12), pp. 2093-2106. Date of Electronic Publication: 2014 Aug 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*pathology , Huntington Disease/*therapy , Mutant Proteins/*metabolism , Nerve Tissue Proteins/*genetics , Oligonucleotides, Antisense/*administration & dosage , Thionucleotides/*administration & dosage, Animals ; Brain/metabolism ; Disease Models, Animal ; Gene Silencing ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; Huntington Disease/pathology ; Injections ; Mice ; Mice, Inbred C57BL ; Molecular Targeted Therapy ; Nerve Tissue Proteins/metabolism ; Oligonucleotides, Antisense/pharmacology ; Polymorphism, Single Nucleotide ; Rats ; Rats, Sprague-Dawley ; Thionucleotides/pharmacology

المؤلفون: Skotte NH; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Southwell AL; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Østergaard ME; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Carroll JB; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, Washington, United States of America., Warby SC; Center for Advanced Research in Sleep Medicine, Department of Psychiatry, University of Montréal, Montréal, Quebec, Canada., Doty CN; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Petoukhov E; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Vaid K; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Kordasiewicz H; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Watt AT; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Freier SM; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Hung G; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Seth PP; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Bennett CF; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Swayze EE; ISIS Pharmaceuticals, Carlsbad, California, United States of America., Hayden MR; Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

المصدر: PloS one [PLoS One] 2014 Sep 10; Vol. 9 (9), pp. e107434. Date of Electronic Publication: 2014 Sep 10 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Therapy* , Mutation*, Huntington Disease/*therapy , Nerve Tissue Proteins/*antagonists & inhibitors , Neurons/*metabolism , Oligonucleotides, Antisense/*genetics, Alleles ; Animals ; Base Sequence ; Drug Design ; Embryo, Mammalian ; Female ; Gene Expression ; Hippocampus/metabolism ; Hippocampus/pathology ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Mice ; Molecular Sequence Data ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/pathology ; Oligonucleotides, Antisense/chemistry ; Polymorphism, Single Nucleotide ; Primary Cell Culture ; RNA Interference ; Structure-Activity Relationship

المؤلفون: Parsons MP; From the Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3 and., Kang R, Buren C, Dau A, Southwell AL, Doty CN, Sanders SS, Hayden MR, Raymond LA

المصدر: The Journal of biological chemistry [J Biol Chem] 2014 Feb 07; Vol. 289 (6), pp. 3518-28. Date of Electronic Publication: 2013 Dec 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Corpus Striatum/*metabolism , Guanylate Kinases/*metabolism , Lipoylation/*physiology , Membrane Proteins/*metabolism , Nerve Tissue Proteins/*metabolism , Neurons/*metabolism , Nuclear Proteins/*metabolism , Post-Synaptic Density/*metabolism, Animals ; Corpus Striatum/cytology ; Disks Large Homolog 4 Protein ; Gene Knockdown Techniques ; Guanylate Kinases/genetics ; Hippocampus/cytology ; Hippocampus/metabolism ; Huntingtin Protein ; Membrane Proteins/genetics ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Neurons/cytology ; Nuclear Proteins/genetics ; Post-Synaptic Density/genetics ; Receptors, AMPA/genetics ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism