المؤلفون: Martino Bertoni, Yuanpeng Xiong, Jing Tang, Charles Karan, Ziaurrehman Tanoli, Tingzhong Tian, Julio Saez-Rodriguez, Chung, Fangping Wan, Robert J. Allaway, Miquel Duran-Frigola, Shuya Li, Andrea Califano, Patrick Aloy, Justin Guinney, Daniela S. Gerhard, Shuyu Zheng, Ronald Realubit, Jianyang Zeng, Bence Szalai, Oriol Guitart-Pla, Wenyu Wang, Pau Badia-i-Mompel, Mohieddin Jafari, Alberto Pessia, Lidia Mateo, Adrià Fernández-Torras, Douglass Ef

مصطلحات موضوعية: Drug, Clinical Oncology, 0303 health sciences, Computational model, Computer science, media_common.quotation_subject, Inference, Computational biology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Mechanism of action, 030220 oncology & carcinogenesis, Pharmacogenomics, medicine, Polypharmacology, medicine.symptom, 030304 developmental biology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8d6105a6b5772c0f9a74a4d1989ec2ee
https://doi.org/10.1101/2020.12.21.423514

المؤلفون: Mundi PS; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Dela Cruz FS; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Grunn A; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Diolaiti D; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Mauguen A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Rainey AR; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Guillan K; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Siddiquee A; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., You D; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Realubit R; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Karan C; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Ortiz MV; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Douglass EF; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Accordino M; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Mistretta S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Brogan F; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Bruce JN; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York., Caescu CI; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Carvajal RD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Crew KD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Decastro G; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Columbia University Irving Medical Center, New York, New York., Heaney M; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Henick BS; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Hershman DL; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York., Hou JY; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Iwamoto FM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurology, Columbia University Irving Medical Center, New York, New York., Jurcic JG; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Kiran RP; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Surgery, Columbia University Irving Medical Center, New York, New York., Kluger MD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Surgery, Columbia University Irving Medical Center, New York, New York., Kreisl T; Department of Otolaryngology Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York., Lamanna N; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Lassman AB; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurology, Columbia University Irving Medical Center, New York, New York., Lim EA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Manji GA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., McKhann GM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York., McKiernan JM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Columbia University Irving Medical Center, New York, New York., Neugut AI; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York., Olive KP; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Rosenblat T; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Schwartz GK; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Shu CA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Sisti MB; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York.; Department of Otolaryngology Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York.; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, New York., Tergas A; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Vattakalam RM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Welch M; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurology, Columbia University Irving Medical Center, New York, New York., Wenske S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Columbia University Irving Medical Center, New York, New York., Wright JD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Canoll P; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York., Hibshoosh H; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York., Kalinsky K; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Winship Cancer Institute of Emory University and Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Aburi M; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, New York., Alvarez MJ; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; DarwinHealth Inc., New York, New York., Kung AL; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, New York.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York.; J.P. Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, New York.

المصدر: Cancer discovery [Cancer Discov] 2023 Jun 02; Vol. 13 (6), pp. 1386-1407.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/genetics , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Transcriptome ; Precision Medicine/methods ; Medical Oncology/methods

المؤلفون: Vasciaveo A; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Arriaga JM; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., de Almeida FN; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Zou M; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Douglass EF; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Picech F; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Shibata M; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Rodriguez-Calero A; Department for Biomedical Research, University of Bern, Bern, Switzerland.; Institute of Pathology, University of Bern and Inselspital, Bern, Switzerland., de Brot S; COMPATH, Institute of Animal Pathology, University of Bern, Bern, Switzerland., Mitrofanova A; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Chua CW; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Karan C; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; J.P. Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, New York., Realubit R; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; J.P. Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, New York., Pampou S; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; J.P. Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, New York., Kim JY; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Afari SN; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Mukhammadov T; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Zanella L; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Corey E; Department of Urology, University of Washington, Seattle, Washington., Alvarez MJ; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; DarwinHealth Inc., New York, New York., Rubin MA; Department for Biomedical Research, University of Bern, Bern, Switzerland.; Bern Center for Precision Medicine (BCPM), Bern, Switzerland., Shen MM; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Califano A; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; J.P. Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Biomedical Informatics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York., Abate-Shen C; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

المصدر: Cancer discovery [Cancer Discov] 2023 Feb 06; Vol. 13 (2), pp. 386-409.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Prostatic Neoplasms, Castration-Resistant*/pathology, Male ; Mice ; Animals ; Humans ; Precision Medicine ; Androgen Receptor Antagonists ; Transcriptome ; Gene Expression Profiling ; Nitriles ; Receptors, Androgen/genetics

المؤلفون: Douglass EF Jr; Department of Systems Biology, Columbia University Irving Medical Center, 1130 Saint Nicholas Ave., New York, NY 10032, USA.; Pharmaceutical and Biomedical Sciences, University of Georgia, 250 W. Green Street, Athens, GA 30602, USA., Allaway RJ; Computational Oncology Group, Sage Bionetworks, 2901 Third Ave., Ste 330, Seattle, WA 98121, USA., Szalai B; Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary., Wang W; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Tian T; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China., Fernández-Torras A; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Realubit R; Department of Systems Biology, Columbia University Irving Medical Center, 1130 Saint Nicholas Ave., New York, NY 10032, USA., Karan C; Department of Systems Biology, Columbia University Irving Medical Center, 1130 Saint Nicholas Ave., New York, NY 10032, USA., Zheng S; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Pessia A; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Tanoli Z; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Jafari M; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Wan F; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China., Li S; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China., Xiong Y; Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China., Duran-Frigola M; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Bertoni M; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Badia-I-Mompel P; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Mateo L; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Guitart-Pla O; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Chung V; Computational Oncology Group, Sage Bionetworks, 2901 Third Ave., Ste 330, Seattle, WA 98121, USA., Tang J; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Zeng J; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China.; MOE Key Laboratory of Bioinformatics, Tsinghua University, Beijing 100084, China., Aloy P; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany., Guinney J; Computational Oncology Group, Sage Bionetworks, 2901 Third Ave., Ste 330, Seattle, WA 98121, USA., Gerhard DS; Office of Cancer Genomics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, 1130 Saint Nicholas Ave., New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, 1130 Saint Nicholas Ave., New York, NY 10032, USA.; Department of Medicine, Columbia University Irving Medical Center, 630 W 168th Street, New York, NY 10032, USA.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, 701 W 168th Street, New York, NY 10032, USA.; Department of Biomedical Informatics, Columbia University Irving Medical Center, 622 W 168th Street, New York, NY 10032, USA.

مؤلفون مشاركون: DREAM CTD-squared Pancancer Drug Activity Challenge Consortium

المصدر: Cell reports. Medicine [Cell Rep Med] 2022 Jan 18; Vol. 3 (1), pp. 100492. Date of Electronic Publication: 2022 Jan 18 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

مواضيع طبية MeSH: Polypharmacology*, Neoplasms/*drug therapy, Algorithms ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Neural Networks, Computer ; Protein Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic

المؤلفون: Paull EO; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Aytes A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell), Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Barcelona 08908, Spain; Program Against Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Barcelona 08908, Spain., Jones SJ; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Subramaniam PS; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Giorgi FM; Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy., Douglass EF; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Tagore S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Chu B; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Vasciaveo A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Zheng S; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Verhaak R; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Abate-Shen C; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Urology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: ca2319@cumc.columbia.edu., Alvarez MJ; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; DarwinHealth, Inc. New York, NY 10018, USA. Electronic address: malvarez@darwinhealth.com., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; DarwinHealth, Inc. New York, NY 10018, USA; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: ac2248@columbia.edu.

المصدر: Cell [Cell] 2021 Jan 21; Vol. 184 (2), pp. 334-351.e20. Date of Electronic Publication: 2021 Jan 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Transcription, Genetic*, Neoplasms/*genetics, Adenocarcinoma/genetics ; Animals ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Genome, Human ; HEK293 Cells ; Humans ; Mice, Nude ; Mutation/genetics ; Reproducibility of Results ; Mice

المؤلفون: Douglass EF Jr; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA. Electronic address: eugene.douglass@uga.edu., Spiegel DA; Department of Chemistry, Yale University, New Haven, Connecticut, USA; Department of Pharmacology, Yale University, New Haven, Connecticut, USA.

المصدر: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100331. Date of Electronic Publication: 2021 Mar 01.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitin-Protein Ligases*/metabolism, Kinetics ; Ligands ; Proteolysis

المؤلفون: Douglass EF Jr; Department of Systems Biology, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA.

المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Nov 02; Vol. 21 (21), pp. 3047-3050. Date of Electronic Publication: 2020 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

مواضيع طبية MeSH: Big Data* , Precision Medicine*, Databases, Factual ; Humans

المؤلفون: Laise P; DarwinHealth Inc, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Bosker G; DarwinHealth Inc, New York, NY, USA., Sun X; DarwinHealth Inc, New York, NY, USA., Shen Y; DarwinHealth Inc, New York, NY, USA., Douglass EF; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Karan C; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Realubit RB; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Pampou S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA., Alvarez MJ; DarwinHealth Inc, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2020 May 17. Date of Electronic Publication: 2020 May 17.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Ding H; Department of Systems Biology, Columbia University, New York, NY, 10032, USA.; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA., Douglass EF Jr; Department of Systems Biology, Columbia University, New York, NY, 10032, USA., Sonabend AM; Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA., Mela A; Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA., Bose S; Department of Systems Biology, Columbia University, New York, NY, 10032, USA.; GlaxoSmithKline, King of Prussia, PA, 19406, USA., Gonzalez C; Department of Systems Biology, Columbia University, New York, NY, 10032, USA.; Amsterdam Neuroscience, Amsterdam, 1081, The Netherlands., Canoll PD; Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA., Sims PA; Department of Systems Biology, Columbia University, New York, NY, 10032, USA., Alvarez MJ; Department of Systems Biology, Columbia University, New York, NY, 10032, USA. malvarez@darwinhealth.com.; DarwinHealth Inc, New York, NY, 10032, USA. malvarez@darwinhealth.com., Califano A; Department of Systems Biology, Columbia University, New York, NY, 10032, USA. andrea.califano@columbia.edu.; DarwinHealth Inc, New York, NY, 10032, USA. andrea.califano@columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA. andrea.califano@columbia.edu.; J.P. Sulzberger Columbia Genome Center, Columbia University, New York, NY, 10032, USA. andrea.califano@columbia.edu.; Department of Biomedical Informatics, Columbia University, New York, NY, 10032, USA. andrea.califano@columbia.edu.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA. andrea.califano@columbia.edu.

المصدر: Nature communications [Nat Commun] 2018 Apr 16; Vol. 9 (1), pp. 1471. Date of Electronic Publication: 2018 Apr 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Algorithms* , Gene Regulatory Networks*, Brain Neoplasms/*genetics , Cell Lineage/*genetics , Glioblastoma/*genetics , Transcription Factors/*genetics, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Lineage/immunology ; Disease Models, Animal ; Gene Expression Regulation ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mice ; Organ Specificity ; Protein Interaction Mapping ; Single-Cell Analysis/methods ; Transcription Factors/immunology

المؤلفون: Santori FR; The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: fsantof01@gmail.com., Huang P; Metabolic Disease Program, Sanford-Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA., van de Pavert SA; VU University Medical Center, Department of Molecular Cell Biology and Immunology, van der Boechorststraat 7, 1081BT Amsterdam, the Netherlands., Douglass EF Jr; The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA., Leaver DJ; Center for Chemical Biology and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Haubrich BA; Center for Chemical Biology and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Keber R; Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domzale, Slovenia., Lorbek G; Institute of Biochemistry, Center for Functional Genomics and Bio-chips, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia., Konijn T; VU University Medical Center, Department of Molecular Cell Biology and Immunology, van der Boechorststraat 7, 1081BT Amsterdam, the Netherlands., Rosales BN; Center for Chemical Biology and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Rozman D; Institute of Biochemistry, Center for Functional Genomics and Bio-chips, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia., Horvat S; Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domzale, Slovenia; National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia., Rahier A; Institut de Biologie Moleculaire des Plantes (IBMP), CNRS-UPR2357, 67083 Strasbourg, France., Mebius RE; VU University Medical Center, Department of Molecular Cell Biology and Immunology, van der Boechorststraat 7, 1081BT Amsterdam, the Netherlands., Rastinejad F; Metabolic Disease Program, Sanford-Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA., Nes WD; Center for Chemical Biology and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Littman DR; The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.

المصدر: Cell metabolism [Cell Metab] 2015 Feb 03; Vol. 21 (2), pp. 286-298.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

مواضيع طبية MeSH: Lymphocytes/*metabolism , Nuclear Receptor Subfamily 1, Group F, Member 3/*metabolism , Sterols/*metabolism, Animals ; Cell Line ; Cholesterol/biosynthesis ; Drosophila melanogaster/cytology ; HEK293 Cells ; Humans ; Ligands ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Sterol 14-Demethylase/deficiency ; Sterol 14-Demethylase/metabolism ; Sterols/chemistry ; Th17 Cells